PSMB5 | ENSG00000100804 | NCBI 5693

Details for: PSMB5

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Activation of nf-kappab in b cells
(R-HSA-1169091)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Asymmetric localization of pcp proteins
(R-HSA-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Autodegradation of the e3 ubiquitin ligase cop1
(R-HSA-349425)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-HSA-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-HSA-5607761)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Er-phagosome pathway
(R-HSA-1236974)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-HSA-8854050)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m transition
(R-HSA-69275)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Negative regulation of notch4 signaling
(R-HSA-9604323)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Orc1 removal from chromatin
(R-HSA-68949)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
P53-independent dna damage response
(R-HSA-69610)
P53-independent g1/s dna damage checkpoint
(R-HSA-69613)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Pten regulation
(R-HSA-6807070)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of apoptosis
(R-HSA-169911)
Regulation of expression of slits and robos
(R-HSA-9010553)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of ras by gaps
(R-HSA-5658442)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Regulation of runx3 expression and activity
(R-HSA-8941858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Scf-beta-trcp mediated degradation of emi1
(R-HSA-174113)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Somitogenesis
(R-HSA-9824272)
S phase
(R-HSA-69242)
Stabilization of p53
(R-HSA-69541)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Ubiquitin mediated degradation of phosphorylated cdc25a
(R-HSA-69601)
Uch proteinases
(R-HSA-5689603)
Vif-mediated degradation of apobec3g
(R-HSA-180585)
Viral infection pathways
(R-HSA-9824446)
Vpu mediated degradation of cd4
(R-HSA-180534)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endopeptidase activity
(GO:0004175)
Extracellular exosome
(GO:0070062)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Proteasome complex
(GO:0000502)
Proteasome core complex
(GO:0005839)
Proteasome core complex, beta-subunit complex
(GO:0019774)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Response to oxidative stress
(GO:0006979)
Threonine-type endopeptidase activity
(GO:0004298)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

