Details for: ZNF44

Gene ID: 51710

Symbol: ZNF44

Ensembl ID: ENSG00000197857

Description: zinc finger protein 44

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.5040
    Cell Significance Index: -26.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.6067
    Cell Significance Index: -24.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.3124
    Cell Significance Index: -25.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.3295
    Cell Significance Index: -24.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.5845
    Cell Significance Index: -25.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.5661
    Cell Significance Index: -26.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6977
    Cell Significance Index: -23.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7683
    Cell Significance Index: -23.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7852
    Cell Significance Index: -14.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7764
    Cell Significance Index: -26.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7638
    Cell Significance Index: 350.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6458
    Cell Significance Index: 126.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5231
    Cell Significance Index: 20.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0120
    Cell Significance Index: 913.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9387
    Cell Significance Index: 11.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8574
    Cell Significance Index: 172.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8403
    Cell Significance Index: 43.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8160
    Cell Significance Index: 13.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8070
    Cell Significance Index: 15.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7537
    Cell Significance Index: 87.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7081
    Cell Significance Index: 42.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6923
    Cell Significance Index: 75.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6916
    Cell Significance Index: 26.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6651
    Cell Significance Index: 14.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6577
    Cell Significance Index: 29.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6400
    Cell Significance Index: 29.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6219
    Cell Significance Index: 223.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6112
    Cell Significance Index: 38.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6039
    Cell Significance Index: 98.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5953
    Cell Significance Index: 58.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4257
    Cell Significance Index: 5.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4037
    Cell Significance Index: 11.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4015
    Cell Significance Index: 24.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3982
    Cell Significance Index: 71.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3753
    Cell Significance Index: 21.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3614
    Cell Significance Index: 10.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3561
    Cell Significance Index: 24.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3178
    Cell Significance Index: 21.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2843
    Cell Significance Index: 2.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2744
    Cell Significance Index: 33.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2535
    Cell Significance Index: 6.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2509
    Cell Significance Index: 2.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2411
    Cell Significance Index: 6.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2069
    Cell Significance Index: 4.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1489
    Cell Significance Index: 280.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1447
    Cell Significance Index: 19.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1336
    Cell Significance Index: 60.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1186
    Cell Significance Index: 64.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0807
    Cell Significance Index: 15.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0712
    Cell Significance Index: 45.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0657
    Cell Significance Index: 121.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0609
    Cell Significance Index: 93.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0607
    Cell Significance Index: 44.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0577
    Cell Significance Index: 0.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0514
    Cell Significance Index: 22.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0468
    Cell Significance Index: 6.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0338
    Cell Significance Index: 0.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0326
    Cell Significance Index: 2.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0290
    Cell Significance Index: 39.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0289
    Cell Significance Index: 4.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0271
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0056
    Cell Significance Index: -0.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0087
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0379
    Cell Significance Index: -21.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0405
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0428
    Cell Significance Index: -26.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0594
    Cell Significance Index: -7.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0620
    Cell Significance Index: -1.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0638
    Cell Significance Index: -6.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0713
    Cell Significance Index: -3.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0758
    Cell Significance Index: -11.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0783
    Cell Significance Index: -2.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0811
    Cell Significance Index: -23.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0843
    Cell Significance Index: -1.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0873
    Cell Significance Index: -1.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0986
    Cell Significance Index: -10.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1206
    Cell Significance Index: -25.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1209
    Cell Significance Index: -15.6200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1217
    Cell Significance Index: -1.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1444
    Cell Significance Index: -3.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1650
    Cell Significance Index: -13.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1787
    Cell Significance Index: -9.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1802
    Cell Significance Index: -2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2096
    Cell Significance Index: -5.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2136
    Cell Significance Index: -6.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2377
    Cell Significance Index: -6.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2380
    Cell Significance Index: -16.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2411
    Cell Significance Index: -14.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2951
    Cell Significance Index: -3.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3050
    Cell Significance Index: -5.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3093
    Cell Significance Index: -9.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3425
    Cell Significance Index: -7.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3586
    Cell Significance Index: -8.7500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3717
    Cell Significance Index: -4.6800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4029
    Cell Significance Index: -6.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4049
    Cell Significance Index: -5.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4278
    Cell Significance Index: -21.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZNF44 exhibits several key characteristics that enable it to regulate gene expression: 1. **DNA-binding ability**: ZNF44 possesses a unique zinc finger domain that allows it to bind to specific DNA sequences, thereby regulating transcription. 2. **RNA polymerase II specificity**: ZNF44 specifically interacts with RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 3. **Metal ion binding**: ZNF44 binds to metal ions, which are essential for maintaining its structure and function. 4. **Nuclear localization**: ZNF44 is primarily localized to the nucleus, where it regulates transcription. **Pathways and Functions** ZNF44 is involved in several key pathways and functions, including: 1. **Regulation of transcription by RNA polymerase II**: ZNF44 regulates transcription by interacting with RNA polymerase II, thereby controlling the expression of genes involved in immune response and development. 2. **DNA-binding transcription factor activity**: ZNF44 binds to specific DNA sequences, regulating the expression of genes involved in various biological processes. 3. **Metal ion binding**: ZNF44 binds to metal ions, which are essential for maintaining its structure and function. 4. **Regulation of transcriptional regulatory regions**: ZNF44 regulates the expression of genes by binding to specific transcriptional regulatory regions. **Significantly Expressed Cells** ZNF44 is significantly expressed in various cell types, including: 1. **Polychromatophilic erythroblast**: A type of erythroblast that is involved in the production of red blood cells. 2. **Hematopoietic oligopotent progenitor cell**: A type of cell that gives rise to various hematopoietic cells. 3. **Smooth muscle fiber of ileum**: A type of smooth muscle cell found in the ileum. 4. **Peripheral blood mononuclear cell**: A type of immune cell that is involved in the immune response. 5. **Ileal goblet cell**: A type of epithelial cell found in the ileum. 6. **Orthochromatic erythroblast**: A type of erythroblast that is involved in the production of red blood cells. 7. **CD8-alpha-beta-positive, alpha-beta intraepithelial T cell**: A type of T cell that is involved in the immune response. 8. **CD8-positive, alpha-beta regulatory T cell**: A type of regulatory T cell that is involved in maintaining immune tolerance. 9. **Epidermal Langerhans cell**: A type of immune cell found in the skin. 10. **Stromal cell of bone marrow**: A type of cell found in the bone marrow that is involved in supporting hematopoiesis. **Clinical Significance** The dysregulation of ZNF44 has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: ZNF44 plays a crucial role in regulating immune response, and its dysregulation can lead to immunodeficiency disorders. 2. **Cancer**: ZNF44 has been implicated in the regulation of gene expression in various types of cancer, including leukemia and lymphoma. 3. **Autoimmune diseases**: ZNF44 has been implicated in the regulation of gene expression in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, ZNF44 is a critical regulator of gene expression that plays a crucial role in immune response, development, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ZNF44 and its role in human health and disease.

