PSMB5 | ENSG00000100804 | NCBI 5693

Details for: PSMB5

Gene ID: 5693

Symbol: PSMB5

Ensembl ID: ENSG00000100804

Description: proteasome 20S subunit beta 5

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 341.6370
Cell Significance Index: -53.1400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 201.3063
Cell Significance Index: -51.0600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 167.3271
Cell Significance Index: -68.9300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 145.5766
Cell Significance Index: -68.7300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 137.8684
Cell Significance Index: -56.0100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 125.1980
Cell Significance Index: -64.4000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 102.5898
Cell Significance Index: -68.8400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.2411
Cell Significance Index: -56.5600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 51.1292
Cell Significance Index: -63.0400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.0608
Cell Significance Index: -53.7400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.7079
Cell Significance Index: -65.9300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.3027
Cell Significance Index: -43.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.8452
Cell Significance Index: -17.1700
Cell Name: kidney cell (CL1000497)
Fold Change: 6.1847
Cell Significance Index: 49.3800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 4.8678
Cell Significance Index: 52.9200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.8596
Cell Significance Index: 101.7200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.8375
Cell Significance Index: 168.1000
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.4680
Cell Significance Index: 91.1900
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.5727
Cell Significance Index: 1405.0400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.4641
Cell Significance Index: 114.8900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.3316
Cell Significance Index: 29.8600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1437
Cell Significance Index: 159.7700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.0084
Cell Significance Index: 18.5000
Cell Name: lactocyte (CL0002325)
Fold Change: 1.8131
Cell Significance Index: 234.2500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.6755
Cell Significance Index: 22.8600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6705
Cell Significance Index: 205.4000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.6100
Cell Significance Index: 18.2900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.5969
Cell Significance Index: 219.3100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5711
Cell Significance Index: 73.8400
Cell Name: peg cell (CL4033014)
Fold Change: 1.5535
Cell Significance Index: 35.8900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.5301
Cell Significance Index: 275.8200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5107
Cell Significance Index: 245.7100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4380
Cell Significance Index: 635.7800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4077
Cell Significance Index: 99.5600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3702
Cell Significance Index: 37.3000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.3490
Cell Significance Index: 70.0800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.2736
Cell Significance Index: 66.8700
Cell Name: odontoblast (CL0000060)
Fold Change: 1.1680
Cell Significance Index: 149.7300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.1240
Cell Significance Index: 32.2200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9857
Cell Significance Index: 195.6100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7983
Cell Significance Index: 41.5800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7655
Cell Significance Index: 20.4400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6970
Cell Significance Index: 139.8100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6014
Cell Significance Index: 13.0300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4861
Cell Significance Index: 8.5900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4686
Cell Significance Index: 80.0100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.4570
Cell Significance Index: 285.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4506
Cell Significance Index: 44.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3903
Cell Significance Index: 25.1800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3419
Cell Significance Index: 65.0700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2463
Cell Significance Index: 88.3600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2402
Cell Significance Index: 15.1400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2041
Cell Significance Index: 5.4600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1333
Cell Significance Index: 100.9000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1288
Cell Significance Index: 3.4500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1108
Cell Significance Index: 3.2600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1064
Cell Significance Index: 12.5500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0908
Cell Significance Index: 4.1200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0835
Cell Significance Index: 5.7700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0792
Cell Significance Index: 1.3300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0428
Cell Significance Index: 31.3700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0001
Cell Significance Index: 0.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0179
Cell Significance Index: -13.2900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0330
Cell Significance Index: -60.9500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0376
Cell Significance Index: -57.8500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0456
Cell Significance Index: -61.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0521
Cell Significance Index: -5.3200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0613