fallopian tube secretory epithelial cell CL4030006

CSI 57.73

rCSI 55.58%

PRS 14.01
ciliated epithelial cell CL0000067

CSI 55.18

rCSI 48.53%

PRS 9.8
peripheral nervous system neuron CL2000032

CSI 51.51

rCSI 70.18%

PRS 12.07
intestinal epithelial cell CL0002563

CSI 49.91

rCSI 52.16%

PRS 14.21
megakaryocyte-erythroid progenitor cell CL0000050

CSI 49.61

rCSI 44.8%

PRS 11.96
keratinocyte CL0000312

CSI 47.05

rCSI 39.44%

PRS 16.18
stem cell CL0000034

CSI 43.92

rCSI 42.35%

PRS 9.4
pancreatic D cell CL0000173

CSI 41.8

rCSI 41.11%

PRS 14.72
pancreatic A cell CL0000171

CSI 41.16

rCSI 43.12%

PRS 14.46
multi-ciliated epithelial cell CL0005012

CSI 40.07

rCSI 39.99%

PRS 11.54
extravillous trophoblast CL0008036

CSI 39.05

rCSI 48.3%

PRS 11.87
placental villous trophoblast CL2000060

CSI 38.28

rCSI 59.15%

PRS 12.66
colon epithelial cell CL0011108

CSI 36.28

rCSI 38%

PRS 12.6
enteric smooth muscle cell CL0002504

CSI 35.49

rCSI 50.65%

PRS 15.25
common myeloid progenitor CL0000049

CSI 33.87

rCSI 27.39%

PRS 13.36
mesodermal cell CL0000222

CSI 32.46

rCSI 38.96%

PRS 13.35
paneth cell CL0000510

CSI 30.06

rCSI 44.37%

PRS 21.27
neural crest cell CL0011012

CSI 29.18

rCSI 23.07%

PRS 9.29
enteroendocrine cell CL0000164

CSI 28.45

rCSI 38.87%

PRS 14.99
transit amplifying cell of colon CL0009011

CSI 26.57

rCSI 31.2%

PRS 15.89
common dendritic progenitor CL0001029

CSI 24.23

rCSI 30.41%

PRS 17.23
granulocyte monocyte progenitor cell CL0000557

CSI 23.01

rCSI 19.93%

PRS 15.06
lung ciliated cell CL1000271

CSI 21.99

rCSI 25.43%

PRS 9.89
mucous neck cell CL0000651

CSI 21.46

rCSI 30.93%

PRS 21.69
epithelial cell of lung CL0000082

CSI 20.82

rCSI 17.26%

PRS 12.74
type B pancreatic cell CL0000169

CSI 20.75

rCSI 45.94%

PRS 12.58
promyelocyte CL0000836

CSI 20.19

rCSI 29.12%

PRS 18.78
pancreatic acinar cell CL0002064

CSI 20.1

rCSI 26.71%

PRS 14.78
respiratory suprabasal cell CL4033048

CSI 19.98

rCSI 25.62%

PRS 15.62
deuterosomal cell CL4033044

CSI 19.62

rCSI 66.31%

PRS 22.56
bronchus fibroblast of lung CL2000093

CSI 19.25

rCSI 15.64%

PRS 14.27
forebrain radial glial cell CL0013000

CSI 19.16

rCSI 61.49%

PRS 19.76
muscle cell CL0000187

CSI 18.83

rCSI 38.67%

PRS 31.06
microcirculation associated smooth muscle cell CL0008035

CSI 18.66

rCSI 54.03%

PRS 15.34
myofibroblast cell CL0000186

CSI 17.3

rCSI 23.96%

PRS 19.42
hematopoietic stem cell CL0000037

CSI 16.76

rCSI 11.14%

PRS 16.12
retina horizontal cell CL0000745

CSI 16.55

rCSI 25.22%

PRS 12.65
mammary gland epithelial cell CL0002327

CSI 16.48

rCSI 57.82%

PRS 24.37
kidney epithelial cell CL0002518

CSI 16.21

rCSI 30.94%

PRS 31.4
epithelial cell CL0000066

CSI 15.51

rCSI 23.83%

PRS 19.18
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 14.42

rCSI 32.87%

PRS 14.09
type L enteroendocrine cell CL0002279

CSI 13.6

rCSI 25.52%

PRS 26.64
CD4-positive, alpha-beta thymocyte CL0000810

CSI 13.27

rCSI 10.63%

PRS 24.51
fraction A pre-pro B cell CL0002045

CSI 12.8

rCSI 14.66%

PRS 27.66
ionocyte CL0005006

CSI 12.21

rCSI 13.09%

PRS 12.45
early lymphoid progenitor CL0000936

CSI 12.1

rCSI 10.63%

PRS 15.2
retinal pigment epithelial cell CL0002586

CSI 12.1

rCSI 24.03%

PRS 14.4
pro-B cell CL0000826

CSI 11.91

rCSI 9.86%

PRS 13.51
intestine goblet cell CL0019031

CSI 11.84

rCSI 10.51%

PRS 13.53
interstitial cell of Cajal CL0002088

CSI 11.74

rCSI 14.95%

PRS 15.71
ciliated cell CL0000064

CSI 11.71

rCSI 18.97%

PRS 13.77
secretory cell CL0000151

CSI 11.46

rCSI 11.95%

PRS 13.85
goblet cell CL0000160

CSI 11.41

rCSI 10.79%

PRS 14.12
pancreatic stellate cell CL0002410

CSI 11.26

rCSI 65.54%

PRS 20.3
