PPP1R2 | ENSG00000184203 | NCBI 5504

Details for: PPP1R2

Associated with

Generation of precursor metabolites and energy
(GO:0006091)
Glycogen metabolic process
(GO:0005977)
Intracellular signal transduction
(GO:0035556)
Molecular function inhibitor activity
(GO:0140678)
Protein binding
(GO:0005515)
Protein phosphatase inhibitor activity
(GO:0004864)
Protein serine/threonine phosphatase inhibitor activity
(GO:0004865)
Regulation of signal transduction
(GO:0009966)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD8-positive, alpha-beta T cell CL0000907

CSI 52.09

rCSI 35.09%

PRS 40.38
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 36.37

rCSI 62.22%

PRS 53.54
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 32.19

rCSI 64.17%

PRS 49.82
CD4-positive helper T cell CL0000492

CSI 28.67

rCSI 21.69%

PRS 43.18
plasmablast CL0000980

CSI 27.18

rCSI 21.39%

PRS 38.11
common dendritic progenitor CL0001029

CSI 25.53

rCSI 32.04%

PRS 40.79
small pre-B-II cell CL0000954

CSI 23.8

rCSI 22.88%

PRS 56.65
multi-ciliated epithelial cell CL0005012

CSI 22.65

rCSI 22.61%

PRS 27.79
T-helper 1 cell CL0000545

CSI 19.52

rCSI 35.24%

PRS 61.44
helper T cell CL0000912

CSI 18.87

rCSI 26.68%

PRS 42.3
endothelial cell of lymphatic vessel CL0002138

CSI 17.36

rCSI 34.41%

PRS 61.14
double-positive, alpha-beta thymocyte CL0000809

CSI 16.94

rCSI 17.27%

PRS 44.21
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 16.01

rCSI 20.12%

PRS 76.97
deuterosomal cell CL4033044

CSI 15.63

rCSI 52.84%

PRS 44.01
large pre-B-II cell CL0000957

CSI 15.21

rCSI 43.42%

PRS 47.96
immature B cell CL0000816

CSI 13.25

rCSI 9.84%

PRS 44.58
ionocyte CL0005006

CSI 13.23

rCSI 14.17%

PRS 30.25
T-helper 17 cell CL0000899

CSI 12.84

rCSI 10.2%

PRS 52.84
lamp5 GABAergic cortical interneuron CL4023011

CSI 9.89

rCSI 16.6%

PRS 20.43
activated CD4-positive, alpha-beta T cell CL0000896

CSI 9.75

rCSI 9.01%

PRS 52.22
mature B cell CL0000785

CSI 9.57

rCSI 8.32%

PRS 40.07
renal beta-intercalated cell CL0002201

CSI 9.1

rCSI 21.69%

PRS 35.41
alveolar adventitial fibroblast CL4028006

CSI 8.78

rCSI 13.87%

PRS 32.95
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 8.41

rCSI 5.9%

PRS 58.81
transitional stage B cell CL0000818

CSI 8.12

rCSI 26.57%

PRS 66.65
inflammatory macrophage CL0000863

CSI 7.81

rCSI 13.35%

PRS 58.22
pulmonary capillary endothelial cell CL4028001

CSI 7.81

rCSI 14.9%

PRS 48.09
precursor B cell CL0000817

CSI 6.89

rCSI 6.04%

PRS 41.35
ciliated epithelial cell CL0000067

CSI 6.74

rCSI 5.93%

PRS 23.99
mononuclear phagocyte CL0000113

CSI 6.71

rCSI 14.78%

PRS 36.07
T follicular helper cell CL0002038

CSI 6.6

rCSI 4.94%

PRS 46.34
squamous epithelial cell CL0000076

CSI 6.41

rCSI 15.21%

PRS 38.1
lung pericyte CL0009089

CSI 6.33

rCSI 16.7%

PRS 38.15
mesenchymal cell CL0008019

CSI 6.23

rCSI 15.82%

PRS 30.61
lung secretory cell CL1000272

CSI 6.23

rCSI 15.41%

PRS 30.61
astrocyte of the cerebral cortex CL0002605

CSI 6.21

rCSI 13.93%

PRS 20.99
fallopian tube secretory epithelial cell CL4030006

CSI 6.01

rCSI 5.79%

PRS 33.22
natural T-regulatory cell CL0000903

CSI 5.93

rCSI 11.23%

PRS 68.49
dendritic cell, human CL0001056

CSI 5.71

rCSI 8.77%

PRS 38.07
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 5.67

rCSI 6.87%

PRS 33.69
non-classical monocyte CL0000875

CSI 5.48

rCSI 8.78%

PRS 63.79
promonocyte CL0000559

CSI 5.4

rCSI 9.25%

PRS 41.34
inhibitory interneuron CL0000498

