Details for: RBMX2

Gene ID: 51634

Symbol: RBMX2

Ensembl ID: ENSG00000134597

Description: RNA binding motif protein X-linked 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.0668
    Cell Significance Index: -22.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.0984
    Cell Significance Index: -17.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 55.7838
    Cell Significance Index: -22.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.2534
    Cell Significance Index: -24.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.8545
    Cell Significance Index: -20.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.1133
    Cell Significance Index: -23.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.7350
    Cell Significance Index: -24.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.8802
    Cell Significance Index: -20.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.8385
    Cell Significance Index: -24.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9997
    Cell Significance Index: -21.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3811
    Cell Significance Index: -25.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7465
    Cell Significance Index: -17.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0300
    Cell Significance Index: -8.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1689
    Cell Significance Index: 1055.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0584
    Cell Significance Index: 8.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8938
    Cell Significance Index: 122.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8094
    Cell Significance Index: 131.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7541
    Cell Significance Index: 39.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6728
    Cell Significance Index: 9.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5868
    Cell Significance Index: 72.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5352
    Cell Significance Index: 37.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5170
    Cell Significance Index: 282.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5017
    Cell Significance Index: 221.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4758
    Cell Significance Index: 12.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4656
    Cell Significance Index: 83.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4150
    Cell Significance Index: 29.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3916
    Cell Significance Index: 25.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3698
    Cell Significance Index: 12.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3592
    Cell Significance Index: 18.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3518
    Cell Significance Index: 70.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3131
    Cell Significance Index: 2.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3077
    Cell Significance Index: 36.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3019
    Cell Significance Index: 6.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2804
    Cell Significance Index: 35.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2548
    Cell Significance Index: 16.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2509
    Cell Significance Index: 7.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2345
    Cell Significance Index: 11.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2337
    Cell Significance Index: 39.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2113
    Cell Significance Index: 2.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2055
    Cell Significance Index: 9.5800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2041
    Cell Significance Index: 3.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1865
    Cell Significance Index: 66.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1749
    Cell Significance Index: 3.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1659
    Cell Significance Index: 31.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1485
    Cell Significance Index: 19.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1385
    Cell Significance Index: 3.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1212
    Cell Significance Index: 9.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1176
    Cell Significance Index: 5.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0984
    Cell Significance Index: 1.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0747
    Cell Significance Index: 2.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0670
    Cell Significance Index: 6.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0645
    Cell Significance Index: 12.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0372
    Cell Significance Index: 1.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0054
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0063
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0104
    Cell Significance Index: -19.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0111
    Cell Significance Index: -15.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0152
    Cell Significance Index: -0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0156
    Cell Significance Index: -24.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0176
    Cell Significance Index: -1.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0234
    Cell Significance Index: -0.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0247
    Cell Significance Index: -13.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0252
    Cell Significance Index: -15.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0366
    Cell Significance Index: -16.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0411
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0573
    Cell Significance Index: -12.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0630
    Cell Significance Index: -1.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0634
    Cell Significance Index: -18.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0662
    Cell Significance Index: -7.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0801
    Cell Significance Index: -9.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1168
    Cell Significance Index: -13.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1181
    Cell Significance Index: -3.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1249
    Cell Significance Index: -18.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1256
    Cell Significance Index: -1.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1338
    Cell Significance Index: -2.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1504
    Cell Significance Index: -10.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1579
    Cell Significance Index: -2.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1932
    Cell Significance Index: -3.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2094
    Cell Significance Index: -11.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2204
    Cell Significance Index: -16.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2295
    Cell Significance Index: -23.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2351
    Cell Significance Index: -18.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2438
    Cell Significance Index: -4.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3569
    Cell Significance Index: -2.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3599
    Cell Significance Index: -15.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3673
    Cell Significance Index: -9.8300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3699
    Cell Significance Index: -3.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4022
    Cell Significance Index: -24.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4027
    Cell Significance Index: -10.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4072
    Cell Significance Index: -10.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4476
    Cell Significance Index: -16.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4563
    Cell Significance Index: -7.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4621
    Cell Significance Index: -13.6100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4779
    Cell Significance Index: -6.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding motif**: RBMX2 possesses a distinctive RNA-binding motif, which enables it to recognize and interact with specific RNA sequences, thereby modulating their splicing patterns. 2. **X-linked**: As its name suggests, RBMX2 is encoded by an X-linked gene, suggesting its involvement in sex-linked genetic disorders. 3. **Spliceosomal complex**: RBMX2 is integral to the spliceosomal complex, a multi-protein machine responsible for the precise and efficient splicing of pre-mRNAs into mature mRNAs. 4. **Specificity for U2 snRNP**: RBMX2 exhibits a high degree of specificity for binding to the U2 small nuclear ribonucleoprotein (snRNP), a key component of the spliceosome. **Pathways and Functions:** 1. **Pre-mRNA splicing**: RBMX2 is involved in the regulation of pre-mRNA splicing, a critical process that determines the final structure and function of mRNAs. 2. **Metabolism of RNA**: RBMX2 influences the metabolism of RNA, including the processing of capped intron-containing pre-mRNAs and the assembly of the U2-type prespliceosome. 3. **Endoplasmic reticulum (ER) and nuclear membrane**: RBMX2 is also localized to the ER and nuclear membrane, suggesting its involvement in the regulation of protein and RNA trafficking. 4. **Nucleoplasm and nucleolus**: RBMX2 is found in the nucleoplasm and nucleolus, indicating its role in the regulation of RNA processing and the maintenance of chromatin structure. **Clinical Significance:** 1. **Immunological disorders**: RBMX2's involvement in pre-mRNA splicing and its specific interaction with U2 snRNP suggest its potential role in the pathogenesis of immunological disorders, such as autoimmune diseases and immunodeficiencies. 2. **Cancer**: RBMX2's dysregulation has been implicated in various types of cancer, including leukemia and lymphoma, where aberrant splicing patterns contribute to tumorigenesis and disease progression. 3. **Neurological disorders**: RBMX2's expression in specific neuronal populations and its involvement in the regulation of RNA processing suggest its potential role in the pathogenesis of neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 4. **Therapeutic targeting**: The identification of RBMX2 as a therapeutic target offers new avenues for the development of RNA-based therapies, which could potentially modulate RNA processing and improve immunological outcomes in various disease contexts. In conclusion, the molecular mechanisms underlying RBMX2's functional significance in immunology are multifaceted and far-reaching, implicating its role in pre-mRNA splicing, RNA metabolism, and protein trafficking. As a therapeutic target, RBMX2 offers a promising area of research for the development of novel RNA-based therapies, which could potentially revolutionize the treatment of immunological disorders.

