Details for: DNAJC3

Gene ID: 5611

Symbol: DNAJC3

Ensembl ID: ENSG00000102580

Description: DnaJ heat shock protein family (Hsp40) member C3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 372.9462
    Cell Significance Index: -58.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 224.6067
    Cell Significance Index: -56.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 134.4142
    Cell Significance Index: -63.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 131.0500
    Cell Significance Index: -53.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 117.2856
    Cell Significance Index: -60.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 95.0192
    Cell Significance Index: -63.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.9418
    Cell Significance Index: -53.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.1340
    Cell Significance Index: -60.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.9795
    Cell Significance Index: -58.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.5554
    Cell Significance Index: -61.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9701
    Cell Significance Index: -45.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.5338
    Cell Significance Index: -29.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1785
    Cell Significance Index: 29.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.9866
    Cell Significance Index: 69.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5861
    Cell Significance Index: 120.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9262
    Cell Significance Index: 209.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8753
    Cell Significance Index: 112.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8603
    Cell Significance Index: 49.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7428
    Cell Significance Index: 314.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3251
    Cell Significance Index: 34.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2752
    Cell Significance Index: 156.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2305
    Cell Significance Index: 168.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1837
    Cell Significance Index: 32.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1498
    Cell Significance Index: 85.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9978
    Cell Significance Index: 198.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9960
    Cell Significance Index: 199.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9113
    Cell Significance Index: 42.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8802
    Cell Significance Index: 480.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8488
    Cell Significance Index: 65.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7440
    Cell Significance Index: 38.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7375
    Cell Significance Index: 21.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6893
    Cell Significance Index: 88.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6290
    Cell Significance Index: 81.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6289
    Cell Significance Index: 225.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5477
    Cell Significance Index: 378.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5443
    Cell Significance Index: 92.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3591
    Cell Significance Index: 158.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3532
    Cell Significance Index: 5.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3146
    Cell Significance Index: 59.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2905
    Cell Significance Index: 8.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1861
    Cell Significance Index: 18.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0971
    Cell Significance Index: 182.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0557
    Cell Significance Index: 35.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0396
    Cell Significance Index: 29.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0288
    Cell Significance Index: 21.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0281
    Cell Significance Index: 12.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0095
    Cell Significance Index: 14.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0075
    Cell Significance Index: 13.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0081
    Cell Significance Index: -10.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0203
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0205
    Cell Significance Index: -12.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0483
    Cell Significance Index: -27.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0941
    Cell Significance Index: -9.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1007
    Cell Significance Index: -16.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1155
    Cell Significance Index: -24.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1298
    Cell Significance Index: -1.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1431
    Cell Significance Index: -16.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1497
    Cell Significance Index: -3.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1644
    Cell Significance Index: -11.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1722
    Cell Significance Index: -3.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1742
    Cell Significance Index: -50.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1885
    Cell Significance Index: -21.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2163
    Cell Significance Index: -31.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2414
    Cell Significance Index: -15.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2506
    Cell Significance Index: -12.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2835
    Cell Significance Index: -15.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2841
    Cell Significance Index: -4.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2965
    Cell Significance Index: -34.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3163
    Cell Significance Index: -8.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3373
    Cell Significance Index: -38.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3375
    Cell Significance Index: -17.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3759
    Cell Significance Index: -19.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4197
    Cell Significance Index: -28.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4590
    Cell Significance Index: -16.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4748
    Cell Significance Index: -21.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4788
    Cell Significance Index: -49.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5221
    Cell Significance Index: -32.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5307
    Cell Significance Index: -33.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5492
    Cell Significance Index: -14.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5516
    Cell Significance Index: -10.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5703
    Cell Significance Index: -21.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5841
    Cell Significance Index: -12.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5922
    Cell Significance Index: -8.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6645
    Cell Significance Index: -52.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6985
    Cell Significance Index: -20.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7274
    Cell Significance Index: -4.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7601
    Cell Significance Index: -19.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7729
    Cell Significance Index: -16.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8141
    Cell Significance Index: -28.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8821
    Cell Significance Index: -13.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9025
    Cell Significance Index: -18.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9052
    Cell Significance Index: -55.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9145
    Cell Significance Index: -29.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9955
    Cell Significance Index: -24.2900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0154
    Cell Significance Index: -6.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.1284
    Cell Significance Index: -16.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1410
    Cell Significance Index: -30.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1935
    Cell Significance Index: -17.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3345
    Cell Significance Index: -48.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DNAJC3 is a small, cytoplasmic protein that is structurally similar to other Hsp40 family members. It is characterized by its ability to bind to heat shock proteins (HSPs) and other chaperones, facilitating their activity and promoting protein folding. DNAJC3 is also known to interact with various signaling pathways, including the unfolded protein response (UPR) and the interferon (IFN) signaling pathway. **Pathways and Functions** DNAJC3 plays a critical role in several cellular pathways, including: 1. **Endoplasmic Reticulum Stress Response (ER Stress Response)**: DNAJC3 is involved in the regulation of protein homeostasis in the ER, which is essential for maintaining cellular function. It binds to HSPs and other chaperones, facilitating their activity and promoting protein folding. 2. **Antiviral Mechanism**: DNAJC3 has been shown to play a role in the antiviral response by interacting with IFN-stimulated genes, which are essential for the induction of antiviral proteins. 3. **Regulation of Protein Homeostasis**: DNAJC3 is involved in the regulation of protein homeostasis, which is critical for maintaining cellular function. It binds to misfolded proteins, facilitating their degradation. 4. **Innate Immunity**: DNAJC3 plays a role in the innate immune response, particularly in the regulation of cytokine signaling and the response to viral infections. **Clinical Significance** The dysregulation of DNAJC3 has been implicated in various diseases, including: 1. **Prostate Cancer**: DNAJC3 has been shown to be overexpressed in prostate cancer cells, suggesting its potential role as a biomarker for prostate cancer diagnosis. 2. **Influenza Infection**: DNAJC3 has been shown to play a role in the antiviral response to influenza infection, suggesting its potential as a therapeutic target. 3. **Neurodegenerative Diseases**: DNAJC3 has been implicated in the regulation of protein homeostasis in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, DNAJC3 is a critical component of the endoplasmic reticulum stress response and innate immunity. Its dysregulation has been implicated in various diseases, suggesting its potential as a biomarker or therapeutic target. Further research is needed to fully elucidate the role of DNAJC3 in human health and disease. **References** [Insert references cited in the discussion] Note: The references cited in the discussion are not provided as they are not specified in the original text. However, the references should be included in the actual article.

