Details for: SLC25A39

Gene ID: 51629

Symbol: SLC25A39

Ensembl ID: ENSG00000013306

Description: solute carrier family 25 member 39

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.9181
    Cell Significance Index: -27.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.3904
    Cell Significance Index: -38.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.8293
    Cell Significance Index: -33.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.1788
    Cell Significance Index: -36.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.0083
    Cell Significance Index: -37.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.1547
    Cell Significance Index: -37.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.7583
    Cell Significance Index: -34.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9448
    Cell Significance Index: -30.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8418
    Cell Significance Index: -34.8900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 6.5875
    Cell Significance Index: 3.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0632
    Cell Significance Index: -16.2400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 5.5524
    Cell Significance Index: 21.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2043
    Cell Significance Index: -11.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.1574
    Cell Significance Index: -2.6600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9886
    Cell Significance Index: 15.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4804
    Cell Significance Index: 11.8200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4380
    Cell Significance Index: 8.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4151
    Cell Significance Index: 65.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3489
    Cell Significance Index: 100.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3281
    Cell Significance Index: 12.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2451
    Cell Significance Index: 58.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1304
    Cell Significance Index: 617.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0367
    Cell Significance Index: 11.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0179
    Cell Significance Index: 125.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9833
    Cell Significance Index: 27.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8608
    Cell Significance Index: 101.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8494
    Cell Significance Index: 17.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8288
    Cell Significance Index: 24.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7944
    Cell Significance Index: 143.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7479
    Cell Significance Index: 38.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7415
    Cell Significance Index: 95.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7260
    Cell Significance Index: 19.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6514
    Cell Significance Index: 17.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6503
    Cell Significance Index: 18.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5827
    Cell Significance Index: 80.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5699
    Cell Significance Index: 92.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5078
    Cell Significance Index: 458.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5010
    Cell Significance Index: 221.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4993
    Cell Significance Index: 13.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4905
    Cell Significance Index: 34.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4868
    Cell Significance Index: 83.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4757
    Cell Significance Index: 10.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4722
    Cell Significance Index: 30.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4625
    Cell Significance Index: 91.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4492
    Cell Significance Index: 15.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4081
    Cell Significance Index: 81.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4016
    Cell Significance Index: 8.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3966
    Cell Significance Index: 10.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3452
    Cell Significance Index: 65.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3122
    Cell Significance Index: 40.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2914
    Cell Significance Index: 7.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1936
    Cell Significance Index: 22.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1881
    Cell Significance Index: 6.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1816
    Cell Significance Index: 8.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1785
    Cell Significance Index: 9.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1496
    Cell Significance Index: 53.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0882
    Cell Significance Index: 66.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0518
    Cell Significance Index: 1.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0516
    Cell Significance Index: 35.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0472
    Cell Significance Index: 0.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0355
    Cell Significance Index: 26.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0259
    Cell Significance Index: 1.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0203
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0109
    Cell Significance Index: -1.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0167
    Cell Significance Index: -25.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0251
    Cell Significance Index: -34.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0258
    Cell Significance Index: -16.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0441
    Cell Significance Index: -24.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0505
    Cell Significance Index: -1.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0585
    Cell Significance Index: -5.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0605
    Cell Significance Index: -27.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0649
    Cell Significance Index: -13.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0908
    Cell Significance Index: -26.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1125
    Cell Significance Index: -16.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1216
    Cell Significance Index: -13.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1416
    Cell Significance Index: -16.5000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1443
    Cell Significance Index: -1.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1725
    Cell Significance Index: -1.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2020
    Cell Significance Index: -12.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2275
    Cell Significance Index: -17.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2335
    Cell Significance Index: -18.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3201
    Cell Significance Index: -19.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3256
    Cell Significance Index: -33.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3444
    Cell Significance Index: -23.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3474
    Cell Significance Index: -4.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3660
    Cell Significance Index: -9.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3784
    Cell Significance Index: -5.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3879
    Cell Significance Index: -11.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4134
    Cell Significance Index: -25.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4692
    Cell Significance Index: -13.8200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4798
    Cell Significance Index: -6.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4806
    Cell Significance Index: -4.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5131
    Cell Significance Index: -28.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5277
    Cell Significance Index: -32.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6285
    Cell Significance Index: -27.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6593
    Cell Significance Index: -11.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SLC25A39 is a transmembrane protein with a predicted molecular weight of approximately 25 kDa. It belongs to the solute carrier family 25, which is known for its role in transporting various ions and molecules across cellular membranes. The protein's structure consists of a transmembrane domain, a cytoplasmic tail, and a cytosolic domain. Its expression is highly regulated, with significant variations in its levels across different cell types. **Pathways and Functions** SLC25A39 plays a crucial role in maintaining iron and glutathione homeostasis within cells. Its primary function is to transport iron ions into the mitochondria, where it is essential for various cellular processes, including energy production, DNA synthesis, and cell signaling. Additionally, SLC25A39 is involved in the transport of glutathione into the mitochondria, where it is involved in antioxidant defenses and redox regulation. The protein's involvement in iron homeostasis is further supported by its association with the cellular response to iron ion, heme biosynthesis, and metal ion binding pathways. These pathways highlight the protein's importance in regulating iron-dependent cellular processes, such as energy production, DNA synthesis, and cell signaling. **Clinical Significance** Dysregulation of SLC25A39 has been implicated in various diseases, including iron overload disorders, anemia, and immune-related disorders. For instance, mutations in the SLC25A39 gene have been linked to iron overload disorders, such as hemochromatosis and hereditary hemochromatosis. Additionally, alterations in SLC25A39 expression have been observed in immune cells, suggesting its potential role in immune regulation and disease. Furthermore, SLC25A39's involvement in glutathione homeostasis highlights its potential role in antioxidant defenses and redox regulation. Dysregulation of glutathione levels has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. In conclusion, SLC25A39 is a critical protein involved in maintaining iron and glutathione homeostasis within cells. Its widespread expression across various cell types highlights its importance in regulating cellular processes, including energy production, DNA synthesis, and cell signaling. Further research is needed to fully elucidate the protein's role in disease and to develop therapeutic strategies targeting SLC25A39. **References** * [Insert references to relevant studies and literature] Note: The references provided should be cited in the article discussion section.

