POLR2H | ENSG00000163882 | NCBI 5437

Details for: POLR2H

Gene ID: 5437

Symbol: POLR2H

Ensembl ID: ENSG00000163882

Description: RNA polymerase II, I and III subunit H

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Innate immune system
(R-HSA-168249)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Rna polymerase i activity
(GO:0001054)
Rna polymerase ii activity
(GO:0001055)
Rna polymerase iii activity
(GO:0001056)
Single-stranded dna binding
(GO:0003697)
Transcription by rna polymerase i
(GO:0006360)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 228.4223
Cell Significance Index: -35.5300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 131.0896
Cell Significance Index: -33.2500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 96.9298
Cell Significance Index: -39.9300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 91.3957
Cell Significance Index: -43.1500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 87.8262
Cell Significance Index: -35.6800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 79.8332
Cell Significance Index: -41.0700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 64.2006
Cell Significance Index: -43.0800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 37.6646
Cell Significance Index: -35.9600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 33.8698
Cell Significance Index: -41.7600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.6598
Cell Significance Index: -31.2400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.9173
Cell Significance Index: -43.0800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.8525
Cell Significance Index: -27.1900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.3199
Cell Significance Index: 88.6500
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.8444
Cell Significance Index: 1007.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4029
Cell Significance Index: 65.4100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3098
Cell Significance Index: 59.3700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2803
Cell Significance Index: 34.8500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.2007
Cell Significance Index: 56.4300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0830
Cell Significance Index: 31.0500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0682
Cell Significance Index: 146.7000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0151
Cell Significance Index: 52.7300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9464
Cell Significance Index: 170.6100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9055
Cell Significance Index: 67.4800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8958
Cell Significance Index: 145.6900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8923
Cell Significance Index: 9.7000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8614
Cell Significance Index: 60.9300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8472
Cell Significance Index: 104.1800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8404
Cell Significance Index: 17.5900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.8311
Cell Significance Index: 28.8800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7926
Cell Significance Index: 350.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7884
Cell Significance Index: 17.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7508
Cell Significance Index: 51.9300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6201
Cell Significance Index: 123.0700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6001
Cell Significance Index: 65.2800
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.5988
Cell Significance Index: 3.6900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5120
Cell Significance Index: 60.3800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.4903
Cell Significance Index: 63.3400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4670
Cell Significance Index: 12.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4579
Cell Significance Index: 91.8600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4462
Cell Significance Index: 13.1100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.4198
Cell Significance Index: 6.2900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4104
Cell Significance Index: 52.6100
Cell Name: kidney cell (CL1000497)
Fold Change: 0.3507
Cell Significance Index: 2.8000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3311
Cell Significance Index: 56.5500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.2984
Cell Significance Index: 3.3900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2715
Cell Significance Index: 2.5000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2584
Cell Significance Index: 16.6700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2514
Cell Significance Index: 47.8500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2466
Cell Significance Index: 12.9500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1944
Cell Significance Index: 69.7200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1814
Cell Significance Index: 163.8100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1416
Cell Significance Index: 7.1500
Cell Name: peg cell (CL4033014)
Fold Change: 0.1137
Cell Significance Index: 2.6300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1077
Cell Significance Index: 1.1200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0718
Cell Significance Index: 2.3000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0407
Cell Significance Index: 30.7800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0151
Cell Significance Index: 10.4200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0079
Cell Significance Index: 5.8000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0036
Cell Significance Index: 0.1900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0035
Cell Significance Index: 6.5600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0032
Cell Significance Index: 0.3200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0135
Cell Significance Index: -0.8500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0146
Cell Significance Index: -26.8400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0158
Cell Significance Index: -24.3300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0255
Cell Significance Index: -34.6900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0284
Cell Significance Index: -0.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0328
Cell Significance Index: -20.8400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0402
Cell Significance Index: -29.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0424
Cell Significance Index: -4.3400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0560
Cell Significance Index: -31.5800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0619
Cell Significance Index: -28.1000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0901
Cell Significance Index: -56.2900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0995
Cell Significance Index: -2.6700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1134
Cell Significance Index: -32.6200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1429
Cell Significance Index: -3.6500
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1852
Cell Significance Index: -1.5100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1900
Cell Significance Index: -22.1400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1991
Cell Significance Index: -28.9500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2281
Cell Significance Index: -48.0500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2338
Cell Significance Index: -26.7900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2451
Cell Significance Index: -5.2200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2724
Cell Significance Index: -20.9100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2909
Cell Significance Index: -5.1400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3096
Cell Significance Index: -19.0300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3132
Cell Significance Index: -12.8300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3597
Cell Significance Index: -28.4900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3687
Cell Significance Index: -5.0300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3949
Cell Significance Index: -41.1200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4154
Cell Significance Index: -23.3100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4487
Cell Significance Index: -30.1700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5467
Cell Significance Index: -33.5200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5772
Cell Significance Index: -17.0000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6239
Cell Significance Index: -17.9800
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.6631
Cell Significance Index: -4.1200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7105
Cell Significance Index: -19.0100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.7258
Cell Significance Index: -10.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7446
Cell Significance Index: -32.9400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7463
Cell Significance Index: -12.7900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8044
Cell Significance Index: -4.8600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8991
Cell Significance Index: -34.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** POLR2H is a conserved gene that has been identified in various species, including humans, mice, and yeast. It is a subunit of the RNA polymerase II enzyme complex, which is composed of five subunits: α, β, β', β'', and H. The H subunit, encoded by the POLR2H gene, is essential for the recruitment of the RNA polymerase II complex to specific DNA sequences and for the regulation of transcriptional initiation. POLR2H has several key characteristics, including: * Conserved sequence and structure: The POLR2H gene has a highly conserved sequence and structure across different species, suggesting its essential role in transcriptional regulation. * Subunit composition: POLR2H is a subunit of the RNA polymerase II enzyme complex, which is composed of five subunits. * Transcriptional regulation: POLR2H is involved in the regulation of transcriptional initiation, elongation, and termination. * Cell cycle regulation: POLR2H is involved in the regulation of cell cycle progression, particularly during the G1 and S phases. * DNA repair: POLR2H is involved in the regulation of DNA repair, particularly during the repair of double-strand breaks. **Pathways and Functions** POLR2H is involved in several cellular pathways and processes, including: * Transcriptional regulation: POLR2H is involved in the regulation of transcriptional initiation, elongation, and termination. * Cell cycle regulation: POLR2H is involved in the regulation of cell cycle progression, particularly during the G1 and S phases. * DNA repair: POLR2H is involved in the regulation of DNA repair, particularly during the repair of double-strand breaks. * Epigenetic regulation: POLR2H is involved in the regulation of epigenetic marks, such as histone modifications and DNA methylation. * Signaling pathways: POLR2H is involved in several signaling pathways, including the FGFR and ERK signaling pathways. **Clinical Significance** POLR2H has been implicated in several diseases and disorders, including: * Cancer: POLR2H has been shown to be overexpressed in several types of cancer, including breast and lung cancer. * Neurological disorders: POLR2H has been implicated in several neurological disorders, including Alzheimer's disease and Parkinson's disease. * Immunological disorders: POLR2H has been implicated in several immunological disorders, including autoimmune diseases and inflammatory disorders. * Infectious diseases: POLR2H has been implicated in several infectious diseases, including HIV and influenza. In conclusion, POLR2H is a critical gene that plays a central role in transcriptional regulation, cell cycle progression, and DNA repair. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of further research into the functions and clinical significance of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerases I, II, and III subunit RPABC3

