MAP2K1 | ENSG00000169032 | NCBI 5604

Details for: MAP2K1

Gene ID: 5604

Symbol: MAP2K1

Ensembl ID: ENSG00000169032

Description: mitogen-activated protein kinase kinase 1

Associated with

Axon guidance
(R-HSA-422475)
Bacterial infection pathways
(R-HSA-9824439)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Frs2-mediated activation
(R-HSA-170968)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
L1cam interactions
(R-HSA-373760)
Map2k and mapk activation
(R-HSA-5674135)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-HSA-5684264)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk3 (erk1) activation
(R-HSA-110056)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative feedback regulation of mapk pathway
(R-HSA-5674499)
Negative regulation of mapk pathway
(R-HSA-5675221)
Nervous system development
(R-HSA-9675108)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Prolonged erk activation events
(R-HSA-169893)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by interleukins
(R-HSA-449147)
Signaling by map2k mutants
(R-HSA-9652169)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signalling to erks
(R-HSA-187687)
Signal transduction by l1
(R-HSA-445144)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Uptake and function of anthrax toxins
(R-HSA-5210891)
Atp binding
(GO:0005524)
Bergmann glial cell differentiation
(GO:0060020)
Cell motility
(GO:0048870)
Cerebellar cortex formation
(GO:0021697)
Chemotaxis
(GO:0006935)
Endodermal cell differentiation
(GO:0035987)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Face development
(GO:0060324)
Heart development
(GO:0007507)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Keratinocyte differentiation
(GO:0030216)
Map-kinase scaffold activity
(GO:0005078)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Myelination
(GO:0042552)
Negative regulation of cell population proliferation
(GO:0008285)
Neuron differentiation
(GO:0030182)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein kinase activator activity
(GO:0030295)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of axon regeneration
(GO:0048679)
Regulation of stress-activated mapk cascade
(GO:0032872)
Scaffold protein binding
(GO:0097110)
Schwann cell development
(GO:0014044)
Signal transduction
(GO:0007165)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Type b pancreatic cell proliferation
(GO:0044342)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 260.5030
Cell Significance Index: -40.5200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 165.0743
Cell Significance Index: -41.8700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 94.6894
Cell Significance Index: -44.7100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 94.5706
Cell Significance Index: -38.4200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 82.8756
Cell Significance Index: -42.6300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 40.4821
Cell Significance Index: -38.6500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.4538
Cell Significance Index: -42.4800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.4236
Cell Significance Index: -35.9600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.1827
Cell Significance Index: -40.4900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.8136
Cell Significance Index: -25.8600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.8792
Cell Significance Index: -42.9300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2053
Cell Significance Index: 442.3800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.8205
Cell Significance Index: 51.9500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.6042
Cell Significance Index: 107.8700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1711
Cell Significance Index: 232.4100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9984
Cell Significance Index: 26.6600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.9620
Cell Significance Index: 16.2100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.7470
Cell Significance Index: 33.0400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7194
Cell Significance Index: 117.0100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7125
Cell Significance Index: 77.5000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6918
Cell Significance Index: 53.0900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6449
Cell Significance Index: 24.4200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6300
Cell Significance Index: 37.8200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5593
Cell Significance Index: 386.8000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5460
Cell Significance Index: 195.8500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5175
Cell Significance Index: 7.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4835
Cell Significance Index: 13.9300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4174
Cell Significance Index: 49.2300
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.3407
Cell Significance Index: 4.2900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3338
Cell Significance Index: 8.5800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3171
Cell Significance Index: 17.8000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2789
Cell Significance Index: 251.8300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2778
Cell Significance Index: 151.7300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2376
Cell Significance Index: 45.2100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2247
Cell Significance Index: 6.4400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2058
Cell Significance Index: 25.3100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2049
Cell Significance Index: 9.6300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1953
Cell Significance Index: 35.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1896
Cell Significance Index: 5.3000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1650
Cell Significance Index: 8.6700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1560
Cell Significance Index: 10.0700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1445
Cell Significance Index: 91.8000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1085
Cell Significance Index: 1.8600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1084
Cell Significance Index: 2.9000
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.1055
Cell Significance Index: 0.7200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0937
Cell Significance Index: 41.4100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0767
Cell Significance Index: 34.8000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0765
Cell Significance Index: 144.0100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0699
Cell Significance Index: 9.6100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0628
Cell Significance Index: 96.6600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0516