CSI 5.36

rCSI 12.38%

PRS 26.7
alpha-beta T cell CL0000789

CSI 5.33

rCSI 6.25%

PRS 45.08
regulatory T cell CL0000815

CSI 5.24

rCSI 6.08%

PRS 60.86
plasmacytoid dendritic cell, human CL0001058

CSI 5.22

rCSI 3.64%

PRS 33.94
cardiac neuron CL0010022

CSI 5.17

rCSI 16.55%

PRS 29.27
retina horizontal cell CL0000745

CSI 5.14

rCSI 7.84%

PRS 30.04
extravillous trophoblast CL0008036

CSI 5.12

rCSI 6.34%

PRS 28.89
epithelial cell of lower respiratory tract CL0002632

CSI 5.06

rCSI 3.93%

PRS 31.93
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 5.05

rCSI 3.79%

PRS 67.75
centrilobular region hepatocyte CL0019029

CSI 4.95

rCSI 12.91%

PRS 42.96
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 4.65

rCSI 6.38%

PRS 53.37
fibroblast of lung CL0002553

CSI 4.55

rCSI 4.24%

PRS 32.33
small intestine goblet cell CL1000495

CSI 4.41

rCSI 9.66%

PRS 41.57
plasma cell CL0000786

CSI 4.27

rCSI 5.6%

PRS 74.64
peripheral nervous system neuron CL2000032

CSI 3.98

rCSI 5.43%

PRS 27.92
lung interstitial macrophage CL4033043

CSI 3.95

rCSI 8.87%

PRS 54.08
activated CD8-positive, alpha-beta T cell CL0000906

CSI 3.83

rCSI 3.76%

PRS 64.27
kidney connecting tubule epithelial cell CL1000768

CSI 3.68

rCSI 9.32%

PRS 25.23
B cell CL0000236

CSI 3.63

rCSI 4.85%

PRS 69.01
regular atrial cardiac myocyte CL0002129

CSI 3.59

rCSI 11.57%

PRS 32.96
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 3.54

rCSI 4.82%

PRS 61.23
blood vessel endothelial cell CL0000071

CSI 3.53

rCSI 7.33%

PRS 31.53
ciliated cell CL0000064

CSI 3.45

rCSI 5.6%

PRS 31.76
lymphoid lineage restricted progenitor cell CL0000838

CSI 3.45

rCSI 13.42%

PRS 50.75
activated type II NK T cell CL0000931

CSI 3.36

rCSI 3.78%

PRS 47.59
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 3.35

rCSI 3.29%

PRS 46.5
plasmacytoid dendritic cell CL0000784

CSI 3.32

rCSI 3.36%

PRS 79.33
mucosal invariant T cell CL0000940

CSI 3.25

rCSI 2.63%

PRS 43.96
naive B cell CL0000788

CSI 3.23

rCSI 2.77%

PRS 43.53
pancreatic ductal cell CL0002079

CSI 3.21

rCSI 6.25%

PRS 33.57
fibroblast of cardiac tissue CL0002548

CSI 3.17

rCSI 15.2%

PRS 30.06
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 3.16

rCSI 36.74%

PRS 74.53
memory B cell CL0000787

CSI 3.16

rCSI 3.12%

PRS 72.5
epithelial cell CL0000066

CSI 3.13

rCSI 4.82%

PRS 38.29
group 3 innate lymphoid cell CL0001071

CSI 3.04

rCSI 2.28%

PRS 34.77
pancreatic A cell CL0000171

CSI 3.03

rCSI 3.17%

PRS 34.3
mature NK T cell CL0000814

CSI 2.92

rCSI 3.74%

PRS 71.37
syncytiotrophoblast cell CL0000525

CSI 2.89

rCSI 8.34%

PRS 51.27
unswitched memory B cell CL0000970

CSI 2.87

rCSI 2.42%

PRS 48.06
Mueller cell CL0000636

CSI 2.85

rCSI 6.51%

PRS 27.81
naive T cell CL0000898

CSI 2.82

rCSI 1.96%

PRS 43.74
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.78

rCSI 2.23%

PRS 52.66
sst GABAergic cortical interneuron CL4023017

CSI 2.76

rCSI 3.56%

PRS 21.12
myofibroblast cell CL0000186

CSI 2.76

rCSI 3.82%

PRS 39.46
vascular leptomeningeal cell CL4023051

CSI 2.74

rCSI 4.81%

PRS 26.07
perivascular cell CL4033054

CSI 2.67

rCSI 3.66%

PRS 36.18
ON-bipolar cell CL0000749

CSI 2.67

rCSI 3.97%

PRS 35.78
pulmonary ionocyte CL0017000

CSI 2.67

rCSI 3.25%

PRS 39.13
bronchus fibroblast of lung CL2000093

CSI 2.64

rCSI 2.14%

PRS 33.26
club cell CL0000158

CSI 2.6

rCSI 3.81%

PRS 34.21
IgG plasma cell CL0000985

CSI 2.6

rCSI 3.11%

PRS 50.78
