PSMB2 | ENSG00000126067 | NCBI 5690

Details for: PSMB2

Gene ID: 5690

Symbol: PSMB2

Ensembl ID: ENSG00000126067

Description: proteasome 20S subunit beta 2

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 344.0157
Cell Significance Index: -53.5100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 196.5358
Cell Significance Index: -49.8500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 164.8511
Cell Significance Index: -67.9100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 145.1106
Cell Significance Index: -68.5100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 142.3729
Cell Significance Index: -57.8400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.2587
Cell Significance Index: -65.4600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 101.9340
Cell Significance Index: -68.4000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 61.2730
Cell Significance Index: -58.5000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 52.0213
Cell Significance Index: -64.1400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.9796
Cell Significance Index: -67.0000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.7301
Cell Significance Index: -39.4600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.2348
Cell Significance Index: -40.6500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.9327
Cell Significance Index: -19.5500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 5.7546
Cell Significance Index: 670.6300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 2.9263
Cell Significance Index: 24.5800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.7395
Cell Significance Index: 73.1500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.2950
Cell Significance Index: 24.9500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.9497
Cell Significance Index: 57.2600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.9225
Cell Significance Index: 40.2400
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.6738
Cell Significance Index: 914.1000
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.6102
Cell Significance Index: 42.3400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5571
Cell Significance Index: 73.1800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.5428
Cell Significance Index: 21.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4279
Cell Significance Index: 168.4000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4184
Cell Significance Index: 194.7900
Cell Name: kidney cell (CL1000497)
Fold Change: 1.4065
Cell Significance Index: 11.2300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2184
Cell Significance Index: 42.3400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2038
Cell Significance Index: 148.0200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1925
Cell Significance Index: 32.4600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1452
Cell Significance Index: 506.3400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1371
Cell Significance Index: 204.9800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0723
Cell Significance Index: 79.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0664
Cell Significance Index: 49.7200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0625
Cell Significance Index: 68.5500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.9767
Cell Significance Index: 126.1900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9202
Cell Significance Index: 47.8000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9135
Cell Significance Index: 183.2500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7922
Cell Significance Index: 22.7100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7727
Cell Significance Index: 54.6500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7234
Cell Significance Index: 92.7400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5039
Cell Significance Index: 100.0100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4675
Cell Significance Index: 8.6400
Cell Name: peg cell (CL4033014)
Fold Change: 0.4666
Cell Significance Index: 10.7800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4292
Cell Significance Index: 22.5400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4000
Cell Significance Index: 143.4600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3944
Cell Significance Index: 4.4800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3876
Cell Significance Index: 66.1900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3563
Cell Significance Index: 321.7500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3185
Cell Significance Index: 6.9000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2242
Cell Significance Index: 42.6700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1064
Cell Significance Index: 10.5300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0947
Cell Significance Index: 71.7000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0803
Cell Significance Index: 55.5100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0720
Cell Significance Index: 4.5400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0329
Cell Significance Index: 0.5500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0234
Cell Significance Index: 1.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0168
Cell Significance Index: 31.6500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0195
Cell Significance Index: -14.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0215
Cell Significance Index: -15.7500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0228
Cell Significance Index: -0.2100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0287
Cell Significance Index: -52.8500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0366
Cell Significance Index: -56.3000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0407
Cell Significance Index: -25.4200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0410
Cell Significance Index: -55.8000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0438
Cell Significance Index: -4.4700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0581
Cell Significance Index: -36.8800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0778
Cell Significance Index: -43.8700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0880
Cell Significance Index: -39.9400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1272
Cell Significance Index: -3.2700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1343
Cell Significance Index: -4.7200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1464
Cell Significance Index: -16.7800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1468
Cell Significance Index: -30.9300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1809
Cell Significance Index: -52.0500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2396
Cell Significance Index: -6.1200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2456
Cell Significance Index: -6.5800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2639
Cell Significance Index: -3.3800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2650
Cell Significance Index: -12.0100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2994
Cell Significance Index: -9.5900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3020
Cell Significance Index: -18.5600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3207
Cell Significance Index: -18.0000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3492
Cell Significance Index: -9.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3624
Cell Significance Index: -27.8100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3727
Cell Significance Index: -54.1800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3820
Cell Significance Index: -43.6100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3851
Cell Significance Index: -10.3000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4504
Cell Significance Index: -31.1500
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.4614
Cell Significance Index: -3.9700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5067
Cell Significance Index: -34.0700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.5545
Cell Significance Index: -60.3100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6244
Cell Significance Index: -65.0200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6446
Cell Significance Index: -51.0500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6567
Cell Significance Index: -9.8400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6786
Cell Significance Index: -4.1000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9954
Cell Significance Index: -44.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0944
Cell Significance Index: -67.1000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.1374
Cell Significance Index: -20.1000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1514
Cell Significance Index: -33.9200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.1527
Cell Significance Index: -24.5500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.1813
Cell Significance Index: -29.5300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.1840
Cell Significance Index: -44.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit**: PSMB2 is a beta-2 subunit of the 20S proteasome, which is a large protein complex responsible for degrading proteins. 2. **Ubiquitin-proteasome system**: PSMB2 is part of the UPS, which plays a crucial role in protein degradation and cell cycle regulation. 3. **Antigen processing**: The 20S proteasome, including PSMB2, is involved in the processing of antigens for presentation to the immune system. 4. **Cell cycle regulation**: PSMB2 is involved in the regulation of the cell cycle, particularly in the G2/M phase. 5. **Signaling pathways**: PSMB2 is part of various signaling pathways, including adaptive immune system, antigen processing, and cell cycle regulation. **Pathways and Functions** 1. **Adaptive immune system**: PSMB2 is involved in the processing and presentation of antigens to T cells, which is crucial for the adaptive immune response. 2. **Antigen processing**: The 20S proteasome, including PSMB2, is responsible for the degradation of proteins into peptides, which are then presented to the immune system. 3. **Cell cycle regulation**: PSMB2 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it plays a role in the degradation of proteins that promote cell cycle progression. 4. **Protein degradation**: PSMB2 is involved in the degradation of proteins, which is essential for maintaining protein homeostasis and regulating various cellular processes. 5. **Signaling pathways**: PSMB2 is part of various signaling pathways, including adaptive immune system, antigen processing, and cell cycle regulation. **Clinical Significance** 1. **Immunodeficiency diseases**: Mutations in the PSMB2 gene can lead to immunodeficiency diseases, such as severe combined immunodeficiency (SCID), which is characterized by impaired T cell function. 2. **Cancer**: PSMB2 is involved in the regulation of the cell cycle, and its dysregulation can contribute to the development of cancer. 3. **Autoimmune diseases**: PSMB2 is involved in the processing and presentation of antigens, and its dysregulation can contribute to the development of autoimmune diseases, such as multiple sclerosis. 4. **Neurodegenerative diseases**: PSMB2 is involved in the regulation of protein degradation, and its dysregulation can contribute to the development of neurodegenerative diseases, such as Alzheimer's disease. In conclusion, PSMB2 is a crucial gene involved in various cellular processes, including protein degradation, antigen processing, and cell cycle regulation. Its dysregulation can contribute to the development of immunodeficiency diseases, cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of PSMB2 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3457631695

