Details for: RAB14

Gene ID: 51552

Symbol: RAB14

Ensembl ID: ENSG00000119396

Description: RAB14, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 395.1905
    Cell Significance Index: -61.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 229.6531
    Cell Significance Index: -58.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 171.5995
    Cell Significance Index: -70.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 139.8129
    Cell Significance Index: -56.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.0777
    Cell Significance Index: -64.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.7285
    Cell Significance Index: -66.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.0790
    Cell Significance Index: -57.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.0051
    Cell Significance Index: -64.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7812
    Cell Significance Index: -55.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.4380
    Cell Significance Index: -64.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.8394
    Cell Significance Index: -48.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2098
    Cell Significance Index: -22.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4445
    Cell Significance Index: 440.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4294
    Cell Significance Index: 298.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8467
    Cell Significance Index: 50.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7201
    Cell Significance Index: 15.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6624
    Cell Significance Index: 86.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4971
    Cell Significance Index: 300.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4376
    Cell Significance Index: 74.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3014
    Cell Significance Index: 710.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2225
    Cell Significance Index: 167.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2172
    Cell Significance Index: 538.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0952
    Cell Significance Index: 75.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0920
    Cell Significance Index: 70.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0647
    Cell Significance Index: 28.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0122
    Cell Significance Index: 71.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8493
    Cell Significance Index: 39.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8386
    Cell Significance Index: 38.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8224
    Cell Significance Index: 163.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8007
    Cell Significance Index: 37.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7619
    Cell Significance Index: 273.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7124
    Cell Significance Index: 115.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6902
    Cell Significance Index: 36.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6896
    Cell Significance Index: 81.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6359
    Cell Significance Index: 47.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5891
    Cell Significance Index: 37.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5709
    Cell Significance Index: 515.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5061
    Cell Significance Index: 31.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4743
    Cell Significance Index: 60.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3760
    Cell Significance Index: 37.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3417
    Cell Significance Index: 44.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3155
    Cell Significance Index: 60.0500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2660
    Cell Significance Index: 2.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2580
    Cell Significance Index: 5.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2525
    Cell Significance Index: 5.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2072
    Cell Significance Index: 5.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1801
    Cell Significance Index: 30.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1707
    Cell Significance Index: 118.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1376
    Cell Significance Index: 4.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0438
    Cell Significance Index: 32.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0068
    Cell Significance Index: 12.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0035
    Cell Significance Index: 2.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0029
    Cell Significance Index: 0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0026
    Cell Significance Index: 1.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0195
    Cell Significance Index: -12.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0213
    Cell Significance Index: -39.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0255
    Cell Significance Index: -39.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0274
    Cell Significance Index: -20.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0438
    Cell Significance Index: -59.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0457
    Cell Significance Index: -25.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0483
    Cell Significance Index: -21.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0601
    Cell Significance Index: -6.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0751
    Cell Significance Index: -4.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0777
    Cell Significance Index: -1.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0930
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1406
    Cell Significance Index: -29.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1535
    Cell Significance Index: -3.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1739
    Cell Significance Index: -9.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1863
    Cell Significance Index: -5.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1894
    Cell Significance Index: -54.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2001
    Cell Significance Index: -22.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2324
    Cell Significance Index: -17.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2422
    Cell Significance Index: -35.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2483
    Cell Significance Index: -3.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2589
    Cell Significance Index: -17.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2626
    Cell Significance Index: -29.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3023
    Cell Significance Index: -4.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3072
    Cell Significance Index: -35.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3320
    Cell Significance Index: -9.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4423
    Cell Significance Index: -7.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4436
    Cell Significance Index: -2.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4898
    Cell Significance Index: -17.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5045
    Cell Significance Index: -39.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5083
    Cell Significance Index: -10.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5143
    Cell Significance Index: -9.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5896
    Cell Significance Index: -26.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6006
    Cell Significance Index: -62.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6123
    Cell Significance Index: -19.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6795
    Cell Significance Index: -16.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7152
    Cell Significance Index: -19.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7302
    Cell Significance Index: -27.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7350
    Cell Significance Index: -8.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8514
    Cell Significance Index: -52.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9522
    Cell Significance Index: -25.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0188
    Cell Significance Index: -29.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0663
    Cell Significance Index: -27.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1234
    Cell Significance Index: -33.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1753
    Cell Significance Index: -30.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2176
    Cell Significance Index: -20.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3277
    Cell Significance Index: -43.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB14 is a small GTPase that belongs to the RAS superfamily, characterized by its ability to bind GTP and GDP. This gene is specifically expressed in various cell types, including hematopoietic progenitor cells, embryonic stem cells, and mucosal-type mast cells. RAB14 is also found in the plasma membrane and is involved in regulating membrane trafficking, including vesicle-mediated transport and endocytic recycling. **Pathways and Functions:** RAB14 is involved in several cellular pathways, including: 1. **Membrane Trafficking:** RAB14 regulates the formation, movement, and fusion of vesicles, including phagosomes, lysosomes, and recycling endosomes. This process is essential for maintaining cellular homeostasis and responding to environmental cues. 2. **Immune Function:** RAB14 plays a critical role in the regulation of immune cell function, including neutrophil degranulation, phagolysosome assembly, and phagosome maturation. This gene is specifically expressed in neutrophils and other immune cells, highlighting its importance in immune system development and function. 3. **Development:** RAB14 is involved in regulating embryonic development, including the formation of the endomembrane system and the establishment of cellular polarity. This gene is specifically expressed in embryonic stem cells and other developmentally restricted cells. 4. **Signaling Pathways:** RAB14 interacts with various signaling proteins, including myosin V and the fibroblast growth factor receptor, to regulate cellular signaling and response to environmental cues. **Clinical Significance:** Dysregulation of RAB14 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Abnormal RAB14 expression has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, highlighting its importance in regulating immune cell function. 2. **Cancer:** RAB14 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** RAB14 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its importance in regulating cellular trafficking and signaling. In conclusion, RAB14 is a multifaceted gene involved in regulating membrane trafficking, immune function, and development. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of autoimmune and cancer disorders. Further research is needed to fully elucidate the mechanisms by which RAB14 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 2100554549

Symbol: RAB14_HUMAN

Name: N/A

UniProtKB Accession Codes:

P61106 B3KR31 P35287 Q5JVD4 Q6Q7K5 Q969L0 Q9UI11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16962593

Title: Rab14 is part of the early endosomal clathrin-coated TGN microdomain.

PubMed ID: 16962593

DOI: 10.1016/j.febslet.2006.08.053

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20534812

Title: Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.

PubMed ID: 20534812

DOI: 10.1091/mbc.e10-01-0074

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 22595670

Title: Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells.

PubMed ID: 22595670

DOI: 10.1016/j.devcel.2012.04.010

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16034420

Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

PubMed ID: 16034420

DOI: 10.1038/nature03798

Sequence Information:

  • Length: 215
  • Mass: 23897
  • Checksum: BC8A8B98FB9944AC
  • Sequence:
    • MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT RIIEVSGQKI 
KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN HLSSWLTDAR NLTNPNTVII 
LIGNKADLEA QRDVTYEEAK QFAEENGLLF LEASAKTGEN VEDAFLEAAK KIYQNIQDGS 
LDLNAAESGV QHKPSAPQGG RLTSEPQPQR EGCGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.