Details for: PIK3CG

Gene ID: 5294

Symbol: PIK3CG

Ensembl ID: ENSG00000105851

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.2175
    Cell Significance Index: -7.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.8774
    Cell Significance Index: -6.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.6335
    Cell Significance Index: -7.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 16.3496
    Cell Significance Index: -8.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.2850
    Cell Significance Index: -7.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0829
    Cell Significance Index: -7.5000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.5855
    Cell Significance Index: 36.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.1251
    Cell Significance Index: 594.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0498
    Cell Significance Index: -8.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1263
    Cell Significance Index: 210.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9285
    Cell Significance Index: -7.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.8070
    Cell Significance Index: -5.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6814
    Cell Significance Index: -3.6800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.5602
    Cell Significance Index: 3.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0889
    Cell Significance Index: 177.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0297
    Cell Significance Index: 112.0000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.8212
    Cell Significance Index: 2.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7282
    Cell Significance Index: 85.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6339
    Cell Significance Index: 43.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5011
    Cell Significance Index: 32.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4980
    Cell Significance Index: 13.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4937
    Cell Significance Index: 29.6400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2623
    Cell Significance Index: 2.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2554
    Cell Significance Index: 5.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1804
    Cell Significance Index: 3.3400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1344
    Cell Significance Index: 1.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0917
    Cell Significance Index: 2.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0396
    Cell Significance Index: 7.9500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0392
    Cell Significance Index: 0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0371
    Cell Significance Index: 1.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0342
    Cell Significance Index: 6.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0098
    Cell Significance Index: 6.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0068
    Cell Significance Index: 0.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0053
    Cell Significance Index: 0.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0060
    Cell Significance Index: -3.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0140
    Cell Significance Index: -7.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0150
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0174
    Cell Significance Index: -7.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0193
    Cell Significance Index: -6.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0258
    Cell Significance Index: -7.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0272
    Cell Significance Index: -5.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0327
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0375
    Cell Significance Index: -7.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0418
    Cell Significance Index: -7.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0420
    Cell Significance Index: -5.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0456
    Cell Significance Index: -4.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0495
    Cell Significance Index: -1.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0497
    Cell Significance Index: -6.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0601
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0631
    Cell Significance Index: -7.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0644
    Cell Significance Index: -8.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0651
    Cell Significance Index: -2.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0717
    Cell Significance Index: -7.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0830
    Cell Significance Index: -6.3700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0950
    Cell Significance Index: -1.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1013
    Cell Significance Index: -5.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1043
    Cell Significance Index: -8.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1087
    Cell Significance Index: -5.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1104
    Cell Significance Index: -3.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1116
    Cell Significance Index: -8.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1123
    Cell Significance Index: -5.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1160
    Cell Significance Index: -7.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1181
    Cell Significance Index: -7.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1181
    Cell Significance Index: -7.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1338
    Cell Significance Index: -6.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1360
    Cell Significance Index: -3.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1369
    Cell Significance Index: -7.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1383
    Cell Significance Index: -3.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1468
    Cell Significance Index: -7.7100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1487
    Cell Significance Index: -1.0700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1563
    Cell Significance Index: -1.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1740
    Cell Significance Index: -3.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1743
    Cell Significance Index: -7.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1778
    Cell Significance Index: -5.8200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1843
    Cell Significance Index: -3.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1925
    Cell Significance Index: -6.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2070
    Cell Significance Index: -7.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2072
    Cell Significance Index: -7.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2076
    Cell Significance Index: -7.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2089
    Cell Significance Index: -5.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2118
    Cell Significance Index: -3.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2268
    Cell Significance Index: -1.3700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2327
    Cell Significance Index: -1.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2366
    Cell Significance Index: -6.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2401
    Cell Significance Index: -3.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2405
    Cell Significance Index: -5.8300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2433
    Cell Significance Index: -3.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2455
    Cell Significance Index: -10.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **PI3K Complex Subunit:** PIK3CG is a catalytic subunit of the PI3K complex, which is a key regulator of cell signaling pathways. 2. **Signaling Pathways:** PIK3CG is involved in various signaling pathways, including adaptive immune response, angiogenesis, cell migration, and cytokine signaling in the immune system. 3. **Cell Type-Specific Expression:** PIK3CG is significantly expressed in immune cells, endothelial cells, and neurons, highlighting its importance in these cell types. 4. **Regulatory Functions:** PIK3CG regulates cell growth, survival, migration, and immune response, making it a critical regulator of cellular processes. **Pathways and Functions:** 1. **Adaptive Immune Response:** PIK3CG plays a crucial role in regulating the adaptive immune response, including T cell activation, proliferation, and chemotaxis. 2. **Angiogenesis:** PIK3CG is involved in regulating angiogenesis, a process essential for new blood vessel formation. 3. **Cell Migration:** PIK3CG regulates cell migration, including neutrophil chemotaxis and endothelial cell migration. 4. **Cytokine Signaling:** PIK3CG is involved in regulating cytokine signaling, including the production of cytokines and the regulation of immune response. 5. **Metabolism:** PIK3CG is involved in regulating lipid metabolism, including the synthesis and degradation of phospholipids. **Clinical Significance:** 1. **Cancer:** PIK3CG's role in regulating cell growth and survival makes it a potential target for cancer therapy. 2. **Immune-Related Disorders:** PIK3CG's involvement in immune response regulation makes it a potential target for the treatment of immune-related disorders, such as autoimmune diseases. 3. **Neurological Disorders:** PIK3CG's expression in neurons makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease. 4. **Cardiovascular Diseases:** PIK3CG's role in regulating cell migration and angiogenesis makes it a potential target for the treatment of cardiovascular diseases. In conclusion, PIK3CG is a critical regulator of cellular signaling and immune response. Its involvement in various signaling pathways and its expression in multiple cell types highlight its importance in maintaining cellular homeostasis and responding to external stimuli. Further research is needed to fully elucidate the functions of PIK3CG and its potential therapeutic applications.