Genular Protein ID: 2044324934

Symbol: DNJC3_HUMAN

Name: DnaJ homolog subfamily C member 3

UniProtKB Accession Codes:

Q13217 Q86WT9 Q8N4N2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666242

Title: Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase.

PubMed ID: 8666242

DOI: 10.1016/0378-1119(95)00883-7

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8576172

Title: The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.

PubMed ID: 8576172

DOI: 10.1074/jbc.271.3.1702

PubMed ID: 9447982

Title: Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK.

PubMed ID: 9447982

DOI: 10.1128/mcb.18.2.859

PubMed ID: 9920933

Title: The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.

PubMed ID: 9920933

DOI: 10.1074/jbc.274.6.3797

PubMed ID: 12601012

Title: P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.

PubMed ID: 12601012

DOI: 10.1074/jbc.m212074200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25466870

Title: Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration.

PubMed ID: 25466870

DOI: 10.1016/j.ajhg.2014.10.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21799829

Title: The crystal structure of the human co-chaperone P58(IPK).

PubMed ID: 21799829

DOI: 10.1371/journal.pone.0022337

Sequence Information:

  • Length: 504
  • Mass: 57580
  • Checksum: E720A1E7F618B912
  • Sequence:
    • MVAPGSVTSR LGSVFPFLLV LVDLQYEGAE CGVNADVEKH LELGKKLLAA GQLADALSQF 
HAAVDGDPDN YIAYYRRATV FLAMGKSKAA LPDLTKVIQL KMDFTAARLQ RGHLLLKQGK 
LDEAEDDFKK VLKSNPSENE EKEAQSQLIK SDEMQRLRSQ ALNAFGSGDY TAAIAFLDKI 
LEVCVWDAEL RELRAECFIK EGEPRKAISD LKAASKLKND NTEAFYKIST LYYQLGDHEL 
SLSEVRECLK LDQDHKRCFA HYKQVKKLNK LIESAEELIR DGRYTDATSK YESVMKTEPS 
IAEYTVRSKE RICHCFSKDE KPVEAIRVCS EVLQMEPDNV NALKDRAEAY LIEEMYDEAI 
QDYETAQEHN ENDQQIREGL EKAQRLLKQS QKRDYYKILG VKRNAKKQEI IKAYRKLALQ 
WHPDNFQNEE EKKKAEKKFI DIAAAKEVLS DPEMRKKFDD GEDPLDAESQ QGGGGNPFHR 
SWNSWQGFNP FSSGGPFRFK FHFN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.