Details for: PHYH
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.47rCSI 18.74%PRS 67.43
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CSI 9.66rCSI 14.93%PRS 66.45
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CSI 7.8rCSI 7.21%PRS 85.74
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CSI 6.03rCSI 12.39%PRS 83.68
-
CSI 5.91rCSI 6.19%PRS 64.55
-
CSI 5.4rCSI 10.3%PRS 85.3
-
CSI 5.29rCSI 9.51%PRS 60.97
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CSI 4.84rCSI 11.82%PRS 61.04
-
CSI 4.82rCSI 7.8%PRS 63.85
-
CSI 4.8rCSI 3.19%PRS 70.73
-
CSI 4.51rCSI 7.2%PRS 72.17
-
CSI 4.42rCSI 9.41%PRS 77.36
-
CSI 4.23rCSI 13.7%PRS 67.29
-
CSI 4.07rCSI 4.89%PRS 66.08
-
CSI 3.99rCSI 24.95%PRS 59.54
-
CSI 3.94rCSI 8.17%PRS 64.94
-
CSI 3.88rCSI 5.31%PRS 73.03
-
CSI 3.44rCSI 4.77%PRS 67.69
-
CSI 3.37rCSI 3.61%PRS 68.04
-
CSI 3.34rCSI 3.91%PRS 83.23
-
CSI 3.31rCSI 4.89%PRS 81.96
-
CSI 3.3rCSI 3.12%PRS 66.93
-
CSI 3.24rCSI 2.79%PRS 71.9
-
CSI 3.23rCSI 7.58%PRS 71.17
-
CSI 3.13rCSI 7.02%PRS 49.9
-
CSI 3.1rCSI 2.45%PRS 55
-
CSI 3.05rCSI 2.67%PRS 76.82
-
CSI 2.99rCSI 7.59%PRS 61.69
-
CSI 2.88rCSI 4.13%PRS 57.46
-
CSI 2.84rCSI 4.57%PRS 69.9
-
CSI 2.83rCSI 4.2%PRS 68.88
-
CSI 2.81rCSI 3.84%PRS 73.66
-
CSI 2.8rCSI 2.75%PRS 70.53
-
CSI 2.77rCSI 2.43%PRS 73.24
-
CSI 2.72rCSI 2.62%PRS 67.61
-
CSI 2.72rCSI 2.84%PRS 67.76
-
CSI 2.71rCSI 3.45%PRS 74
-
CSI 2.69rCSI 2.69%PRS 61.37
-
CSI 2.67rCSI 4.07%PRS 76.98
-
CSI 2.64rCSI 6.03%PRS 68.46
-
CSI 2.61rCSI 3.56%PRS 59.32
-
CSI 2.59rCSI 1.96%PRS 81.17
-
CSI 2.57rCSI 3.64%PRS 64.38
-
CSI 2.51rCSI 2.08%PRS 70.29
-
CSI 2.48rCSI 2.31%PRS 68.6
-
CSI 2.45rCSI 2.03%PRS 67.61
-
CSI 2.31rCSI 2.09%PRS 65.06
-
CSI 2.3rCSI 1.61%PRS 70.83
-
CSI 2.29rCSI 5.98%PRS 69.88
-
CSI 2.25rCSI 1.82%PRS 69.72
-
CSI 2.23rCSI 2.34%PRS 71.34
-
CSI 2.21rCSI 4.93%PRS 75.61
-
CSI 2.15rCSI 2.88%PRS 76.22
-
CSI 2.13rCSI 2.46%PRS 60.62
-
CSI 2.08rCSI 3.59%PRS 58.38
-
CSI 2.06rCSI 4.95%PRS 76.31
-
CSI 2.06rCSI 3.25%PRS 70.3
-
CSI 2.03rCSI 1.53%PRS 73.57
-
CSI 2.03rCSI 4.49%PRS 66.27
-
CSI 1.98rCSI 1.91%PRS 59.28
-
CSI 1.98rCSI 7.73%PRS 67.66
-
CSI 1.95rCSI 5.05%PRS 62.91
-
CSI 1.88rCSI 10.95%PRS 75.28
-
CSI 1.87rCSI 2.75%PRS 62.95
-
CSI 1.87rCSI 1.72%PRS 77.03
-
