Details for: KLF13

Gene ID: 51621

Symbol: KLF13

Ensembl ID: ENSG00000169926

Description: KLF transcription factor 13

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of erythrocyte differentiation
    (GO:0045647)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 227.7151
    Cell Significance Index: -35.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.7983
    Cell Significance Index: -41.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.2014
    Cell Significance Index: -39.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.2735
    Cell Significance Index: -45.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.1805
    Cell Significance Index: -44.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.6155
    Cell Significance Index: -46.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.7288
    Cell Significance Index: -40.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4295
    Cell Significance Index: -42.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0045
    Cell Significance Index: -40.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3455
    Cell Significance Index: -44.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4999
    Cell Significance Index: -22.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1743
    Cell Significance Index: -31.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.8393
    Cell Significance Index: 95.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4904
    Cell Significance Index: 405.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0777
    Cell Significance Index: 134.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9401
    Cell Significance Index: 101.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2210
    Cell Significance Index: 132.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0972
    Cell Significance Index: 29.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9422
    Cell Significance Index: 189.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8273
    Cell Significance Index: 365.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8127
    Cell Significance Index: 23.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7100
    Cell Significance Index: 87.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6787
    Cell Significance Index: 122.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6720
    Cell Significance Index: 47.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6376
    Cell Significance Index: 44.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5100
    Cell Significance Index: 14.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4679
    Cell Significance Index: 167.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4469
    Cell Significance Index: 20.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4131
    Cell Significance Index: 21.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3770
    Cell Significance Index: 74.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3608
    Cell Significance Index: 197.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3415
    Cell Significance Index: 5.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2436
    Cell Significance Index: 18.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2351
    Cell Significance Index: 44.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2147
    Cell Significance Index: 21.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1504
    Cell Significance Index: 5.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1197
    Cell Significance Index: 16.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1100
    Cell Significance Index: 99.3500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0911
    Cell Significance Index: 0.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0909
    Cell Significance Index: 15.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0711
    Cell Significance Index: 3.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0389
    Cell Significance Index: 28.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0362
    Cell Significance Index: 1.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0140
    Cell Significance Index: 26.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0004
    Cell Significance Index: 0.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0157
    Cell Significance Index: -9.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0181
    Cell Significance Index: -24.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -13.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0265
    Cell Significance Index: -0.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0346
    Cell Significance Index: -15.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0445
    Cell Significance Index: -5.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0452
    Cell Significance Index: -5.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0464
    Cell Significance Index: -26.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0755
    Cell Significance Index: -3.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1005
    Cell Significance Index: -2.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1152
    Cell Significance Index: -11.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1185
    Cell Significance Index: -34.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1186
    Cell Significance Index: -24.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1343
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1411
    Cell Significance Index: -16.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1419
    Cell Significance Index: -16.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1535
    Cell Significance Index: -2.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1633
    Cell Significance Index: -23.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2235
    Cell Significance Index: -3.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2961
    Cell Significance Index: -7.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3051
    Cell Significance Index: -7.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3243
    Cell Significance Index: -6.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3311
    Cell Significance Index: -26.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3376
    Cell Significance Index: -25.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3511
    Cell Significance Index: -40.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3613
    Cell Significance Index: -18.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3682
    Cell Significance Index: -10.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3952
    Cell Significance Index: -4.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4061
    Cell Significance Index: -42.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4730
    Cell Significance Index: -15.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4786
    Cell Significance Index: -12.7800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4937
    Cell Significance Index: -7.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5798
    Cell Significance Index: -8.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5802
    Cell Significance Index: -17.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5909
    Cell Significance Index: -26.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6669
    Cell Significance Index: -42.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7113
    Cell Significance Index: -17.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7130
    Cell Significance Index: -12.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7166
    Cell Significance Index: -24.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7369
    Cell Significance Index: -45.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7405
    Cell Significance Index: -28.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7495
    Cell Significance Index: -23.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7665
    Cell Significance Index: -19.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7900
    Cell Significance Index: -10.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8287
    Cell Significance Index: -33.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8338
    Cell Significance Index: -27.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8577
    Cell Significance Index: -12.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8843
    Cell Significance Index: -30.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9725
    Cell Significance Index: -16.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0000
    Cell Significance Index: -36.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF13 is a transcription factor that belongs to the Krüppel-like factor family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. Its primary characteristics include: 1. **DNA binding**: KLF13 exhibits sequence-specific DNA binding, allowing it to interact with specific DNA sequences and regulate gene expression. 2. **Transcriptional activation**: KLF13 acts as a transcriptional activator, promoting the expression of target genes involved in cellular differentiation, proliferation, and immune response. 3. **Metal ion binding**: KLF13 has been shown to bind to metal ions, which is essential for its DNA binding activity and transcriptional regulation. 4. **Cellular localization**: KLF13 is expressed in various cell types, including hematopoietic cells, immune cells, epithelial cells, and stromal cells. **Pathways and Functions:** KLF13 regulates various cellular processes through the following pathways and functions: 1. **Immune response**: KLF13 plays a crucial role in regulating immune cell development, differentiation, and function, particularly in hematopoietic cells and immune cells. 2. **Cell differentiation**: KLF13 is involved in regulating cellular differentiation, including erythrocyte differentiation and smooth muscle fiber differentiation. 3. **Proliferation**: KLF13 regulates cell proliferation, particularly in hematopoietic cells and epithelial cells. 4. **Transcriptional regulation**: KLF13 acts as a transcriptional activator, promoting the expression of target genes involved in cellular differentiation, proliferation, and immune response. 5. **Chromatin regulation**: KLF13 regulates chromatin structure and function, influencing gene expression and cellular behavior. **Clinical Significance:** KLF13 has been implicated in various immune-related disorders, including: 1. **Hematological malignancies**: KLF13 has been shown to play a role in the development and progression of hematological malignancies, such as leukemia and lymphoma. 2. **Autoimmune diseases**: KLF13 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune cell function and gene expression. 3. **Inflammatory disorders**: KLF13 has been shown to regulate inflammatory responses, particularly in epithelial cells and immune cells. 4. **Cancer**: KLF13 has been implicated in cancer development and progression, particularly in epithelial cells and smooth muscle fibers. In conclusion, KLF13 is a transcription factor that plays a crucial role in regulating various cellular processes, including immune response, cell differentiation, and proliferation. Its clinical significance in immune-related disorders highlights the importance of further research into the molecular mechanisms underlying KLF13's functions and its potential as a therapeutic target for immune-related diseases.

Genular Protein ID: 1101603994

Symbol: KLF13_HUMAN

Name: Krueppel-like factor 13

UniProtKB Accession Codes:

Q9Y2Y9 Q9Y356

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10023774

Title: RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.

PubMed ID: 10023774

DOI: 10.1016/s1074-7613(00)80010-2

PubMed ID: 10415854

Title: Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors.

PubMed ID: 10415854

DOI: 10.1111/j.1749-6632.1999.tb09513.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11477107

Title: The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1.

PubMed ID: 11477107

DOI: 10.1074/jbc.m105831200

PubMed ID: 17513757

Title: Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.

PubMed ID: 17513757

DOI: 10.4049/jimmunol.178.11.7081

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 288
  • Mass: 31180
  • Checksum: DD2765EE00E9C049
  • Sequence:
    • MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE ERRDGKDSAS 
LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP PAPEPTSPGA EGAAAAPPSP 
AWSEPEPEAG LEPEREPGPA GSGEPGLRQR VRRGRSRADL ESPQRKHKCH YAGCEKVYGK 
SSHLKAHLRT HTGERPFACS WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD 
HLTKHARRHA NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.