PPP1CC | ENSG00000186298 | NCBI 5501

Details for: PPP1CC

Gene ID: 5501

Symbol: PPP1CC

Ensembl ID: ENSG00000186298

Description: protein phosphatase 1 catalytic subunit gamma

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Circadian clock
(R-HSA-400253)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of tgf-beta receptor signaling
(R-HSA-2173788)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Gain-of-function mras complexes activate raf signaling
(R-HSA-9726842)
Infectious disease
(R-HSA-5663205)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Oncogenic mapk signaling
(R-HSA-6802957)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Shoc2 m1731 mutant abolishes mras complex function
(R-HSA-9726840)
Signaling by mras-complex mutants
(R-HSA-9660537)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Viral infection pathways
(R-HSA-9824446)
Blastocyst development
(GO:0001824)
Cell division
(GO:0051301)
Chromosome, telomeric region
(GO:0000781)
Circadian regulation of gene expression
(GO:0032922)
Cleavage furrow
(GO:0032154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Focal adhesion
(GO:0005925)
Glutamatergic synapse
(GO:0098978)
Glycogen metabolic process
(GO:0005977)
Kinetochore
(GO:0000776)
Lamin binding
(GO:0005521)
Mapk cascade
(GO:0000165)
Metal ion binding
(GO:0046872)
Microtubule organizing center
(GO:0005815)
Midbody
(GO:0030496)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Mitotic sister chromatid segregation
(GO:0000070)
Myosin phosphatase activity
(GO:0017018)
Neuron differentiation
(GO:0030182)
Nuclear speck
(GO:0016607)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Phosphatase activity
(GO:0016791)
Phosphoprotein phosphatase activity
(GO:0004721)
Positive regulation of glial cell proliferation
(GO:0060252)
Presynapse
(GO:0098793)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein phosphatase 1 binding
(GO:0008157)
Protein serine/threonine phosphatase activity
(GO:0004722)
Ptw/pp1 phosphatase complex
(GO:0072357)
Regulation of circadian rhythm
(GO:0042752)
Regulation of nucleocytoplasmic transport
(GO:0046822)
Rna binding
(GO:0003723)
Spermatogenesis
(GO:0007283)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 294.4481
Cell Significance Index: -45.8000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 191.3710
Cell Significance Index: -48.5400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 152.1067
Cell Significance Index: -62.6600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 137.9176
Cell Significance Index: -56.0300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 135.3038
Cell Significance Index: -63.8800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 125.0036
Cell Significance Index: -64.3000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 95.8240
Cell Significance Index: -64.3000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.0211
Cell Significance Index: -56.3500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 47.6741
Cell Significance Index: -58.7800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.4817
Cell Significance Index: -49.5100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.8513
Cell Significance Index: -62.5500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.4883
Cell Significance Index: -44.5000
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 5.1603
Cell Significance Index: 39.7800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.2651
Cell Significance Index: 171.4300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.7973
Cell Significance Index: 30.4100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.7397
Cell Significance Index: 323.1000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.3386
Cell Significance Index: 48.9500
Cell Name: theca cell (CL0000503)
Fold Change: 2.1532
Cell Significance Index: 12.6500
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.9161
Cell Significance Index: 50.3900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.8676
Cell Significance Index: 54.8500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.8297
Cell Significance Index: 63.5800
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.7113
Cell Significance Index: 20.4000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6274
Cell Significance Index: 115.1000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.5507
Cell Significance Index: 212.9600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.4738
Cell Significance Index: 92.8900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3398
Cell Significance Index: 731.7100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.3266
Cell Significance Index: 61.8500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2845
Cell Significance Index: 157.9400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2685
Cell Significance Index: 1145.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2423
Cell Significance Index: 35.6100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1967
Cell Significance Index: 237.4900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1581
Cell Significance Index: 512.0200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0905
Cell Significance Index: 23.6300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.0321
Cell Significance Index: 296.9600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9153
Cell Significance Index: 165.0000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8744
Cell Significance Index: 41.1000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8492
Cell Significance Index: 54.7900
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.7935
Cell Significance Index: 6.9900
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.7931
Cell Significance Index: 8.9600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7677
Cell Significance Index: 99.1900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7587
Cell Significance Index: 82.5200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7094
Cell Significance Index: 19.3100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6475
Cell Significance Index: 17.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.6343
Cell Significance Index: 108.3100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5707
Cell Significance Index: 73.1600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5626
Cell Significance Index: 8.4300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.5505
Cell Significance Index: 7.0500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5270
Cell Significance Index: 39.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4228
Cell Significance Index: 84.8100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3291
Cell Significance Index: 62.6300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3213
Cell Significance Index: 16.6900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3170