CSI 1.86rCSI 1.95%PRS 65.69
-
CSI 1.86rCSI 1.51%PRS 68.26
-
CSI 1.85rCSI 2.71%PRS 78.98
-
CSI 1.85rCSI 2.82%PRS 64.25
-
CSI 1.84rCSI 4.68%PRS 57.48
-
CSI 1.84rCSI 7.16%PRS 70.91
-
CSI 1.84rCSI 2.56%PRS 66.51
-
CSI 1.8rCSI 2.58%PRS 70.44
-
CSI 1.8rCSI 3.37%PRS 55.9
-
CSI 1.77rCSI 2.27%PRS 64.55
-
CSI 1.76rCSI 2.36%PRS 86.49
-
CSI 1.73rCSI 2.5%PRS 77.25
-
CSI 1.72rCSI 2.29%PRS 74.09
-
CSI 1.72rCSI 2.02%PRS 69.85
-
CSI 1.71rCSI 2.62%PRS 77.22
-
CSI 1.7rCSI 1.96%PRS 58.71
-
CSI 1.68rCSI 1.49%PRS 65.62
-
CSI 1.66rCSI 3.96%PRS 68.35
-
CSI 1.62rCSI 1.97%PRS 75.16
-
CSI 1.62rCSI 2.01%PRS 69.61
-
CSI 1.55rCSI 1.93%PRS 47.32
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CSI 1.48rCSI 2.79%PRS 78.03
-
CSI 1.45rCSI 2.39%PRS 73.36
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CSI 1.39rCSI 3.35%PRS 74.43
-
CSI 1.38rCSI 3.95%PRS 86.65
-
CSI 1.24rCSI 2%PRS 57.39
-
CSI 1.24rCSI 2.41%PRS 70.96
-
CSI 1.24rCSI 3.41%PRS 78.94
-
CSI 1.2rCSI 1.76%PRS 72.64
-
CSI 1.15rCSI 2.73%PRS 75.68
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CSI 1.02rCSI 1.54%PRS 72.85
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CSI 0.73rCSI 1.78%PRS 47.65
-
CSI 0.68rCSI 1.98%PRS 68.63
-
CSI 0.68rCSI 5.11%PRS 81.88
-
CSI 0.66rCSI 3.49%PRS 76.05
-
CSI 0.3rCSI 1.8%PRS 75.9%
-
CSI 0.7rCSI 3.5%PRS 76.1%
-
CSI 0.7rCSI 5.1%PRS 81.9%
-
CSI 0.7rCSI 2.0%PRS 68.6%
-
CSI 0.7rCSI 1.8%PRS 47.7%
-
CSI 1.0rCSI 1.5%PRS 72.9%
-
CSI 1.2rCSI 2.7%PRS 75.7%
-
CSI 1.2rCSI 1.8%PRS 72.6%
-
CSI 1.2rCSI 3.4%PRS 78.9%
-
CSI 1.2rCSI 2.4%PRS 71.0%
-
CSI 1.2rCSI 2.0%PRS 57.4%
-
CSI 1.4rCSI 4.0%PRS 86.7%
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CSI 1.4rCSI 3.4%PRS 74.4%
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CSI 1.5rCSI 2.4%PRS 73.4%
-
CSI 1.5rCSI 2.8%PRS 78.0%
-
CSI 1.6rCSI 1.9%PRS 47.3%
-
CSI 1.6rCSI 2.0%PRS 69.6%
-
CSI 1.6rCSI 2.0%PRS 75.2%
-
CSI 1.7rCSI 4.0%PRS 68.4%
-
CSI 1.7rCSI 1.5%PRS 65.6%
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CSI 1.7rCSI 2.0%PRS 58.7%
-
CSI 1.7rCSI 2.6%PRS 77.2%
-
CSI 1.7rCSI 2.0%PRS 69.9%
-
CSI 1.7rCSI 2.3%PRS 74.1%
-
CSI 1.7rCSI 2.5%PRS 77.3%
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CSI 1.8rCSI 2.4%PRS 86.5%
-
CSI 1.8rCSI 2.3%PRS 64.6%
-
CSI 1.8rCSI 3.4%PRS 55.9%