early lymphoid progenitor CL0000936

CSI 2.54

rCSI 2.23%

PRS 36.79
Kupffer cell CL0000091

CSI 2.5

rCSI 5.72%

PRS 31.86
melanocyte CL0000148

CSI 2.49

rCSI 1.84%

PRS 27.82
secretory cell CL0000151

CSI 2.45

rCSI 2.56%

PRS 32.95
CD8-positive, alpha-beta memory T cell CL0000909

CSI 2.45

rCSI 2.56%

PRS 66.61
dendritic cell CL0000451

CSI 2.41

rCSI 2.97%

PRS 63.09
pro-B cell CL0000826

CSI 2.4

rCSI 1.99%

PRS 32.94

epithelial cell of urethra CL1000296

CSI 0.1

rCSI 3.5%

PRS 63.7%
enteric neuron CL0007011

CSI 0.2

rCSI 3.3%

PRS 58.3%
lung microvascular endothelial cell CL2000016

CSI 0.2

rCSI 4.6%

PRS 62.4%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.3

rCSI 1.4%

PRS 68.8%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 3.0%

PRS 53.7%
Cajal-Retzius cell CL0000695

CSI 0.3

rCSI 2.5%

PRS 51.9%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.3

rCSI 1.7%

PRS 55.6%
pre-conventional dendritic cell CL0002010

CSI 0.4

rCSI 4.6%

PRS 68.5%
acinar cell of salivary gland CL0002623

CSI 0.4

rCSI 8.3%

PRS 54.9%
endothelial cell of placenta CL0009092

CSI 0.4

rCSI 1.8%

PRS 42.4%
tracheal goblet cell CL1000329

CSI 0.4

rCSI 0.8%

PRS 53.3%
vein endothelial cell of respiratory system CL4033008

CSI 0.4

rCSI 2.5%

PRS 53.1%
kidney epithelial cell CL0002518

CSI 0.4

rCSI 0.7%

PRS 56.7%
cytotoxic T cell CL0000910

CSI 0.4

rCSI 2.2%

PRS 44.5%
enteroglial cell CL4040002

CSI 0.4

rCSI 2.1%

PRS 43.8%
paneth cell CL0000510

CSI 0.4

rCSI 0.6%

PRS 47.9%
eosinophil CL0000771

CSI 0.4

rCSI 2.7%

PRS 65.2%
megakaryocyte CL0000556

CSI 0.4

rCSI 1.8%

PRS 48.9%
retinal ganglion cell CL0000740

CSI 0.4

rCSI 0.9%

PRS 23.6%
intestinal crypt stem cell of colon CL0009043

CSI 0.4

rCSI 3.2%

PRS 52.7%
regular ventricular cardiac myocyte CL0002131

CSI 0.5

rCSI 2.9%

PRS 26.6%
Hofbauer cell CL3000001

CSI 0.5

rCSI 0.9%

PRS 40.8%
group 2 innate lymphoid cell CL0001069

CSI 0.5

rCSI 2.6%

PRS 72.3%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.5

rCSI 2.9%

PRS 21.5%
colon macrophage CL0009038

CSI 0.5

rCSI 2.3%

PRS 55.8%
bronchial goblet cell CL1000312

CSI 0.5

rCSI 2.0%

PRS 55.6%
microcirculation associated smooth muscle cell CL0008035

CSI 0.5

rCSI 1.5%

PRS 35.2%
stromal cell of ovary CL0002132

CSI 0.5

rCSI 1.4%

PRS 48.3%
P/D1 enteroendocrine cell CL0002268

CSI 0.5

rCSI 2.8%

PRS 58.2%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.8%

PRS 25.3%
paneth cell of epithelium of small intestine CL1000343

CSI 0.6

rCSI 1.5%

PRS 46.8%
pancreatic PP cell CL0002275

CSI 0.6

rCSI 2.3%

PRS 48.6%
tracheobronchial serous cell CL0019001

CSI 0.6

rCSI 2.5%

PRS 50.2%
respiratory epithelial cell CL0002368

CSI 0.6

rCSI 3.6%

PRS 70.9%
prostate gland microvascular endothelial cell CL2000059

CSI 0.6

rCSI 14.2%

PRS 65.2%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.6

rCSI 3.6%

PRS 59.0%
enterocyte of epithelium of large intestine CL0002071

CSI 0.6

rCSI 3.2%

PRS 48.4%
direct pathway medium spiny neuron CL4023026

CSI 0.6

rCSI 14.6%

PRS 19.7%
myeloid dendritic cell, human CL0001057

CSI 0.6

rCSI 3.4%

PRS 68.3%
forebrain radial glial cell CL0013000

CSI 0.6

rCSI 2.0%

PRS 41.2%
central nervous system neuron CL2000029

CSI 0.6

rCSI 4.7%

PRS 22.5%
pancreatic stellate cell CL0002410

CSI 0.6

rCSI 3.8%

PRS 44.0%
enteroendocrine cell of colon CL0009042

CSI 0.7

rCSI 3.1%

PRS 61.4%
memory T cell CL0000813

CSI 0.7

rCSI 1.3%

PRS 62.4%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.6%

