PIK3CD | ENSG00000171608 | NCBI 5293

Details for: PIK3CD

Gene ID: 5293

Symbol: PIK3CD

Ensembl ID: ENSG00000171608

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Axon guidance
(R-HSA-422475)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-HSA-9027276)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Immune system
(R-HSA-168256)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin receptor shc signaling
(R-HSA-912526)
Intracellular signaling by second messengers
(R-HSA-9006925)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Phospholipid metabolism
(R-HSA-1483257)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pi metabolism
(R-HSA-1483255)
Pip3 activates akt signaling
(R-HSA-1257604)
Regulation of signaling by cbl
(R-HSA-912631)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Ret signaling
(R-HSA-8853659)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by interleukins
(R-HSA-449147)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
1-phosphatidylinositol-3-kinase activity
(GO:0016303)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
(GO:0046934)
1-phosphatidylinositol-4-phosphate 3-kinase activity
(GO:0035005)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
B cell activation
(GO:0042113)
B cell chemotaxis
(GO:0035754)
B cell differentiation
(GO:0030183)
B cell receptor signaling pathway
(GO:0050853)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Kinase activity
(GO:0016301)
Mast cell chemotaxis
(GO:0002551)
Mast cell degranulation
(GO:0043303)
Mast cell differentiation
(GO:0060374)
Natural killer cell activation
(GO:0030101)
Natural killer cell chemotaxis
(GO:0035747)
Natural killer cell differentiation
(GO:0001779)
Neutrophil chemotaxis
(GO:0030593)
Neutrophil extravasation
(GO:0072672)
Phosphatidylinositol-3-phosphate biosynthetic process
(GO:0036092)
Phosphatidylinositol-mediated signaling
(GO:0048015)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase complex
(GO:0005942)
Phosphatidylinositol 3-kinase complex, class ia
(GO:0005943)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial tube formation
(GO:1905278)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neutrophil apoptotic process
(GO:0033031)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Respiratory burst involved in defense response
(GO:0002679)
Signal transduction
(GO:0007165)
T cell activation
(GO:0042110)
T cell chemotaxis
(GO:0010818)
T cell differentiation
(GO:0030217)
T cell receptor signaling pathway
(GO:0050852)
Vascular endothelial growth factor signaling pathway
(GO:0038084)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 73.3549
Cell Significance Index: -11.4100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 40.2928
Cell Significance Index: -10.2200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 29.9195
Cell Significance Index: -12.1600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 26.0505
Cell Significance Index: -13.4000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.0114
Cell Significance Index: -12.4200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.1812
Cell Significance Index: -11.3200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.9598
Cell Significance Index: -10.8600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.7897
Cell Significance Index: -11.6400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.5164
Cell Significance Index: -9.4200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 3.2518
Cell Significance Index: 104.1500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.9244
Cell Significance Index: -11.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.7775
Cell Significance Index: 108.9800
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 1.7545
Cell Significance Index: 4.7000
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.9933
Cell Significance Index: 6.5900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.6616
Cell Significance Index: 19.4300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6487
Cell Significance Index: 76.5100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5147
Cell Significance Index: 23.3300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5091
Cell Significance Index: 9.4100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4995
Cell Significance Index: 32.2300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4879
Cell Significance Index: 92.8500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3841
Cell Significance Index: 38.0000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3260
Cell Significance Index: 65.3900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3159
Cell Significance Index: 218.5000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2918
Cell Significance Index: 263.4900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2049
Cell Significance Index: 33.3300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1712
Cell Significance Index: 61.4100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1424
Cell Significance Index: 8.7500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1308
Cell Significance Index: 14.2300
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.1306
Cell Significance Index: 1.3100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1222
Cell Significance Index: 3.2700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1070
Cell Significance Index: 2.9900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.0692
Cell Significance Index: 1.1400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0469
Cell Significance Index: 0.9700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0404
Cell Significance Index: 0.8600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0382
Cell Significance Index: 71.8900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0362
Cell Significance Index: 66.7200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0348
Cell Significance Index: 6.9100
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0217
Cell Significance Index: 0.5200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0174
Cell Significance Index: 26.7800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0142
Cell Significance Index: 19.3100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0126
Cell Significance Index: 6.8800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0049
Cell Significance Index: 0.1400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0015
Cell Significance Index: 0.9400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0006
Cell Significance Index: 0.0200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0121
Cell Significance Index: -5.3400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0125
Cell Significance Index: -2.2500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0140
Cell Significance Index: -0.3500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0147
Cell Significance Index: -10.8100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0153
Cell Significance Index: -11.5500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0154
Cell Significance Index: -11.3900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0172
