Details for: LARP7

Gene ID: 51574

Symbol: LARP7

Ensembl ID: ENSG00000174720

Description: La ribonucleoprotein 7, transcriptional regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 326.3038
    Cell Significance Index: -50.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.5107
    Cell Significance Index: -49.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 137.6631
    Cell Significance Index: -56.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.0901
    Cell Significance Index: -59.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.6195
    Cell Significance Index: -47.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.7962
    Cell Significance Index: -54.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.0284
    Cell Significance Index: -59.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.8302
    Cell Significance Index: -47.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.4210
    Cell Significance Index: -57.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.3940
    Cell Significance Index: -49.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.0049
    Cell Significance Index: -59.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1343
    Cell Significance Index: -37.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1762
    Cell Significance Index: -24.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.8048
    Cell Significance Index: 23.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4779
    Cell Significance Index: 266.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3409
    Cell Significance Index: 164.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1731
    Cell Significance Index: 161.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0023
    Cell Significance Index: 69.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9514
    Cell Significance Index: 25.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9402
    Cell Significance Index: 120.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9083
    Cell Significance Index: 496.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8867
    Cell Significance Index: 392.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8573
    Cell Significance Index: 7.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8185
    Cell Significance Index: 52.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7312
    Cell Significance Index: 145.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6617
    Cell Significance Index: 46.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5973
    Cell Significance Index: 37.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5959
    Cell Significance Index: 70.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5728
    Cell Significance Index: 12.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5531
    Cell Significance Index: 28.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5360
    Cell Significance Index: 24.9900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5162
    Cell Significance Index: 7.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4899
    Cell Significance Index: 13.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4894
    Cell Significance Index: 98.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4466
    Cell Significance Index: 20.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4182
    Cell Significance Index: 68.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3173
    Cell Significance Index: 31.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2424
    Cell Significance Index: 4.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2371
    Cell Significance Index: 8.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2307
    Cell Significance Index: 6.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1994
    Cell Significance Index: 9.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1903
    Cell Significance Index: 171.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1891
    Cell Significance Index: 14.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1882
    Cell Significance Index: 35.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1728
    Cell Significance Index: 4.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1721
    Cell Significance Index: 29.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1625
    Cell Significance Index: 20.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1618
    Cell Significance Index: 58.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1427
    Cell Significance Index: 98.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1004
    Cell Significance Index: 7.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0603
    Cell Significance Index: 2.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0432
    Cell Significance Index: 31.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0431
    Cell Significance Index: 1.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0323
    Cell Significance Index: 1.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0235
    Cell Significance Index: -17.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0314
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0337
    Cell Significance Index: -21.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0402
    Cell Significance Index: -54.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0503
    Cell Significance Index: -22.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0520
    Cell Significance Index: -5.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0646
    Cell Significance Index: -36.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0659
    Cell Significance Index: -1.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0756
    Cell Significance Index: -1.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0898
    Cell Significance Index: -2.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1198
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1260
    Cell Significance Index: -26.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1485
    Cell Significance Index: -17.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1559
    Cell Significance Index: -44.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1611
    Cell Significance Index: -8.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1754
    Cell Significance Index: -5.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2058
    Cell Significance Index: -29.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2374
    Cell Significance Index: -2.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2584
    Cell Significance Index: -30.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2686
    Cell Significance Index: -16.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4282
    Cell Significance Index: -7.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4318
    Cell Significance Index: -34.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4632
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4863
    Cell Significance Index: -55.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4999
    Cell Significance Index: -7.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5484
    Cell Significance Index: -14.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5524
    Cell Significance Index: -57.5200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5749
    Cell Significance Index: -4.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5906
    Cell Significance Index: -6.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6159
    Cell Significance Index: -16.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6519
    Cell Significance Index: -43.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7287
    Cell Significance Index: -36.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8155
    Cell Significance Index: -50.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8481
    Cell Significance Index: -9.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8860
    Cell Significance Index: -39.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9309
    Cell Significance Index: -24.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9771
    Cell Significance Index: -25.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9782
    Cell Significance Index: -28.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0671
    Cell Significance Index: -40.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0722
    Cell Significance Index: -15.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1038
    Cell Significance Index: -40.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LARP7 is a 60-kDa protein that belongs to the La autoantigen family. It is characterized by its ability to bind to specific RNA sequences, including the 3'-end of U6 snRNA, and regulate various aspects of RNA processing and transcription. The protein's interactions with other RNA-binding proteins and the spliceosome complex highlight its central role in the regulation of mRNA splicing and transcription elongation. **Pathways and Functions:** LARP7's involvement in RNA processing and transcriptional regulation is multifaceted and involves several key pathways: 1. **mRNA Splicing:** LARP7 interacts with the spliceosome complex to regulate the splicing of specific mRNAs, influencing the expression of genes involved in cellular differentiation and development. 2. **Transcription Elongation:** LARP7 inhibits transcription elongation by RNA polymerase II, thereby regulating the expression of genes involved in cell growth, differentiation, and survival. 3. **Viral Transcription Regulation:** LARP7 can regulate the expression of viral genes by interacting with viral RNAs and influencing the activity of RNA polymerase II. 4. **RNA Binding:** LARP7's ability to bind to specific RNA sequences allows it to regulate the expression of genes involved in RNA processing and transcription. **Clinical Significance:** LARP7's involvement in RNA processing and transcriptional regulation has significant implications for various diseases, including: 1. **Immune System Disorders:** Alterations in LARP7 expression have been linked to immune system disorders, such as autoimmune diseases and cancer. 2. **Neurological Disorders:** LARP7's role in RNA processing and transcriptional regulation may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** LARP7's ability to regulate the expression of genes involved in cell growth and differentiation may contribute to the development and progression of cancer. In conclusion, LARP7 is a multifunctional protein that plays a critical role in RNA processing and transcriptional regulation. Its widespread expression across different cell types and its involvement in various cellular processes highlight its significance in maintaining cellular homeostasis. Further research on LARP7's role in disease is necessary to fully understand its clinical significance and potential therapeutic applications.

