Details for: PPIA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 965.4427
Cell Significance Index: -150.1700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 571.4421
Cell Significance Index: -144.9400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 478.0948
Cell Significance Index: -196.9500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 450.9213
Cell Significance Index: -183.1900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 406.7587
Cell Significance Index: -192.0400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 385.6059
Cell Significance Index: -198.3500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 287.4123
Cell Significance Index: -192.8600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 192.8530
Cell Significance Index: -184.1300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 143.7197
Cell Significance Index: -177.2000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 48.4586
Cell Significance Index: -191.2200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 47.4381
Cell Significance Index: -127.0800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 40.8666
Cell Significance Index: -125.5200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.5390
Cell Significance Index: -47.1400 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 11.8550
Cell Significance Index: 101.8700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 9.0914
Cell Significance Index: 116.4300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 8.7138
Cell Significance Index: 255.9200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.7857
Cell Significance Index: 365.9200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 7.2033
Cell Significance Index: 849.4900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.9062
Cell Significance Index: 75.0800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 6.5485
Cell Significance Index: 137.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.6128
Cell Significance Index: 690.1400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.5549
Cell Significance Index: 102.6700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 5.3460
Cell Significance Index: 378.0900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.1627
Cell Significance Index: 930.6800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.1483
Cell Significance Index: 178.9000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.0633
Cell Significance Index: 133.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.9815
Cell Significance Index: 2202.4500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.9611
Cell Significance Index: 56.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.7741
Cell Significance Index: 655.6200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.7614
Cell Significance Index: 307.1800 - Cell Name: lactocyte (CL0002325)
Fold Change: 4.4903
Cell Significance Index: 580.1200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.3396
Cell Significance Index: 124.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.1557
Cell Significance Index: 218.1900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.1190
Cell Significance Index: 112.1200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.9901
Cell Significance Index: 2179.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.6862
Cell Significance Index: 274.7300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.1895
Cell Significance Index: 148.7100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.9222
Cell Significance Index: 26.9100 - Cell Name: epidermal cell (CL0000362)
Fold Change: 2.8299
Cell Significance Index: 6.3800 - Cell Name: peg cell (CL4033014)
Fold Change: 2.7857
Cell Significance Index: 64.3600 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.3579
Cell Significance Index: 302.2700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.0883
Cell Significance Index: 58.3600 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.0263
Cell Significance Index: 12.4700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9796
Cell Significance Index: 392.8600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.8311
Cell Significance Index: 181.1400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.6739
Cell Significance Index: 29.5800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2590
Cell Significance Index: 252.5600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.9883
Cell Significance Index: 748.0700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9505
Cell Significance Index: 25.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9373
Cell Significance Index: 48.6900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.7911
Cell Significance Index: 135.0800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.7591
Cell Significance Index: 86.6500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.6022
Cell Significance Index: 173.2600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4818
Cell Significance Index: 172.8100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.3775
Cell Significance Index: 276.7900 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.2787
Cell Significance Index: 2.2200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1228
Cell Significance Index: 2.0600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0052
Cell Significance Index: -0.5400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0283
Cell Significance Index: -20.9400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0507
Cell Significance Index: -95.4900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0612
Cell Significance Index: -112.8700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0839
Cell Significance Index: -129.1300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0883
Cell Significance Index: -55.1300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1199
Cell Significance Index: -163.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1346
Cell Significance Index: -25.6100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1682
Cell Significance Index: -27.3600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2156
Cell Significance Index: -12.1000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2197
Cell Significance Index: -123.8800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2433
Cell Significance Index: -154.5300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3611
Cell Significance Index: -76.0600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3804
Cell Significance Index: -172.6300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8353
Cell Significance Index: -21.3400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8381
Cell Significance Index: -96.0200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9475
Cell Significance Index: -75.0400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0536
Cell Significance Index: -33.7500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.0725
Cell Significance Index: -6.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0772
Cell Significance Index: -125.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.1158
Cell Significance Index: -162.2000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.1326
Cell Significance Index: -69.6200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.1676
Cell Significance Index: -52.9300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.1863
Cell Significance Index: -74.7700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.2322
Cell Significance Index: -73.9800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6191
Cell Significance Index: -22.0900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6667
Cell Significance Index: -112.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.7000
Cell Significance Index: -36.8300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.8188
Cell Significance Index: -189.3800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.0860
Cell Significance Index: -55.8000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -2.1266
Cell Significance Index: -163.2000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -2.5125
Cell Significance Index: -173.7500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.8407
Cell Significance Index: -48.9700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -3.0441
Cell Significance Index: -25.5700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -3.1106
Cell Significance Index: -46.6100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.1426
Cell Significance Index: -192.6700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -3.1575
Cell Significance Index: -164.4700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.4830
Cell Significance Index: -102.5900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.8772
Cell Significance Index: -171.5000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -4.0253
Cell Significance Index: -103.4700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -4.2550
Cell Significance Index: -28.8300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -4.3012
Cell Significance Index: -157.9000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.3831
Cell Significance Index: -125.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2426384294
Symbol: PPIA_HUMAN
Name: Peptidyl-prolyl cis-trans isomerase A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3297675
Title: Complementary DNA for human T-cell cyclophilin.
