PHB1 | ENSG00000167085 | NCBI 5245

Details for: PHB1

Gene ID: 5245

Symbol: PHB1

Ensembl ID: ENSG00000167085

Description: prohibitin 1

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mitochondrial calcium ion transport
(R-HSA-8949215)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Processing of smdt1
(R-HSA-8949664)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Transport of small molecules
(R-HSA-382551)
Antiviral innate immune response
(GO:0140374)
B cell activation
(GO:0042113)
Cell surface
(GO:0009986)
Cellular response to interleukin-6
(GO:0071354)
Complement component c3a binding
(GO:0001850)
Complement component c3b binding
(GO:0001851)
Cytoplasm
(GO:0005737)
Dna biosynthetic process
(GO:0071897)
Early endosome
(GO:0005769)
Enzyme binding
(GO:0019899)
Epigenetic regulation of gene expression
(GO:0040029)
Extracellular exosome
(GO:0070062)
Histone deacetylase binding
(GO:0042826)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial prohibitin complex
(GO:0035632)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Modulation by host of viral rna genome replication
(GO:0044830)
Negative regulation of androgen receptor signaling pathway
(GO:0060766)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of glucocorticoid receptor signaling pathway
(GO:2000323)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Plasma membrane
(GO:0005886)
Positive regulation of complement activation
(GO:0045917)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of g protein-coupled receptor signaling pathway
(GO:0045745)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Progesterone receptor signaling pathway
(GO:0050847)
Proteinase activated receptor binding
(GO:0031871)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein stabilization
(GO:0050821)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Rig-i signaling pathway
(GO:0039529)
Signal transduction
(GO:0007165)
Symbiont entry into host cell
(GO:0046718)
T-helper 17 type immune response
(GO:0072538)
Transcription corepressor activity
(GO:0003714)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 279.8543
Cell Significance Index: -43.5300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 140.0786
Cell Significance Index: -35.5300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 129.1184
Cell Significance Index: -53.1900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 118.4102
Cell Significance Index: -48.1100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 115.9444
Cell Significance Index: -54.7400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 106.7293
Cell Significance Index: -54.9000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 82.0390
Cell Significance Index: -55.0500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 42.2643
Cell Significance Index: -52.1100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.0495
Cell Significance Index: -55.4400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.2407
Cell Significance Index: -35.4700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.6827
Cell Significance Index: -29.7400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 7.4494
Cell Significance Index: 347.3300
Cell Name: kidney cell (CL1000497)
Fold Change: 5.3292
Cell Significance Index: 42.5500
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 5.0586
Cell Significance Index: 105.5000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 4.2001
Cell Significance Index: 35.2800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 4.1798
Cell Significance Index: 45.4400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.2644
Cell Significance Index: 68.3300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.2142
Cell Significance Index: 20.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.2095
Cell Significance Index: 103.8500
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.1951
Cell Significance Index: 57.7200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.1382
Cell Significance Index: 74.3000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1015
Cell Significance Index: 57.2000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8138
Cell Significance Index: 135.1800
Cell Name: lactocyte (CL0002325)
Fold Change: 1.7795
Cell Significance Index: 229.9000
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7697
Cell Significance Index: 966.4700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.5914
Cell Significance Index: 218.5500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4291
Cell Significance Index: 101.0700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4139
Cell Significance Index: 91.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4028
Cell Significance Index: 172.4900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.3924
Cell Significance Index: 72.3300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3919
Cell Significance Index: 250.9200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.2064
Cell Significance Index: 15.4500
Cell Name: peg cell (CL4033014)
Fold Change: 1.1829
Cell Significance Index: 27.3300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1752
Cell Significance Index: 191.1400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0480
Cell Significance Index: 123.5900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.9888
Cell Significance Index: 6.0900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9876
Cell Significance Index: 436.6400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.9841
Cell Significance Index: 11.1800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9830
Cell Significance Index: 28.8700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9130
Cell Significance Index: 181.1900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8305
Cell Significance Index: 106.4700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7455
Cell Significance Index: 33.7900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6245
Cell Significance Index: 61.7800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5038
Cell Significance Index: 95.8700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4711
Cell Significance Index: 12.5800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4097
Cell Significance Index: 69.9600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1483
Cell Significance Index: 4.7500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1480
Cell Significance Index: 29.6800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1312
Cell Significance Index: 6.8900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1267
Cell Significance Index: 92.8900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1008
Cell Significance Index: 2.8900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0961
Cell Significance Index: 1.4400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0780
Cell Significance Index: 2.7400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0753