primitive red blood cell CL0002355

CSI 11.05

rCSI 59.65%

PRS 25.18
transit amplifying cell CL0009010

CSI 11.05

rCSI 16.9%

PRS 21.95
lung secretory cell CL1000272

CSI 11.02

rCSI 27.27%

PRS 12.49
melanocyte CL0000148

CSI 10.99

rCSI 8.14%

PRS 11.98
neuroblast (sensu Vertebrata) CL0000031

CSI 10.64

rCSI 13.66%

PRS 13.16
cerebral cortex GABAergic interneuron CL0010011

CSI 10.6

rCSI 31.28%

PRS 16.53
pancreatic PP cell CL0002275

CSI 10.31

rCSI 41.04%

PRS 23.78
syncytiotrophoblast cell CL0000525

CSI 10.3

rCSI 29.66%

PRS 26.15
Cajal-Retzius cell CL0000695

CSI 10.29

rCSI 80.66%

PRS 29.01
mucus secreting cell CL0000319

CSI 10.22

rCSI 16.22%

PRS 17.47
respiratory hillock cell CL4030023

CSI 9.91

rCSI 17.68%

PRS 22.89
fibroblast of lung CL0002553

CSI 9.67

rCSI 9%

PRS 13.54
radial glial cell CL0000681

CSI 9.5

rCSI 13.19%

PRS 13.92
acinar cell CL0000622

CSI 9.5

rCSI 13.92%

PRS 17.75
activated CD4-positive, alpha-beta T cell CL0000896

CSI 9.43

rCSI 8.72%

PRS 24.62
midzonal region hepatocyte CL0019028

CSI 9.32

rCSI 21.88%

PRS 20.25
tracheal goblet cell CL1000329

CSI 9.11

rCSI 19.9%

PRS 27.11
bronchial goblet cell CL1000312

CSI 9.08

rCSI 36.28%

PRS 29.49
pancreatic ductal cell CL0002079

CSI 8.84

rCSI 17.18%

PRS 13.81
Mueller cell CL0000636

CSI 8.74

rCSI 19.95%

PRS 11.85
intermediate monocyte CL0002393

CSI 8.73

rCSI 13.18%

PRS 13.36
endothelial cell of artery CL1000413

CSI 8.61

rCSI 12.61%

PRS 58.55
duct epithelial cell CL0000068

CSI 8.56

rCSI 12.52%

PRS 14.29
luminal epithelial cell of mammary gland CL0002326

CSI 8.49

rCSI 15.43%

PRS 20.69
unswitched memory B cell CL0000970

CSI 8.03

rCSI 6.76%

PRS 21.74
nasal mucosa goblet cell CL0002480

CSI 8.03

rCSI 9.31%

PRS 19.98
interneuron CL0000099

CSI 8.01

rCSI 16.09%

PRS 10.02
retinal ganglion cell CL0000740

CSI 7.99

rCSI 17.66%

PRS 9.75
vascular associated smooth muscle cell CL0000359

CSI 7.91

rCSI 25.66%

PRS 16.51
M cell of gut CL0000682

CSI 7.9

rCSI 8.39%

PRS 23.89
Schwann cell CL0002573

CSI 7.58

rCSI 21.55%

PRS 16.04
foveolar cell of stomach CL0002179

CSI 7.51

rCSI 15.98%

PRS 21.77
erythroid lineage cell CL0000764

CSI 7.5

rCSI 48.27%

PRS 31.42
hematopoietic precursor cell CL0008001

CSI 7.33

rCSI 7.54%

PRS 22.1
erythrocyte CL0000232

CSI 7.28

rCSI 16.51%

PRS 18.77
type EC enteroendocrine cell CL0000577

CSI 7.27

rCSI 25.82%

PRS 22.11
elicited macrophage CL0000861

CSI 7.25

rCSI 6.65%

PRS 15.5
enterocyte CL0000584

CSI 7.19

rCSI 11.59%

PRS 21.55
promonocyte CL0000559

CSI 7.06

rCSI 12.09%

PRS 18.13
pulmonary capillary endothelial cell CL4028001

CSI 7.03

rCSI 13.4%

PRS 21.58
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 6.9

rCSI 7.97%

PRS 11.87
mesenchymal cell CL0008019

CSI 6.82

rCSI 17.31%

PRS 13.72
glutamatergic neuron CL0000679

CSI 6.79

rCSI 13.95%

PRS 13.74
rod bipolar cell CL0000751

CSI 6.69

rCSI 12.02%

PRS 11.3
P/D1 enteroendocrine cell CL0002268

CSI 6.59

rCSI 35.86%

PRS 33.17
plasmablast CL0000980

CSI 6.54

rCSI 5.15%

PRS 16.07

regular ventricular cardiac myocyte CL0002131

CSI -2.7

rCSI -16.8%

PRS 10.6%
L6b glutamatergic cortical neuron CL4023038

CSI -2.4

rCSI -7.6%

PRS 8.5%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -1.9

rCSI -6.9%

PRS 7.4%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -1.9

rCSI -11.2%

PRS 8.3%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -1.7

rCSI -5.0%

PRS 19.7%
thymocyte CL0000893

CSI -0.9

rCSI -3.1%

PRS 41.8%
renal beta-intercalated cell CL0002201

CSI -0.4

rCSI -1.0%

PRS 16.0%
megakaryocyte progenitor cell CL0000553

CSI 0.2

rCSI 2.9%

PRS 38.6%
macroglial cell CL0000126

CSI 0.2

rCSI 0.5%

PRS 18.8%
