Details for: PRKAG1

Gene ID: 5571

Symbol: PRKAG1

Ensembl ID: ENSG00000181929

Description: protein kinase AMP-activated non-catalytic subunit gamma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.8115
    Cell Significance Index: -26.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.7644
    Cell Significance Index: -24.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.1350
    Cell Significance Index: -28.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.3251
    Cell Significance Index: -25.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.3188
    Cell Significance Index: -28.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.9685
    Cell Significance Index: -28.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.1431
    Cell Significance Index: -28.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.7140
    Cell Significance Index: -25.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.5345
    Cell Significance Index: -30.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9447
    Cell Significance Index: -31.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4696
    Cell Significance Index: -20.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3711
    Cell Significance Index: -22.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7486
    Cell Significance Index: -14.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7095
    Cell Significance Index: 199.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3153
    Cell Significance Index: 1187.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0598
    Cell Significance Index: 14.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7975
    Cell Significance Index: 158.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7795
    Cell Significance Index: 126.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6670
    Cell Significance Index: 133.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6197
    Cell Significance Index: 15.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6095
    Cell Significance Index: 109.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5649
    Cell Significance Index: 77.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5533
    Cell Significance Index: 16.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5528
    Cell Significance Index: 42.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5454
    Cell Significance Index: 37.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5359
    Cell Significance Index: 14.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5164
    Cell Significance Index: 33.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4941
    Cell Significance Index: 269.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4863
    Cell Significance Index: 25.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4558
    Cell Significance Index: 56.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4191
    Cell Significance Index: 19.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4151
    Cell Significance Index: 148.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4083
    Cell Significance Index: 180.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3961
    Cell Significance Index: 39.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3639
    Cell Significance Index: 9.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3550
    Cell Significance Index: 7.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3456
    Cell Significance Index: 24.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3444
    Cell Significance Index: 25.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3244
    Cell Significance Index: 6.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3153
    Cell Significance Index: 16.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3135
    Cell Significance Index: 8.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3089
    Cell Significance Index: 14.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3028
    Cell Significance Index: 38.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2958
    Cell Significance Index: 34.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2903
    Cell Significance Index: 8.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2894
    Cell Significance Index: 2.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2848
    Cell Significance Index: 36.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2628
    Cell Significance Index: 12.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1466
    Cell Significance Index: 3.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1134
    Cell Significance Index: 3.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1104
    Cell Significance Index: 6.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1019
    Cell Significance Index: 2.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1008
    Cell Significance Index: 4.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0985
    Cell Significance Index: 5.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0690
    Cell Significance Index: 1.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0682
    Cell Significance Index: 12.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0621
    Cell Significance Index: 1.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0596
    Cell Significance Index: 10.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0552
    Cell Significance Index: 2.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0271
    Cell Significance Index: 51.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0114
    Cell Significance Index: 20.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0110
    Cell Significance Index: 5.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0096
    Cell Significance Index: 7.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0069
    Cell Significance Index: 9.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0168
    Cell Significance Index: -0.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0249
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0254
    Cell Significance Index: -18.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0387
    Cell Significance Index: -5.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0391
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0454
    Cell Significance Index: -0.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0477
    Cell Significance Index: -26.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0489
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0532
    Cell Significance Index: -33.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0706
    Cell Significance Index: -4.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0877
    Cell Significance Index: -25.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0889
    Cell Significance Index: -2.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0970
    Cell Significance Index: -3.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0974
    Cell Significance Index: -1.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1030
    Cell Significance Index: -2.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1071
    Cell Significance Index: -0.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1200
    Cell Significance Index: -1.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1319
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1399
    Cell Significance Index: -16.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1530
    Cell Significance Index: -32.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2572
    Cell Significance Index: -6.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2680
    Cell Significance Index: -27.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2848
    Cell Significance Index: -22.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4194
    Cell Significance Index: -9.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4250
    Cell Significance Index: -4.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4710
    Cell Significance Index: -28.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5049
    Cell Significance Index: -10.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5085
    Cell Significance Index: -14.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5385
    Cell Significance Index: -13.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5448
    Cell Significance Index: -10.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5536
    Cell Significance Index: -15.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5579
    Cell Significance Index: -5.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5605
    Cell Significance Index: -16.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of AMPK**: PRKAG1 is the gamma-1 subunit of AMPK, a heterotrimeric enzyme complex that regulates cellular energy metabolism. 2. **Energy Sensing**: AMPK is activated in response to decreased energy levels within the cell, and PRKAG1 plays a critical role in this process. 3. **Regulation of Metabolic Pathways**: PRKAG1 modulates various metabolic pathways, including glycolysis, fatty acid biosynthesis, and autophagy. 4. **Immune Response**: PRKAG1 has been implicated in modulating immune responses, particularly in the context of inflammation and autophagy. 5. **Expression in Various Tissues**: PRKAG1 is significantly expressed in pulmonary interstitial fibroblasts, choroid plexus epithelial cells, and cardiac myocytes. **Pathways and Functions:** 1. **Activation of AMPK Downstream Pathways**: PRKAG1, along with the alpha-1 and beta-1 subunits, activates downstream pathways, including the activation of PPARGC1A (PGC-1α) and the regulation of mTOR signaling. 2. **Regulation of Glycolytic Process**: PRKAG1 modulates the glycolytic process by regulating the activity of key enzymes, including pyruvate kinase and phosphofructokinase-2. 3. **Autophagy**: PRKAG1 has been implicated in regulating autophagy, a process by which cells recycle damaged or dysfunctional cellular components. 4. **Inflammation**: PRKAG1 has been shown to modulate inflammatory responses by regulating the activity of key pro-inflammatory transcription factors, including NF-κB. 5. **Regulation of Protein Kinase Activity**: PRKAG1 regulates the activity of protein kinases, including AMPK, mTOR, and PKA. **Clinical Significance:** 1. **Metabolic Disorders**: PRKAG1 mutations have been associated with metabolic disorders, including type 2 diabetes and obesity. 2. **Inflammatory Diseases**: PRKAG1 has been implicated in the pathogenesis of inflammatory diseases, including atherosclerosis and rheumatoid arthritis. 3. **Cancer**: PRKAG1 has been shown to regulate cancer cell metabolism and survival. 4. **Autophagy Disorders**: PRKAG1 has been implicated in autophagy disorders, including autophagy-related proteinopathies. In conclusion, PRKAG1 plays a critical role in regulating cellular energy homeostasis and modulating immune responses. Further research is necessary to fully elucidate the mechanisms by which PRKAG1 regulates these processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2569029239