Genular Protein ID: 1482891747

Symbol: ZNF44_HUMAN

Name: Zinc finger protein 44

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 663
  • Mass: 76524
  • Checksum: 6B66F4715A972432
  • Sequence:
  • MALCYGTFWG YPKMLEAANL MEGLVDIGPW VTLPRGQPEV LEWGLPKDQD SVAFEDVAVN 
    FTHEEWALLG PSQKNLYRDV MRETIRNLNC IGMKWENQNI DDQHQNLRRN PRCDVVERFG 
    KSKDGSQCGE TLSQIRNSIV NKNTPARVDA CGSSVNGEVI MGHSSLNCYI RVDTGHKHRE 
    CHEYAEKSYT HKQCGKGLSY RHSFQTCERP HTGKKPYDCK ECGKTFSSPG NLRRHMVVKG 
    GDGPYKCELC GKAFFWPSLL RMHERTHTGE KPYECKQCSK AFPVYSSYLR HEKIHTGEKP 
    YECKQCSKAF PDYSSYLRHE RTHTGEKPYK CKQCGKAFSV SGSLRVHERI HTGEKPYTCK 
    QCGKAFCHLG SFQRHMIMHS GDGPHKCKIC GKGFDFPGSA RIHEGTHTLE KPYECKQCGK 
    LLSHRSSFRR HMMAHTGDGP HKCTVCGKAF DSPSVFQRHE RTHTGEKPYE CKQCGKAFRT 
    SSSLRKHETT HTGEQPYKCK CGKAFSDLFS FQSHETTHSE EEPYECKECG KAFSSFKYFC 
    RHERTHSEEK SYECQICGKA FSRFSYLKTH ERTHTAEKPY ECKQCRKAFF WPSFLLRHER 
    THTGERPYEC KHCGKAFSRS SFCREHERTH TGEKPYECKE CGKAFSSLSS FNRHKRTHWK 
    DIL

Genular Protein ID: 2994086194

Symbol: F8W7T7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 615
  • Mass: 71150
  • Checksum: BCB3EA10EF0CBAA6
  • Sequence:
  • MDSVAFEDVA VNFTHEEWAL LGPSQKNLYR DVMRETIRNL NCIGMKWENQ NIDDQHQNLR 
    RNPRCDVVER FGKSKDGSQC GETLSQIRNS IVNKNTPARV DACGSSVNGE VIMGHSSLNC 
    YIRVDTGHKH RECHEYAEKS YTHKQCGKGL SYRHSFQTCE RPHTGKKPYD CKECGKTFSS 
    PGNLRRHMVV KGGDGPYKCE LCGKAFFWPS LLRMHERTHT GEKPYECKQC SKAFPVYSSY 
    LRHEKIHTGE KPYECKQCSK AFPDYSSYLR HERTHTGEKP YKCKQCGKAF SVSGSLRVHE 
    RIHTGEKPYT CKQCGKAFCH LGSFQRHMIM HSGDGPHKCK ICGKGFDFPG SARIHEGTHT 
    LEKPYECKQC GKLLSHRSSF RRHMMAHTGD GPHKCTVCGK AFDSPSVFQR HERTHTGEKP 
    YECKQCGKAF RTSSSLRKHE TTHTGEQPYK CKCGKAFSDL FSFQSHETTH SEEEPYECKE 
    CGKAFSSFKY FCRHERTHSE EKSYECQICG KAFSRFSYLK THERTHTAEK PYECKQCRKA 
    FFWPSFLLRH ERTHTGERPY ECKHCGKAFS RSSFCREHER THTGEKPYEC KECGKAFSSL 
    SSFNRHKRTH WKDIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.