Symbol: PSB2_HUMAN

Name: Macropain subunit C7-I

UniProtKB Accession Codes:

P49721 D3DPS0 P31145 Q9BWZ9

Database IDs:

Citations:

PubMed ID: 7918633

Title: Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.

PubMed ID: 7918633

DOI: 10.1016/0167-4781(94)90060-4

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19787249

Title: Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.

PubMed ID: 19787249

DOI: 10.3892/ijo_00000410

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 26657688

Title: Disassembly of the self-assembled, double-ring structure of proteasome alpha7 homo-tetradecamer by alpha6.

PubMed ID: 26657688

DOI: 10.1038/srep18167

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 201
Mass: 22836
Checksum: 04D085D7BAA76130
Sequence:

MEYLIGIQGP DYVLVASDRV AASNIVQMKD DHDKMFKMSE KILLLCVGEA GDTVQFAEYI 
QKNVQLYKMR NGYELSPTAA ANFTRRNLAD CLRSRTPYHV NLLLAGYDEH EGPALYYMDY 
LAALAKAPFA AHGYGAFLTL SILDRYYTPT ISRERAVELL RKCLEELQKR FILNLPTFSV 
RIIDKNGIHD LDNISFPKQG S

Genular Protein ID: 1058896516

Symbol: A0A087WVV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVV1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 84
Mass: 9557
Checksum: CFF6BA35FD56AAE3
Sequence:

MDYLAALAKA PFAAHGYGAF LTLSILDRYY TPTISRERAV ELLRKCLEEL QKRFILNLPT 
FSVRIIDKNG IHDLDNISFP KQGS

Genular Protein ID: 3602077165

Symbol: B7Z478_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z478

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 176
Mass: 20207
Checksum: 9F0DE24E01DA2139
Sequence:

MEYLIDHDKM FKMSEKILLL CVGEAGDTVQ FAEYIQKNVQ LYKMRNGYEL SPTAAANFTR 
RNLADCLRSR TPYHVNLLLA GYDEHEGPAL YYMDYLAALA KAPFAAHGYG AFLTLSILDR 
YYTPTISRER AVELLRKCLE ELQKRFILNL PTFSVRIIDK NGIHDLDNIS FPKQGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMB2

Associated with

Cells (max top 100)

Other Information

Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. PubMed ID: 7918633

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

Human proteasome subunits from 2-dimensional gels identified by partial sequencing. PubMed ID: 7811265

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries. PubMed ID: 19787249

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

Disassembly of the self-assembled, double-ring structure of proteasome alpha7 homo-tetradecamer by alpha6. PubMed ID: 26657688

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The sequence of the human genome. PubMed ID: 11181995

Database document:

PubMed ID: 7918633

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 1286667

PubMed ID: 7811265

PubMed ID: 8610016

PubMed ID: 12181345

PubMed ID: 14550573

PubMed ID: 15244466

PubMed ID: 17323924

PubMed ID: 19413330

PubMed ID: 19787249

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 23495936

PubMed ID: 25944712

PubMed ID: 27176742

PubMed ID: 26133119

PubMed ID: 25599644

PubMed ID: 27428775

PubMed ID: 27342858

PubMed ID: 27493187

PubMed ID: 26657688

PubMed ID: 34711951

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 17323924

PubMed ID: 21269460

PubMed ID: 25944712

PubMed ID: 11181995