Details for: PFDN2

Gene ID: 5202

Symbol: PFDN2

Ensembl ID: ENSG00000143256

Description: prefoldin subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.66
    Marker Score: 124602
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.91
    Marker Score: 7104.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.78
    Marker Score: 1157
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.72
    Marker Score: 920
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.61
    Marker Score: 12838
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.58
    Marker Score: 2030
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.55
    Marker Score: 2724
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.53
    Marker Score: 2161
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.45
    Marker Score: 84970
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.45
    Marker Score: 2559
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.42
    Marker Score: 860
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.35
    Marker Score: 584
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.33
    Marker Score: 584
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.3
    Marker Score: 2581
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.29
    Marker Score: 3789.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.28
    Marker Score: 3283
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.27
    Marker Score: 5583.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.24
    Marker Score: 8640
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.21
    Marker Score: 56505
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.2
    Marker Score: 854
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.2
    Marker Score: 4585.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.14
    Marker Score: 3507
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.11
    Marker Score: 9119
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.09
    Marker Score: 7723.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.08
    Marker Score: 4218
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.06
    Marker Score: 23220
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.06
    Marker Score: 1297
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.04
    Marker Score: 2448
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.03
    Marker Score: 15870
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.02
    Marker Score: 2860
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.02
    Marker Score: 1349.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.01
    Marker Score: 3420
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.01
    Marker Score: 4012
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2
    Marker Score: 3221
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2
    Marker Score: 494
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.99
    Marker Score: 26314
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.99
    Marker Score: 8160
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2934
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.98
    Marker Score: 1998
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.98
    Marker Score: 7768.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.98
    Marker Score: 1241
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.98
    Marker Score: 3142
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.96
    Marker Score: 1310
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.96
    Marker Score: 3319.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.95
    Marker Score: 718
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.95
    Marker Score: 2079
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.93
    Marker Score: 3360.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.92
    Marker Score: 786
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.92
    Marker Score: 2028
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.91
    Marker Score: 903
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.91
    Marker Score: 1090
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.9
    Marker Score: 4804
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.9
    Marker Score: 3569
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.9
    Marker Score: 978
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.88
    Marker Score: 3339
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.88
    Marker Score: 4427
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.88
    Marker Score: 1902.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.87
    Marker Score: 1759.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.85
    Marker Score: 880
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.84
    Marker Score: 11773
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.84
    Marker Score: 618
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.83
    Marker Score: 15814
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.83
    Marker Score: 1977
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.83
    Marker Score: 21312
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.83
    Marker Score: 1084
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.82
    Marker Score: 4886
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.81
    Marker Score: 1707
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.81
    Marker Score: 872.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.81
    Marker Score: 1919
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8
    Marker Score: 2172
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8
    Marker Score: 429
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.79
    Marker Score: 1688
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.79
    Marker Score: 2089
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.79
    Marker Score: 1788.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.79
    Marker Score: 4934
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.78
    Marker Score: 1596
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.78
    Marker Score: 9336
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.77
    Marker Score: 1866
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.76
    Marker Score: 971
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.76
    Marker Score: 11439.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.76
    Marker Score: 2708
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.76
    Marker Score: 17792
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.75
    Marker Score: 4771.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.75
    Marker Score: 17600.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.74
    Marker Score: 781.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.74
    Marker Score: 1552
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.74
    Marker Score: 11316
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.73
    Marker Score: 1673
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.73
    Marker Score: 1833
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.72
    Marker Score: 4680.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.71
    Marker Score: 3128
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.7
    Marker Score: 1212
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.7
    Marker Score: 1989.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.7
    Marker Score: 14744
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.69
    Marker Score: 900
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.68
    Marker Score: 395
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.68
    Marker Score: 2381
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.68
    Marker Score: 16651
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.68
    Marker Score: 5955
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.67
    Marker Score: 3244

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Other Information

**Key Characteristics:** PFDN2 is a subunit of the prefoldin complex, a chaperone-mediated protein folding system that assists in the proper folding of proteins into their native conformation. PFDN2 has been shown to interact with other proteins, such as CCT/TRIC, to facilitate the transfer of substrates and regulate protein folding. Its expression is widespread, with significant levels detected in various cell types, including fibroblasts, epithelial cells, and stem cells. **Pathways and Functions:** PFDN2 is involved in several key pathways, including: 1. **Chaperone-mediated protein folding:** PFDN2 works in conjunction with other chaperones, such as CCT/TRIC, to facilitate the proper folding of proteins into their native conformation. 2. **Amyloid-beta binding:** PFDN2 has been shown to interact with amyloid-beta, a protein implicated in Alzheimer's disease, suggesting a potential role in regulating amyloid-beta aggregation. 3. **Cooperation of prefoldin and tric/cct in actin and tubulin folding:** PFDN2 has been shown to interact with tric/cct, a protein complex involved in the folding of actin and tubulin, highlighting its role in regulating the folding of cytoskeletal proteins. 4. **Negative regulation of amyloid fibril formation:** PFDN2 has been shown to inhibit the formation of amyloid fibrils, suggesting a potential role in preventing the progression of amyloid-related diseases. **Clinical Significance:** Dysregulation of PFDN2 has been implicated in various diseases, including: 1. **Alzheimer's disease:** PFDN2 has been shown to interact with amyloid-beta, suggesting a potential role in regulating amyloid-beta aggregation and disease progression. 2. **Prostate cancer:** PFDN2 has been found to be significantly expressed in prostate cancer cells, suggesting a potential role in cancer progression. 3. **Muscular dystrophy:** PFDN2 has been implicated in the regulation of protein folding in skeletal muscle, highlighting its potential role in muscular dystrophy. In conclusion, PFDN2 plays a critical role in protein folding and regulation, with implications for disease pathogenesis. Further research is needed to fully elucidate the functions and mechanisms of PFDN2, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 381843863

Symbol: PFD2_HUMAN

Name: Prefoldin subunit 2

UniProtKB Accession Codes:

Q9UHV9 Q9P0P7 Q9UN05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 17936702

Title: S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.

PubMed ID: 17936702

DOI: 10.1016/j.molcel.2007.08.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

Sequence Information:

  • Length: 154
  • Mass: 16648
  • Checksum: 2FC68A7425412198
  • Sequence:
    • MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME LNEHSLVIDT 
LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI IETLTQQLQA KGKELNEFRE 
KHNIRLMGED EKPAAKENSE GAGAKASSAG VLVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.