Details for: ERGIC3

Gene ID: 51614

Symbol: ERGIC3

Ensembl ID: ENSG00000125991

Description: ERGIC and golgi 3

Associated with

  • Copii-coated er to golgi transport vesicle
    (GO:0030134)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum-golgi intermediate compartment membrane
    (GO:0033116)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Endoplasmic reticulum to golgi vesicle-mediated transport
    (GO:0006888)
  • Golgi membrane
    (GO:0000139)
  • Membrane
    (GO:0016020)
  • Positive regulation of intracellular protein transport
    (GO:0090316)
  • Protein binding
    (GO:0005515)
  • Retrograde transporter complex, golgi to er
    (GO:0061852)
  • Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
    (GO:0006890)
  • Transporter complex
    (GO:1990351)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 363.0455
    Cell Significance Index: -56.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.2891
    Cell Significance Index: -43.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 168.4923
    Cell Significance Index: -69.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 151.8496
    Cell Significance Index: -61.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 150.0669
    Cell Significance Index: -70.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.6267
    Cell Significance Index: -69.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 105.8236
    Cell Significance Index: -71.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.2951
    Cell Significance Index: -62.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.2704
    Cell Significance Index: -65.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.5759
    Cell Significance Index: -55.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.4124
    Cell Significance Index: -68.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9506
    Cell Significance Index: -45.9200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.5459
    Cell Significance Index: 44.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7464
    Cell Significance Index: 221.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.8014
    Cell Significance Index: 79.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.5946
    Cell Significance Index: 46.0400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.2302
    Cell Significance Index: 24.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0429
    Cell Significance Index: 33.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6918
    Cell Significance Index: 347.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6682
    Cell Significance Index: 198.8600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.4433
    Cell Significance Index: 25.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0131
    Cell Significance Index: 52.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0025
    Cell Significance Index: 1808.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9899
    Cell Significance Index: 1086.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9676
    Cell Significance Index: 354.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9586
    Cell Significance Index: 68.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9415
    Cell Significance Index: 238.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8677
    Cell Significance Index: 256.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.6154
    Cell Significance Index: 43.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5978
    Cell Significance Index: 43.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4866
    Cell Significance Index: 13.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4359
    Cell Significance Index: 38.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4098
    Cell Significance Index: 229.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4030
    Cell Significance Index: 41.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3850
    Cell Significance Index: 97.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3231
    Cell Significance Index: 68.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1902
    Cell Significance Index: 117.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1493
    Cell Significance Index: 508.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1163
    Cell Significance Index: 190.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1160
    Cell Significance Index: 143.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9395
    Cell Significance Index: 186.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8504
    Cell Significance Index: 39.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8503
    Cell Significance Index: 54.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8357
    Cell Significance Index: 37.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7830
    Cell Significance Index: 92.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7409
    Cell Significance Index: 21.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5679
    Cell Significance Index: 29.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4115
    Cell Significance Index: 11.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3658
    Cell Significance Index: 6.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3244
    Cell Significance Index: 61.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3026
    Cell Significance Index: 6.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2840
    Cell Significance Index: 56.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1819
    Cell Significance Index: 1.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1686
    Cell Significance Index: 5.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1452
    Cell Significance Index: 1.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1402
    Cell Significance Index: 50.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1079
    Cell Significance Index: 2.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1021
    Cell Significance Index: 70.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0966
    Cell Significance Index: 73.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0783
    Cell Significance Index: 1.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0407
    Cell Significance Index: 1.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0090
    Cell Significance Index: -16.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0207
