Details for: ACKR4

Gene ID: 51554

Symbol: ACKR4

Ensembl ID: ENSG00000129048

Description: atypical chemokine receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.7546
    Cell Significance Index: -10.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.7865
    Cell Significance Index: -10.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7808
    Cell Significance Index: 338.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1648
    Cell Significance Index: 60.5100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.0774
    Cell Significance Index: 8.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0303
    Cell Significance Index: 61.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8069
    Cell Significance Index: 79.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7262
    Cell Significance Index: 78.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7021
    Cell Significance Index: 633.9500
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.4787
    Cell Significance Index: 3.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4649
    Cell Significance Index: 75.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4399
    Cell Significance Index: 9.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4043
    Cell Significance Index: 27.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3980
    Cell Significance Index: 78.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3695
    Cell Significance Index: 10.6500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3685
    Cell Significance Index: 5.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3547
    Cell Significance Index: 11.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3407
    Cell Significance Index: 6.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1889
    Cell Significance Index: 22.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1812
    Cell Significance Index: 32.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1779
    Cell Significance Index: 6.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1597
    Cell Significance Index: 12.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1548
    Cell Significance Index: 7.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1385
    Cell Significance Index: 2.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1365
    Cell Significance Index: 8.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1304
    Cell Significance Index: 90.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1056
    Cell Significance Index: 4.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0962
    Cell Significance Index: 1.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0911
    Cell Significance Index: 3.4500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0788
    Cell Significance Index: 1.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0664
    Cell Significance Index: 102.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0618
    Cell Significance Index: 1.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0568
    Cell Significance Index: 6.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0560
    Cell Significance Index: 76.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0480
    Cell Significance Index: 9.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0479
    Cell Significance Index: 88.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0405
    Cell Significance Index: 5.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0342
    Cell Significance Index: 64.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0227
    Cell Significance Index: 0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0206
    Cell Significance Index: 7.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0155
    Cell Significance Index: 0.2400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0153
    Cell Significance Index: 0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0005
    Cell Significance Index: -0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0025
    Cell Significance Index: -1.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0077
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0104
    Cell Significance Index: -3.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0140
    Cell Significance Index: -0.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0140
    Cell Significance Index: -0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0176
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -13.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0239
    Cell Significance Index: -0.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0246
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0274
    Cell Significance Index: -4.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0376
    Cell Significance Index: -1.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0482
    Cell Significance Index: -3.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0593
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0605
    Cell Significance Index: -12.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0650
    Cell Significance Index: -7.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0660
    Cell Significance Index: -4.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0687
    Cell Significance Index: -9.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0702
    Cell Significance Index: -7.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0768
    Cell Significance Index: -2.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0809
    Cell Significance Index: -3.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0858
    Cell Significance Index: -8.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0933
    Cell Significance Index: -12.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1086
    Cell Significance Index: -12.4400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1131
    Cell Significance Index: -1.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1150
    Cell Significance Index: -1.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1251
    Cell Significance Index: -3.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1269
    Cell Significance Index: -7.1200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1358
    Cell Significance Index: -1.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1481
    Cell Significance Index: -4.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1601
    Cell Significance Index: -4.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1630
    Cell Significance Index: -12.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1698
    Cell Significance Index: -10.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1791
    Cell Significance Index: -11.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1844
    Cell Significance Index: -8.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2049
    Cell Significance Index: -5.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2061
    Cell Significance Index: -5.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2194
    Cell Significance Index: -11.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2414
    Cell Significance Index: -5.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2592
    Cell Significance Index: -9.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2658
    Cell Significance Index: -10.8900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2660
    Cell Significance Index: -4.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2674
    Cell Significance Index: -3.8400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2711
    Cell Significance Index: -3.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2868
    Cell Significance Index: -9.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2898
    Cell Significance Index: -3.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2928
    Cell Significance Index: -9.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3035
    Cell Significance Index: -4.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3052
    Cell Significance Index: -5.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3114
    Cell Significance Index: -3.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3292
    Cell Significance Index: -11.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3299
    Cell Significance Index: -12.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine Receptor Activity:** ACKR4 exhibits chemokine receptor activity, which enables it to bind to chemokines and initiate downstream signaling cascades. 2. **Diverse Cellular Expression:** ACKR4 is expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, enteroendocrine cells, bladder urothelial cells, and others. 3. **Signaling Pathways:** The ACKR4 receptor is involved in various signaling pathways, including calcium-mediated signaling, cell chemotaxis, and chemokine-mediated signaling. 4. **GPCR Characteristics:** ACKR4 belongs to the GPCR family, which is characterized by its ability to bind ligands and initiate signaling cascades. **Pathways and Functions:** 1. **Chemokine Signaling:** ACKR4 binds to chemokines, leading to the activation of downstream signaling pathways that regulate cellular functions, including chemotaxis, immune response, and cell proliferation. 2. **Calcium-Mediated Signaling:** The ACKR4 receptor is involved in calcium-mediated signaling, which regulates various cellular processes, including muscle contraction, neuronal signaling, and immune response. 3. **Cell Chemotaxis:** ACKR4 plays a critical role in cell chemotaxis, which is the movement of cells in response to chemical stimuli. 4. **Immune Response:** The ACKR4 receptor is involved in the regulation of immune response, including the activation of immune cells and the production of cytokines. **Clinical Significance:** 1. **Cancer Research:** ACKR4 has been implicated in the development and progression of various cancers, including colorectal cancer, breast cancer, and leukemia. 2. **Immune-Mediated Diseases:** The ACKR4 receptor is involved in the regulation of immune response, making it a potential target for the treatment of immune-mediated diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological Disorders:** ACKR4 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 4. **Infectious Diseases:** The ACKR4 receptor is involved in the regulation of immune response, making it a potential target for the treatment of infectious diseases, such as tuberculosis and HIV. In conclusion, the ACKR4 gene is a critical regulator of various cellular processes, including chemotaxis, immune response, and signaling pathways. Its involvement in various diseases has significant implications for the development of novel therapeutic strategies. Further research is needed to fully understand the function and significance of ACKR4 and its potential applications in human disease.