parietal cell CL0000162

CSI 0.3

rCSI 2.4%

PRS 62.3%
lung microvascular endothelial cell CL2000016

CSI 0.4

rCSI 7.1%

PRS 41.5%
luminal cell of prostate epithelium CL0002340

CSI 0.5

rCSI 2.4%

PRS 24.3%
myelocyte CL0002193

CSI 0.5

rCSI 2.9%

PRS 42.4%
kidney loop of Henle epithelial cell CL1000909

CSI 0.5

rCSI 10.8%

PRS 72.6%
Merkel cell CL0000242

CSI 0.5

rCSI 12.1%

PRS 73.5%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.5

rCSI 2.1%

PRS 8.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.6

rCSI 1.0%

PRS 7.9%
enterocyte of epithelium of small intestine CL1000334

CSI 0.7

rCSI 10.3%

PRS 33.4%
common lymphoid progenitor CL0000051

CSI 0.7

rCSI 0.9%

PRS 25.8%
sncg GABAergic cortical interneuron CL4023015

CSI 0.7

rCSI 1.1%

PRS 8.7%
T follicular helper cell CL0002038

CSI 0.8

rCSI 0.6%

PRS 21.9%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.9

rCSI 2.4%

PRS 17.4%
peptic cell CL0000155

CSI 0.9

rCSI 8.9%

PRS 39.1%
uterine smooth muscle cell CL0002601

CSI 0.9

rCSI 6.1%

PRS 65.9%
vasa recta descending limb cell CL1001285

CSI 1.0

rCSI 8.0%

PRS 52.0%
OFF-bipolar cell CL0000750

CSI 1.0

rCSI 1.4%

PRS 22.0%
blood vessel smooth muscle cell CL0019018

CSI 1.0

rCSI 8.3%

PRS 13.9%
periportal region hepatocyte CL0019026

CSI 1.1

rCSI 4.1%

PRS 18.8%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 1.1

rCSI 4.8%

PRS 46.1%
mature alpha-beta T cell CL0000791

CSI 1.1

rCSI 4.0%

PRS 23.2%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 1.1

rCSI 1.7%

PRS 32.4%
intestinal tuft cell CL0019032

CSI 1.1

rCSI 1.7%

PRS 15.5%
Hofbauer cell CL3000001

CSI 1.1

rCSI 2.1%

PRS 16.8%
CD4-positive helper T cell CL0000492

CSI 1.2

rCSI 0.9%

PRS 18.7%
acinar cell of salivary gland CL0002623

CSI 1.2

rCSI 27.8%

PRS 24.4%
germinal center B cell CL0000844

CSI 1.2

rCSI 3.6%

PRS 33.1%
ventricular cardiac muscle cell CL2000046

CSI 1.3

rCSI 4.4%

PRS 50.7%
small intestine goblet cell CL1000495

CSI 1.3

rCSI 2.9%

PRS 18.0%
epithelial cell of urethra CL1000296

CSI 1.3

rCSI 33.7%

PRS 42.1%
IgG plasma cell CL0000985

CSI 1.3

rCSI 1.6%

PRS 23.2%
paneth cell of colon CL0009009

CSI 1.4

rCSI 13.2%

PRS 37.8%
myoepithelial cell CL0000185

CSI 1.4

rCSI 3.5%

PRS 16.8%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.4

rCSI 3.5%

PRS 7.8%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.5

rCSI 2.2%

PRS 12.6%
T-helper 17 cell CL0000899

CSI 1.6

rCSI 1.3%

PRS 23.9%
hair follicular keratinocyte CL2000092

CSI 1.6

rCSI 28.5%

PRS 51.4%
basal cell of epithelium of trachea CL1000348

CSI 1.7

rCSI 11.8%

PRS 40.7%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.7

rCSI 3.5%

PRS 22.5%
neuroplacodal cell CL0000032

CSI 1.9

rCSI 17.4%

PRS 38.3%
bronchiolar smooth muscle cell CL4033017

CSI 1.9

rCSI 28.8%

PRS 41.5%
mesenchymal lymphangioblast CL0005021

CSI 2.0

rCSI 52.0%

PRS 57.2%
stromal cell of ovary CL0002132

CSI 2.0

rCSI 5.6%

PRS 22.3%
tracheobronchial smooth muscle cell CL0019019

CSI 2.0

rCSI 3.6%

PRS 17.9%
retinal blood vessel endothelial cell CL0002585

CSI 2.1

rCSI 3.3%

PRS 14.8%
tracheobronchial serous cell CL0019001

CSI 2.1

rCSI 9.0%

PRS 25.7%
vasa recta ascending limb cell CL1001131

CSI 2.1

rCSI 9.5%

PRS 46.9%
retinal cone cell CL0000573

CSI 2.1

rCSI 3.4%

PRS 10.4%
lung endothelial cell CL1001567

CSI 2.2

rCSI 5.1%

PRS 32.0%
hepatocyte CL0000182

CSI 2.2

rCSI 4.0%

PRS 12.6%
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.2

rCSI 8.7%

PRS 22.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 2.3

rCSI 7.2%

PRS 9.1%
prostate gland microvascular endothelial cell CL2000059

CSI 2.4

rCSI 57.5%

PRS 44.7%
hematopoietic multipotent progenitor cell CL0000837