Cell Significance Index: 70.1300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0491
Cell Significance Index: 3.0200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0428
Cell Significance Index: 78.8500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0199
Cell Significance Index: 3.4000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0122
Cell Significance Index: 1.5700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0149
Cell Significance Index: -9.2900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0216
Cell Significance Index: -2.7900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0252
Cell Significance Index: -18.6800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0272
Cell Significance Index: -20.6100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0298
Cell Significance Index: -2.2200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0381
Cell Significance Index: -0.2300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0402
Cell Significance Index: -29.4700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0406
Cell Significance Index: -5.9000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0436
Cell Significance Index: -4.4500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0560
Cell Significance Index: -31.6000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0757
Cell Significance Index: -7.4900
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0997
Cell Significance Index: -1.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1139
Cell Significance Index: -5.3100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1195
Cell Significance Index: -25.1800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1299
Cell Significance Index: -2.4000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1315
Cell Significance Index: -37.8400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1470
Cell Significance Index: -17.1300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1697
Cell Significance Index: -19.3700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1975
Cell Significance Index: -22.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1995
Cell Significance Index: -5.4300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2112
Cell Significance Index: -10.9700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2414
Cell Significance Index: -7.0900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2432
Cell Significance Index: -4.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2474
Cell Significance Index: -5.3600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2642
Cell Significance Index: -9.1800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2913
Cell Significance Index: -7.6600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3144
Cell Significance Index: -32.7400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3155
Cell Significance Index: -6.7200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3193
Cell Significance Index: -11.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3466
Cell Significance Index: -15.7100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3540
Cell Significance Index: -18.4400
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3598
Cell Significance Index: -8.7800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3625
Cell Significance Index: -7.5200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3808
Cell Significance Index: -24.0000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4150
Cell Significance Index: -29.3500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4400
Cell Significance Index: -9.6400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4769
Cell Significance Index: -37.7700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5020
Cell Significance Index: -7.4100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5055
Cell Significance Index: -12.9200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5209
Cell Significance Index: -11.1400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5738
Cell Significance Index: -12.0100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.6455
Cell Significance Index: -15.4800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6560
Cell Significance Index: -21.0100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6804
Cell Significance Index: -13.2800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6876
Cell Significance Index: -21.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** MAP2K1 is a serine/threonine kinase that belongs to the MAPK kinase family. It is activated by various stimuli, including growth factors, cytokines, and bacterial toxins, leading to the phosphorylation and activation of downstream MAPKs, such as ERK1/2. MAP2K1 is highly expressed in various cell types, including neurons, immune cells, and epithelial cells. The gene is also known for its involvement in developmental processes, such as axon guidance, cerebellar cortex formation, and nervous system development. **Pathways and Functions** MAP2K1 plays a central role in various signaling pathways, including: 1. **MAPK signaling cascade**: MAP2K1 activates downstream MAPKs, such as ERK1/2, which regulate cell proliferation, differentiation, and survival. 2. **Cytokine signaling**: MAP2K1 is involved in the signaling of cytokines, such as IL-1β, TNF-α, and IL-17, which regulate immune responses and inflammation. 3. **Receptor tyrosine kinase signaling**: MAP2K1 is activated by receptor tyrosine kinases, such as TRK, which regulate cell growth, differentiation, and survival. 4. **Toll-like receptor signaling**: MAP2K1 is involved in the signaling of Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns (PAMPs) and activate immune responses. MAP2K1 functions as a scaffold protein, recruiting and activating downstream kinases, such as MAPKs and PKC. It also regulates cell migration, adhesion, and proliferation through the activation of various signaling pathways. **Clinical Significance** Dysregulation of MAP2K1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of MAP2K1 has been observed in various types of cancer, including breast, lung, and colon cancer, where it promotes cell proliferation and survival. 2. **Neurological disorders**: MAP2K1 is involved in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and stroke, where it regulates axon regeneration and neuronal survival. 3. **Autoimmune diseases**: MAP2K1 is involved in the regulation of immune responses and inflammation in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Infectious diseases**: MAP2K1 is activated by bacterial toxins, such as anthrax toxins, which regulate immune responses and inflammation. In conclusion, MAP2K1 is a critical gene involved in various cellular processes, including signal transduction, cell differentiation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its regulation and function in normal and pathological conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ERK activator kinase 1
B4DFY5_HUMAN

