PSMB7 | ENSG00000136930 | NCBI 5695

Details for: PSMB7

Gene ID: 5695

Symbol: PSMB7

Ensembl ID: ENSG00000136930

Description: proteasome 20S subunit beta 7

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 377.2536
Cell Significance Index: -58.6800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 207.9297
Cell Significance Index: -52.7400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 178.8577
Cell Significance Index: -73.6800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 166.3974
Cell Significance Index: -78.5600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 144.5415
Cell Significance Index: -74.3500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 117.4924
Cell Significance Index: -78.8400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 58.2016
Cell Significance Index: -71.7600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.5892
Cell Significance Index: -77.3000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.3329
Cell Significance Index: -51.7900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.1450
Cell Significance Index: -52.6600
Cell Name: kidney cell (CL1000497)
Fold Change: 4.6855
Cell Significance Index: 37.4100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.1153
Cell Significance Index: 65.2100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.9126
Cell Significance Index: 101.2100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.6906
Cell Significance Index: 29.2500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.4011
Cell Significance Index: 144.1500
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.3381
Cell Significance Index: 61.4800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 2.1739
Cell Significance Index: 58.1500
Cell Name: lactocyte (CL0002325)
Fold Change: 1.9523
Cell Significance Index: 252.2200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.9096
Cell Significance Index: 50.9900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.9041
Cell Significance Index: 88.7800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.8582
Cell Significance Index: 87.3400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5836
Cell Significance Index: 700.1300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5657
Cell Significance Index: 116.6900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4439
Cell Significance Index: 102.1200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4376
Cell Significance Index: 288.3900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4084
Cell Significance Index: 193.4100
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.4006
Cell Significance Index: 764.9000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3726
Cell Significance Index: 37.3600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3417
Cell Significance Index: 86.5600
Cell Name: odontoblast (CL0000060)
Fold Change: 1.2519
Cell Significance Index: 160.4800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2219
Cell Significance Index: 150.2500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1967
Cell Significance Index: 62.8300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1724
Cell Significance Index: 232.6600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1531
Cell Significance Index: 207.8700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7997
Cell Significance Index: 41.5400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7469
Cell Significance Index: 88.0800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5429
Cell Significance Index: 194.7300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5078
Cell Significance Index: 50.2300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5013
Cell Significance Index: 14.3700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4246
Cell Significance Index: 12.4700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2539
Cell Significance Index: 14.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2044
Cell Significance Index: 33.2500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1806
Cell Significance Index: 124.8900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1746
Cell Significance Index: 3.0900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1571
Cell Significance Index: 4.3900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1557
Cell Significance Index: 29.6400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1411
Cell Significance Index: 3.7800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1300
Cell Significance Index: 3.7500
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0922
Cell Significance Index: 0.9800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0717
Cell Significance Index: 54.2400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0705
Cell Significance Index: 12.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0640
Cell Significance Index: 120.5600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0400
Cell Significance Index: 0.6700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0310
Cell Significance Index: 1.0900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0274
Cell Significance Index: 20.0800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0204
Cell Significance Index: 18.4600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0124
Cell Significance Index: 0.7800
Cell Name: peg cell (CL4033014)
Fold Change: 0.0123
Cell Significance Index: 0.2800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0090
Cell Significance Index: 13.8500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0089
Cell Significance Index: 16.4900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0062
Cell Significance Index: -0.2800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0075
Cell Significance Index: -10.2300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0089
Cell Significance Index: -5.6400
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.0465
Cell Significance Index: -0.4000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0503
Cell Significance Index: -22.8500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0587
Cell Significance Index: -1.5100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0607
Cell Significance Index: -6.6000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0646
Cell Significance Index: -4.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0660
Cell Significance Index: -6.7400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0673
Cell Significance Index: -49.8900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1094
Cell Significance Index: -15.9000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1208
Cell Significance Index: -68.1300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1413
Cell Significance Index: -88.2600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1468
Cell Significance Index: -9.0200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1474
Cell Significance Index: -4.7200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2002
Cell Significance Index: -23.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2279
Cell Significance Index: -65.5600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2920
Cell Significance Index: -7.4600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3233
Cell Significance Index: -21.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4044
Cell Significance Index: -85.1900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4890
Cell Significance Index: -56.0300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4977
Cell Significance Index: -34.4200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5694
Cell Significance Index: -45.1000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5944
Cell Significance Index: -8.1100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6693
Cell Significance Index: -11.2800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6845
Cell Significance Index: -71.2800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7021
Cell Significance Index: -10.5200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7800
Cell Significance Index: -34.5000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9090
Cell Significance Index: -34.4200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9169
Cell Significance Index: -22.9200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.9712
Cell Significance Index: -17.9500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.9893
Cell Significance Index: -9.1100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.0066
Cell Significance Index: -17.2500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.0528
Cell Significance Index: -11.9600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0697
Cell Significance Index: -65.5800
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.1041
Cell Significance Index: -26.9400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.1263
Cell Significance Index: -24.4000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.2596
Cell Significance Index: -7.6100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3227
Cell Significance Index: -38.9600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.4144
Cell Significance Index: -16.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit beta 7**: PSMB7 is a subunit of the 20S proteasome, a large protein complex responsible for degrading damaged or unneeded proteins in cells. 2. **Highly expressed in various cell types**: PSMB7 is highly expressed in pancreatic acinar cells, erythroid progenitor cells, mesenchymal stem cells, and other cell types. 3. **Involved in protein degradation**: PSMB7 plays a crucial role in protein degradation, which is essential for maintaining protein homeostasis and regulating cellular processes. 4. **Implicated in disease**: Dysregulation of PSMB7 has been implicated in various diseases, including cancer and autoimmune disorders. **Pathways and Functions** 1. **Antigen processing and presentation**: PSMB7 is involved in antigen processing and presentation, which is essential for the immune system to recognize and respond to pathogens. 2. **Cell cycle regulation**: PSMB7 plays a role in regulating the cell cycle, particularly in the G1/S transition, by degrading proteins that inhibit cell cycle progression. 3. **Apoptosis regulation**: PSMB7 is involved in regulating apoptosis, or programmed cell death, which is essential for eliminating damaged or unneeded cells. 4. **Protein degradation**: PSMB7 is a key component of the 20S proteasome, which degrades damaged or unneeded proteins in cells. 5. **Signaling pathways**: PSMB7 is involved in various signaling pathways, including the Wnt/β-catenin pathway, the NF-κB pathway, and the MAPK pathway. **Clinical Significance** 1. **Cancer**: Dysregulation of PSMB7 has been implicated in various types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Autoimmune disorders**: PSMB7 has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus, where it plays a role in antigen presentation and immune system regulation. 3. **Neurological disorders**: PSMB7 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it plays a role in protein degradation and aggregation. 4. **Infectious diseases**: PSMB7 has been implicated in infectious diseases, such as HIV and tuberculosis, where it plays a role in antigen presentation and immune system regulation. In conclusion, the PSMB7 gene plays a crucial role in various cellular processes, including protein degradation, antigen presentation, and cell cycle regulation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully understand the mechanisms by which PSMB7 regulates cellular processes and its role in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Macropain chain Z

