Details for: PFDN2

Gene ID: 5202

Symbol: PFDN2

Ensembl ID: ENSG00000143256

Description: prefoldin subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 394.9334
    Cell Significance Index: -61.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 232.4721
    Cell Significance Index: -58.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 180.6298
    Cell Significance Index: -74.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 159.3971
    Cell Significance Index: -75.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 137.7956
    Cell Significance Index: -70.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.9096
    Cell Significance Index: -71.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9040
    Cell Significance Index: -53.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.9772
    Cell Significance Index: -74.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3315
    Cell Significance Index: -47.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5267
    Cell Significance Index: -20.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 6.8061
    Cell Significance Index: 793.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.5575
    Cell Significance Index: 159.3100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.8665
    Cell Significance Index: 8.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.8015
    Cell Significance Index: 20.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4325
    Cell Significance Index: 42.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1230
    Cell Significance Index: 99.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1015
    Cell Significance Index: 57.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0291
    Cell Significance Index: 1108.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0278
    Cell Significance Index: 53.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8926
    Cell Significance Index: 141.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8451
    Cell Significance Index: 253.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7574
    Cell Significance Index: 285.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7000
    Cell Significance Index: 209.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6024
    Cell Significance Index: 33.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5625
    Cell Significance Index: 201.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4706
    Cell Significance Index: 265.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4607
    Cell Significance Index: 15.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4130
    Cell Significance Index: 74.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3760
    Cell Significance Index: 608.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3356
    Cell Significance Index: 94.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2170
    Cell Significance Index: 78.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1104
    Cell Significance Index: 32.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0709
    Cell Significance Index: 55.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9403
    Cell Significance Index: 43.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9358
    Cell Significance Index: 110.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8679
    Cell Significance Index: 30.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8120
    Cell Significance Index: 162.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7465
    Cell Significance Index: 5.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7405
    Cell Significance Index: 94.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7209
    Cell Significance Index: 19.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6925
    Cell Significance Index: 137.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4912
    Cell Significance Index: 5.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3463
    Cell Significance Index: 34.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3451
    Cell Significance Index: 21.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3337
    Cell Significance Index: 9.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2457
    Cell Significance Index: 88.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2184
    Cell Significance Index: 37.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1998
    Cell Significance Index: 1.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1836
    Cell Significance Index: 1.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1646
    Cell Significance Index: 148.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1496
    Cell Significance Index: 103.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1277
    Cell Significance Index: 24.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1017
    Cell Significance Index: 2.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0779
    Cell Significance Index: 58.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0245
    Cell Significance Index: 0.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0187
    Cell Significance Index: 13.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0209
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0229
    Cell Significance Index: -43.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0386
    Cell Significance Index: -3.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0430
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0450
    Cell Significance Index: -82.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0533
    Cell Significance Index: -82.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0583
    Cell Significance Index: -79.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0675
    Cell Significance Index: -38.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0849
    Cell Significance Index: -53.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1340
    Cell Significance Index: -60.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1532
    Cell Significance Index: -32.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1791
    Cell Significance Index: -11.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1867
    Cell Significance Index: -53.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1901
    Cell Significance Index: -21.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1932
    Cell Significance Index: -3.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2479
    Cell Significance Index: -14.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2811
    Cell Significance Index: -7.8600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3616
    Cell Significance Index: -2.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3633
    Cell Significance Index: -9.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4104
    Cell Significance Index: -59.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4198
    Cell Significance Index: -45.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4429
    Cell Significance Index: -5.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5512
    Cell Significance Index: -7.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5593
    Cell Significance Index: -44.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6285
    Cell Significance Index: -71.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6322
    Cell Significance Index: -16.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6535
    Cell Significance Index: -29.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6741
    Cell Significance Index: -45.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6834
    Cell Significance Index: -52.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7109
    Cell Significance Index: -74.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8536
    Cell Significance Index: -27.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9354
    Cell Significance Index: -52.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0542
    Cell Significance Index: -22.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1054
    Cell Significance Index: -32.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1438
    Cell Significance Index: -24.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1556
    Cell Significance Index: -7.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2062
    Cell Significance Index: -73.9500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.2085
    Cell Significance Index: -5.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2629
    Cell Significance Index: -55.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2989
    Cell Significance Index: -22.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3916
    Cell Significance Index: -35.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4329
    Cell Significance Index: -21.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFDN2 is a subunit of the prefoldin complex, a chaperone-mediated protein folding system that assists in the proper folding of proteins into their native conformation. PFDN2 has been shown to interact with other proteins, such as CCT/TRIC, to facilitate the transfer of substrates and regulate protein folding. Its expression is widespread, with significant levels detected in various cell types, including fibroblasts, epithelial cells, and stem cells. **Pathways and Functions:** PFDN2 is involved in several key pathways, including: 1. **Chaperone-mediated protein folding:** PFDN2 works in conjunction with other chaperones, such as CCT/TRIC, to facilitate the proper folding of proteins into their native conformation. 2. **Amyloid-beta binding:** PFDN2 has been shown to interact with amyloid-beta, a protein implicated in Alzheimer's disease, suggesting a potential role in regulating amyloid-beta aggregation. 3. **Cooperation of prefoldin and tric/cct in actin and tubulin folding:** PFDN2 has been shown to interact with tric/cct, a protein complex involved in the folding of actin and tubulin, highlighting its role in regulating the folding of cytoskeletal proteins. 4. **Negative regulation of amyloid fibril formation:** PFDN2 has been shown to inhibit the formation of amyloid fibrils, suggesting a potential role in preventing the progression of amyloid-related diseases. **Clinical Significance:** Dysregulation of PFDN2 has been implicated in various diseases, including: 1. **Alzheimer's disease:** PFDN2 has been shown to interact with amyloid-beta, suggesting a potential role in regulating amyloid-beta aggregation and disease progression. 2. **Prostate cancer:** PFDN2 has been found to be significantly expressed in prostate cancer cells, suggesting a potential role in cancer progression. 3. **Muscular dystrophy:** PFDN2 has been implicated in the regulation of protein folding in skeletal muscle, highlighting its potential role in muscular dystrophy. In conclusion, PFDN2 plays a critical role in protein folding and regulation, with implications for disease pathogenesis. Further research is needed to fully elucidate the functions and mechanisms of PFDN2, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 381843863

Symbol: PFD2_HUMAN

Name: Prefoldin subunit 2

UniProtKB Accession Codes:

Q9UHV9 Q9P0P7 Q9UN05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 6 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 17936702

Title: S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.

PubMed ID: 17936702

DOI: 10.1016/j.molcel.2007.08.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

Sequence Information:

  • Length: 154
  • Mass: 16648
  • Checksum: 2FC68A7425412198
  • Sequence:
    • MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME LNEHSLVIDT 
LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI IETLTQQLQA KGKELNEFRE 
KHNIRLMGED EKPAAKENSE GAGAKASSAG VLVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.