Cell Significance Index: 56.9900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0672
Cell Significance Index: 1.1300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0535
Cell Significance Index: 0.9400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0356
Cell Significance Index: 12.7600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0164
Cell Significance Index: -30.7900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0176
Cell Significance Index: -13.0300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0176
Cell Significance Index: -0.8900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0178
Cell Significance Index: -1.8200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0292
Cell Significance Index: -18.2100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0311
Cell Significance Index: -17.5200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0330
Cell Significance Index: -3.7800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0386
Cell Significance Index: -71.1700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0452
Cell Significance Index: -69.5600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0487
Cell Significance Index: -1.3600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0502
Cell Significance Index: -45.2900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0521
Cell Significance Index: -70.7800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0653
Cell Significance Index: -41.4700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0703
Cell Significance Index: -1.0600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0911
Cell Significance Index: -19.1900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1114
Cell Significance Index: -50.5400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1292
Cell Significance Index: -3.3000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1328
Cell Significance Index: -38.2200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1440
Cell Significance Index: -5.9000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2010
Cell Significance Index: -5.3900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2071
Cell Significance Index: -16.4000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2599
Cell Significance Index: -1.5700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2640
Cell Significance Index: -5.7200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2841
Cell Significance Index: -41.2900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2899
Cell Significance Index: -18.2700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3090
Cell Significance Index: -8.2700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.3210
Cell Significance Index: -22.2000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4498
Cell Significance Index: -51.3400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4999
Cell Significance Index: -6.8200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5379
Cell Significance Index: -56.0100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5402
Cell Significance Index: -32.4300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5553
Cell Significance Index: -13.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6358
Cell Significance Index: -35.6800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6426
Cell Significance Index: -49.3100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7081
Cell Significance Index: -15.0800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7189
Cell Significance Index: -48.3400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.7336
Cell Significance Index: -10.2900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7462
Cell Significance Index: -45.7500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.8995
Cell Significance Index: -46.8500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9075
Cell Significance Index: -26.7300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.0756
Cell Significance Index: -19.8800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0924
Cell Significance Index: -28.0800
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.1905
Cell Significance Index: -10.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PHB1 is a small protein (~14 kDa) that belongs to the prohibitin family, which is known for its role in regulating mitochondrial dynamics and preventing mitochondrial fission. PHB1 is highly conserved across species, with high sequence identity to its human ortholog. The protein is localized in the mitochondria, nucleus, and cytoplasm, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** PHB1 is involved in various signaling pathways, including: 1. **Antiviral innate immune response**: PHB1 is involved in the regulation of antiviral responses, particularly in the activation of protein kinase C (PKC) activity and the modulation of MAPK signaling pathways. 2. **B cell activation**: PHB1 is required for the proper activation of B cells, which is essential for the immune response against pathogens. 3. **Cd40 signaling pathway**: PHB1 is involved in the regulation of Cd40 signaling, which is critical for the activation of immune cells, including T cells and B cells. 4. **Mitochondrial calcium ion transport**: PHB1 regulates mitochondrial calcium ion transport, which is essential for maintaining mitochondrial function and cellular homeostasis. PHB1 also plays a role in regulating various cellular processes, including: 1. **Cell growth and proliferation**: PHB1 negatively regulates cell growth and proliferation, which is essential for preventing cancer. 2. **Apoptosis**: PHB1 regulates apoptosis, particularly in the context of immune cells, where it prevents excessive cell death. 3. **DNA biosynthetic process**: PHB1 is involved in the regulation of DNA biosynthesis, which is essential for maintaining genome stability. **Clinical Significance:** PHB1 has been implicated in various immune-related diseases, including: 1. **Autoimmune diseases**: PHB1 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to the dysregulation of immune responses. 2. **Cancer**: PHB1 is involved in the regulation of cell growth and proliferation, and its dysfunction has been linked to various cancers, including leukemia and lymphoma. 3. **Infectious diseases**: PHB1 plays a role in the regulation of antiviral responses, and its dysfunction has been linked to severe viral infections, such as HIV-1 and HCV. In conclusion, PHB1 is a multifaceted protein that plays a critical role in regulating various cellular processes, including immune responses, cell growth, and apoptosis. Its dysfunction has been implicated in various immune-related diseases, highlighting the importance of PHB1 in maintaining immune homeostasis. Further research is necessary to fully elucidate the mechanisms by which PHB1 regulates cellular processes and to explore its therapeutic potential in immune-related diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PHB1_HUMAN
Q53FV0_HUMAN

