Details for: PMAIP1

Gene ID: 5366

Symbol: PMAIP1

Ensembl ID: ENSG00000141682

Description: phorbol-12-myristate-13-acetate-induced protein 1

Associated with

  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Activation of noxa and translocation to mitochondria
    (R-HSA-111448)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Programmed cell death
    (R-HSA-5357801)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic process
    (GO:0006915)
  • Bcl-2 family protein complex
    (GO:0097136)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cytosol
    (GO:0005829)
  • Defense response to virus
    (GO:0051607)
  • Dna damage response
    (GO:0006974)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of mitochondrial membrane potential
    (GO:0010917)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043517)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902043)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Proteasomal protein catabolic process
    (GO:0010498)
  • Protein binding
    (GO:0005515)
  • Reactive oxygen species metabolic process
    (GO:0072593)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Response to dsrna
    (GO:0043331)
  • T cell homeostasis
    (GO:0043029)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.5531
    Cell Significance Index: -24.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.8343
    Cell Significance Index: -29.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.0877
    Cell Significance Index: -17.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.6153
    Cell Significance Index: -29.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.3269
    Cell Significance Index: -30.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.2624
    Cell Significance Index: -29.0300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 27.7336
    Cell Significance Index: 82.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3714
    Cell Significance Index: -26.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4406
    Cell Significance Index: -25.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.0739
    Cell Significance Index: -27.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0729
    Cell Significance Index: -27.9100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.5965
    Cell Significance Index: 15.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.5315
    Cell Significance Index: 235.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6974
    Cell Significance Index: 100.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.6889
    Cell Significance Index: 50.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9827
    Cell Significance Index: 192.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7124
    Cell Significance Index: 62.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3382
    Cell Significance Index: 14.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0848
    Cell Significance Index: 97.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8736
    Cell Significance Index: 220.9600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.8512
    Cell Significance Index: 15.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6801
    Cell Significance Index: 36.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5758
    Cell Significance Index: 111.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4977
    Cell Significance Index: 67.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4850
    Cell Significance Index: 656.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4560
    Cell Significance Index: 41.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4463
    Cell Significance Index: 186.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1752
    Cell Significance Index: 87.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0475
    Cell Significance Index: 27.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9649
    Cell Significance Index: 13.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9572
    Cell Significance Index: 25.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8716
    Cell Significance Index: 13.0600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.7061
    Cell Significance Index: 12.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6683
    Cell Significance Index: 82.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6598
    Cell Significance Index: 595.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6353
    Cell Significance Index: 346.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5445
    Cell Significance Index: 98.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5331
    Cell Significance Index: 32.0100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5180
    Cell Significance Index: 3.7200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.5173
    Cell Significance Index: 4.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5066
    Cell Significance Index: 4.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5055
    Cell Significance Index: 54.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4604
    Cell Significance Index: 74.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4561
    Cell Significance Index: 45.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3646
    Cell Significance Index: 69.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3602
    Cell Significance Index: 6.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3588
    Cell Significance Index: 45.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3278
    Cell Significance Index: 11.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2519
    Cell Significance Index: 6.6300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1777
    Cell Significance Index: 1.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1528
    Cell Significance Index: 2.8300
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.1498
    Cell Significance Index: 0.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1435
    Cell Significance Index: 2.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1306
    Cell Significance Index: 9.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1127
    Cell Significance Index: 12.8700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0075
    Cell Significance Index: 0.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0080
    Cell Significance Index: -1.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0141
    Cell Significance Index: -8.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0141
    Cell Significance Index: -26.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0144
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0257
    Cell Significance Index: -4.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0266
    Cell Significance Index: -2.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0346
    Cell Significance Index: -25.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0387
    Cell Significance Index: -1.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0449
    Cell Significance Index: -28.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0613
    Cell Significance Index: -0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0617
    Cell Significance Index: -12.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0619
    Cell Significance Index: -13.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0622
    Cell Significance Index: -1.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0632
    Cell Significance Index: -28.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0767
    Cell Significance Index: -27.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1005
    Cell Significance Index: -4.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1033
    Cell Significance Index: -29.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1091
    Cell Significance Index: -12.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1123
    Cell Significance Index: -2.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1427
    Cell Significance Index: -28.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1638
    Cell Significance Index: -19.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1771
    Cell Significance Index: -1.0700
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1836
    Cell Significance Index: -1.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1925
    Cell Significance Index: -27.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1928
    Cell Significance Index: -8.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2374
    Cell Significance Index: -6.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2554
    Cell Significance Index: -26.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2884
    Cell Significance Index: -8.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3027
    Cell Significance Index: -10.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3665
    Cell Significance Index: -29.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3708
    Cell Significance Index: -9.2700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.3735
    Cell Significance Index: -1.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3758
    Cell Significance Index: -21.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3759
    Cell Significance Index: -28.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4284
    Cell Significance Index: -4.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4312
    Cell Significance Index: -12.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4317
    Cell Significance Index: -29.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4598
    Cell Significance Index: -6.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4729
    Cell Significance Index: -29.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4772
    Cell Significance Index: -29.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4963
    Cell Significance Index: -18.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PMAIP1 is a pro-apoptotic protein that belongs to the BCL-2 protein family. It is characterized by its ability to activate BH3-only proteins, which are pro-apoptotic proteins that interact with anti-apoptotic BCL-2 family members and inactivate them. This results in the release of cytochrome c from the mitochondria, leading to the activation of the caspase cascade and apoptosis. PMAIP1 is also involved in the regulation of glucose metabolism, oxidative stress, and DNA damage response. **Pathways and Functions** PMAIP1 is involved in several key signaling pathways, including: 1. **Activation of BH3-only proteins**: PMAIP1 activates BH3-only proteins, such as BAX and BAK, which in turn regulate the anti-apoptotic members of the BCL-2 family. 2. **Apoptosis**: PMAIP1 is involved in the regulation of apoptosis, either by promoting or inhibiting the process, depending on the cellular context. 3. **Mitochondrial outer membrane permeabilization**: PMAIP1 regulates the release of cytochrome c from the mitochondria, which is a key event in the apoptotic process. 4. **DNA damage response**: PMAIP1 is involved in the regulation of DNA damage response, including the activation of p53 and the induction of apoptosis. 5. **Glucose metabolic process**: PMAIP1 regulates glucose metabolism, particularly in the context of cellular stress. **Clinical Significance** PMAIP1 has been implicated in several diseases, including: 1. **Cancer**: PMAIP1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Autoimmune diseases**: PMAIP1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it is thought to regulate the immune response and tissue damage. 3. **Neurodegenerative diseases**: PMAIP1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it is thought to regulate apoptosis and inflammation. 4. **Infectious diseases**: PMAIP1 has been implicated in infectious diseases, such as HIV and tuberculosis, where it is thought to regulate the immune response and tissue damage. In summary, PMAIP1 is a critical regulator of apoptosis and cellular stress response, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the role of PMAIP1 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 1779246448