CSI 2.4

rCSI 5.8%

PRS 21.4%
centrilobular region hepatocyte CL0019029

CSI 2.5

rCSI 6.4%

PRS 21.3%
mesenchymal stem cell of adipose tissue CL0002570

CSI 2.5

rCSI 13.8%

PRS 37.7%
colonocyte CL1000347

CSI 2.6

rCSI 3.7%

PRS 18.6%
keratocyte CL0002363

CSI 2.6

rCSI 6.2%

PRS 20.2%
astrocyte of the cerebral cortex CL0002605

CSI 2.6

rCSI 5.8%

PRS 8.3%
paneth cell of epithelium of small intestine CL1000343

CSI 2.6

rCSI 7.3%

PRS 20.9%
neural progenitor cell CL0011020

CSI 2.6

rCSI 11.5%

PRS 13.1%
retinal bipolar neuron CL0000748

CSI 2.6

rCSI 4.9%

PRS 9.8%
osteoblast CL0000062

CSI 2.6

rCSI 65.2%

PRS 75.8%
eosinophil CL0000771

CSI 2.7

rCSI 17.7%

PRS 34.7%
amacrine cell CL0000561

CSI 2.7

rCSI 7.9%

PRS 10.5%
pluripotent stem cell CL0002248

CSI 2.7

rCSI 81.8%

PRS 30.9%
pulmonary alveolar type 1 cell CL0002062

CSI 2.7

rCSI 15.8%

PRS 17.8%
podocyte CL0000653

CSI 2.8

rCSI 12.2%

PRS 13.3%
basal cell of prostate epithelium CL0002341

CSI 2.8

rCSI 8.1%

PRS 30.0%
stromal cell CL0000499

CSI 2.8

rCSI 8.0%

PRS 19.2%
alveolar macrophage CL0000583

CSI 2.9

rCSI 4.8%

PRS 15.8%
enteroendocrine cell of small intestine CL0009006

CSI 3.0

rCSI 6.5%

PRS 20.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.0

rCSI 7.8%

PRS 12.6%
glial cell CL0000125

CSI 3.0

rCSI 11.5%

PRS 13.6%
myeloid lineage restricted progenitor cell CL0000839

CSI 3.0

rCSI 15.7%

PRS 26.5%
primordial germ cell CL0000670

CSI 3.0

rCSI 15.2%

PRS 65.2%
intrahepatic cholangiocyte CL0002538

CSI 3.1

rCSI 7.4%

PRS 24.4%
regular atrial cardiac myocyte CL0002129

CSI 3.1

rCSI 10.0%

PRS 14.4%
glioblast CL0000030

CSI 3.1

rCSI 5.0%

PRS 11.6%
double negative thymocyte CL0002489

CSI 3.2

rCSI 2.2%

PRS 15.9%
alveolar type 1 fibroblast cell CL4028004

CSI 3.2

rCSI 3.5%

PRS 15.5%
retinal rod cell CL0000604

CSI 3.2

rCSI 5.6%

PRS 13.4%
conjunctival epithelial cell CL1000432

CSI 3.2

rCSI 4.9%

PRS 13.5%
lung macrophage CL1001603

CSI 3.2

rCSI 7.2%

PRS 15.4%
megakaryocyte CL0000556

CSI 3.2

rCSI 14.0%

PRS 24.2%
cell of skeletal muscle CL0000188

CSI 3.3

rCSI 35.4%

PRS 62.5%
Bergmann glial cell CL0000644

CSI 3.3

rCSI 4.5%

PRS 13.7%
endocrine cell CL0000163

CSI 3.4

rCSI 17.3%

PRS 52.1%
lung pericyte CL0009089

CSI 3.4

rCSI 8.9%

PRS 16.2%
basophil mast progenitor cell CL0002028

CSI 3.4

rCSI 18.1%

PRS 48.1%
cerebral cortex endothelial cell CL1001602

CSI 3.4

rCSI 6.0%

PRS 10.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PSMB5](/details-gene/5693) (Proteasome 20S Subunit Beta 5) is a protein-coding gene located on chromosome 14q11.2 that encodes a core catalytic subunit of the 20S proteasome complex. As an integral component of the ubiquitin-proteasome system, [PSMB5](/details-gene/5693) possesses threonine-type endopeptidase activity essential for the degradation of a wide variety of intracellular proteins. This function is critical for maintaining cellular homeostasis, regulating the cell cycle, and processing antigens for immune surveillance. Expression data indicates that [PSMB5](/details-gene/5693) is highly significant in metabolically active and proliferative cell populations, particularly diverse epithelial lineages and progenitor cells, suggesting a foundational role in cellular protein quality control and turnover. The gene is associated with OMIM entry [600306](https://omim.org/entry/600306). ## Cellular Roles and Expression Landscape The expression profile of [PSMB5](/details-gene/5693) highlights its role as a fundamental housekeeping gene, with particularly high significance in cells requiring high rates of protein turnover for specialized functions or proliferation. **Overall**, the gene shows