Details for: PPM1G

Gene ID: 5496

Symbol: PPM1G

Ensembl ID: ENSG00000115241

Description: protein phosphatase, Mg2+/Mn2+ dependent 1G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.2961
    Cell Significance Index: -41.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 187.4285
    Cell Significance Index: -47.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 128.2929
    Cell Significance Index: -60.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.6162
    Cell Significance Index: -51.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.5165
    Cell Significance Index: -59.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.9624
    Cell Significance Index: -52.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.9651
    Cell Significance Index: -55.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.6759
    Cell Significance Index: -50.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.7413
    Cell Significance Index: -58.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.1827
    Cell Significance Index: -40.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0619
    Cell Significance Index: -24.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.5556
    Cell Significance Index: 95.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0941
    Cell Significance Index: 90.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0204
    Cell Significance Index: 18.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8121
    Cell Significance Index: 213.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7667
    Cell Significance Index: 964.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7365
    Cell Significance Index: 213.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6871
    Cell Significance Index: 304.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6674
    Cell Significance Index: 107.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6117
    Cell Significance Index: 262.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5283
    Cell Significance Index: 41.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4703
    Cell Significance Index: 291.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2512
    Cell Significance Index: 10.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2283
    Cell Significance Index: 57.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1167
    Cell Significance Index: 153.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0071
    Cell Significance Index: 35.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9748
    Cell Significance Index: 50.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9704
    Cell Significance Index: 45.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8788
    Cell Significance Index: 388.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8734
    Cell Significance Index: 25.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8561
    Cell Significance Index: 60.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7852
    Cell Significance Index: 8.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7794
    Cell Significance Index: 156.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7690
    Cell Significance Index: 8.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7543
    Cell Significance Index: 20.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7276
    Cell Significance Index: 32.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7176
    Cell Significance Index: 15.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7152
    Cell Significance Index: 53.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6724
    Cell Significance Index: 86.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6495
    Cell Significance Index: 33.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5770
    Cell Significance Index: 12.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5540
    Cell Significance Index: 60.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3960
    Cell Significance Index: 142.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3959
    Cell Significance Index: 50.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2691
    Cell Significance Index: 51.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2491
    Cell Significance Index: 172.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2303
    Cell Significance Index: 5.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1941
    Cell Significance Index: 11.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1882
    Cell Significance Index: 5.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1259
    Cell Significance Index: 3.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0302
    Cell Significance Index: 0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0093
    Cell Significance Index: 6.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0030
    Cell Significance Index: 2.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0228
    Cell Significance Index: -42.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0250
    Cell Significance Index: -38.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0357
    Cell Significance Index: -48.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0400
    Cell Significance Index: -25.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0410
    Cell Significance Index: -4.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0535
    Cell Significance Index: -5.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0643
    Cell Significance Index: -47.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0851
    Cell Significance Index: -38.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0972
    Cell Significance Index: -2.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0973
    Cell Significance Index: -54.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1077
    Cell Significance Index: -6.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1265
    Cell Significance Index: -78.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1500
    Cell Significance Index: -2.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1717
    Cell Significance Index: -49.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1854
    Cell Significance Index: -1.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2308
    Cell Significance Index: -12.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2365
    Cell Significance Index: -8.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2660
    Cell Significance Index: -38.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2779
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2898
    Cell Significance Index: -33.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3110
    Cell Significance Index: -23.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3298
    Cell Significance Index: -38.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3368
    Cell Significance Index: -70.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4266
    Cell Significance Index: -7.3100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4490
    Cell Significance Index: -3.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4727
    Cell Significance Index: -6.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4914
    Cell Significance Index: -25.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5162
    Cell Significance Index: -34.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5418
    Cell Significance Index: -56.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5892
    Cell Significance Index: -10.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5922
    Cell Significance Index: -46.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6603
    Cell Significance Index: -21.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8907
    Cell Significance Index: -15.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9085
    Cell Significance Index: -40.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9236
    Cell Significance Index: -13.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9895
    Cell Significance Index: -60.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0698
    Cell Significance Index: -27.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1013
    Cell Significance Index: -41.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2243
    Cell Significance Index: -36.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2706
    Cell Significance Index: -41.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2811
    Cell Significance Index: -30.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2871
    Cell Significance Index: -25.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3122
    Cell Significance Index: -45.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3368
    Cell Significance Index: -42.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3495
    Cell Significance Index: -13.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mg2+/Mn2+ dependent phosphatase activity**: PPM1G uses Mg2+ and Mn2+ ions as cofactors to catalyze the dephosphorylation of proteins, which is a critical step in regulating various cellular processes. 2. **Regulation of cell cycle**: PPM1G has been implicated in the regulation of cell cycle progression, particularly in the G2/M phase, where it dephosphorylates proteins involved in the cell cycle machinery. 3. **Protein binding and dephosphorylation**: PPM1G interacts with various proteins, including those involved in protein serine/threonine phosphatase activity, and dephosphorylates them, thereby modulating their function. 4. **Expression in multiple cell types**: PPM1G is expressed in a wide range of cell types, including pancreatic acinar cells, T cells, and germinal center B cells, highlighting its importance in various physiological and pathological processes. **Pathways and Functions:** 1. **Cell cycle regulation**: PPM1G dephosphorylates proteins involved in the cell cycle machinery, regulating cell cycle progression and preventing excessive cell proliferation. 2. **Protein dephosphorylation**: PPM1G interacts with proteins involved in protein serine/threonine phosphatase activity, dephosphorylating them and modulating their function. 3. **Signaling pathways**: PPM1G has been implicated in various signaling pathways, including those involved in immune responses, cell growth, and differentiation. 4. **Metal ion binding**: PPM1G binds to Mg2+ and Mn2+ ions, which are essential cofactors for its phosphatase activity. **Clinical Significance:** Dysregulation of PPM1G has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PPM1G has been observed in various types of cancer, including pancreatic cancer, where it contributes to tumorigenesis and cancer progression. 2. **Autoimmune diseases**: Alterations in PPM1G expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: PPM1G has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it contributes to protein misfolding and aggregation. In conclusion, PPM1G is a critical regulator of cellular processes, and its dysregulation has been implicated in various diseases. Further research is needed to elucidate the mechanisms by which PPM1G regulates cellular processes and to develop therapeutic strategies to target its dysregulation in disease.

Genular Protein ID: 486783615

Symbol: PPM1G_HUMAN

Name: Protein phosphatase 1G

UniProtKB Accession Codes:

O15355

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DNASU 1 DisGeNET 1 EC 3 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9276438

Title: PP2C gamma: a human protein phosphatase with a unique acidic domain.

PubMed ID: 9276438

DOI: 10.1016/s0014-5793(97)00837-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

Sequence Information:

  • Length: 546
  • Mass: 59272
  • Checksum: 084C16F8252330D9
  • Sequence:
    • MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 
GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 
PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE 
PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS 
CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 
AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL 
DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA 
LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL 
DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK 
KKAKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.