Genular Protein ID: 2335153763

Symbol: PSB7_HUMAN

Name: Macropain chain Z

UniProtKB Accession Codes:

Q99436 B4E0P1 Q5TBG6 Q96AG8 Q9BWA7

Database IDs:

Citations:

PubMed ID: 8666937

Title: Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

PubMed ID: 8666937

DOI: 10.1084/jem.183.4.1807

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18549262

Title: Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.

PubMed ID: 18549262

DOI: 10.1021/pr8000892

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 277
Mass: 29965
Checksum: A610C949A0ACF1CE
Sequence:

MAAVSVYAPP VGGFSFDNCR RNAVLEADFA KRGYKLPKVR KTGTTIAGVV YKDGIVLGAD 
TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ LISSNLELHS LSTGRLPRVV 
TANRMLKQML FRYQGYIGAA LVLGGVDVTG PHLYSIYPHG STDKLPYVTM GSGSLAAMAV 
FEDKFRPDME EEEAKNLVSE AIAAGIFNDL GSGSNIDLCV ISKNKLDFLR PYTVPNKKGT 
RLGRYRCEKG TTAVLTEKIT PLEIEVLEET VQTMDTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMB7

Associated with

Cells (max top 100)

Other Information

Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. PubMed ID: 8666937

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. PubMed ID: 18549262

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951