Genular Protein ID: 897448710

Symbol: S2539_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BZJ4 A8JZZ2 D3DX51 D3DX54 Q4V9M1 Q9P182 Q9UF66 Q9Y379

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11139402

Title: Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69.

PubMed ID: 11139402

DOI: 10.1042/bj3530369

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11256614

Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PubMed ID: 11256614

DOI: 10.1093/embo-reports/kvd058

PubMed ID: 34707288

Title: SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.

PubMed ID: 34707288

DOI: 10.1038/s41586-021-04025-w

PubMed ID: 35513392

Title: Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.

PubMed ID: 35513392

DOI: 10.1038/s41467-022-30126-9

PubMed ID: 38157846

Title: Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.

PubMed ID: 38157846

DOI: 10.1016/j.molcel.2023.12.008

PubMed ID: 37917749

Title: Autoregulatory control of mitochondrial glutathione homeostasis.

PubMed ID: 37917749

DOI: 10.1126/science.adf4154

Sequence Information:

  • Length: 359
  • Mass: 39249
  • Checksum: C29C750032E94D0A
  • Sequence:
    • MADQDPAGIS PLQQMVASGT GAVVTSLFMT PLDVVKVRLQ SQRPSMASEL MPSSRLWSLS 
YTKLPSSLQS TGKCLLYCNG VLEPLYLCPN GARCATWFQD PTRFTGTMDA FVKIVRHEGT 
RTLWSGLPAT LVMTVPATAI YFTAYDQLKA FLCGRALTSD LYAPMVAGAL ARLGTVTVIS 
PLELMRTKLQ AQHVSYRELG ACVRTAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV 
KSWLNGFRPK DQTSVGMSFV AGGISGTVAA VLTLPFDVVK TQRQVALGAM EAVRVNPLHV 
DSTWLLLRRI RAESGTKGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR LNQDRLLGG

Genular Protein ID: 1507369470

Symbol: B4DFG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFG5

Database IDs:

ARBA 15 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 RuleBase 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 336
  • Mass: 36655
  • Checksum: D59D03D3A1840B37
  • Sequence:
    • MADQDPAGIS PLQQMVASGT GAVVTSLFMT PLDVVKVRLQ SQRPSMASGK CLLYCNGVLE 
PLYLCPNGAR CATWFQDPTR FTGTMDAFVK IVRHEGTRTL WSGLPATLVM TVPATAIYFT 
AYDQLKAFLC GRALTSDLYA PMVAGALARL GTVTVISPLE LMRTKLQAQH VSYRELGACV 
RTAVAQGGWR SLWLGWGPTA LRDVPFSALY WFNYELVKSW LNGFRPKDQT SVGMSFVAGG 
ISGTVAAVLT LPFDVVKTQR QVALGAMEAV RVNPLHVDST WLLLRRIRAE SGTKGLFAGF 
LPRIIKAAPS CAIMISTYEF GKSFFQRLNQ DRLLGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.