Cell Significance Index: -2.5000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0175
Cell Significance Index: -7.9400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0208
Cell Significance Index: -1.4400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0212
Cell Significance Index: -11.9800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0245
Cell Significance Index: -0.3100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0271
Cell Significance Index: -0.4700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0308
Cell Significance Index: -3.5900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0328
Cell Significance Index: -4.5100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0346
Cell Significance Index: -9.9500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0374
Cell Significance Index: -2.8700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0385
Cell Significance Index: -2.3100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0394
Cell Significance Index: -1.8500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0435
Cell Significance Index: -7.4300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0460
Cell Significance Index: -2.5800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0462
Cell Significance Index: -1.0000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0520
Cell Significance Index: -6.3900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0614
Cell Significance Index: -7.8700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0619
Cell Significance Index: -13.0300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0660
Cell Significance Index: -0.9500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0751
Cell Significance Index: -9.7000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0818
Cell Significance Index: -8.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0908
Cell Significance Index: -9.4500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0909
Cell Significance Index: -10.4100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0976
Cell Significance Index: -6.5600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1027
Cell Significance Index: -2.9300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1056
Cell Significance Index: -7.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1060
Cell Significance Index: -4.9400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1096
Cell Significance Index: -2.1400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1230
Cell Significance Index: -2.6300
Cell Name: early promyelocyte (CL0002154)
Fold Change: -0.1269
Cell Significance Index: -0.8100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1333
Cell Significance Index: -3.8200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1374
Cell Significance Index: -9.7200
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1637
Cell Significance Index: -2.4900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1641
Cell Significance Index: -13.0000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1650
Cell Significance Index: -4.4900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1669
Cell Significance Index: -3.3000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1822
Cell Significance Index: -9.4900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1862
Cell Significance Index: -9.6700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1921
Cell Significance Index: -12.1100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1947
Cell Significance Index: -8.6100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1973
Cell Significance Index: -5.0400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1998
Cell Significance Index: -4.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2047
Cell Significance Index: -10.7500
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.2211
Cell Significance Index: -2.9500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2247
Cell Significance Index: -8.5100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2366
Cell Significance Index: -10.2900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2444
Cell Significance Index: -6.5500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2474
Cell Significance Index: -8.1000
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2610
Cell Significance Index: -4.5000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2620
Cell Significance Index: -5.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **PI3K pathway regulation**: PIK3CD is a key regulatory subunit of the PI3K complex, which is involved in the phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) to produce phosphatidylinositol-3-phosphate (PIP3). 2. **Cellular signaling**: PIK3CD is involved in the activation of various cellular signaling pathways, including the B cell receptor signaling pathway, mast cell chemotaxis, and natural killer cell activation. 3. **Isoform specificity**: PIK3CD has multiple isoforms, which are specifically expressed in different cell types, including retinal cone cells, colon goblet cells, and mature T cells. 4. **Regulation of immune response**: PIK3CD plays a critical role in the regulation of immune responses, including B cell differentiation, natural killer cell activation, and mast cell degranulation. **Pathways and Functions:** 1. **Adaptive immune response**: PIK3CD is involved in the activation of B cells, which is essential for the development of adaptive immune responses. 2. **Antigen presentation**: PIK3CD regulates the activation of antigen-presenting cells, which is critical for the initiation of immune responses. 3. **Cell migration**: PIK3CD is involved in the regulation of cell migration, including the migration of B cells, mast cells, and natural killer cells. 4. **Cancer progression**: PIK3CD has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 5. **Neurological disorders**: PIK3CD has been implicated in the development of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. **Clinical Significance:** 1. **Cancer therapy**: PIK3CD is a potential target for cancer therapy, as it is involved in the development and progression of various cancers. 2. **Autoimmune disorders**: PIK3CD has been implicated in the development of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 3. **Inflammatory conditions**: PIK3CD is involved in the regulation of inflammatory responses, which is critical for the development of inflammatory conditions, including asthma and arthritis. 4. **Immunotherapy**: PIK3CD is a potential target for immunotherapy, as it is involved in the activation of immune cells, including B cells and natural killer cells. In conclusion, PIK3CD is a critical regulator of cellular signaling and immune response, and its dysregulation has been implicated in the development and progression of various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Further research is needed to fully understand the role of PIK3CD in human disease and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Genular Protein ID: 3195879274