Genular Protein ID: 4256404049

Symbol: MP2K1_HUMAN

Name: ERK activator kinase 1

UniProtKB Accession Codes:

Q02750

Database IDs:

Citations:

PubMed ID: 1281467

Title: Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

PubMed ID: 1281467

DOI: 10.1016/s0021-9258(18)35648-5

PubMed ID: 8388392

Title: Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.

PubMed ID: 8388392

DOI: 10.1016/s0021-9258(18)82142-1

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 8131746

Title: Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

PubMed ID: 8131746

DOI: 10.1002/j.1460-2075.1994.tb06361.x

PubMed ID: 9563949

Title: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.

PubMed ID: 9563949

DOI: 10.1126/science.280.5364.734

PubMed ID: 11104681

Title: Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.

PubMed ID: 11104681

DOI: 10.1042/bj3520739

PubMed ID: 14737111

Title: The MAP kinase pathway is required for entry into mitosis and cell survival.

PubMed ID: 14737111

DOI: 10.1038/sj.onc.1207188

PubMed ID: 16129686

Title: Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.

PubMed ID: 16129686

DOI: 10.1074/jbc.m502306200

PubMed ID: 16728640

Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

PubMed ID: 16728640

DOI: 10.1126/science.1126867

PubMed ID: 17101779

Title: Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma.

PubMed ID: 17101779

DOI: 10.1128/mcb.00601-06

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19447520

Title: Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

PubMed ID: 19447520

DOI: 10.1016/j.jhep.2009.02.027

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20679487

Title: VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.

PubMed ID: 20679487

DOI: 10.1128/mcb.01581-09

PubMed ID: 9779990

Title: Signaling by dual specificity kinases.

PubMed ID: 9779990

DOI: 10.1038/sj.onc.1202251

PubMed ID: 15520807

Title: The RAF proteins take centre stage.

PubMed ID: 15520807

DOI: 10.1038/nrm1498

PubMed ID: 19565474

Title: The ERK signaling cascade--views from different subcellular compartments.

PubMed ID: 19565474

DOI: 10.1002/biof.52

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21779493

Title: The ERK cascade: distinct functions within various subcellular organelles.

PubMed ID: 21779493

DOI: 10.1177/1947601911407328

PubMed ID: 20956560

Title: Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.

PubMed ID: 20956560

DOI: 10.1128/mcb.00648-10

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26195727

Title: T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi.

PubMed ID: 26195727

DOI: 10.1084/jem.20150110

PubMed ID: 29433126

Title: MEK drives BRAF activation through allosteric control of KSR proteins.

PubMed ID: 29433126

DOI: 10.1038/nature25478

PubMed ID: 32721402

Title: Enhanced MAPK1 function causes a neurodevelopmental disorder within the RASopathy clinical spectrum.

PubMed ID: 32721402

DOI: 10.1016/j.ajhg.2020.06.018

PubMed ID: 34779126

Title: Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation.

PubMed ID: 34779126

DOI: 10.15252/emmm.202114887

PubMed ID: 35670744

Title: Biallelic variants in MOS cause large polar body in oocyte and human female infertility.

PubMed ID: 35670744

DOI: 10.1093/humrep/deac120

PubMed ID: 15543157

Title: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

PubMed ID: 15543157

DOI: 10.1038/nsmb859

PubMed ID: 17880056

Title: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

PubMed ID: 17880056

DOI: 10.1021/jm0704548

PubMed ID: 18951019

Title: 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

PubMed ID: 18951019

DOI: 10.1016/j.bmcl.2008.10.015

PubMed ID: 19161339

Title: Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.

PubMed ID: 19161339

DOI: 10.1021/bi801898e

PubMed ID: 19019675

Title: Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

PubMed ID: 19019675

DOI: 10.1016/j.bmcl.2008.10.108

PubMed ID: 19706763

Title: RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.