Cell Significance Index: 14.3700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3032
Cell Significance Index: 108.7500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2487
Cell Significance Index: 19.0900
Cell Name: kidney cell (CL1000497)
Fold Change: 0.2029
Cell Significance Index: 1.6200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1440
Cell Significance Index: 5.0600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0314
Cell Significance Index: 0.5300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0011
Cell Significance Index: 0.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0015
Cell Significance Index: -2.9000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0108
Cell Significance Index: -8.2000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0140
Cell Significance Index: -8.7600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0205
Cell Significance Index: -15.1500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0312
Cell Significance Index: -57.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0326
Cell Significance Index: -23.8800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0340
Cell Significance Index: -52.3500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0412
Cell Significance Index: -56.0200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0447
Cell Significance Index: -2.5100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0517
Cell Significance Index: -32.8600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0560
Cell Significance Index: -1.5000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0587
Cell Significance Index: -33.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0614
Cell Significance Index: -6.2700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0828
Cell Significance Index: -37.5700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1036
Cell Significance Index: -6.3700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1073
Cell Significance Index: -3.0000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1246
Cell Significance Index: -26.2400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1384
Cell Significance Index: -15.8000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1605
Cell Significance Index: -18.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2321
Cell Significance Index: -33.7400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2610
Cell Significance Index: -29.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2635
Cell Significance Index: -8.4400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2781
Cell Significance Index: -5.1400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3186
Cell Significance Index: -3.6200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3490
Cell Significance Index: -18.1800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4083
Cell Significance Index: -10.4300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4247
Cell Significance Index: -7.5100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5157
Cell Significance Index: -12.8900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5198
Cell Significance Index: -34.9500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5561
Cell Significance Index: -3.3600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5722
Cell Significance Index: -15.3100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5758
Cell Significance Index: -59.9500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6180
Cell Significance Index: -17.8100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6621
Cell Significance Index: -52.4400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6758
Cell Significance Index: -9.2200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.7858
Cell Significance Index: -8.1400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.8139
Cell Significance Index: -7.5000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8516
Cell Significance Index: -37.6700
Cell Name: peg cell (CL4033014)
Fold Change: -0.8717
Cell Significance Index: -20.1400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9010
Cell Significance Index: -55.2400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0946
Cell Significance Index: -41.4500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.1612
Cell Significance Index: -19.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PPP1CC is a gamma subunit of the PP1 enzyme, which is a serine/threonine phosphatase that regulates the activity of numerous proteins by removing phosphate groups. The gamma subunit is essential for the activity of PP1, as it interacts with the catalytic subunit and other regulatory subunits to form the PP1 complex. PPP1CC is highly expressed in various cell types, including germinal center B cells, mesodermal cells, and neural crest cells. **Pathways and Functions** PPP1CC is involved in several key cellular pathways, including: 1. **Cell cycle regulation**: PPP1CC regulates the activity of cyclin-dependent kinases (CDKs) and other proteins involved in cell cycle progression. 2. **Signal transduction**: PPP1CC interacts with various signaling molecules, including MAP kinases, Smads, and Rho GTPases, to regulate cell proliferation, differentiation, and survival. 3. **Circadian rhythm entrainment**: PPP1CC regulates the activity of clock genes, such as PER2 and BMAL1, to entrain the circadian clock. 4. **Mitotic spindle formation**: PPP1CC interacts with proteins involved in mitotic spindle formation, such as Embl4 and Nudc, to regulate cell division. **Clinical Significance** Dysregulation of PPP1CC has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PPP1CC has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: PPP1CC has been implicated in neurodevelopmental disorders, such as autism and schizophrenia. 3. **Infectious diseases**: PPP1CC has been shown to regulate the replication of certain viruses, such as Respiratory Syncytial Virus (RSV). 4. **Metabolic disorders**: PPP1CC has been implicated in metabolic disorders, such as diabetes and obesity. In conclusion, PPP1CC is a critical regulator of various cellular processes, including cell cycle regulation, signal transduction, and circadian rhythm entrainment. Dysregulation of PPP1CC has been implicated in various diseases, highlighting the need for further research into the role of this gene in human health and disease. **References** [Insert references to relevant studies and reviews] **Author's Note** This article is a summary of the current understanding of PPP1CC and its role in various cellular processes. Further research is needed to fully elucidate the mechanisms by which PPP1CC regulates cellular functions and to explore its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Genular Protein ID: 995606380