Cell Significance Index: -38.9600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0750
Cell Significance Index: -42.3000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0751
Cell Significance Index: -2.1000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0998
Cell Significance Index: -45.3000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1194
Cell Significance Index: -25.1400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1809
Cell Significance Index: -52.0500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1986
Cell Significance Index: -4.2300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2342
Cell Significance Index: -8.2300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2342
Cell Significance Index: -26.8300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2443
Cell Significance Index: -5.9600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2533
Cell Significance Index: -3.0200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2715
Cell Significance Index: -31.6500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3027
Cell Significance Index: -9.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3490
Cell Significance Index: -50.7400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3586
Cell Significance Index: -9.1600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.3697
Cell Significance Index: -2.2800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3842
Cell Significance Index: -43.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4179
Cell Significance Index: -23.4500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4409
Cell Significance Index: -33.8400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4652
Cell Significance Index: -36.8400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4865
Cell Significance Index: -7.2900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5198
Cell Significance Index: -34.9500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5917
Cell Significance Index: -10.1400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5958
Cell Significance Index: -3.6000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6111
Cell Significance Index: -18.0000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6156
Cell Significance Index: -64.1000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.0423
Cell Significance Index: -10.7900
Cell Name: type II muscle cell (CL0002212)
Fold Change: -1.0864
Cell Significance Index: -17.5300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0909
Cell Significance Index: -66.8800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.0994
Cell Significance Index: -9.2400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.1288
Cell Significance Index: -49.9300
Cell Name: perivascular cell (CL4033054)
Fold Change: -1.1825
Cell Significance Index: -5.4600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1831
Cell Significance Index: -30.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The PSMB5 gene exhibits several key characteristics that distinguish it from other genes. These include: 1. **High expression in various cell types**: PSMB5 is highly expressed in erythroid progenitor cells, mesodermal cells, epithelial cells of the nephron, and neural crest cells, suggesting its importance in these cell types. 2. **Conservation across species**: The PSMB5 gene is conserved across species, including humans, mice, and rats, indicating its essential role in cellular processes. 3. **Association with disease**: Abnormalities in the PSMB5 gene have been associated with several diseases, including cancer and inflammatory disorders. 4. **Regulation of protein degradation**: The PSMB5 gene plays a critical role in regulating protein degradation through the 20S proteasome. **Pathways and Functions** The PSMB5 gene is involved in various cellular pathways and functions, including: 1. **Antigen processing and presentation**: The 20S proteasome, encoded by the PSMB5 gene, is essential for the degradation of ubiquitinated proteins and the presentation of antigens to the immune system. 2. **Cell cycle regulation**: The PSMB5 gene regulates cell cycle progression by degrading proteins involved in cell cycle arrest and apoptosis. 3. **Apoptosis**: The PSMB5 gene plays a role in regulating apoptosis by degrading proteins involved in the apoptotic pathway. 4. **Innate immune response**: The PSMB5 gene is involved in the regulation of the innate immune response by degrading proteins involved in the recognition of pathogens. 5. **Metabolism**: The PSMB5 gene regulates protein degradation, which is essential for various metabolic processes, including amino acid metabolism and protein synthesis. **Clinical Significance** Abnormalities in the PSMB5 gene have been associated with several diseases, including: 1. **Cancer**: Mutations in the PSMB5 gene have been identified in various types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: The PSMB5 gene is involved in the regulation of the innate immune response, and abnormalities in this gene have been associated with inflammatory disorders, including rheumatoid arthritis and lupus. 3. **Neurological disorders**: The PSMB5 gene is involved in the regulation of protein degradation and has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immunodeficiency disorders**: Mutations in the PSMB5 gene have been identified in individuals with immunodeficiency disorders, including severe combined immunodeficiency (SCID). In conclusion, the PSMB5 gene plays a critical role in various cellular processes, including protein degradation, antigen presentation, and cell cycle regulation. Abnormalities in this gene have been associated with several diseases, including cancer, inflammatory disorders, and neurological disorders. Further research is needed to fully understand the functional significance of the PSMB5 gene and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Macropain epsilon chain
A0A140VJS7_HUMAN

Genular Protein ID: 3409025733

Symbol: PSB5_HUMAN

Name: Macropain epsilon chain

UniProtKB Accession Codes:

P28074 B2R4N9 B4DUM9 D3DS43 E9PAV2 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9

Database IDs:

Citations:

PubMed ID: 8753855

Title: Divergent intron arrangement in the MB1/LMP7 proteasome gene pair.