PRS 48.1%
follicular B cell CL0000843

CSI 0.7

rCSI 2.5%

PRS 70.9%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.7

rCSI 0.6%

PRS 29.7%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.7

rCSI 3.2%

PRS 71.9%
thymocyte CL0000893

CSI 0.7

rCSI 2.5%

PRS 71.6%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.7

rCSI 1.3%

PRS 19.8%
amacrine cell CL0000561

CSI 0.7

rCSI 2.1%

PRS 25.9%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.8

rCSI 2.1%

PRS 40.8%
respiratory suprabasal cell CL4033048

CSI 0.8

rCSI 1.0%

PRS 36.9%
intestinal tuft cell CL0019032

CSI 0.8

rCSI 1.2%

PRS 36.5%
cardiac muscle cell CL0000746

CSI 0.8

rCSI 1.1%

PRS 25.7%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.8

rCSI 2.8%

PRS 19.4%
retinal bipolar neuron CL0000748

CSI 0.8

rCSI 1.5%

PRS 24.5%
colon epithelial cell CL0011108

CSI 0.8

rCSI 0.9%

PRS 30.2%
pancreatic epsilon cell CL0005019

CSI 0.8

rCSI 3.9%

PRS 57.7%
colon goblet cell CL0009039

CSI 0.8

rCSI 2.0%

PRS 44.5%
luminal epithelial cell of mammary gland CL0002326

CSI 0.9

rCSI 1.6%

PRS 47.2%
enteroendocrine cell of small intestine CL0009006

CSI 0.9

rCSI 1.9%

PRS 46.1%
respiratory basal cell CL0002633

CSI 0.9

rCSI 0.9%

PRS 37.5%
podocyte CL0000653

CSI 0.9

rCSI 4.0%

PRS 31.2%
placental villous trophoblast CL2000060

CSI 0.9

rCSI 1.5%

PRS 30.7%
germinal center B cell CL0000844

CSI 1.0

rCSI 2.8%

PRS 57.8%
basal cell of prostate epithelium CL0002341

CSI 1.0

rCSI 2.7%

PRS 54.2%
VIP GABAergic cortical interneuron CL4023016

CSI 1.0

rCSI 1.1%

PRS 20.3%
mucus secreting cell CL0000319

CSI 1.0

rCSI 1.5%

PRS 41.2%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.0

rCSI 2.2%

PRS 32.0%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.0

rCSI 2.5%

PRS 65.3%
class switched memory B cell CL0000972

CSI 1.0

rCSI 0.7%

PRS 49.9%
acinar cell CL0000622

CSI 1.0

rCSI 1.4%

PRS 41.6%
retinal pigment epithelial cell CL0002586

CSI 1.0

rCSI 2.0%

PRS 32.8%
muscle cell CL0000187

CSI 1.0

rCSI 2.1%

PRS 55.7%
pro-T cell CL0000827

CSI 1.0

rCSI 23.5%

PRS 90.3%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.5%

PRS 34.5%
granulocyte monocyte progenitor cell CL0000557

CSI 1.0

rCSI 0.9%

PRS 35.7%
stromal cell CL0000499

CSI 1.1

rCSI 2.9%

PRS 36.0%
common myeloid progenitor CL0000049

CSI 1.1

rCSI 0.9%

PRS 32.5%
L6b glutamatergic cortical neuron CL4023038

CSI 1.1

rCSI 3.3%

PRS 21.4%
indirect pathway medium spiny neuron CL4023029

CSI 1.1

rCSI 26.1%

PRS 20.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.1

rCSI 3.5%

PRS 23.1%
mammary gland epithelial cell CL0002327

CSI 1.1

rCSI 3.9%

PRS 49.1%
hepatocyte CL0000182

CSI 1.1

rCSI 2.0%

PRS 30.6%
pancreatic acinar cell CL0002064

CSI 1.1

rCSI 1.5%

PRS 35.8%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.2

rCSI 1.6%

PRS 30.2%
luminal cell of prostate epithelium CL0002340

CSI 1.2

rCSI 6.2%

PRS 48.9%
Langerhans cell CL0000453

CSI 1.2

rCSI 1.8%

PRS 50.2%
alveolar macrophage CL0000583

CSI 1.2

rCSI 1.9%

PRS 37.2%
retinal rod cell CL0000604

CSI 1.2

rCSI 2.1%

PRS 31.5%
foveolar cell of stomach CL0002179

CSI 1.2

rCSI 2.6%

PRS 47.2%
innate lymphoid cell CL0001065

CSI 1.2

rCSI 2.5%

PRS 41.9%
mesodermal cell CL0000222

CSI 1.2

rCSI 1.4%

PRS 31.2%
glial cell CL0000125

CSI 1.2

rCSI 4.6%

PRS 28.8%
glandular epithelial cell CL0000150

CSI 1.2

rCSI 3.2%

PRS 55.3%
vascular associated smooth muscle cell CL0000359

CSI 1.2