    Cell Significance Index: -2.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0226
    Cell Significance Index: -1.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0238
    Cell Significance Index: -43.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0268
    Cell Significance Index: -16.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0315
    Cell Significance Index: -48.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0508
    Cell Significance Index: -69.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0734
    Cell Significance Index: -46.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0876
    Cell Significance Index: -49.4000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1188
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1346
    Cell Significance Index: -61.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1570
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1870
    Cell Significance Index: -39.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2025
    Cell Significance Index: -23.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2058
    Cell Significance Index: -59.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2552
    Cell Significance Index: -6.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2576
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2798
    Cell Significance Index: -32.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2897
    Cell Significance Index: -5.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3786
    Cell Significance Index: -23.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3966
    Cell Significance Index: -57.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5360
    Cell Significance Index: -61.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5779
    Cell Significance Index: -32.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6225
    Cell Significance Index: -15.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6231
    Cell Significance Index: -47.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6491
    Cell Significance Index: -67.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6899
    Cell Significance Index: -20.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7219
    Cell Significance Index: -9.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7620
    Cell Significance Index: -60.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7954
    Cell Significance Index: -48.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8151
    Cell Significance Index: -17.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8844
    Cell Significance Index: -54.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8898
    Cell Significance Index: -59.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0239
    Cell Significance Index: -29.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3031
    Cell Significance Index: -57.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3249
    Cell Significance Index: -22.8400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.3266
    Cell Significance Index: -18.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERGIC3 is a membrane-bound protein that belongs to the retrograde transporter complex, facilitating the transport of proteins from the Golgi apparatus to the ER. This process is essential for the proper folding, maturation, and quality control of proteins. ERGIC3 is also involved in the regulation of protein binding and the positive regulation of intracellular protein transport. **Pathways and Functions:** ERGIC3 is integral to several key pathways, including: 1. **Copii-coated ER to Golgi transport vesicle formation**: ERGIC3 plays a crucial role in the formation of transport vesicles that carry proteins from the ER to the Golgi apparatus. 2. **Endoplasmic reticulum-golgi intermediate compartment membrane**: ERGIC3 is involved in the maintenance of the intermediate compartment between the ER and Golgi apparatus, ensuring proper protein transport and quality control. 3. **Retrograde vesicle-mediated transport**: ERGIC3 facilitates the transport of proteins from the Golgi apparatus to the ER, allowing for the return of misfolded proteins to the ER for degradation. 4. **Golgi to ER transport**: ERGIC3 is involved in the transport of proteins from the Golgi apparatus to the ER, ensuring proper protein function and quality control. **Clinical Significance:** ERGIC3's dysregulation has been implicated in various diseases, including: 1. **Immune disorders**: ERGIC3's involvement in immune cell function and protein transport makes it a potential target for the treatment of immune-related disorders, such as autoimmune diseases and cancer. 2. **Neurological disorders**: ERGIC3's role in protein transport and quality control makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: ERGIC3's dysregulation has been implicated in various types of cancer, including leukemia and lymphoma, highlighting its potential as a therapeutic target. In conclusion, ERGIC3 plays a critical role in regulating intracellular protein transport and immune function. Further research into the mechanisms underlying ERGIC3's function and its involvement in disease will provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3536409681

Symbol: ERGI3_HUMAN

Name: Endoplasmic reticulum-Golgi intermediate compartment protein 3

UniProtKB Accession Codes:

Q9Y282 Q5JWS3 Q6ZWP7 Q9H276 Q9P1L3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12747765

Title: Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.

PubMed ID: 12747765

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15308636

Title: Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.

PubMed ID: 15308636

DOI: 10.1074/jbc.m406644200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31142615

Title: The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.

PubMed ID: 31142615

DOI: 10.1074/jbc.ra119.007435

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 383
  • Mass: 43222
  • Checksum: 8370FB3067AD95CE
  • Sequence:
    • MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL TTEVHPELYV 
DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DGIPVSSEAE 
RHELGKVEVT VFDPDSLDPD RCESCYGAEA EDIKCCNTCE DVREAYRRRG WAFKNPDTIE 
QCRREGFSQK MQEQKNEGCQ VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI 
NMTHYIQHLS FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF 
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA IIGGMFTVAG 
LIDSLIYHSA RAIQKKIDLG KTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.