Details for: PLRG1

Gene ID: 5356

Symbol: PLRG1

Ensembl ID: ENSG00000171566

Description: pleiotropic regulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.5327
    Cell Significance Index: -26.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.9719
    Cell Significance Index: -27.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.8868
    Cell Significance Index: -34.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.9651
    Cell Significance Index: -32.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.0204
    Cell Significance Index: -26.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.5975
    Cell Significance Index: -32.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.7928
    Cell Significance Index: -26.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5808
    Cell Significance Index: -31.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9628
    Cell Significance Index: -24.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2538
    Cell Significance Index: -32.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6972
    Cell Significance Index: -20.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7474
    Cell Significance Index: -10.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9335
    Cell Significance Index: 26.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8829
    Cell Significance Index: 1700.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5171
    Cell Significance Index: 91.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2179
    Cell Significance Index: 10.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7701
    Cell Significance Index: 53.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7402
    Cell Significance Index: 148.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6808
    Cell Significance Index: 93.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6124
    Cell Significance Index: 99.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5996
    Cell Significance Index: 12.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5686
    Cell Significance Index: 69.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5308
    Cell Significance Index: 289.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5306
    Cell Significance Index: 24.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4709
    Cell Significance Index: 84.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4680
    Cell Significance Index: 206.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4622
    Cell Significance Index: 87.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4311
    Cell Significance Index: 14.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4142
    Cell Significance Index: 82.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4101
    Cell Significance Index: 26.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4091
    Cell Significance Index: 52.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4058
    Cell Significance Index: 145.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3915
    Cell Significance Index: 27.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3865
    Cell Significance Index: 10.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3851
    Cell Significance Index: 24.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3702
    Cell Significance Index: 17.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3648
    Cell Significance Index: 18.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3458
    Cell Significance Index: 34.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3425
    Cell Significance Index: 7.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2898
    Cell Significance Index: 3.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2741
    Cell Significance Index: 32.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2719
    Cell Significance Index: 7.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2485
    Cell Significance Index: 6.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2346
    Cell Significance Index: 5.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1979
    Cell Significance Index: 25.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1810
    Cell Significance Index: 125.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1628
    Cell Significance Index: 4.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1257
    Cell Significance Index: 9.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1185
    Cell Significance Index: 20.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0825
    Cell Significance Index: 4.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0360
    Cell Significance Index: 1.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0353
    Cell Significance Index: 2.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0107
    Cell Significance Index: -19.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0110
    Cell Significance Index: -6.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0219
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0237
    Cell Significance Index: -32.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0251
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0377
    Cell Significance Index: -17.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0543
    Cell Significance Index: -5.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0578
    Cell Significance Index: -8.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0793
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0804
    Cell Significance Index: -16.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0853
    Cell Significance Index: -24.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0874
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0900
    Cell Significance Index: -10.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0908
    Cell Significance Index: -10.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1138
    Cell Significance Index: -3.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1335
    Cell Significance Index: -4.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1429
    Cell Significance Index: -7.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1689
    Cell Significance Index: -4.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1826
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1841
    Cell Significance Index: -21.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1932
    Cell Significance Index: -12.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2105
    Cell Significance Index: -16.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2767
    Cell Significance Index: -7.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2827
    Cell Significance Index: -22.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2985
    Cell Significance Index: -3.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3077
    Cell Significance Index: -32.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3244
    Cell Significance Index: -6.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3509
    Cell Significance Index: -15.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3752
    Cell Significance Index: -6.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3900
    Cell Significance Index: -10.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4029
    Cell Significance Index: -24.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4132
    Cell Significance Index: -10.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4165
    Cell Significance Index: -15.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4198
    Cell Significance Index: -11.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4465
    Cell Significance Index: -22.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4568
    Cell Significance Index: -5.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5167
    Cell Significance Index: -11.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5351
    Cell Significance Index: -15.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5503
    Cell Significance Index: -6.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5555
    Cell Significance Index: -14.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5613
    Cell Significance Index: -7.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Spliceosomal Complex Member:** PLRG1 is a critical component of the spliceosome complex, which is responsible for the splicing of pre-mRNAs. This process is essential for the removal of introns and the joining of exons to form mature mRNAs. 2. **Multifunctional Gene:** PLRG1's pleiotropic nature indicates its involvement in multiple cellular processes, including gene expression, cell signaling, and cellular homeostasis. 3. **Wide Expression Pattern:** PLRG1 is expressed in various cell types, including male germ cells, epithelial cells, and neurons, suggesting its importance in different tissues and cell types. 4. **Catalytic Step 2 Spliceosome:** PLRG1 is involved in catalytic step 2 of the spliceosome, which is responsible for the formation of the lariat structure during the splicing process. **Pathways and Functions:** 1. **RNA Splicing:** PLRG1's primary function is to participate in the splicing of pre-mRNAs, which is a critical step in the processing of RNA transcripts. 2. **Cell Signaling:** PLRG1's expression in various cell types, including neurons, suggests its involvement in cell signaling pathways, including the regulation of the G1/S transition of the mitotic cell cycle. 3. **Gene Regulation:** PLRG1's pleiotropic nature indicates its involvement in regulating gene expression, including the positive regulation of the G1/S transition of the mitotic cell cycle. 4. **Metabolism of RNA:** PLRG1's involvement in the metabolism of RNA transcripts, including the splicing of pre-mRNAs, highlights its role in RNA processing and regulation. **Clinical Significance:** 1. **Cancer:** PLRG1's expression in various cell types and its involvement in cell signaling pathways make it a potential biomarker for cancer diagnosis and prognosis. 2. **Neurological Disorders:** PLRG1's expression in neurons and its involvement in cell signaling pathways suggest its potential involvement in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Reproductive Health:** PLRG1's expression in male germ cells and its involvement in RNA splicing pathways make it a potential biomarker for reproductive health and fertility issues. 4. **Kidney Disease:** PLRG1's expression in kidney cells and its involvement in cell signaling pathways suggest its potential involvement in kidney disease and kidney function regulation. In conclusion, PLRG1 is a multifunctional gene that plays a critical role in regulating gene expression, cell signaling, and cellular processes. Its widespread expression and pleiotropic nature make it a potential biomarker for various diseases and disorders, including cancer, neurological disorders, reproductive health issues, and kidney disease. Further research is needed to fully understand the complexities of PLRG1 and its role in maintaining cellular homeostasis.