the highest significance in various epithelial and progenitor cell types. Top cell types include [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 57.73), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 55.18), [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 49.91), and [keratinocyte](/details-cell/CL0000312) (CSI: 47.05). Its prominence in hematopoietic progenitors, such as [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 49.61) and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 33.87), is consistent with a crucial role in cell division and differentiation. This pattern suggests that [PSMB5](/details-gene/5693) is indispensable for the maintenance of tissues with high cellular turnover and complex protein synthesis demands. Conversely, [PSMB5](/details-gene/5693) shows low to negative significance in terminally differentiated, long-lived cell types. These include [regular ventricular cardiac myocyte](/details-cell/CL0002131) (CSI: -2.69) and several subtypes of glutamatergic neurons, such as [L6b glutamatergic cortical neuron](/details-cell/CL4023038) (CSI: -2.43). This reduced significance in relatively static cellular populations reinforces the idea that its primary role is tied to dynamic cellular processes like proliferation, differentiation, and high-volume protein secretion, rather than baseline maintenance in quiescent cells. ## Pathways and Molecular Function [PSMB5](/details-gene/5693) is a core component of the [proteasome complex](/details-go/GO:0000502) and its function is central to protein degradation. Gene Ontology annotations confirm its involvement in [Proteasome-mediated ubiquitin-dependent protein catabolic process](/details-go/GO:0043161) and its intrinsic [Threonine-type endopeptidase activity](/details-go/GO:0004298). The gene's involvement is reflected across a vast landscape of Reactome pathways, underscoring the proteasome's role as a master regulator of cellular processes. Key functional themes include: * **Immune System Regulation:** [PSMB5](/details-gene/5693) is essential for the [Adaptive immune system](/details-reactome/R-HSA-1280218), particularly in [Class I MHC mediated antigen processing & presentation](/details-reactome/R-HSA-983169). By degrading intracellular proteins into peptides, it generates the antigenic fragments that are presented on the cell surface to cytotoxic T lymphocytes, a cornerstone of anti-viral and anti-tumor immunity. Studies have detailed the replacement of constitutive subunits like [PSMB5](/details-gene/5693) with inducible subunits (e.g., LMP7) upon interferon-gamma stimulation to alter peptidase activity for more efficient antigen processing ([Link](https://pubmed.ncbi.nlm.nih.gov/8163024/)). * **Cell Cycle Control:** The gene plays a pivotal role in the [Cell cycle](/details-reactome/R-HSA-1640170) by mediating the timely degradation of key regulatory proteins. This includes pathways such as [Apc/c-mediated degradation of cell cycle proteins](/details-reactome/R-HSA-174143) and [Scf(skp2)-mediated degradation of p27/p21](/details-reactome/R-HSA-187577), which are critical for controlling transitions between cell cycle phases (e.g., [G1/S transition](/details-reactome/R-HSA-69206)). * **Signal Transduction:** [PSMB5](/details-gene/5693) is a downstream effector that regulates numerous major signaling cascades by controlling the stability of key transcription factors and pathway components. This is evident in its connection to pathways like [Signaling by wnt](/details-reactome/R-HSA-195721) (via degradation of beta-catenin), [Signaling by hedgehog](/details-reactome/R-HSA-5358351) (via processing of Gli proteins), and NF-kappaB signaling pathways