rCSI 4.0%

PRS 36.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.2

rCSI 4.7%

PRS 21.2%
intermediate monocyte CL0002393

CSI 1.2

rCSI 1.9%

PRS 33.5%
choroid plexus epithelial cell CL0000706

CSI 1.3

rCSI 2.1%

PRS 25.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PPP1R2](/details-gene/5504) encodes Protein Phosphatase 1 Regulatory Inhibitor Subunit 2, a key endogenous inhibitor of protein phosphatase-1 (PP1), a ubiquitously expressed serine/threonine phosphatase. By binding to and inhibiting the catalytic subunit of PP1, [PPP1R2](/details-gene/5504) plays a critical role in modulating a wide range of cellular processes that are controlled by reversible protein phosphorylation. Expression data indicate that **Overall**, [PPP1R2](/details-gene/5504) is a significant gene in the adaptive immune system, with particularly high significance in various T cell subsets, including [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907) and [activated CD8-positive, alpha-beta T cells, human](/details-cell/CL0001049). This expression pattern suggests a pivotal function in regulating T cell activation, differentiation, and memory. The gene is associated with OMIM entry [601792](https://omim.org/entry/601792). ## Cellular Roles and Expression Landscape The expression profile of [PPP1R2](/details-gene/5504) highlights its pronounced role within the hematopoietic system, particularly in lymphocytes. **Overall**, the gene shows the highest significance in T lymphocytes, with top-ranking cell types including [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 52.09), [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049) (CSI: 36.37), and various helper T cell populations such as [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 28.67) and [T-helper 1 cell](/details-cell/CL0000545) (CSI: 19.52). Its high significance in both memory and activated T cell states suggests its function is not limited to a single stage of the T cell life cycle but is likely involved in regulating transitions between quiescence, activation, and effector function. Beyond the T cell lineage, [PPP1R2](/details-gene/5504) is also significantly expressed in B-lineage cells, including [plasmablasts](/details-cell/CL0000980) and both [small pre-B-II cells](/details-cell/CL0000954) and [large pre-B-II cells](/details-cell/CL0000957). This indicates a broader role in regulating signal transduction during lymphocyte development and terminal differentiation. Notably, the gene also demonstrates relevance in non-immune cells such as [multi-ciliated epithelial cells](/details-cell/CL0005012) and [endothelial cells of lymphatic vessels](/details-cell/CL0002138), implying its regulatory function extends to processes like ciliogenesis and lymphatic vessel biology. ## Pathways and Molecular Function The primary molecular function of [PPP1R2](/details-gene/5504) is defined by its role as a potent [protein serine/threonine phosphatase inhibitor](/details-go/GO:0004865), specifically exhibiting [protein phosphatase inhibitor activity](/details-go/GO:0004864) against PP1. This inhibitory function is central to its involvement in biological processes such as [intracellular signal transduction](/details-go/GO:0035556) and the broader [regulation of signal transduction](/details-go/GO:0009966). By preventing the dephosphorylation of PP1 substrates, [PPP1R2](/details-gene/5504) helps sustain phosphorylation-dependent signaling cascades. This function