Details for: YPEL5

Gene ID: 51646

Symbol: YPEL5

Ensembl ID: ENSG00000119801

Description: yippee like 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 326.5288
    Cell Significance Index: -50.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 174.0633
    Cell Significance Index: -44.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 154.7284
    Cell Significance Index: -63.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.8837
    Cell Significance Index: -57.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 133.0586
    Cell Significance Index: -62.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.3256
    Cell Significance Index: -64.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 93.5886
    Cell Significance Index: -62.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.6603
    Cell Significance Index: -57.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.2213
    Cell Significance Index: -53.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5676
    Cell Significance Index: -49.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5464
    Cell Significance Index: -47.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3521
    Cell Significance Index: -60.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2160
    Cell Significance Index: -20.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.6762
    Cell Significance Index: 544.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9184
    Cell Significance Index: 188.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0930
    Cell Significance Index: 56.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9976
    Cell Significance Index: 324.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5843
    Cell Significance Index: 74.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4521
    Cell Significance Index: 75.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2156
    Cell Significance Index: 143.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1865
    Cell Significance Index: 21.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1602
    Cell Significance Index: 209.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1425
    Cell Significance Index: 140.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1310
    Cell Significance Index: 617.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0281
    Cell Significance Index: 206.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0086
    Cell Significance Index: 130.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9235
    Cell Significance Index: 55.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9147
    Cell Significance Index: 125.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9098
    Cell Significance Index: 67.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8746
    Cell Significance Index: 386.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7209
    Cell Significance Index: 25.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7114
    Cell Significance Index: 91.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7011
    Cell Significance Index: 18.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6994
    Cell Significance Index: 18.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6891
    Cell Significance Index: 32.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6708
    Cell Significance Index: 19.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6300
    Cell Significance Index: 33.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4064
    Cell Significance Index: 28.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3486
    Cell Significance Index: 3.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3414
    Cell Significance Index: 122.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3304
    Cell Significance Index: 62.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2601
    Cell Significance Index: 51.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2218
    Cell Significance Index: 6.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2195
    Cell Significance Index: 9.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1898
    Cell Significance Index: 18.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1359
    Cell Significance Index: 1.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1017
    Cell Significance Index: 17.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0909
    Cell Significance Index: 5.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0615
    Cell Significance Index: 1.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0553
    Cell Significance Index: 2.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0013
    Cell Significance Index: 1.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0210
    Cell Significance Index: -38.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0244
    Cell Significance Index: -11.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0251
    Cell Significance Index: -15.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0296
    Cell Significance Index: -45.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0356
    Cell Significance Index: -3.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0365
    Cell Significance Index: -26.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0389
    Cell Significance Index: -52.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0643
    Cell Significance Index: -2.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0646
    Cell Significance Index: -36.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0661
    Cell Significance Index: -45.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1153
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1536
    Cell Significance Index: -32.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1728
    Cell Significance Index: -49.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1881
    Cell Significance Index: -12.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2306
    Cell Significance Index: -26.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2814
    Cell Significance Index: -40.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2983
    Cell Significance Index: -8.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3136
    Cell Significance Index: -24.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3188
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3341
    Cell Significance Index: -38.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3348
    Cell Significance Index: -20.5800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3843
    Cell Significance Index: -5.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3980
    Cell Significance Index: -8.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4745
    Cell Significance Index: -10.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5364
    Cell Significance Index: -14.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5399
    Cell Significance Index: -56.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5684
    Cell Significance Index: -31.9000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5874
    Cell Significance Index: -3.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6012
    Cell Significance Index: -6.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6302
    Cell Significance Index: -16.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6575
    Cell Significance Index: -52.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7133
    Cell Significance Index: -31.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7400
    Cell Significance Index: -23.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7659
    Cell Significance Index: -13.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7700
    Cell Significance Index: -17.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8810
    Cell Significance Index: -33.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9239
    Cell Significance Index: -26.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9306
    Cell Significance Index: -19.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9310
    Cell Significance Index: -47.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0354
    Cell Significance Index: -63.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0399
    Cell Significance Index: -27.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3132
    Cell Significance Index: -38.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3620
    Cell Significance Index: -35.0100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.3677
    Cell Significance Index: -19.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.3780
    Cell Significance Index: -56.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3828
    Cell Significance Index: -50.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** YPEL5 is a gene located on chromosome 1q, with an Ensembl ID of ENSG00000119801. Its protein product, YPEL5_HUMAN, is a member of the Yippee-like protein family, which is characterized by its distinctive domain structure. The YPEL5 protein exhibits a unique structure, comprising multiple domains, including a metal ion binding domain, a protein binding domain, and a ubiquitin ligase complex domain. These domains suggest that YPEL5 plays a crucial role in regulating various cellular processes, including metal ion homeostasis, protein-protein interactions, and the ubiquitin-proteasome pathway. **Pathways and Functions** YPEL5 is involved in several cellular pathways, including: 1. **Cell population proliferation**: YPEL5 regulates cell cycle progression and proliferation by interacting with key cell cycle regulators, such as cyclin-dependent kinases and cyclin-dependent kinase inhibitors. 2. **Centrosome and midbody formation**: YPEL5 is involved in the formation of centrosomes and midbodies, which are essential structures for maintaining cell polarity and regulating cell division. 3. **Extracellular region formation**: YPEL5 is expressed in epithelial cells and regulates the formation of the extracellular matrix, which is crucial for tissue development and maintenance. 4. **Neutrophil degranulation**: YPEL5 is involved in the regulation of neutrophil degranulation, a process that is critical for the immune response. 5. **Ubiquitin ligase complex**: YPEL5 interacts with the ubiquitin-proteasome pathway, which regulates protein degradation and is essential for maintaining protein homeostasis. **Clinical Significance** YPEL5 has been implicated in several diseases, including: 1. **Neutropenia**: YPEL5 has been shown to play a role in regulating neutrophil homeostasis, and its dysregulation has been implicated in neutropenia, a condition characterized by low neutrophil counts. 2. **Immunodeficiency**: YPEL5 has been shown to interact with key immune regulators, such as T cell receptors and cytokines, and its dysregulation has been implicated in immunodeficiency disorders. 3. **Cancer**: YPEL5 has been shown to regulate cell cycle progression and proliferation, and its dysregulation has been implicated in various cancers, including leukemia and lymphoma. 4. **Neurological disorders**: YPEL5 has been implicated in the regulation of neuronal function and has been shown to interact with key neuronal proteins, such as synaptophysin and GAP-43. In conclusion, YPEL5 is a novel gene that encodes a protein involved in various cellular processes, including cell proliferation, immune response, and granule formation. Its dysregulation has been implicated in several diseases, including neutropenia, immunodeficiency, cancer, and neurological disorders. Further studies are needed to fully elucidate the function and clinical significance of YPEL5.