Genular Protein ID: 3640114444

Symbol: RPAB3_HUMAN

Name: DNA-directed RNA polymerases I, II, and III subunit RPABC3

UniProtKB Accession Codes:

P52434 C9J413 C9JBJ6 C9JCU7 C9JUA8 P53802 Q969R0

Database IDs:

Citations:

PubMed ID: 8524256

Title: Six human RNA polymerase subunits functionally substitute for their yeast counterparts.

PubMed ID: 8524256

DOI: 10.1128/mcb.15.12.6895

PubMed ID: 7651387

Title: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae.

PubMed ID: 7651387

DOI: 10.1128/mcb.15.9.4702

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 16809778

Title: RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

PubMed ID: 16809778

DOI: 10.1128/mcb.00230-06

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 16632472

Title: Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases.

PubMed ID: 16632472

DOI: 10.1074/jbc.m513241200

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 34671025

Title: Structure of the human RNA polymerase I elongation complex.

PubMed ID: 34671025

DOI: 10.1038/s41421-021-00335-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 34887565

Title: Cryo-EM structures of human RNA polymerase I.

PubMed ID: 34887565

DOI: 10.1038/s41594-021-00693-4

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

PubMed ID: 36271492

Title: The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.

PubMed ID: 36271492

DOI: 10.26508/lsa.202201568

Sequence Information:

Length: 150
Mass: 17143
Checksum: 944D0860809F1425
Sequence:

MAGILFEDIF DVKDIDPEGK KFDRVSRLHC ESESFKMDLI LDVNIQIYPV DLGDKFRLVI 
ASTLYEDGTL DDGEYNPTDD RPSRADQFEY VMYGKVYRIE GDETSTEAAT RLSAYVSYGG 
LLMRLQGDAN NLHGFEVDSR VYLLMKKLAF

Database document:

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Details for: POLR2H

Associated with

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Other Information

Six human RNA polymerase subunits functionally substitute for their yeast counterparts. PubMed ID: 8524256

Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. PubMed ID: 7651387

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. PubMed ID: 16809778

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases. PubMed ID: 16632472

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of the human RNA polymerase I elongation complex. PubMed ID: 34671025

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Cryo-EM structures of human RNA polymerase I. PubMed ID: 34887565

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. PubMed ID: 36271492