such as [Activation of nf-kappab in b cells](/details-reactome/R-HSA-1169091). ## Research Directions The ubiquitous and critical nature of [PSMB5](/details-gene/5693) makes it a central node in cellular physiology and pathology. Future research could explore its specific roles in different cellular contexts and its potential as a therapeutic target. ### Proposed Hypotheses: 1. **Tissue-Specific Proteostasis and Disease:** The high significance of [PSMB5](/details-gene/5693) in specialized secretory cells, like [fallopian tube secretory epithelial cell](/details-cell/CL4030006), suggests that these cells may have a heightened dependency on proteasome capacity to manage the protein folding load of their secretome. It is hypothesized that subtle reductions in [PSMB5](/details-gene/5693) expression or function could lead to proteotoxic stress and contribute to tissue-specific diseases, such as chronic obstructive pulmonary disease (in ciliated cells) or infertility (in fallopian tube cells), independent of systemic proteasome dysfunction. 2. **Oncogenic Dependency in Proliferative Cancers:** Given its essential role in cell cycle progression and high expression in progenitor populations, it is hypothesized that rapidly proliferating cancer cells, particularly carcinomas derived from the highly expressing epithelial tissues, exhibit a state of "proteasome addiction." This dependency makes them exquisitely sensitive to inhibition of [PSMB5](/details-gene/5693), presenting a therapeutic window compared to their quiescent, non-malignant counterparts. ### Experimental Approach: To test the hypothesis of oncogenic dependency (Hypothesis 2), a targeted genetic screening approach could be employed. * **Experiment:** Utilize CRISPR-Cas9 to systematically knock out [PSMB5](/details-gene/5693) in a panel of cancer cell lines derived from high-expressing tissues (e.g., colon carcinoma, ovarian carcinoma) and compare the effects to those in corresponding primary epithelial cells or terminally differentiated cell lines (e.g., primary neurons). The primary readouts would be cell viability (e.g., using a CellTiter-Glo assay) and apoptosis rates (e.g., via Annexin V staining and flow cytometry). A significantly greater reduction in viability and induction of apoptosis in the cancer cell lines following [PSMB5](/details-gene/5693) knockout would provide strong evidence for synthetic lethality and oncogenic dependency. ### Therapeutic Potential: [PSMB5](/details-gene/5693), as a core catalytic subunit of the proteasome, is a well-established and clinically validated therapeutic target. The primary therapeutic strategy is **inhibition**. Proteasome inhibitors (e.g., Bortezomib, Carfilzomib) are already standard-of-care for hematological malignancies like multiple myeloma. The broad expression of [PSMB5](/details-gene/5693) in healthy proliferative tissues, however, contributes to significant on-target toxicities, such as peripheral neuropathy and myelosuppression. Future opportunities lie in developing more specific inhibitors that can distinguish between the constitutive proteasome and the immunoproteasome or designing delivery systems (e.g., antibody-drug conjugates) to selectively target cancer cells, thereby widening the therapeutic window.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Macropain epsilon chain
A0A140VJS7_HUMAN

Genular Protein ID: 3409025733

Symbol: PSB5_HUMAN

Name: Macropain epsilon chain

UniProtKB Accession Codes:

P28074 B2R4N9 B4DUM9 D3DS43 E9PAV2 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9

Database IDs:

Citations:

PubMed ID: 8753855

Title: Divergent intron arrangement in the MB1/LMP7 proteasome gene pair.