Genular Protein ID: 2861426843

Symbol: YPEL5_HUMAN

Name: Protein yippee-like 5

UniProtKB Accession Codes:

P62699 D6W568 Q65Z97 Q8R174 Q9D6M1 Q9UMX7 Q9Y3C9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 1 Ensembl 5 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15556292

Title: Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species.

PubMed ID: 15556292

DOI: 10.1016/j.gene.2004.06.014

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11240639

Title: The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes.

PubMed ID: 11240639

DOI: 10.1046/j.1365-2583.2001.00239.x

PubMed ID: 20580816

Title: YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.

PubMed ID: 20580816

DOI: 10.1016/j.ygeno.2010.05.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29911972

Title: The multi-subunit GID/CTLH E3 ligase promotes proliferation and targets the transcription factor Hbp1 for degradation.

PubMed ID: 29911972

DOI: 10.7554/elife.35528

Sequence Information:

  • Length: 121
  • Mass: 13842
  • Checksum: ADCF8C4C3B154EAB
  • Sequence:
    • MGRIFLDHIG GTRLFSCANC DTILTNRSEL ISTRFTGATG RAFLFNKVVN LQYSEVQDRV 
MLTGRHMVRD VSCKNCNSKL GWIYEFATED SQRYKEGRVI LERALVRESE GFEEHVPSDN 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.