Details for: PPIA
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 7.77
Marker Score: 5,863 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.61
Marker Score: 4,390 - Cell Name: malignant cell (CL0001064)
Fold Change: 5
Marker Score: 67,128 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.92
Marker Score: 7,578 - Cell Name: mature T cell (CL0002419)
Fold Change: 4.91
Marker Score: 48,638 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.68
Marker Score: 14,782 - Cell Name: radial glial cell (CL0000681)
Fold Change: 4.47
Marker Score: 1,647 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.41
Marker Score: 9,249 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.4
Marker Score: 232,873 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.39
Marker Score: 12,814 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.3
Marker Score: 7,380 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.26
Marker Score: 145,007 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.22
Marker Score: 11,319 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.22
Marker Score: 55,645 - Cell Name: blood cell (CL0000081)
Fold Change: 4.14
Marker Score: 48,133 - Cell Name: naive B cell (CL0000788)
Fold Change: 4.1
Marker Score: 3,663 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.09
Marker Score: 228,832 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.05
Marker Score: 14,383 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4
Marker Score: 10,162 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.98
Marker Score: 20,908 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.93
Marker Score: 3,802 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.93
Marker Score: 16,857 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.92
Marker Score: 4,181 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.91
Marker Score: 4,084 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.91
Marker Score: 9,557 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.85
Marker Score: 9,717 - Cell Name: chondrocyte (CL0000138)
Fold Change: 3.84
Marker Score: 1,728 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.81
Marker Score: 1,219 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.79
Marker Score: 10,631 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.79
Marker Score: 2,974 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.78
Marker Score: 5,565 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.77
Marker Score: 3,308 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.75
Marker Score: 10,368 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.75
Marker Score: 2,667 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.75
Marker Score: 6,694 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.75
Marker Score: 2,279 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.73
Marker Score: 1,992 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.73
Marker Score: 27,765 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.73
Marker Score: 9,092 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.71
Marker Score: 4,472 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.71
Marker Score: 3,490 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.68
Marker Score: 23,931 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.62
Marker Score: 2,121 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.62
Marker Score: 864 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.61
Marker Score: 3,406 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.6
Marker Score: 23,461 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.59
Marker Score: 4,331 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.57
Marker Score: 5,848 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.57
Marker Score: 3,512 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.55
Marker Score: 3,160 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.55
Marker Score: 3,599 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.53
Marker Score: 4,362 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.5
Marker Score: 5,070 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.49
Marker Score: 2,935 - Cell Name: lung macrophage (CL1001603)
Fold Change: 3.48
Marker Score: 3,986 - Cell Name: memory B cell (CL0000787)
Fold Change: 3.47
Marker Score: 2,627 - Cell Name: naive T cell (CL0000898)
Fold Change: 3.47
Marker Score: 2,235 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.45
Marker Score: 20,443 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.43
Marker Score: 2,806 - Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 3.42
Marker Score: 1,553 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.42
Marker Score: 3,674 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.41
Marker Score: 5,656 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.4
Marker Score: 4,008 - Cell Name: immature B cell (CL0000816)
Fold Change: 3.4
Marker Score: 2,250 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.39
Marker Score: 26,498 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.39
Marker Score: 2,818 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.39
Marker Score: 21,636 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.39
Marker Score: 1,748 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.38
Marker Score: 1,981 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.38
Marker Score: 3,677 - Cell Name: epithelial cell (CL0000066)
Fold Change: 3.34
Marker Score: 5,313 - Cell Name: centroblast (CL0009112)
Fold Change: 3.33
Marker Score: 1,639 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.33
Marker Score: 2,823 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.32
Marker Score: 16,302 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.32
Marker Score: 2,405 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.31
Marker Score: 2,395 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.3
Marker Score: 4,665 - Cell Name: endothelial cell (CL0000115)
Fold Change: 3.29
Marker Score: 2,947 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.27
Marker Score: 2,152 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.25
Marker Score: 6,332 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.24
Marker Score: 3,246 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.24
Marker Score: 1,664 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.24
Marker Score: 10,163 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 3.23
Marker Score: 3,422 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.23
Marker Score: 2,542 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.23
Marker Score: 3,019 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.22
Marker Score: 2,142 - Cell Name: secretory cell (CL0000151)
Fold Change: 3.22
Marker Score: 5,877 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.21
Marker Score: 1,774 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.21
Marker Score: 1,603 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.2
Marker Score: 2,012 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.2
Marker Score: 847 - Cell Name: supporting cell (CL0000630)
Fold Change: 3.19
Marker Score: 5,990 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.19
Marker Score: 2,810 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.18
Marker Score: 2,740 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.17
Marker Score: 9,414 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.17
Marker Score: 3,508 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.17
Marker Score: 2,131 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.15
Marker Score: 109,247 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.13
Marker Score: 1,091
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2426384294
Symbol: PPIA_HUMAN
Name: Peptidyl-prolyl cis-trans isomerase A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3297675
Title: Complementary DNA for human T-cell cyclophilin.
