Details for: LSM7

Gene ID: 51690

Symbol: LSM7

Ensembl ID: ENSG00000130332

Description: LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 394.9977
    Cell Significance Index: -61.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 195.0127
    Cell Significance Index: -80.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 167.6771
    Cell Significance Index: -68.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 160.7845
    Cell Significance Index: -75.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.5404
    Cell Significance Index: -40.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.0067
    Cell Significance Index: -78.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 113.2302
    Cell Significance Index: -75.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.5955
    Cell Significance Index: -69.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.3881
    Cell Significance Index: -71.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.7248
    Cell Significance Index: -77.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.1947
    Cell Significance Index: -51.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.7417
    Cell Significance Index: -48.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.1298
    Cell Significance Index: -22.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.9676
    Cell Significance Index: 159.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.1369
    Cell Significance Index: 55.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5467
    Cell Significance Index: 95.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.1810
    Cell Significance Index: 109.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.5846
    Cell Significance Index: 28.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.4924
    Cell Significance Index: 225.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0615
    Cell Significance Index: 361.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.0501
    Cell Significance Index: 143.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.8919
    Cell Significance Index: 37.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5118
    Cell Significance Index: 1371.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2412
    Cell Significance Index: 51.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1964
    Cell Significance Index: 270.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1404
    Cell Significance Index: 62.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0719
    Cell Significance Index: 373.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0595
    Cell Significance Index: 282.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8042
    Cell Significance Index: 127.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8028
    Cell Significance Index: 293.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7764
    Cell Significance Index: 229.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7211
    Cell Significance Index: 119.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7019
    Cell Significance Index: 752.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6524
    Cell Significance Index: 13.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5913
    Cell Significance Index: 118.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4639
    Cell Significance Index: 50.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4042
    Cell Significance Index: 65.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3474
    Cell Significance Index: 38.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2728
    Cell Significance Index: 57.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2385
    Cell Significance Index: 33.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1894
    Cell Significance Index: 31.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1267
    Cell Significance Index: 12.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1135
    Cell Significance Index: 31.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1104
    Cell Significance Index: 57.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8934
    Cell Significance Index: 114.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7985
    Cell Significance Index: 78.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7889
    Cell Significance Index: 7.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7697
    Cell Significance Index: 40.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7542
    Cell Significance Index: 16.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6950
    Cell Significance Index: 132.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6536
    Cell Significance Index: 12.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6109
    Cell Significance Index: 551.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5677
    Cell Significance Index: 112.6600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.5297
    Cell Significance Index: 3.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3263
    Cell Significance Index: 4.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2389
    Cell Significance Index: 47.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2065
    Cell Significance Index: 10.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1448
    Cell Significance Index: 109.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1209
    Cell Significance Index: 3.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0872
    Cell Significance Index: 1.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0613
    Cell Significance Index: 22.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0229
    Cell Significance Index: -43.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0384
    Cell Significance Index: -3.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0444
    Cell Significance Index: -81.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0541
    Cell Significance Index: -83.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0610
    Cell Significance Index: -82.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0825
    Cell Significance Index: -61.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0950
    Cell Significance Index: -16.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1007
    Cell Significance Index: -63.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1165
    Cell Significance Index: -3.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1169
    Cell Significance Index: -65.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1274
    Cell Significance Index: -8.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1499
    Cell Significance Index: -93.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1560
    Cell Significance Index: -70.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1785
    Cell Significance Index: -4.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2091
    Cell Significance Index: -60.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2497
    Cell Significance Index: -15.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2532
    Cell Significance Index: -15.2000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2962
    Cell Significance Index: -5.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3167
    Cell Significance Index: -36.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3194
    Cell Significance Index: -1.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3234
    Cell Significance Index: -18.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3314
    Cell Significance Index: -37.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4128
    Cell Significance Index: -86.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4781
    Cell Significance Index: -69.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5467
    Cell Significance Index: -13.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5564
    Cell Significance Index: -11.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7394
    Cell Significance Index: -76.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7403
    Cell Significance Index: -10.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7624
    Cell Significance Index: -60.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8242
    Cell Significance Index: -63.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9881
    Cell Significance Index: -66.4400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9946
    Cell Significance Index: -6.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0165
    Cell Significance Index: -29.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1212
    Cell Significance Index: -68.7400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1471
    Cell Significance Index: -16.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.2035
    Cell Significance Index: -7.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2978
    Cell Significance Index: -15.4700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.3854
    Cell Significance Index: -8.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding protein**: LSM7 is a member of the Lsm1-7 complex, a group of proteins that bind to U6 snRNA and regulate mRNA degradation. 2. **Spliceosomal-mediated mRNA decay**: LSM7 facilitates the degradation of mRNA through 5' to 3' exoribonuclease activity, a crucial step in the spliceosomal-mediated mRNA decay pathway. 3. **U6 snRNA interaction**: LSM7 interacts with U6 snRNA, a key component of the spliceosome, to regulate mRNA processing and degradation. 4. **Expression in various cell types**: LSM7 is expressed in a wide range of cell types, including hematopoietic cells, epithelial cells, stem cells, and immune cells. **Pathways and Functions:** 1. **Catalytic step 2 spliceosome**: LSM7 participates in the catalytic step 2 of the spliceosome, facilitating the recognition of splice sites and the subsequent degradation of introns. 2. **Deadenylation-dependent mRNA decay**: LSM7 is involved in the deadenylation-dependent mRNA decay pathway, which regulates the degradation of mRNA by 5' to 3' exoribonuclease activity. 3. **Lsm1-7-pat1 complex**: LSM7 interacts with the Lsm1-7-pat1 complex, a regulatory complex that controls the activity of the Lsm1-7 complex. 4. **Metabolism of RNA**: LSM7 plays a role in the metabolism of RNA, particularly in the regulation of mRNA degradation and processing. **Clinical Significance:** 1. **Immunological disorders**: LSM7 has been implicated in the regulation of immune responses, and its dysregulation may contribute to the development of immunological disorders, such as autoimmune diseases and cancer. 2. **Hematopoietic disorders**: LSM7 expression has been found to be altered in hematopoietic disorders, such as leukemia and lymphoma, highlighting its potential role in the regulation of hematopoiesis. 3. **Cancer progression**: LSM7 may play a role in the regulation of cancer progression, particularly in the context of immune evasion and tumor microenvironment modulation. 4. **Stem cell regulation**: LSM7 expression has been found to be altered in stem cell disorders, such as leukemia and lymphoma, highlighting its potential role in the regulation of stem cell maintenance and differentiation. In conclusion, LSM7 is a critical regulator of RNA processing and degradation, particularly in the context of spliceosomal-mediated mRNA decay. Its expression has been identified in various cell types, including hematopoietic cells, epithelial cells, and stem cells. The LSM7 protein's interaction with U6 snRNA and its role in regulating mRNA degradation highlight its significance in maintaining cellular homeostasis and modulating immune responses. Further studies are needed to elucidate the clinical significance of LSM7 and its potential role in the development of immunological disorders.

Genular Protein ID: 942060466

Symbol: LSM7_HUMAN

Name: U6 snRNA-associated Sm-like protein LSm7

UniProtKB Accession Codes:

Q9UK45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 18 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10523320

Title: A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.

PubMed ID: 10523320

DOI: 10.1093/emboj/18.20.5789

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12165861

Title: Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators.

PubMed ID: 12165861

DOI: 10.1038/sj.onc.1205658

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

Sequence Information:

  • Length: 103
  • Mass: 11602
  • Checksum: 7429DC0FB365C9C8
  • Sequence:
    • MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG TIEYMRDPDD 
QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ QDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.