is highly consistent with its expression pattern in T cells, where precise control of phosphorylation is essential for T cell receptor (TCR) signaling. Indeed, quantitative phosphoproteomic studies have identified its involvement in the TCR signaling network ([Link](https://doi.org/10.1126/scisignal.2000007)). Furthermore, its annotation in the [glycogen metabolic process](/details-go/GO:0005977) suggests a role in cellular energy regulation, a critical aspect of lymphocyte activation and proliferation. Early studies successfully cloned and characterized the human gene, confirming its identity and inhibitor function ([Link](https://doi.org/10.1007/bf00369318), [Link](https://doi.org/10.1016/0014-5793(94)80179-7)). ## Research Directions The specific and high expression of [PPP1R2](/details-gene/5504) in distinct functional states of lymphocytes, such as memory versus activated T cells, provides a foundation for several testable hypotheses regarding its role in immunity. **Testable Hypotheses:** 1. Given its top significance in [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907), [PPP1R2](/details-gene/5504) may be essential for maintaining T cell quiescence and establishing the threshold for memory T cell reactivation. Its inhibition of PP1 could preserve critical phosphorylation patterns required for long-term survival and rapid recall responses. 2. The high expression of [PPP1R2](/details-gene/5504) in [activated CD8-positive, alpha-beta T cells, human](/details-cell/CL0001049) and [plasmablasts](/details-cell/CL0000980) suggests that its upregulation is a key event during terminal lymphocyte differentiation, necessary to sustain the high levels of signaling and metabolic activity required for robust effector function. **Proposed Experiment:** To test the hypothesis that [PPP1R2](/details-gene/5504) is critical for memory T cell function (Hypothesis 1), a T cell-specific conditional knockout mouse model (e.g., Ppp1r2-floxed x CD4-Cre) could be employed. These mice, alongside wild-type controls, would be subjected to an acute viral infection (e.g., Lymphocytic Choriomeningitis Virus, LCMV). Following resolution of the primary infection, memory CD8+ T cells would be isolated and analyzed via single-cell RNA-seq and functional assays (e.g., ex vivo restimulation) to assess their stability, phenotype, and reactivation potential. A secondary challenge with the same pathogen would reveal the in vivo requirement of [PPP1R2](/details-gene/5504) for a protective recall response. **Therapeutic Potential:** As an intracellular enzyme inhibitor, [PPP1R2](/details-gene/5504) is not a direct target for antibody-based therapies but could be modulated by small molecules. Its role in amplifying phosphorylation-dependent signals makes it a context-dependent therapeutic target. In autoimmune diseases, promoting [PPP1R2](/details-gene/5504) activity (or inhibiting PP1) could exacerbate T cell activation, whereas inhibiting [PPP1R2](/details-gene/5504) could raise the activation threshold and potentially dampen autoimmune responses. Conversely, in oncology, inhibiting [PPP1R2](/details-gene/5504) in tumor-infiltrating lymphocytes might lower their activation threshold, thereby enhancing anti-tumor immunity. Therefore, developing selective small-molecule inhibitors of [PPP1R2](/details-gene/5504) could represent a novel strategy for immunomodulation.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein phosphatase inhibitor 2