PubMed ID: 3297675
PubMed ID: 2197089
Title: Characterization of the human cyclophilin gene and of related processed pseudogenes.
PubMed ID: 2197089
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7657784
Title: Identification of cyclophilin A from human decidual and placental tissue in the first trimester of pregnancy.
PubMed ID: 7657784
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 2001362
Title: Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.
PubMed ID: 2001362
DOI: 10.1021/bi00223a003
PubMed ID: 8513493
Title: Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
PubMed ID: 8513493
PubMed ID: 11353871
Title: CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.
PubMed ID: 11353871
PubMed ID: 11943775
Title: Active site residues of cyclophilin A are crucial for its signaling activity via CD147.
PubMed ID: 11943775
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15130913
Title: Cyclophilin A is a proinflammatory cytokine that activates endothelial cells.
PubMed ID: 15130913
PubMed ID: 15688292
Title: Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus.
PubMed ID: 15688292
DOI: 10.1086/427811
PubMed ID: 16527992
Title: Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.
PubMed ID: 16527992
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19207730
Title: Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication.
PubMed ID: 19207730
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20147391
Title: CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.
PubMed ID: 20147391
DOI: 10.1128/jvi.02168-09
PubMed ID: 20676357
Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PubMed ID: 20676357
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21245143
Title: Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CD147.
PubMed ID: 21245143
PubMed ID: 21593166
Title: Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.
PubMed ID: 21593166
DOI: 10.1128/jvi.00393-11
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22347431
Title: Cyclophilin A restricts influenza A virus replication through degradation of the M1 protein.
PubMed ID: 22347431
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23180369
Title: Antiapoptotic and proapoptotic signaling of cyclophilin A in endothelial cells.
PubMed ID: 23180369
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26095851
Title: Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1.
PubMed ID: 26095851
PubMed ID: 25678563
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
PubMed ID: 25678563
DOI: 10.1093/brain/awv005
PubMed ID: 25489052
Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
PubMed ID: 25489052
DOI: 10.1093/hmg/ddu611
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30328013
Title: CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus.
PubMed ID: 30328013
PubMed ID: 31063815
Title: Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.
PubMed ID: 31063815
PubMed ID: 1896075
Title: Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy.
PubMed ID: 1896075
DOI: 10.1038/353276a0
PubMed ID: 1946361
Title: Crystal structure of recombinant human T-cell cyclophilin A at 2.5-A resolution.
PubMed ID: 1946361
PubMed ID: 8421501
Title: X-ray structure of a decameric cyclophilin-cyclosporin crystal complex.
PubMed ID: 8421501
DOI: 10.1038/361091a0
PubMed ID: 8263916
Title: X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1-A resolution.
PubMed ID: 8263916
PubMed ID: 8652511
Title: Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization.
PubMed ID: 8652511
DOI: 10.1021/bi9602775
PubMed ID: 9385632
Title: Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
PubMed ID: 9385632
PubMed ID: 9769216
Title: X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.
PubMed ID: 9769216
PubMed ID: 12218175
Title: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.
PubMed ID: 12218175
PubMed ID: 12357034
Title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.
PubMed ID: 12357034
PubMed ID: 8421500
Title: Solution structure of the cyclosporin A/cyclophilin complex by NMR.
PubMed ID: 8421500
DOI: 10.1038/361088a0
PubMed ID: 9299338
Title: The NMR solution conformation of unligated human cyclophilin A.
PubMed ID: 9299338
PubMed ID: 20364129
Title: Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization.
PubMed ID: 20364129
DOI: 10.1038/nchembio.342
Sequence Information:
- Length: 165
- Mass: 18012
- Checksum: 9B2E637A555E4434
- Sequence:
MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.