-
CSI 1.8rCSI 2.6%PRS 70.4%
-
CSI 1.8rCSI 2.6%PRS 66.5%
-
CSI 1.8rCSI 7.2%PRS 70.9%
-
CSI 1.8rCSI 4.7%PRS 57.5%
-
CSI 1.9rCSI 2.8%PRS 64.3%
-
CSI 1.9rCSI 2.7%PRS 79.0%
-
CSI 1.9rCSI 1.5%PRS 68.3%
-
CSI 1.9rCSI 2.0%PRS 65.7%
-
CSI 1.9rCSI 1.7%PRS 77.0%
-
CSI 1.9rCSI 2.8%PRS 63.0%
-
CSI 1.9rCSI 11.0%PRS 75.3%
-
CSI 2.0rCSI 5.1%PRS 62.9%
-
CSI 2.0rCSI 7.7%PRS 67.7%
-
CSI 2.0rCSI 1.9%PRS 59.3%
-
CSI 2.0rCSI 4.5%PRS 66.3%
-
CSI 2.0rCSI 1.5%PRS 73.6%
-
CSI 2.1rCSI 3.3%PRS 70.3%
-
CSI 2.1rCSI 5.0%PRS 76.3%
-
CSI 2.1rCSI 3.6%PRS 58.4%
-
CSI 2.1rCSI 2.5%PRS 60.6%
-
CSI 2.2rCSI 2.9%PRS 76.2%
-
CSI 2.2rCSI 4.9%PRS 75.6%
-
CSI 2.2rCSI 2.3%PRS 71.3%
-
CSI 2.3rCSI 1.8%PRS 69.7%
-
CSI 2.3rCSI 6.0%PRS 69.9%
-
CSI 2.3rCSI 1.6%PRS 70.8%
-
CSI 2.3rCSI 2.1%PRS 65.1%
-
CSI 2.5rCSI 2.0%PRS 67.6%
-
CSI 2.5rCSI 2.3%PRS 68.6%
-
CSI 2.5rCSI 2.1%PRS 70.3%
-
CSI 2.6rCSI 3.6%PRS 64.4%
-
CSI 2.6rCSI 2.0%PRS 81.2%
-
CSI 2.6rCSI 3.6%PRS 59.3%
-
CSI 2.6rCSI 6.0%PRS 68.5%
-
CSI 2.7rCSI 4.1%PRS 77.0%
-
CSI 2.7rCSI 2.7%PRS 61.4%
-
CSI 2.7rCSI 3.5%PRS 74.0%
-
CSI 2.7rCSI 2.8%PRS 67.8%
-
CSI 2.7rCSI 2.6%PRS 67.6%
-
CSI 2.8rCSI 2.4%PRS 73.2%
-
CSI 2.8rCSI 2.8%PRS 70.5%
-
CSI 2.8rCSI 3.8%PRS 73.7%
-
CSI 2.8rCSI 4.2%PRS 68.9%
-
CSI 2.8rCSI 4.6%PRS 69.9%
-
CSI 2.9rCSI 4.1%PRS 57.5%
-
CSI 3.0rCSI 7.6%PRS 61.7%
-
CSI 3.1rCSI 2.7%PRS 76.8%
-
CSI 3.1rCSI 2.5%PRS 55.0%
-
CSI 3.1rCSI 7.0%PRS 49.9%
-
CSI 3.2rCSI 7.6%PRS 71.2%
-
CSI 3.2rCSI 2.8%PRS 71.9%
-
CSI 3.3rCSI 3.1%PRS 66.9%
-
CSI 3.3rCSI 4.9%PRS 82.0%
-
CSI 3.3rCSI 3.9%PRS 83.2%
-
CSI 3.4rCSI 3.6%PRS 68.0%
-
CSI 3.4rCSI 4.8%PRS 67.7%
-
CSI 3.9rCSI 5.3%PRS 73.0%
-
CSI 3.9rCSI 8.2%PRS 64.9%
-
CSI 4.0rCSI 25.0%PRS 59.5%
-
CSI 4.1rCSI 4.9%PRS 66.1%
-
CSI 4.2rCSI 13.7%PRS 67.3%
-
CSI 4.4rCSI 9.4%PRS 77.4%
-
CSI 4.5rCSI 7.2%PRS 72.2%
-
CSI 4.8rCSI 3.2%PRS 70.7%
-
CSI 4.8rCSI 7.8%PRS 63.9%
-
CSI 4.8rCSI 11.8%PRS 61.0%
-
CSI 5.3rCSI 9.5%PRS 61.0%
-
CSI 5.4rCSI 10.3%PRS 85.3%
-
CSI 5.9rCSI 6.2%PRS 64.6%
-
CSI 6.0rCSI 12.4%PRS 83.7%
-
CSI 7.8rCSI 7.2%PRS 85.7%
-
CSI 9.7rCSI 14.9%PRS 66.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3014940384
Symbol: PAHX_HUMAN
Name: Phytanoyl-CoA dioxygenase, peroxisomal
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9326939
