PSMC3 | ENSG00000165916 | NCBI 5702

Details for: PSMC3

Gene ID: 5702

Symbol: PSMC3

Ensembl ID: ENSG00000165916

Description: proteasome 26S subunit, ATPase 3

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 238.2587
Cell Significance Index: -37.0600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 186.0486
Cell Significance Index: -47.1900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 131.3759
Cell Significance Index: -54.1200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 117.9143
Cell Significance Index: -55.6700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 113.0811
Cell Significance Index: -45.9400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 103.3855
Cell Significance Index: -53.1800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 83.3206
Cell Significance Index: -55.9100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 48.5995
Cell Significance Index: -46.4000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 43.6918
Cell Significance Index: -53.8700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.5614
Cell Significance Index: -57.4600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.4278
Cell Significance Index: -38.6500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.4892
Cell Significance Index: -38.3600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.2695
Cell Significance Index: -15.9100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.4190
Cell Significance Index: 236.4400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0622
Cell Significance Index: 123.8100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.0549
Cell Significance Index: 22.3400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.8501
Cell Significance Index: 38.7300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.7519
Cell Significance Index: 284.9400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.6124
Cell Significance Index: 56.0300
Cell Name: kidney cell (CL1000497)
Fold Change: 1.5668
Cell Significance Index: 12.5100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4645
Cell Significance Index: 68.2800
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.3288
Cell Significance Index: 34.9400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2372
Cell Significance Index: 169.9000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.2006
Cell Significance Index: 530.8100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1988
Cell Significance Index: 32.6300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0672
Cell Significance Index: 131.2300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0332
Cell Significance Index: 48.5600
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0261
Cell Significance Index: 560.3800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0137
Cell Significance Index: 75.5500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9764
Cell Significance Index: 176.0100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9398
Cell Significance Index: 120.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9098
Cell Significance Index: 58.7000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8917
Cell Significance Index: 105.1600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8809
Cell Significance Index: 62.3000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8680
Cell Significance Index: 112.1500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.6453
Cell Significance Index: 33.8800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6133
Cell Significance Index: 17.5800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5506
Cell Significance Index: 15.8700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5339
Cell Significance Index: 15.6800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5099
Cell Significance Index: 23.1100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5026
Cell Significance Index: 5.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4929
Cell Significance Index: 25.6100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4730
Cell Significance Index: 90.0200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4578
Cell Significance Index: 8.0900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4494
Cell Significance Index: 12.0000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4295
Cell Significance Index: 9.3100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4202
Cell Significance Index: 21.8900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3784
Cell Significance Index: 23.8500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3345
Cell Significance Index: 57.1200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2685
Cell Significance Index: 53.8700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2373
Cell Significance Index: 7.6000
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.1587
Cell Significance Index: 2.4100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1130
Cell Significance Index: 22.4300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1117
Cell Significance Index: 3.9300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0901
Cell Significance Index: 1.3500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0535
Cell Significance Index: 0.9000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0452
Cell Significance Index: 34.1900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0174
Cell Significance Index: 12.7300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0111
Cell Significance Index: 3.9700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0167
Cell Significance Index: -12.4000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0199
Cell Significance Index: -12.4200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0203
Cell Significance Index: -38.3000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0362
Cell Significance Index: -3.7000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0379
Cell Significance Index: -69.8500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0422
Cell Significance Index: -57.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0426
Cell Significance Index: -65.5300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0453
Cell Significance Index: -31.3000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0521
Cell Significance Index: -29.3800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0608
Cell Significance Index: -38.6400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1095
Cell Significance Index: -49.7100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1186
Cell Significance Index: -13.5900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1334
Cell Significance Index: -28.1000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1481
Cell Significance Index: -42.6200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1579
Cell Significance Index: -18.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1868
Cell Significance Index: -18.4800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2259
Cell Significance Index: -5.7700
Cell Name: peg cell (CL4033014)
Fold Change: -0.2987
Cell Significance Index: -6.9000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3228
Cell Significance Index: -46.9200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3763
Cell Significance Index: -23.1300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3969
Cell Significance Index: -3.6600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4026
Cell Significance Index: -11.2500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4193
Cell Significance Index: -11.2200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4241
Cell Significance Index: -33.5900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4471
Cell Significance Index: -51.0400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4813
Cell Significance Index: -10.2500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5145
Cell Significance Index: -7.0200
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5218
Cell Significance Index: -6.2200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5526
Cell Significance Index: -57.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5546
Cell Significance Index: -31.1200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6215
Cell Significance Index: -47.7000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6603
Cell Significance Index: -19.4500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7122
Cell Significance Index: -47.8900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.7476
Cell Significance Index: -6.2800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.8067
Cell Significance Index: -14.9100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8922
Cell Significance Index: -15.2900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8990
Cell Significance Index: -55.1200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9095
Cell Significance Index: -40.2300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9181
Cell Significance Index: -22.9500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.9370
Cell Significance Index: -12.0000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9774
Cell Significance Index: -5.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit**: PSMC3 is a subunit of the 26S proteasome complex, which is a large protein complex responsible for degrading and recycling proteins within cells. 2. **ATPase activity**: PSMC3 has ATPase activity, which is essential for the degradation of proteins by the proteasome complex. 3. **Cellular localization**: PSMC3 is primarily localized to the cytosol of cells, where it plays a crucial role in protein degradation and recycling. 4. **Signaling pathways**: PSMC3 is involved in various signaling pathways, including the adaptive immune response, apoptosis, and cell cycle regulation. **Pathways and Functions** 1. **Adaptive immune response**: PSMC3 plays a crucial role in the adaptive immune response by regulating the degradation and presentation of antigens to T-cells. 2. **Apoptosis**: PSMC3 is involved in the regulation of apoptosis by degrading and recycling pro-apoptotic proteins. 3. **Cell cycle regulation**: PSMC3 regulates the cell cycle by degrading and recycling proteins involved in cell cycle progression. 4. **Antigen presentation**: PSMC3 is involved in the presentation of antigens to T-cells by degrading and presenting antigens to the proteasome complex. 5. **Signaling pathways**: PSMC3 is involved in various signaling pathways, including the Wnt/β-catenin pathway, the Hedgehog pathway, and the Notch pathway. **Clinical Significance** 1. **Cancer**: Mutations or alterations in the PSMC3 gene have been linked to various types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Autoimmune disorders**: PSMC3 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative diseases**: PSMC3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: PSMC3 has been implicated in infectious diseases, such as HIV-1 infection and tuberculosis. In conclusion, the PSMC3 gene plays a crucial role in various cellular processes, including protein degradation, antigen presentation, and signaling pathways. Mutations or alterations in the PSMC3 gene have been linked to various diseases, highlighting the importance of this gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome regulatory subunit 6A

