Details for: PPP1R2

Gene ID: 5504

Symbol: PPP1R2

Ensembl ID: ENSG00000184203

Description: protein phosphatase 1 regulatory inhibitor subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 340.2869
    Cell Significance Index: -52.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.1415
    Cell Significance Index: -49.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.5276
    Cell Significance Index: -57.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 129.0070
    Cell Significance Index: -52.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.7313
    Cell Significance Index: -57.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.2614
    Cell Significance Index: -58.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.0046
    Cell Significance Index: -57.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.2295
    Cell Significance Index: -52.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.7356
    Cell Significance Index: -56.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.5994
    Cell Significance Index: -57.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1889
    Cell Significance Index: -38.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0297
    Cell Significance Index: -40.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8485
    Cell Significance Index: -28.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5383
    Cell Significance Index: 41.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4164
    Cell Significance Index: 407.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3761
    Cell Significance Index: 248.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2517
    Cell Significance Index: 93.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2006
    Cell Significance Index: 56.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1814
    Cell Significance Index: 76.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1551
    Cell Significance Index: 142.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0409
    Cell Significance Index: 208.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0009
    Cell Significance Index: 546.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9456
    Cell Significance Index: 49.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9450
    Cell Significance Index: 129.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8946
    Cell Significance Index: 807.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8909
    Cell Significance Index: 105.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8272
    Cell Significance Index: 106.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7875
    Cell Significance Index: 282.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7679
    Cell Significance Index: 152.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7590
    Cell Significance Index: 39.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6619
    Cell Significance Index: 84.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5760
    Cell Significance Index: 254.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5298
    Cell Significance Index: 15.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4234
    Cell Significance Index: 19.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3603
    Cell Significance Index: 10.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2880
    Cell Significance Index: 54.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2175
    Cell Significance Index: 9.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2018
    Cell Significance Index: 14.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1551
    Cell Significance Index: 2.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1042
    Cell Significance Index: 0.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0966
    Cell Significance Index: 5.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0787
    Cell Significance Index: 2.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0592
    Cell Significance Index: 5.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0521
    Cell Significance Index: 98.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0454
    Cell Significance Index: 7.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0338
    Cell Significance Index: 0.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0215
    Cell Significance Index: 13.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0109
    Cell Significance Index: 0.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0233
    Cell Significance Index: -10.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0267
    Cell Significance Index: -36.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0305
    Cell Significance Index: -1.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0351
    Cell Significance Index: -26.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0525
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0539
    Cell Significance Index: -33.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0574
    Cell Significance Index: -5.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0574
    Cell Significance Index: -32.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0947
    Cell Significance Index: -1.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0973
    Cell Significance Index: -3.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1286
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1373
    Cell Significance Index: -28.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1763
    Cell Significance Index: -20.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1798
    Cell Significance Index: -11.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2013
    Cell Significance Index: -29.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2187
    Cell Significance Index: -3.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2421
    Cell Significance Index: -16.2800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2441
    Cell Significance Index: -2.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2490
    Cell Significance Index: -6.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2698
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2763
    Cell Significance Index: -31.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2843
    Cell Significance Index: -7.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3115
    Cell Significance Index: -6.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3157
    Cell Significance Index: -16.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3254
    Cell Significance Index: -37.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3264
    Cell Significance Index: -11.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4140
    Cell Significance Index: -18.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4782
    Cell Significance Index: -10.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5146
    Cell Significance Index: -53.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5158
    Cell Significance Index: -16.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5541
    Cell Significance Index: -7.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5659
    Cell Significance Index: -44.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5905
    Cell Significance Index: -22.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6140
    Cell Significance Index: -14.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6193
    Cell Significance Index: -15.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6276
    Cell Significance Index: -17.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8245
    Cell Significance Index: -49.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8283
    Cell Significance Index: -9.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8429
    Cell Significance Index: -14.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8673
    Cell Significance Index: -24.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9001
    Cell Significance Index: -19.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9016
    Cell Significance Index: -15.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9265
    Cell Significance Index: -56.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9699
    Cell Significance Index: -25.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9936
    Cell Significance Index: -23.8300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1041
    Cell Significance Index: -8.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1069
    Cell Significance Index: -27.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1326
    Cell Significance Index: -6.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit composition:** PPP1R2 is a regulatory subunit that associates with protein phosphatase 1 (PP1) to form a complex that inhibits PP1 activity. 2. **Inhibitory function:** PPP1R2 inhibits PP1 activity, thereby modulating the dephosphorylation of target proteins. 3. **Cellular localization:** PPP1R2 is primarily expressed in immune cells, including T cells, B cells, and natural killer cells. 4. **Tissue specificity:** PPP1R2 is specifically expressed in cells involved in immune responses, such as mature alpha-beta T cells and T-helper 22 cells. **Pathways and Functions:** PPP1R2 is involved in several key pathways, including: 1. **Generation of precursor metabolites and energy:** PPP1R2 regulates the activity of PP1, which is essential for the dephosphorylation of proteins involved in energy metabolism, such as glycogen synthase. 2. **Glycogen metabolic process:** PPP1R2 modulates the activity of PP1, which is involved in glycogen synthesis and degradation. 3. **Regulation of phosphoprotein phosphatase activity:** PPP1R2 inhibits PP1 activity, which is essential for maintaining the balance of cellular signaling pathways. 4. **Regulation of signal transduction:** PPP1R2 modulates the activity of PP1, which is involved in signal transduction pathways, including those involved in immune responses. **Clinical Significance:** Dysregulation of PPP1R2 has been implicated in various diseases, including: 1. **Immunodeficiency disorders:** Mutations in PPP1R2 have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** Altered expression of PPP1R2 has been observed in various types of cancer, including leukemia and lymphoma. 3. **Metabolic disorders:** PPP1R2 has been implicated in the regulation of energy metabolism, and alterations in its expression have been observed in metabolic disorders, such as type 2 diabetes. In conclusion, PPP1R2 is a crucial protein that plays a pivotal role in regulating cellular metabolism and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of PPP1R2 and its clinical significance.

Genular Protein ID: 1966857239

Symbol: IPP2_HUMAN

Name: Protein phosphatase inhibitor 2

UniProtKB Accession Codes:

P41236

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7949733

Title: Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences.

PubMed ID: 7949733

DOI: 10.1007/bf00369318

PubMed ID: 8119416

Title: Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli.

PubMed ID: 8119416

DOI: 10.1016/0014-5793(94)80179-7

PubMed ID: 9126490

Title: Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians.

PubMed ID: 9126490

DOI: 10.1006/geno.1997.4649

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18250156

Title: A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.

PubMed ID: 18250156

DOI: 10.1128/mcb.01711-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23506001

Title: Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.

PubMed ID: 23506001

DOI: 10.1186/1471-2121-14-15

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 205
  • Mass: 23015
  • Checksum: FFC005B07CD5ABFC
  • Sequence:
    • MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM NILATYHPAD 
KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL ARKLAAAEGL EPKYRIQEQE 
SSGEEDSDLS PEEREKKRQF EMKRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMLETADG 
ESMNTEESNQ GSTPSDQQQN KLRSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.