Genular Protein ID: 2403167209

Symbol: PLRG1_HUMAN

Name: Pleiotropic regulator 1

UniProtKB Accession Codes:

O43660 B3KMK4 Q3KQY5 Q8WUD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 23 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9765207

Title: Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis.

PubMed ID: 9765207

DOI: 10.1101/gad.12.19.3059

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11101529

Title: Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

PubMed ID: 11101529

DOI: 10.1093/emboj/19.23.6569

PubMed ID: 11544257

Title: A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.

PubMed ID: 11544257

DOI: 10.1074/jbc.m105453200

PubMed ID: 12176931

Title: Large-scale proteomic analysis of the human spliceosome.

PubMed ID: 12176931

DOI: 10.1101/gr.473902

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20176811

Title: Molecular architecture of the human Prp19/CDC5L complex.

PubMed ID: 20176811

DOI: 10.1128/mcb.01505-09

PubMed ID: 23022480

Title: Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.

PubMed ID: 23022480

DOI: 10.1016/j.celrep.2012.08.031

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 514
  • Mass: 57194
  • Checksum: 8C914CAF5F7887BD
  • Sequence:
    • MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 
SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE 
SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK 
KAPTMPKPQW HPPWKLYRVI SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL 
SLTGHISTVR GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI 
DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH DTTIRLWDLV 
AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF PDGSFIQNLS GHNAIINTLT 
VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV HAAVQPGSLD SESGIFACAF DQSESRLLTA 
EADKTIKVYR EDDTATEETH PVSWKPEIIK RKRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.