Genular Protein ID: 2272370181

Symbol: PRS6A_HUMAN

Name: 26S proteasome regulatory subunit 6A

UniProtKB Accession Codes:

P17980 B2R8V1 Q3B757 Q3B865 Q53HU5 Q6GPG8 Q6IBS1 Q96HD3

Database IDs:

Citations:

PubMed ID: 8419915

Title: The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.

PubMed ID: 8419915

DOI: 10.1073/pnas.90.1.138

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2194290

Title: A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator.

PubMed ID: 2194290

DOI: 10.1126/science.2194290

PubMed ID: 8621709

Title: Identification, purification, and characterization of a PA700-dependent activator of the proteasome.

PubMed ID: 8621709

DOI: 10.1074/jbc.271.6.3112

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 15831487

Title: Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.

PubMed ID: 15831487

DOI: 10.1128/mcb.25.9.3842-3853.2005

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 32500975

Title: Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress.

PubMed ID: 32500975

DOI: 10.15252/emmm.201911861

Sequence Information:

Length: 439
Mass: 49204
Checksum: 0E443465DDDEBB0B
Sequence:

MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IIQRTRLLDS EIKIMKSEVL 
RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK 
CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER 
PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC 
AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK 
AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE 
ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY 
MEGILEVQAK KKANLQYYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMC3

Associated with

Cells (max top 100)

Other Information

The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. PubMed ID: 8419915

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. PubMed ID: 2194290

Identification, purification, and characterization of a PA700-dependent activator of the proteasome. PubMed ID: 8621709

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. PubMed ID: 15831487

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. PubMed ID: 17709345

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. PubMed ID: 32500975