Genular Protein ID: 133953602

Symbol: PHB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35232 B4DY47 Q4VBQ0

Database IDs:

Citations:

PubMed ID: 1540973

Title: The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.

PubMed ID: 1540973

PubMed ID: 8244394

Title: The human prohibitin (PHB) gene family and its somatic mutations in human tumors.

PubMed ID: 8244394

DOI: 10.1006/geno.1993.1402

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11302691

Title: Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.

PubMed ID: 11302691

DOI: 10.1006/excr.2001.5166

PubMed ID: 14500729

Title: Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling.

PubMed ID: 14500729

DOI: 10.1074/jbc.m305171200

PubMed ID: 19640993

Title: Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.

PubMed ID: 19640993

DOI: 10.1128/jvi.00842-09

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19906925

Title: Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein.

PubMed ID: 19906925

DOI: 10.1128/jvi.01641-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20959514

Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

PubMed ID: 20959514

DOI: 10.1096/fj.10-167502

PubMed ID: 21746876

Title: Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function.

PubMed ID: 21746876

DOI: 10.1128/mcb.05393-11

PubMed ID: 22997079

Title: Identification of prohibitin as a Chikungunya virus receptor protein.

PubMed ID: 22997079

DOI: 10.1002/jmv.23403

PubMed ID: 24003225

Title: Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration.

PubMed ID: 24003225

DOI: 10.1074/jbc.m113.510826

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28017329

Title: Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.

PubMed ID: 28017329

DOI: 10.1016/j.cell.2016.11.042

PubMed ID: 31522117

Title: Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.

PubMed ID: 31522117

DOI: 10.1016/j.isci.2019.08.056

PubMed ID: 31899195

Title: Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells.

PubMed ID: 31899195

DOI: 10.1016/j.imlet.2019.12.008

Sequence Information:

Length: 272
Mass: 29804
Checksum: 915494273E342C76
Sequence:

MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW 
VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIFTSI GEDYDERVLP 
SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT 
EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK 
LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ

Genular Protein ID: 3197874835

Symbol: Q53FV0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FV0

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

Length: 272
Mass: 29803
Checksum: 9154942F9CBE0C76
Sequence:

MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW 
VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIFTSI GEDYDERVLP 
SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT 
EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIKLRK 
LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PHB1

Associated with

Cells (max top 100)

Other Information

The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. PubMed ID: 1540973

The human prohibitin (PHB) gene family and its somatic mutations in human tumors. PubMed ID: 8244394

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. PubMed ID: 11302691

Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. PubMed ID: 14500729

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling. PubMed ID: 19640993

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. PubMed ID: 19906925

Initial characterization of the human central proteome. PubMed ID: 21269460

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. PubMed ID: 20959514

Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. PubMed ID: 21746876

Identification of prohibitin as a Chikungunya virus receptor protein. PubMed ID: 22997079

Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration. PubMed ID: 24003225

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. PubMed ID: 28017329

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region. PubMed ID: 31522117

Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells. PubMed ID: 31899195

Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. PubMed ID: 8125298

Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. PubMed ID: 9373149