Genular Protein ID: 2858967535

Symbol: ACKR4_HUMAN

Name: Atypical chemokine receptor 4

UniProtKB Accession Codes:

Q9NPB9 B2R9U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10767544

Title: Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart.

PubMed ID: 10767544

DOI: 10.1016/s0378-1119(00)00076-7

PubMed ID: 10734104

Title: CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines.

PubMed ID: 10734104

DOI: 10.1074/jbc.275.13.9550

PubMed ID: 10706668

Title: Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.

PubMed ID: 10706668

DOI: 10.4049/jimmunol.164.6.2851

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11981810

Title: Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.

PubMed ID: 11981810

DOI: 10.1002/1521-4141(200205)32:5<1230::aid-immu1230>3.0.co;2-l

PubMed ID: 20373092

Title: Chemokine decoy receptors: structure-function and biological properties.

PubMed ID: 20373092

DOI: 10.1007/82_2010_19

PubMed ID: 22698181

Title: The biochemistry and biology of the atypical chemokine receptors.

PubMed ID: 22698181

DOI: 10.1016/j.imlet.2012.04.004

PubMed ID: 23356288

Title: Atypical chemokine receptors: from silence to sound.

PubMed ID: 23356288

DOI: 10.1042/bst20120246

PubMed ID: 23121557

Title: Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.

PubMed ID: 23121557

DOI: 10.1111/bph.12042

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

Sequence Information:

  • Length: 350
  • Mass: 39914
  • Checksum: 8E26049D2D5757C8
  • Sequence:
    • MALEQNQSTD YYYEENEMNG TYDYSQYELI CIKEDVREFA KVFLPVFLTI VFVIGLAGNS 
MVVAIYAYYK KQRTKTDVYI LNLAVADLLL LFTLPFWAVN AVHGWVLGKI MCKITSALYT 
LNFVSGMQFL ACISIDRYVA VTKVPSQSGV GKPCWIICFC VWMAAILLSI PQLVFYTVND 
NARCIPIFPR YLGTSMKALI QMLEICIGFV VPFLIMGVCY FITARTLMKM PNIKISRPLK 
VLLTVVIVFI VTQLPYNIVK FCRAIDIIYS LITSCNMSKR MDIAIQVTES IALFHSCLNP 
ILYVFMGASF KNYVMKVAKK YGSWRRQRQS VEEFPFDSEG PTEPTSTFSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.