Details for: PKIA

Gene ID: 5569

Symbol: PKIA

Ensembl ID: ENSG00000171033

Description: cAMP-dependent protein kinase inhibitor alpha

Associated with

  • Camp-dependent protein kinase inhibitor activity
    (GO:0004862)
  • Cytoplasm
    (GO:0005737)
  • Negative regulation of camp-dependent protein kinase activity
    (GO:2000480)
  • Negative regulation of camp/pka signal transduction
    (GO:0141162)
  • Negative regulation of protein import into nucleus
    (GO:0042308)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Protein kinase a catalytic subunit binding
    (GO:0034236)
  • Regulation of g2/m transition of mitotic cell cycle
    (GO:0010389)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 230.8010
    Cell Significance Index: -35.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.9763
    Cell Significance Index: -36.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.5955
    Cell Significance Index: -36.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2664
    Cell Significance Index: -25.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.6337
    Cell Significance Index: 1333.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.1005
    Cell Significance Index: 50.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.4220
    Cell Significance Index: 74.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.8525
    Cell Significance Index: 69.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8267
    Cell Significance Index: 125.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6613
    Cell Significance Index: 100.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.3609
    Cell Significance Index: 56.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2174
    Cell Significance Index: 136.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1299
    Cell Significance Index: 119.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.9694
    Cell Significance Index: 33.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9121
    Cell Significance Index: 146.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8692
    Cell Significance Index: 374.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8082
    Cell Significance Index: 51.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6557
    Cell Significance Index: 111.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3907
    Cell Significance Index: 30.1300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.1506
    Cell Significance Index: 18.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9885
    Cell Significance Index: 354.5600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.9869
    Cell Significance Index: 10.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9601
    Cell Significance Index: 664.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.9275
    Cell Significance Index: 12.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9162
    Cell Significance Index: 23.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8839
    Cell Significance Index: 46.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8128
    Cell Significance Index: 99.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8087
    Cell Significance Index: 22.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7887
    Cell Significance Index: 142.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7639
    Cell Significance Index: 39.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4606
    Cell Significance Index: 3.5500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.4417
    Cell Significance Index: 5.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4395
    Cell Significance Index: 396.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.2956
    Cell Significance Index: 3.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2596
    Cell Significance Index: 42.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1924
    Cell Significance Index: 2.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1899
    Cell Significance Index: 36.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1297
    Cell Significance Index: 12.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0937
    Cell Significance Index: 10.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0764
    Cell Significance Index: 143.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0433
    Cell Significance Index: 19.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0243
    Cell Significance Index: 10.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0098
    Cell Significance Index: 13.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0047
    Cell Significance Index: 2.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0268
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0393
    Cell Significance Index: -28.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0493
    Cell Significance Index: -37.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0498
    Cell Significance Index: -1.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0503
    Cell Significance Index: -1.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0570
    Cell Significance Index: -32.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0644
    Cell Significance Index: -40.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0702
    Cell Significance Index: -10.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0877
    Cell Significance Index: -3.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1199
    Cell Significance Index: -15.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1365
    Cell Significance Index: -13.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1403
    Cell Significance Index: -8.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1472
    Cell Significance Index: -29.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1522
    Cell Significance Index: -17.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1867
    Cell Significance Index: -39.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1917
    Cell Significance Index: -11.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1984
    Cell Significance Index: -5.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2109
    Cell Significance Index: -24.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2126
    Cell Significance Index: -14.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2253
    Cell Significance Index: -7.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2421
    Cell Significance Index: -25.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2426
    Cell Significance Index: -33.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2441
    Cell Significance Index: -41.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2561
    Cell Significance Index: -33.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2740
    Cell Significance Index: -6.8500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2783
    Cell Significance Index: -2.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2982
    Cell Significance Index: -6.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3096
    Cell Significance Index: -9.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3254
    Cell Significance Index: -6.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3301
    Cell Significance Index: -15.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3464
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3493
    Cell Significance Index: -40.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3769
    Cell Significance Index: -4.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3808
    Cell Significance Index: -30.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3812
    Cell Significance Index: -26.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3846
    Cell Significance Index: -24.8100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4003
    Cell Significance Index: -5.3400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4081
    Cell Significance Index: -2.6600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4104
    Cell Significance Index: -3.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4267
    Cell Significance Index: -31.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4291
    Cell Significance Index: -14.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4692
    Cell Significance Index: -29.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4937
    Cell Significance Index: -14.5000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4985
    Cell Significance Index: -6.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5066
    Cell Significance Index: -10.7900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5402
    Cell Significance Index: -9.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5514
    Cell Significance Index: -11.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5528
    Cell Significance Index: -17.7100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5769
    Cell Significance Index: -6.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6126
    Cell Significance Index: -28.7900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6200
    Cell Significance Index: -7.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6263
    Cell Significance Index: -21.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inhibitory function:** PKIA acts as a negative regulator of PKA activity, preventing its excessive activation and subsequent cellular consequences. 2. **Cell type specificity:** PKIA is highly expressed in neurons, cardiac myocytes, and astrocytes, indicating its role in regulating specific cellular processes in these cell types. 3. **Regulation of cell cycle:** PKIA is involved in the regulation of the G2/M transition of the mitotic cell cycle, ensuring proper cell proliferation and preventing uncontrolled cell growth. 4. **Protein binding:** PKIA interacts with PKA catalytic subunits, modulating its activity and preventing its aberrant signaling. **Pathways and Functions:** 1. **cAMP-dependent protein kinase activity:** PKIA inhibits PKA activity, preventing its excessive activation and subsequent signaling cascades. 2. **Negative regulation of transcription by RNA polymerase II:** PKIA regulates transcription by inhibiting RNA polymerase II activity, ensuring proper gene expression and preventing aberrant transcription. 3. **Negative regulation of protein import into the nucleus:** PKIA regulates the import of proteins into the nucleus, preventing their aberrant localization and subsequent signaling. 4. **Regulation of the G2/M transition of the mitotic cell cycle:** PKIA ensures proper cell proliferation by regulating the G2/M transition, preventing uncontrolled cell growth. **Clinical Significance:** 1. **Neurological disorders:** Dysregulation of PKIA has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cardiac diseases:** PKIA dysfunction has been linked to cardiac diseases, including hypertension, heart failure, and arrhythmias. 3. **Cancer:** PKIA regulation of the cell cycle and transcriptional processes makes it a potential target for cancer therapy. 4. **Neurodevelopmental disorders:** PKIA dysregulation has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, PKIA plays a critical role in regulating various cellular processes by inhibiting PKA activity. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is necessary to fully understand the mechanisms of PKIA regulation and its clinical significance.

Genular Protein ID: 4035982914

Symbol: IPKA_HUMAN

Name: cAMP-dependent protein kinase inhibitor alpha

UniProtKB Accession Codes:

P61925 P04541 Q6IAV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 30 ELM 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1770951

Title: Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor.

PubMed ID: 1770951

DOI: 10.1210/mend-5-9-1246

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 76
  • Mass: 7989
  • Checksum: BDCE072810435951
  • Sequence:
    • MTDVETTYAD FIASGRTGRR NAIHDILVSS ASGNSNELAL KLAGLDINKT EGEEDAQRSS 
TEQSGEAQGE AAKSES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.