Symbol: APR_HUMAN

Name: Phorbol-12-myristate-13-acetate-induced protein 1

UniProtKB Accession Codes:

Q13794 B2R4T7 Q8N589

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2398525

Title: Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line.

PubMed ID: 2398525

DOI: 10.1128/jvi.64.10.4632-4639.1990

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10807576

Title: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

PubMed ID: 10807576

DOI: 10.1126/science.288.5468.1053

PubMed ID: 15705586

Title: Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.

PubMed ID: 15705586

DOI: 10.1074/jbc.m412630200

PubMed ID: 15694340

Title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

PubMed ID: 15694340

DOI: 10.1016/j.molcel.2004.12.030

PubMed ID: 17374615

Title: Functional linkage between NOXA and Bim in mitochondrial apoptotic events.

PubMed ID: 17374615

DOI: 10.1074/jbc.m611186200

PubMed ID: 17389404

Title: Structural insights into the degradation of Mcl-1 induced by BH3 domains.

PubMed ID: 17389404

DOI: 10.1073/pnas.0701297104

PubMed ID: 23563182

Title: Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

PubMed ID: 23563182

DOI: 10.1038/onc.2013.99

Sequence Information:

  • Length: 54
  • Mass: 6030
  • Checksum: 291A142B27167E70
  • Sequence:
    • MPGKKARKNA QPSPARAPAE LEVECATQLR RFGDKLNFRQ KLLNLISKLF CSGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.