Symbol: AAKG1_HUMAN

Name: 5'-AMP-activated protein kinase subunit gamma-1

UniProtKB Accession Codes:

P54619 B4DDT7 Q8N7V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 35 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 6 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8621499

Title: Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.

PubMed ID: 8621499

DOI: 10.1074/jbc.271.15.8675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14722619

Title: CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.

PubMed ID: 14722619

DOI: 10.1172/jci19874

PubMed ID: 17028174

Title: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

PubMed ID: 17028174

DOI: 10.1073/pnas.0603781103

PubMed ID: 17255938

Title: Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.

PubMed ID: 17255938

DOI: 10.1038/sj.emboj.7601542

PubMed ID: 18403135

Title: Identification and characterization of a novel folliculin-interacting protein FNIP2.

PubMed ID: 18403135

DOI: 10.1016/j.gene.2008.02.022

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21680840

Title: AMPK is a direct adenylate charge-regulated protein kinase.

PubMed ID: 21680840

DOI: 10.1126/science.1200094

PubMed ID: 24563466

Title: Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

PubMed ID: 24563466

DOI: 10.1074/jbc.m113.523068

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17452784

Title: Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

PubMed ID: 17452784

DOI: 10.1107/s0907444907009110

PubMed ID: 24352254

Title: Structural basis of AMPK regulation by small molecule activators.

PubMed ID: 24352254

DOI: 10.1038/ncomms4017

PubMed ID: 25412657

Title: Structural basis of AMPK regulation by adenine nucleotides and glycogen.

PubMed ID: 25412657

DOI: 10.1038/cr.2014.150

PubMed ID: 26952388

Title: Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

PubMed ID: 26952388

DOI: 10.1038/ncomms10912

Sequence Information:

  • Length: 331
  • Mass: 37579
  • Checksum: 0F22B9CA1DBD87AE
  • Sequence:
    • METVISSDSS PAVENEHPQE TPESNNSVYT SFMKSHRCYD LIPTSSKLVV FDTSLQVKKA 
FFALVTNGVR AAPLWDSKKQ SFVGMLTITD FINILHRYYK SALVQIYELE EHKIETWREV 
YLQDSFKPLV CISPNASLFD AVSSLIRNKI HRLPVIDPES GNTLYILTHK RILKFLKLFI 
TEFPKPEFMS KSLEELQIGT YANIAMVRTT TPVYVALGIF VQHRVSALPV VDEKGRVVDI 
YSKFDVINLA AEKTYNNLDV SVTKALQHRS HYFEGVLKCY LHETLETIIN RLVEAEVHRL 
VVVDENDVVK GIVSLSDILQ ALVLTGGEKK P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.