PubMed ID: 8753855

DOI: 10.1007/bf02602554

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8066462

Title: cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y.

PubMed ID: 8066462

DOI: 10.1126/science.8066462

PubMed ID: 7820546

Title: Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins.

PubMed ID: 7820546

DOI: 10.1016/s0960-9822(00)00174-3

PubMed ID: 2306472

Title: Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).

PubMed ID: 2306472

DOI: 10.1016/0167-4838(90)90165-c

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8163024

Title: Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing.

PubMed ID: 8163024

DOI: 10.1016/0014-5793(94)80612-8

PubMed ID: 7864893

Title:

PubMed ID: 7864893

DOI: 10.1006/bbrc.1995.1294

PubMed ID: 8663318

Title: Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7.

PubMed ID: 8663318

DOI: 10.1074/jbc.271.29.17275

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 15488952

Title: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

PubMed ID: 15488952

DOI: 10.1016/j.molimm.2004.07.005

PubMed ID: 15944226

Title: IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.

PubMed ID: 15944226

DOI: 10.1073/pnas.0501711102

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17004105

Title: Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics.

PubMed ID: 17004105

DOI: 10.1007/s10549-006-9393-7

PubMed ID: 18565852

Title: Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.

PubMed ID: 18565852

DOI: 10.1182/blood-2007-08-104950

PubMed ID: 18502982

Title: Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line.

PubMed ID: 18502982

DOI: 10.1124/jpet.108.138131

PubMed ID: 19426847

Title: Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line.

PubMed ID: 19426847

DOI: 10.1016/j.exphem.2009.04.001

PubMed ID: 18602823

Title: Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.

PubMed ID: 18602823

DOI: 10.1016/j.jnutbio.2008.02.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 263
Mass: 28480
Checksum: AED4A73DF41AA6EF
Sequence:

MALASVLERP LPVNQRGFFG LGGRADLLDL GPGSLSDGLS LAAPGWGVPE EPGIEMLHGT 
TTLAFKFRHG VIVAADSRAT AGAYIASQTV KKVIEINPYL LGTMAGGAAD CSFWERLLAR 
QCRIYELRNK ERISVAAASK LLANMVYQYK GMGLSMGTMI CGWDKRGPGL YYVDSEGNRI 
SGATFSVGSG SVYAYGVMDR GYSYDLEVEQ AYDLARRAIY QATYRDAYSG GAVNLYHVRE 
DGWIRVSSDN VADLHEKYSG STP

Genular Protein ID: 2893850597

Symbol: A0A140VJS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJS7

Database IDs:

Sequence Information:

Length: 160
Mass: 17782
Checksum: 47A97A3A9A849846
Sequence:

MAGGAADCSF WERLLARQCR IYELRNKERI SVAAASKLLA NMVYQYKGMG LSMGTMICGW 
DKRGPGLYYV DSEGNRISGA TFSVGSGSVY AYGVMDRGYS YDLEVEQAYD LARRAIYQAT 
YRDAYSGGAV NLYHVREDGW IRVSSDNVAD LHEKYSGSTP

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Ascending colon UBERON0001156
	Basal cell carcinoma MONDO0020804
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: PSMB5

Cell Significance Landscape

Associated with

Significant Cells

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Other Information

Divergent intron arrangement in the MB1/LMP7 proteasome gene pair. PubMed ID: 8753855

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. PubMed ID: 8066462

Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. PubMed ID: 7820546

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). PubMed ID: 2306472

Human proteasome subunits from 2-dimensional gels identified by partial sequencing. PubMed ID: 7811265

Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing. PubMed ID: 8163024

PubMed ID: 7864893

Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7. PubMed ID: 8663318

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. PubMed ID: 15488952

IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. PubMed ID: 15944226

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. PubMed ID: 17004105

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. PubMed ID: 18565852

Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. PubMed ID: 18502982

Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. PubMed ID: 19426847

Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane. PubMed ID: 18602823

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951