Symbol: PK3CD_HUMAN

Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

UniProtKB Accession Codes:

O00329 A6NCG0 G1FFP1 O15445 Q5SR49

Database IDs:

Citations:

PubMed ID: 9113989

Title: P110delta, a novel phosphoinositide 3-kinase in leukocytes.

PubMed ID: 9113989

DOI: 10.1073/pnas.94.9.4330

PubMed ID: 9235916

Title: p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.

PubMed ID: 9235916

DOI: 10.1074/jbc.272.31.19236

PubMed ID: 22020336

Title: p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors.

PubMed ID: 22020336

DOI: 10.1038/onc.2011.492

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15135396

Title: Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.

PubMed ID: 15135396

DOI: 10.1016/j.pep.2003.12.010

PubMed ID: 10064595

Title: Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.

PubMed ID: 10064595

DOI: 10.1093/emboj/18.5.1292

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20081091

Title: PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.

PubMed ID: 20081091

DOI: 10.1182/blood-2009-07-232330

PubMed ID: 17290298

Title: PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

PubMed ID: 17290298

DOI: 10.1038/nri2036

PubMed ID: 20940048

Title: Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function.

PubMed ID: 20940048

DOI: 10.1016/j.cellsig.2010.10.002

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24136356

Title: Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage.

PubMed ID: 24136356

DOI: 10.1126/science.1243292

PubMed ID: 29180244

Title: Dual loss of p110delta PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features.

PubMed ID: 29180244

DOI: 10.1016/j.jaci.2017.10.033

PubMed ID: 30040974

Title: Primary immunodeficiency disorder caused by phosphoinositide 3-kinase delta deficiency.

PubMed ID: 30040974

DOI: 10.1016/j.jaci.2018.06.039

PubMed ID: 30336224

Title: Human primary immunodeficiency caused by expression of a kinase-dead p110delta mutant.

PubMed ID: 30336224

DOI: 10.1016/j.jaci.2018.10.005

Sequence Information:

Length: 1044
Mass: 119479
Checksum: A38B5D1A1081A3D0
Sequence:

MPPGVDCPME FWTKEENQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQLLW HRAQYEPLFH 
MLSGPEAYVF TCINQTAEQQ ELEDEQRRLC DVQPFLPVLR LVAREGDRVK KLINSQISLL 
IGKGLHEFDS LCDPEVNDFR AKMCQFCEEA AARRQQLGWE AWLQYSFPLQ LEPSAQTWGP 
GTLRLPNRAL LVNVKFEGSE ESFTFQVSTK DVPLALMACA LRKKATVFRQ PLVEQPEDYT 
LQVNGRHEYL YGSYPLCQFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 
AKPPPIPAKK PSSVSLWSLE QPFRIELIQG SKVNADERMK LVVQAGLFHG NEMLCKTVSS 
SEVSVCSEPV WKQRLEFDIN ICDLPRMARL CFALYAVIEK AKKARSTKKK SKKADCPIAW 
ANLMLFDYKD QLKTGERCLY MWPSVPDEKG ELLNPTGTVR SNPNTDSAAA LLICLPEVAP 
HPVYYPALEK ILELGRHSEC VHVTEEEQLQ LREILERRGS GELYEHEKDL VWKLRHEVQE 
HFPEALARLL LVTKWNKHED VAQMLYLLCS WPELPVLSAL ELLDFSFPDC HVGSFAIKSL 
RKLTDDELFQ YLLQLVQVLK YESYLDCELT KFLLDRALAN RKIGHFLFWH LRSEMHVPSV 
ALRFGLILEA YCRGSTHHMK VLMKQGEALS KLKALNDFVK LSSQKTPKPQ TKELMHLCMR 
QEAYLEALSH LQSPLDPSTL LAEVCVEQCT FMDSKMKPLW IMYSNEEAGS GGSVGIIFKN 
GDDLRQDMLT LQMIQLMDVL WKQEGLDLRM TPYGCLPTGD RTGLIEVVLR SDTIANIQLN 
KSNMAATAAF NKDALLNWLK SKNPGEALDR AIEEFTLSCA GYCVATYVLG IGDRHSDNIM 
IRESGQLFHI DFGHFLGNFK TKFGINRERV PFILTYDFVH VIQQGKTNNS EKFERFRGYC 
ERAYTILRRH GLLFLHLFAL MRAAGLPELS CSKDIQYLKD SLALGKTEEE ALKHFRVKFN 
EALRESWKTK VNWLAHNVSK DNRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIK3CD

Associated with

Cells (max top 100)

Other Information

P110delta, a novel phosphoinositide 3-kinase in leukocytes. PubMed ID: 9113989

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. PubMed ID: 9235916

p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. PubMed ID: 22020336

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms. PubMed ID: 15135396

Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. PubMed ID: 10064595

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. PubMed ID: 20081091

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? PubMed ID: 17290298

Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function. PubMed ID: 20940048

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage. PubMed ID: 24136356

Dual loss of p110delta PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features. PubMed ID: 29180244

Primary immunodeficiency disorder caused by phosphoinositide 3-kinase delta deficiency. PubMed ID: 30040974

Human primary immunodeficiency caused by expression of a kinase-dead p110delta mutant. PubMed ID: 30336224