Genular Protein ID: 592353492

Symbol: LARP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4G0J3 B2ZHN6 Q3B7A9 Q9P1S7 Q9Y3Z8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 2 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 18483487

Title: The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.

PubMed ID: 18483487

DOI: 10.1038/embor.2008.72

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18249148

Title: A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.

PubMed ID: 18249148

DOI: 10.1016/j.molcel.2008.01.003

PubMed ID: 18281698

Title: LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.

PubMed ID: 18281698

DOI: 10.1093/nar/gkn061

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19906723

Title: A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.

PubMed ID: 19906723

DOI: 10.1093/nar/gkp977

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21937992

Title: Deep sequencing reveals 50 novel genes for recessive cognitive disorders.

PubMed ID: 21937992

DOI: 10.1038/nature10423

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22865833

Title: Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.

PubMed ID: 22865833

DOI: 10.1002/humu.22175

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26374271

Title: Compound heterozygous variants in the LARP7 gene as a cause of Alazami syndrome in a Caucasian female with significant failure to thrive, short stature, and developmental disability.

PubMed ID: 26374271

DOI: 10.1002/ajmg.a.37396

PubMed ID: 27766953

Title: Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency.

PubMed ID: 27766953

DOI: 10.1186/s12864-016-3093-4

PubMed ID: 28254838

Title: The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.

PubMed ID: 28254838

DOI: 10.15252/embj.201695740

PubMed ID: 29051200

Title: Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

PubMed ID: 29051200

DOI: 10.15252/embr.201744940

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29619239

Title: Novel compound heterozygous variants in the LARP7 gene in a patient with Alazami syndrome.

PubMed ID: 29619239

DOI: 10.1038/hgv.2018.14

PubMed ID: 29576627

Title: Correction: Broadening the phenotypic spectrum of pathogenic LARP7 variants: two cases with intellectual disability, variable growth retardation and distinct facial features.

PubMed ID: 29576627

DOI: 10.1038/s10038-017-0373-z

PubMed ID: 30006060

Title: LARP7 variants and further delineation of the Alazami syndrome phenotypic spectrum among primordial dwarfisms: 2 sisters.

PubMed ID: 30006060

DOI: 10.1016/j.ejmg.2018.07.003

PubMed ID: 30824372

Title: P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.

PubMed ID: 30824372

DOI: 10.1016/j.molcel.2019.01.033

PubMed ID: 32017898

Title: The Alazami syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness.

PubMed ID: 32017898

DOI: 10.1016/j.molcel.2020.01.001

PubMed ID: 25753663

Title: Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.

PubMed ID: 25753663

DOI: 10.1093/nar/gkv173

PubMed ID: 27679474

Title: hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA.

PubMed ID: 27679474

DOI: 10.1093/nar/gkw833

PubMed ID: 29946027

Title: Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7.

PubMed ID: 29946027

DOI: 10.1073/pnas.1806276115

Sequence Information:

  • Length: 582
  • Mass: 66899
  • Checksum: 04209B8159A5738C
  • Sequence:
    • METESGNQEK VMEEESTEKK KEVEKKKRSR VKQVLADIAK QVDFWFGDAN LHKDRFLREQ 
IEKSRDGYVD ISLLVSFNKM KKLTTDGKLI ARALRSSAVV ELDLEGTRIR RKKPLGERPK 
DEDERTVYVE LLPKNVNHSW IERVFGKCGN VVYISIPHYK STGDPKGFAF VEFETKEQAA 
KAIEFLNNPP EEAPRKPGIF PKTVKNKPIP ALRVVEEKKK KKKKKGRMKK EDNIQAKEEN 
MDTSNTSISK MKRSRPTSEG SDIESTEPQK QCSKKKKKRD RVEASSLPEV RTGKRKRSSS 
EDAESLAPRS KVKKIIQKDI IKEASEASKE NRDIEISTEE EKDTGDLKDS SLLKTKRKHK 
KKHKERHKMG EEVIPLRVLS KSEWMDLKKE YLALQKASMA SLKKTISQIK SESEMETDSG 
VPQNTGMKNE KTANREECRT QEKVNATGPQ FVSGVIVKII STEPLPGRKQ VRDTLAAISE 
VLYVDLLEGD TECHARFKTP EDAQAVINAY TEINKKHCWK LEILSGDHEQ RYWQKILVDR 
QAKLNQPREK KRGTEKLITK AEKIRLAKTQ QASKHIRFSE YD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.