Genular Protein ID: 1485820804

Symbol: PK3CG_HUMAN

Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

UniProtKB Accession Codes:

P48736 A4D0Q6 Q8IV23 Q9BZC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 3 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EC 4 EMBL 6 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 10 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7624799

Title: Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.

PubMed ID: 7624799

DOI: 10.1126/science.7624799

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11277933

Title: Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.

PubMed ID: 11277933

DOI: 10.1046/j.1432-1327.2001.02089.x

PubMed ID: 11416136

Title: The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.

PubMed ID: 11416136

DOI: 10.1128/mcb.21.14.4579-4597.2001

PubMed ID: 12163475

Title: Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.

PubMed ID: 12163475

DOI: 10.1083/jcb.200202113

PubMed ID: 12502714

Title: Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.

PubMed ID: 12502714

DOI: 10.1074/jbc.m210351200

PubMed ID: 15294162

Title: PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

PubMed ID: 15294162

DOI: 10.1016/j.cell.2004.07.017

PubMed ID: 15135396

Title: Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.

PubMed ID: 15135396

DOI: 10.1016/j.pep.2003.12.010

PubMed ID: 15797027

Title: p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.

PubMed ID: 15797027

DOI: 10.1016/j.cub.2005.02.020

PubMed ID: 16094730

Title: Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.

PubMed ID: 16094730

DOI: 10.1038/ncb1278

PubMed ID: 16123124

Title: Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.

PubMed ID: 16123124

DOI: 10.1073/pnas.0506184102

PubMed ID: 17290298

Title: PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

PubMed ID: 17290298

DOI: 10.1038/nri2036

PubMed ID: 18278175

Title: Targeting phosphoinositide 3-kinase gamma to fight inflammation and more.

PubMed ID: 18278175

DOI: 10.1160/th07-10-0632

PubMed ID: 19147653

Title: Cardiac regulation by phosphoinositide 3-kinases and PTEN.

PubMed ID: 19147653

DOI: 10.1093/cvr/cvp014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21393242

Title: A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.

PubMed ID: 21393242

DOI: 10.1074/jbc.m110.217026

PubMed ID: 10580505

Title: Structural insights into phosphoinositide 3-kinase catalysis and signalling.

PubMed ID: 10580505

DOI: 10.1038/46319

PubMed ID: 16127437

Title: Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

PubMed ID: 16127437

DOI: 10.1038/nm1284

PubMed ID: 31554793

Title: Human PI3Kgamma deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

PubMed ID: 31554793

DOI: 10.1038/s41467-019-12311-5

PubMed ID: 33054089

Title: Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation.