PubMed ID: 3297675
PubMed ID: 2197089
Title: Characterization of the human cyclophilin gene and of related processed pseudogenes.
PubMed ID: 2197089
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7657784
Title: Identification of cyclophilin A from human decidual and placental tissue in the first trimester of pregnancy.
PubMed ID: 7657784
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 2001362
Title: Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.
PubMed ID: 2001362
DOI: 10.1021/bi00223a003
PubMed ID: 8513493
Title: Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
PubMed ID: 8513493
PubMed ID: 11353871
Title: CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.
PubMed ID: 11353871
PubMed ID: 11943775
Title: Active site residues of cyclophilin A are crucial for its signaling activity via CD147.
PubMed ID: 11943775
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15130913
Title: Cyclophilin A is a proinflammatory cytokine that activates endothelial cells.
PubMed ID: 15130913
PubMed ID: 15688292
Title: Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus.
PubMed ID: 15688292
DOI: 10.1086/427811
PubMed ID: 16527992
Title: Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.
PubMed ID: 16527992
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19207730
Title: Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication.
PubMed ID: 19207730
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20147391
Title: CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.
PubMed ID: 20147391
DOI: 10.1128/jvi.02168-09
PubMed ID: 20676357
Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PubMed ID: 20676357
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21245143
Title: Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CD147.
PubMed ID: 21245143
PubMed ID: 21593166
Title: Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.
PubMed ID: 21593166
DOI: 10.1128/jvi.00393-11
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22347431
Title: Cyclophilin A restricts influenza A virus replication through degradation of the M1 protein.
PubMed ID: 22347431
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23180369
Title: Antiapoptotic and proapoptotic signaling of cyclophilin A in endothelial cells.
PubMed ID: 23180369
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26095851
Title: Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1.
PubMed ID: 26095851
PubMed ID: 25678563
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
PubMed ID: 25678563
DOI: 10.1093/brain/awv005
PubMed ID: 25489052
Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
PubMed ID: 25489052
DOI: 10.1093/hmg/ddu611
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30328013
Title: CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus.
PubMed ID: 30328013
PubMed ID: 31063815
Title: Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.
PubMed ID: 31063815
PubMed ID: 1896075
Title: Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy.
PubMed ID: 1896075
DOI: 10.1038/353276a0
PubMed ID: 1946361
Title: Crystal structure of recombinant human T-cell cyclophilin A at 2.5-A resolution.
PubMed ID: 1946361
PubMed ID: 8421501
Title: X-ray structure of a decameric cyclophilin-cyclosporin crystal complex.
PubMed ID: 8421501
DOI: 10.1038/361091a0
PubMed ID: 8263916
Title: X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1-A resolution.
PubMed ID: 8263916
PubMed ID: 8652511
Title: Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization.
PubMed ID: 8652511
DOI: 10.1021/bi9602775
PubMed ID: 9385632
Title: Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
PubMed ID: 9385632
PubMed ID: 9769216
Title: X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.
PubMed ID: 9769216
PubMed ID: 12218175
Title: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.
PubMed ID: 12218175
PubMed ID: 12357034
Title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.
PubMed ID: 12357034
PubMed ID: 8421500
Title: Solution structure of the cyclosporin A/cyclophilin complex by NMR.
PubMed ID: 8421500
DOI: 10.1038/361088a0
PubMed ID: 9299338
Title: The NMR solution conformation of unligated human cyclophilin A.
PubMed ID: 9299338
PubMed ID: 20364129
Title: Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization.
PubMed ID: 20364129
DOI: 10.1038/nchembio.342
Sequence Information:
- Length: 165
- Mass: 18012
- Checksum: 9B2E637A555E4434
- Sequence:
MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.