PubMed ID: 19706763

DOI: 10.1158/0008-5472.can-09-0679

PubMed ID: 20621728

Title: Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.

PubMed ID: 20621728

DOI: 10.1016/j.bmcl.2010.05.058

PubMed ID: 21310613

Title: Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.

PubMed ID: 21310613

DOI: 10.1016/j.bmcl.2011.01.071

PubMed ID: 21316218

Title: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

PubMed ID: 21316218

DOI: 10.1016/j.bmcl.2011.01.062

PubMed ID: 16439621

Title: Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.

PubMed ID: 16439621

DOI: 10.1126/science.1124642

PubMed ID: 18042262

Title: Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.

PubMed ID: 18042262

DOI: 10.1111/j.1399-0004.2007.00931.x

PubMed ID: 29643386

Title: Somatic activating mutations in MAP2K1 cause melorheostosis.

PubMed ID: 29643386

DOI: 10.1038/s41467-018-03720-z

Sequence Information:

Length: 393
Mass: 43439
Checksum: 0344118FFC842D51
Sequence:

MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 
GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 
CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 
REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 
SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY 
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 
IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV

Genular Protein ID: 2367271117

Symbol: B4DFY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFY5

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

Length: 371
Mass: 41379
Checksum: 34BDCD7C6B3CCD6A
Sequence:

MKLERTNLEA LQKKLEELEL DEQQRKRLEA FLTQKQKVGE LKDDDFEKIS ELGAGNGGVV 
FKVSHKPSGL VMARKLIHLE IKPAIRNQII RELQVLHECN SPYIVGFYGA FYSDGEISIC 
MEHMDGGSLD QVLKKAGRIP EQILGKVSIA VIKGLTYLRE KHKIMHRDVK PSNILVNSRG 
EIKLCDFGVS GQLIDSMANS FVGTRSYMSP ERLQGTHYSV QSDIWSMGLS LVEMAVGRYP 
IPPPDAKELE LMFGCQVEGD AAETPPRPRT PGRPLSSYGM DSRPPMAIFE LLDYIVNEPP 
PKLPSGVFSL EFQDFVNKCL IKNPAERADL KQLMVHAFIK RSDAEEVDFA GWLCSTIGLN 
QPSTPTHAAG V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAP2K1

Associated with

Cells (max top 100)

Other Information

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. PubMed ID: 1281467

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. PubMed ID: 8388392

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. PubMed ID: 10409742

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. PubMed ID: 8131746

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. PubMed ID: 9563949

Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. PubMed ID: 11104681

The MAP kinase pathway is required for entry into mitosis and cell survival. PubMed ID: 14737111

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. PubMed ID: 16129686

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. PubMed ID: 16728640

Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. PubMed ID: 17101779

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. PubMed ID: 18329369

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. PubMed ID: 19447520

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. PubMed ID: 20679487

Signaling by dual specificity kinases. PubMed ID: 9779990

The RAF proteins take centre stage. PubMed ID: 15520807

The ERK signaling cascade--views from different subcellular compartments. PubMed ID: 19565474

Initial characterization of the human central proteome. PubMed ID: 21269460

The ERK cascade: distinct functions within various subcellular organelles. PubMed ID: 21779493

Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. PubMed ID: 20956560

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. PubMed ID: 26195727

MEK drives BRAF activation through allosteric control of KSR proteins. PubMed ID: 29433126

Enhanced MAPK1 function causes a neurodevelopmental disorder within the RASopathy clinical spectrum. PubMed ID: 32721402

Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation. PubMed ID: 34779126

Biallelic variants in MOS cause large polar body in oocyte and human female infertility. PubMed ID: 35670744

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. PubMed ID: 15543157

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. PubMed ID: 17880056

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). PubMed ID: 18951019

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors. PubMed ID: 19161339

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? PubMed ID: 19019675

RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. PubMed ID: 19706763

Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. PubMed ID: 20621728

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. PubMed ID: 21310613

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. PubMed ID: 21316218

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. PubMed ID: 16439621

Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. PubMed ID: 18042262

Somatic activating mutations in MAP2K1 cause melorheostosis. PubMed ID: 29643386

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The sequence of the human genome. PubMed ID: 11181995

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171