Genular Protein ID: 118847198

Symbol: RBMX2_HUMAN

Name: RNA-binding motif protein, X-linked 2

UniProtKB Accession Codes:

Q9Y388 A8K9Z0 Q5JY82 Q9Y3I8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 6 EMDB 7 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29361316

Title: Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

PubMed ID: 29361316

DOI: 10.1016/j.cell.2018.01.010

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 322
  • Mass: 37336
  • Checksum: 05EF1C0FD17BD45F
  • Sequence:
    • MNPLTKVKLI NELNEREVQL GVADKVSWHS EYKDSAWIFL GGLPYELTEG DIICVFSQYG 
EIVNINLVRD KKTGKSKGFC FLCYEDQRST ILAVDNFNGI KIKGRTIRVD HVSNYRAPKD 
SEEIDDVTRQ LQEKGCGART PSPSLSESSE DEKPTKKHKK DKKEKKKKKK EKEKADREVQ 
AEQPSSSSPR RKTVKEKDDT GPKKHSSKNS ERAQKSEPRE GQKLPKSRTA YSGGAEDLER 
ELKKEKPKHE HKSSSRREAR EEKTRIRDRG RSSDAHSSWY NGRSEGRSYR SRSRSRDKSH 
RHKRARRSRE RESSNPSDRW RH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.