Symbol: PP1G_HUMAN

Name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

UniProtKB Accession Codes:

P36873

Database IDs:

Citations:

PubMed ID: 8394140

Title: Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.

PubMed ID: 8394140

DOI: 10.1016/0167-4889(93)90014-g

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8111128

Title: Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.

PubMed ID: 8111128

DOI: 10.1007/bf00360567

PubMed ID: 7556599

Title: The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.

PubMed ID: 7556599

DOI: 10.1016/0014-5793(95)00888-g

PubMed ID: 9414128

Title: PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1.

PubMed ID: 9414128

DOI: 10.1016/s0014-5793(97)01385-9

PubMed ID: 11739654

Title: Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PubMed ID: 11739654

DOI: 10.1242/jcs.114.23.4219

PubMed ID: 11564868

Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

PubMed ID: 11564868

DOI: 10.1128/mcb.21.20.6841-6850.2001

PubMed ID: 12226088

Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PubMed ID: 12226088

DOI: 10.1074/jbc.m206838200

PubMed ID: 12529430

Title: Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.

PubMed ID: 12529430

DOI: 10.1091/mbc.e02-07-0376

PubMed ID: 15659832

Title: Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception.

PubMed ID: 15659832

DOI: 10.1196/annals.1329.059

PubMed ID: 15705855

Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

PubMed ID: 15705855

DOI: 10.1126/science.1101902

PubMed ID: 16492807

Title: Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.

PubMed ID: 16492807

DOI: 10.1083/jcb.200508154

PubMed ID: 17283141

Title: Protein phosphatase-1alpha regulates centrosome splitting through Nek2.

PubMed ID: 17283141

DOI: 10.1158/0008-5472.can-06-3071

PubMed ID: 17936702

Title: S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.

PubMed ID: 17936702

DOI: 10.1016/j.molcel.2007.08.010

PubMed ID: 17965019

Title: NOM1 targets protein phosphatase I to the nucleolus.

PubMed ID: 17965019

DOI: 10.1074/jbc.m706708200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20516061

Title: Identification and characterization of a novel human PP1 phosphatase complex.

PubMed ID: 20516061

DOI: 10.1074/jbc.m110.109801

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 21712997

Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PubMed ID: 21712997

DOI: 10.1371/journal.pone.0021325

PubMed ID: 23789093

Title: TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network.

PubMed ID: 23789093

DOI: 10.1242/bio.20131065

PubMed ID: 23506001

Title: Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.

PubMed ID: 23506001

DOI: 10.1186/1471-2121-14-15

PubMed ID: 23846654

Title: Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

PubMed ID: 23846654

DOI: 10.1038/nature12308

PubMed ID: 23396208

Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.

PubMed ID: 23396208

DOI: 10.1038/nm.3085

PubMed ID: 24867636

Title: Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.

PubMed ID: 24867636

DOI: 10.7554/elife.01641

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28982702

Title: Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores.

PubMed ID: 28982702

DOI: 10.1242/bio.026930

PubMed ID: 34260926

Title: Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.

PubMed ID: 34260926

DOI: 10.1016/j.celrep.2021.109343

PubMed ID: 7500362

Title: Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.

PubMed ID: 7500362

DOI: 10.1006/jmbi.1995.0667

PubMed ID: 11535607

Title: Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.

PubMed ID: 11535607

DOI: 10.1074/jbc.m107656200

PubMed ID: 15280359

Title: Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.

PubMed ID: 15280359

DOI: 10.1074/jbc.m407184200

Sequence Information:

Length: 323
Mass: 36984
Checksum: 0EEEF0E842188536
Sequence:

MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK 
ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 
LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 
QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
KKKPNATRPV TPPRGMITKQ AKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPP1CC

Associated with

Cells (max top 100)

Other Information

Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. PubMed ID: 8394140

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA. PubMed ID: 8111128

The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. PubMed ID: 7556599

PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1. PubMed ID: 9414128

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. PubMed ID: 11739654

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. PubMed ID: 11564868

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. PubMed ID: 12226088

Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. PubMed ID: 12529430

Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception. PubMed ID: 15659832

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. PubMed ID: 15705855

Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. PubMed ID: 16492807

Protein phosphatase-1alpha regulates centrosome splitting through Nek2. PubMed ID: 17283141

S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. PubMed ID: 17936702

NOM1 targets protein phosphatase I to the nucleolus. PubMed ID: 17965019

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 19377461

Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 24336203

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Identification and characterization of a novel human PP1 phosphatase complex. PubMed ID: 20516061

RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits. PubMed ID: 20926688

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PubMed ID: 21712997

TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. PubMed ID: 23789093

Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. PubMed ID: 23506001

Temporal regulation of EGF signalling networks by the scaffold protein Shc1. PubMed ID: 23846654

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. PubMed ID: 23396208

Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. PubMed ID: 24867636

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores. PubMed ID: 28982702

Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. PubMed ID: 34260926

Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. PubMed ID: 7500362

Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1. PubMed ID: 11535607

Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding. PubMed ID: 15280359