PubMed ID: 9326940
Title: Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene.
PubMed ID: 9326940
DOI: 10.1038/ng1097-190
PubMed ID: 10051602
Title: Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-CoA alpha-hydroxylase is a new FKBP-associated protein.
PubMed ID: 10051602
PubMed ID: 10767344
Title: Human phytanoyl-CoA hydroxylase: resolution of the gene structure and the molecular basis of Refsum's disease.
PubMed ID: 10767344
DOI: 10.1093/hmg/9.8.1195
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10686344
Title: Identification of a brain specific protein that associates with a Refsum disease gene product, phytanoyl-CoA alpha-hydroxylase.
PubMed ID: 10686344
PubMed ID: 10744784
Title: Phytanoyl-CoA hydroxylase: recognition of 3-methyl-branched acyl-coAs and requirement for GTP or ATP and Mg(2+) in addition to its known hydroxylation cofactors.
PubMed ID: 10744784
PubMed ID: 12031666
Title: Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid.
PubMed ID: 12031666
PubMed ID: 12923223
Title: Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: implications for Refsum disease?
PubMed ID: 12923223
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16186124
Title: Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
PubMed ID: 16186124
PubMed ID: 14974078
Title: Molecular basis of Refsum disease: sequence variations in phytanoyl-CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7).
PubMed ID: 14974078
DOI: 10.1002/humu.10315
PubMed ID: 10709665
Title: Phytanoyl-CoA hydroxylase deficiency. Enzymological and molecular basis of classical Refsum disease.
PubMed ID: 10709665
PubMed ID: 27535533
Title: Analysis of protein-coding genetic variation in 60,706 humans.
PubMed ID: 27535533
DOI: 10.1038/nature19057
Sequence Information:
- Length: 338
- Mass: 38538
- Checksum: FBF9639E7C79A6B0
- Sequence:
MEQLRAAARL QIVLGHLGRP SAGAVVAHPT SGTISSASFH PQQFQYTLDN NVLTLEQRKF YEENGFLVIK NLVPDADIQR FRNEFEKICR KEVKPLGLTV MRDVTISKSE YAPSEKMITK VQDFQEDKEL FRYCTLPEIL KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHY FPFRPSDLIV CAWTAMEHIS RNNGCLVVLP GTHKGSLKPH DYPKWEGGVN KMFHGIQDYE ENKARVHLVM EKGDTVFFHP LLIHGSGQNK TQGFRKAISC HFASADCHYI DVKGTSQENI EKEVVGIAHK FFGAENSVNL KDIWMFRARL VKGERTNL