Genular Protein ID: 1966857239

Symbol: IPP2_HUMAN

Name: Protein phosphatase inhibitor 2

UniProtKB Accession Codes:

P41236

Database IDs:

Citations:

PubMed ID: 7949733

Title: Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences.

PubMed ID: 7949733

DOI: 10.1007/bf00369318

PubMed ID: 8119416

Title: Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli.

PubMed ID: 8119416

DOI: 10.1016/0014-5793(94)80179-7

PubMed ID: 9126490

Title: Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians.

PubMed ID: 9126490

DOI: 10.1006/geno.1997.4649

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18250156

Title: A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.

PubMed ID: 18250156

DOI: 10.1128/mcb.01711-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23506001

Title: Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.

PubMed ID: 23506001

DOI: 10.1186/1471-2121-14-15

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 205
Mass: 23015
Checksum: FFC005B07CD5ABFC
Sequence:

MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM NILATYHPAD 
KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL ARKLAAAEGL EPKYRIQEQE 
SSGEEDSDLS PEEREKKRQF EMKRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMLETADG 
ESMNTEESNQ GSTPSDQQQN KLRSS

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Ovary UBERON0000992
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: PPP1R2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. PubMed ID: 7949733

Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. PubMed ID: 8119416

Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. PubMed ID: 9126490

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. PubMed ID: 18250156

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. PubMed ID: 23506001

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163