Details for: PKIA

Gene ID: 5569

Symbol: PKIA

Ensembl ID: ENSG00000171033

Description: cAMP-dependent protein kinase inhibitor alpha

Associated with

  • Camp-dependent protein kinase inhibitor activity
    (GO:0004862)
  • Cytoplasm
    (GO:0005737)
  • Negative regulation of camp-dependent protein kinase activity
    (GO:2000480)
  • Negative regulation of protein import into nucleus
    (GO:0042308)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Protein kinase a catalytic subunit binding
    (GO:0034236)
  • Regulation of g2/m transition of mitotic cell cycle
    (GO:0010389)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.41
    Marker Score: 115278
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.32
    Marker Score: 7763
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.18
    Marker Score: 48737
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.14
    Marker Score: 11218
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.1
    Marker Score: 1600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.89
    Marker Score: 10171
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.88
    Marker Score: 4325
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.87
    Marker Score: 14137
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.86
    Marker Score: 3786
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.8
    Marker Score: 38489
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 16980
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.77
    Marker Score: 2497
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.77
    Marker Score: 108976
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15056
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.69
    Marker Score: 650
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.69
    Marker Score: 17403.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.67
    Marker Score: 1872
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.67
    Marker Score: 33125
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.63
    Marker Score: 782
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.57
    Marker Score: 6377
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.56
    Marker Score: 11921
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.55
    Marker Score: 23136
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.53
    Marker Score: 888
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2338
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.49
    Marker Score: 6172
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.47
    Marker Score: 5701
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168751
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.46
    Marker Score: 53906
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1456
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.45
    Marker Score: 13640
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.41
    Marker Score: 53704.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.39
    Marker Score: 781
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.39
    Marker Score: 6441
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.33
    Marker Score: 1601
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.32
    Marker Score: 870
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.27
    Marker Score: 2137
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.26
    Marker Score: 526
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.21
    Marker Score: 1140
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18831
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.15
    Marker Score: 4242
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4786
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.1
    Marker Score: 502
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.09
    Marker Score: 19296.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.09
    Marker Score: 938
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.08
    Marker Score: 356
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.07
    Marker Score: 3812
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.06
    Marker Score: 337
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.05
    Marker Score: 811
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.05
    Marker Score: 933
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.04
    Marker Score: 2274.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.96
    Marker Score: 3734
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.93
    Marker Score: 462
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5264
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.92
    Marker Score: 2322
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.91
    Marker Score: 571
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.91
    Marker Score: 2606
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.91
    Marker Score: 1262
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.9
    Marker Score: 1124
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.89
    Marker Score: 299
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.86
    Marker Score: 173
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.85
    Marker Score: 353
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.85
    Marker Score: 590
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.83
    Marker Score: 943
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.82
    Marker Score: 225
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.8
    Marker Score: 253
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8
    Marker Score: 479
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.79
    Marker Score: 983
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.77
    Marker Score: 3207
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.76
    Marker Score: 936
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.75
    Marker Score: 650
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 485
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.73
    Marker Score: 3062.5
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.73
    Marker Score: 222
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.72
    Marker Score: 1721
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.72
    Marker Score: 420
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.69
    Marker Score: 1016
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.68
    Marker Score: 962
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.67
    Marker Score: 220
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1303
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.63
    Marker Score: 331
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.62
    Marker Score: 251
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.62
    Marker Score: 745
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.61
    Marker Score: 458
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.61
    Marker Score: 286
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.6
    Marker Score: 316

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Other Information

**Key Characteristics:** 1. **Inhibitory function:** PKIA acts as a negative regulator of PKA activity, preventing its excessive activation and subsequent cellular consequences. 2. **Cell type specificity:** PKIA is highly expressed in neurons, cardiac myocytes, and astrocytes, indicating its role in regulating specific cellular processes in these cell types. 3. **Regulation of cell cycle:** PKIA is involved in the regulation of the G2/M transition of the mitotic cell cycle, ensuring proper cell proliferation and preventing uncontrolled cell growth. 4. **Protein binding:** PKIA interacts with PKA catalytic subunits, modulating its activity and preventing its aberrant signaling. **Pathways and Functions:** 1. **cAMP-dependent protein kinase activity:** PKIA inhibits PKA activity, preventing its excessive activation and subsequent signaling cascades. 2. **Negative regulation of transcription by RNA polymerase II:** PKIA regulates transcription by inhibiting RNA polymerase II activity, ensuring proper gene expression and preventing aberrant transcription. 3. **Negative regulation of protein import into the nucleus:** PKIA regulates the import of proteins into the nucleus, preventing their aberrant localization and subsequent signaling. 4. **Regulation of the G2/M transition of the mitotic cell cycle:** PKIA ensures proper cell proliferation by regulating the G2/M transition, preventing uncontrolled cell growth. **Clinical Significance:** 1. **Neurological disorders:** Dysregulation of PKIA has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cardiac diseases:** PKIA dysfunction has been linked to cardiac diseases, including hypertension, heart failure, and arrhythmias. 3. **Cancer:** PKIA regulation of the cell cycle and transcriptional processes makes it a potential target for cancer therapy. 4. **Neurodevelopmental disorders:** PKIA dysregulation has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, PKIA plays a critical role in regulating various cellular processes by inhibiting PKA activity. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is necessary to fully understand the mechanisms of PKIA regulation and its clinical significance.

Genular Protein ID: 4035982914

Symbol: IPKA_HUMAN

Name: cAMP-dependent protein kinase inhibitor alpha

UniProtKB Accession Codes:

P61925 P04541 Q6IAV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisProt 1 DrugBank 30 ELM 1 EMBL 4 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1770951

Title: Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor.

PubMed ID: 1770951

DOI: 10.1210/mend-5-9-1246

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 76
  • Mass: 7989
  • Checksum: BDCE072810435951
  • Sequence:
    • MTDVETTYAD FIASGRTGRR NAIHDILVSS ASGNSNELAL KLAGLDINKT EGEEDAQRSS 
TEQSGEAQGE AAKSES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.