PubMed ID: 8753855

DOI: 10.1007/bf02602554

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8066462

Title: cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y.

PubMed ID: 8066462

DOI: 10.1126/science.8066462

PubMed ID: 7820546

Title: Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins.

PubMed ID: 7820546

DOI: 10.1016/s0960-9822(00)00174-3

PubMed ID: 2306472

Title: Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).

PubMed ID: 2306472

DOI: 10.1016/0167-4838(90)90165-c

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8163024

Title: Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing.

PubMed ID: 8163024

DOI: 10.1016/0014-5793(94)80612-8

PubMed ID: 7864893

Title:

PubMed ID: 7864893

DOI: 10.1006/bbrc.1995.1294

PubMed ID: 8663318

Title: Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7.

PubMed ID: 8663318

DOI: 10.1074/jbc.271.29.17275

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 15488952

Title: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

PubMed ID: 15488952

DOI: 10.1016/j.molimm.2004.07.005

PubMed ID: 15944226

Title: IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.

PubMed ID: 15944226

DOI: 10.1073/pnas.0501711102

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17004105

Title: Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics.

PubMed ID: 17004105

DOI: 10.1007/s10549-006-9393-7

PubMed ID: 18565852

Title: Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.

PubMed ID: 18565852

DOI: 10.1182/blood-2007-08-104950

PubMed ID: 18502982

Title: Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line.

PubMed ID: 18502982

DOI: 10.1124/jpet.108.138131

PubMed ID: 19426847

Title: Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line.

PubMed ID: 19426847

DOI: 10.1016/j.exphem.2009.04.001

PubMed ID: 18602823

Title: Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.

PubMed ID: 18602823

DOI: 10.1016/j.jnutbio.2008.02.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 263
Mass: 28480
Checksum: AED4A73DF41AA6EF
Sequence:

MALASVLERP LPVNQRGFFG LGGRADLLDL GPGSLSDGLS LAAPGWGVPE EPGIEMLHGT 
TTLAFKFRHG VIVAADSRAT AGAYIASQTV KKVIEINPYL LGTMAGGAAD CSFWERLLAR 
QCRIYELRNK ERISVAAASK LLANMVYQYK GMGLSMGTMI CGWDKRGPGL YYVDSEGNRI 
SGATFSVGSG SVYAYGVMDR GYSYDLEVEQ AYDLARRAIY QATYRDAYSG GAVNLYHVRE 
DGWIRVSSDN VADLHEKYSG STP

Genular Protein ID: 2893850597

Symbol: A0A140VJS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJS7

Database IDs:

Sequence Information:

Length: 160
Mass: 17782
Checksum: 47A97A3A9A849846
Sequence:

MAGGAADCSF WERLLARQCR IYELRNKERI SVAAASKLLA NMVYQYKGMG LSMGTMICGW 
DKRGPGLYYV DSEGNRISGA TFSVGSGSVY AYGVMDRGYS YDLEVEQAYD LARRAIYQAT 
YRDAYSGGAV NLYHVREDGW IRVSSDNVAD LHEKYSGSTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMB5

Associated with

Cells (max top 100)

Other Information

Divergent intron arrangement in the MB1/LMP7 proteasome gene pair. PubMed ID: 8753855

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. PubMed ID: 8066462

Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. PubMed ID: 7820546

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). PubMed ID: 2306472

Human proteasome subunits from 2-dimensional gels identified by partial sequencing. PubMed ID: 7811265

Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing. PubMed ID: 8163024

PubMed ID: 7864893

Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7. PubMed ID: 8663318

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. PubMed ID: 15488952

IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. PubMed ID: 15944226

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. PubMed ID: 17004105

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. PubMed ID: 18565852

Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. PubMed ID: 18502982

Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. PubMed ID: 19426847

Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane. PubMed ID: 18602823

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951