PubMed ID: 33054089

DOI: 10.3324/haematol.2019.231399

Sequence Information:

  • Length: 1102
  • Mass: 126454
  • Checksum: EF2B1A0E1CBEF406
  • Sequence:
    • MELENYKQPV VLREDNCRRR RRMKPRSAAA SLSSMELIPI EFVLPTSQRK CKSPETALLH 
VAGHGNVEQM KAQVWLRALE TSVAADFYHR LGPHHFLLLY QKKGQWYEIY DKYQVVQTLD 
CLRYWKATHR SPGQIHLVQR HPPSEESQAF QRQLTALIGY DVTDVSNVHD DELEFTRRGL 
VTPRMAEVAS RDPKLYAMHP WVTSKPLPEY LWKKIANNCI FIVIHRSTTS QTIKVSPDDT 
PGAILQSFFT KMAKKKSLMD IPESQSEQDF VLRVCGRDEY LVGETPIKNF QWVRHCLKNG 
EEIHVVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK 
FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFTEEVLW NVWLEFSIKI 
KDLPKGALLN LQIYCGKAPA LSSKASAESP SSESKGKVQL LYYVNLLLID HRFLLRRGEY 
VLHMWQISGK GEDQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHQPTPDPEG 
DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ 
QEIVAKTYQL LARREVWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL 
LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY 
LRGCGTAMLH DFTQQVQVIE MLQKVTLDIK SLSAEKYDVS SQVISQLKQK LENLQNSQLP 
ESFRVPYDPG LKAGALAIEK CKVMASKKKP LWLEFKCADP TALSNETIGI IFKHGDDLRQ 
DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAK IQQSTVGNTG 
AFKDEVLNHW LKEKSPTEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMITETGNL 
FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGTSGK KTSPHFQKFQ DICVKAYLAL 
RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKN EEDAKKYFLD QIEVCRDKGW 
TVQFNWFLHL VLGIKQGEKH SA

Genular Protein ID: 2929168866

Symbol: A8K9G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K9G9

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 8 Gene3D 4 InterPro 14 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 12 PeptideAtlas 1 Pfam 5 RefSeq 2 Rhea 2 SMART 4 SUPFAM 4 UniPathway 1

Sequence Information:

  • Length: 1102
  • Mass: 126411
  • Checksum: 743B54DFA8D413C0
  • Sequence:
    • MELENYKQPV VLREDNCRRR RRMKPRSAAA SLSSMELIPI EFVLPTSQRK CKSPETALLH 
VAGHGNVEQM KAQVWLRALE TSVAADFYHR LGPHHFLLLY QKKGQWYEIY DKYQVVQTLD 
CLRYWKATHR SPGQIHLVQR HPPSEESQAF QRQLTALIGY DVTDVSNVHD DELEFTRRGL 
VTPRMAEVAS RDPKLYAMHP WVTSKPLPEY LWKKIANNCI FIVIHRSTTS QTIKVSPDDT 
PGAILQSFFT KMAKKKSLMD IPESQSEQDF VLRVCGRDEY LVGETPIKNF QWVRHCLKNG 
EEIHVVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK 
FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFTEEVLW NVWLEFSIKI 
KDLPKGALLN LQIYCGKAPA LSSKASAESP SSESKGKVQL LYYVNLLLID HRFLLCRGEY 
VLHMWQISGK GEDQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHQPTPDPEG 
DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ 
QEIVAKTYQL LARREVWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL 
LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY 
LRGCGTAMLH DFTQQVQVIE MLQKVTLDIK PLSAEKYDVS SQVISQLKQK LENLQNSQLP 
ESFRVPYDPG LKAGALAIEK CKVMASKKKP LWLEFKCADP TALSNETIGI IFKHGDDLRQ 
DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAK IQQSTVGNTG 
AFKDEVLNHW LKEKSPTEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMITETGNL 
FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGTSGK KTSPHFQKFQ DICVKAYLAL 
RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKN EEDAKKYFLD QIEVCRDKGW 
TVQFNWFLHL VLGIKQGEKH SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.