PSMC4 | ENSG00000013275 | NCBI 5704

Details for: PSMC4

Gene ID: 5704

Symbol: PSMC4

Ensembl ID: ENSG00000013275

Description: proteasome 26S subunit, ATPase 4

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 239.9624
Cell Significance Index: -37.3300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 167.7946
Cell Significance Index: -42.5600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 123.2438
Cell Significance Index: -50.7700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 103.5112
Cell Significance Index: -48.8700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 99.1860
Cell Significance Index: -40.3000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 90.6033
Cell Significance Index: -46.6100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.6921
Cell Significance Index: -40.7600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.8237
Cell Significance Index: -46.6400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.3921
Cell Significance Index: -48.9000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.6911
Cell Significance Index: -28.6400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.7934
Cell Significance Index: -30.0800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.0489
Cell Significance Index: -11.0500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 3.5093
Cell Significance Index: 408.9800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 2.2762
Cell Significance Index: 19.1200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.4261
Cell Significance Index: 40.8800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4060
Cell Significance Index: 228.6800
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2614
Cell Significance Index: 688.8900
Cell Name: kidney cell (CL1000497)
Fold Change: 1.1999
Cell Significance Index: 9.5800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.1645
Cell Significance Index: 34.2000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1540
Cell Significance Index: 31.4100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0660
Cell Significance Index: 79.4500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0246
Cell Significance Index: 53.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0169
Cell Significance Index: 125.0400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9986
Cell Significance Index: 180.0300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9462
Cell Significance Index: 32.8800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9016
Cell Significance Index: 814.0700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8581
Cell Significance Index: 117.8400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8102
Cell Significance Index: 358.2100
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7785
Cell Significance Index: 20.4700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7469
Cell Significance Index: 48.1900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7420
Cell Significance Index: 34.8800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7331
Cell Significance Index: 34.1800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.7090
Cell Significance Index: 14.8400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.6706
Cell Significance Index: 7.2900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6459
Cell Significance Index: 45.6800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6352
Cell Significance Index: 82.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6107
Cell Significance Index: 13.2300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5678
Cell Significance Index: 6.4500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5565
Cell Significance Index: 14.8600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5346
Cell Significance Index: 63.0500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5196
Cell Significance Index: 4.7900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5147
Cell Significance Index: 26.8100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4659
Cell Significance Index: 32.2200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3829
Cell Significance Index: 20.1100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3777
Cell Significance Index: 48.4200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3140
Cell Significance Index: 8.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2820
Cell Significance Index: 56.5700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2420
Cell Significance Index: 10.9700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2286
Cell Significance Index: 45.3700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2224
Cell Significance Index: 14.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1588
Cell Significance Index: 30.2200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1208
Cell Significance Index: 83.5700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1074
Cell Significance Index: 1.6100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0857
Cell Significance Index: 1.5200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0641
Cell Significance Index: 3.2400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0596
Cell Significance Index: 21.4000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0334
Cell Significance Index: 5.7000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0091
Cell Significance Index: 0.3200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0083
Cell Significance Index: 6.2600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0077
Cell Significance Index: -5.6500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0093
Cell Significance Index: -17.5700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0206
Cell Significance Index: -38.0700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0209
Cell Significance Index: -2.1300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0231
Cell Significance Index: -35.6200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0315
Cell Significance Index: -42.8100
Cell Name: peg cell (CL4033014)
Fold Change: -0.0320
Cell Significance Index: -0.7400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0380
Cell Significance Index: -1.1000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0431
Cell Significance Index: -27.4000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0485
Cell Significance Index: -35.9100
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0518
Cell Significance Index: -5.1300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0529
Cell Significance Index: -0.8900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0555
Cell Significance Index: -1.5500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0596
Cell Significance Index: -33.6300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0781
Cell Significance Index: -35.4400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0988
Cell Significance Index: -61.7200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1088
Cell Significance Index: -2.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1310
Cell Significance Index: -2.7900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1332
Cell Significance Index: -4.2700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1342
Cell Significance Index: -1.6000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1389
Cell Significance Index: -39.9600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1922
Cell Significance Index: -5.1500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2228
Cell Significance Index: -25.5300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2476
Cell Significance Index: -10.1500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2521
Cell Significance Index: -36.6500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2616
Cell Significance Index: -55.1100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3212
Cell Significance Index: -3.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3876
Cell Significance Index: -29.7500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4066
Cell Significance Index: -32.2000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4680
Cell Significance Index: -48.7300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4977
Cell Significance Index: -6.7900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5683
Cell Significance Index: -31.8900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6155
Cell Significance Index: -18.1300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6985
Cell Significance Index: -11.9700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.7255
Cell Significance Index: -13.4100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7873
Cell Significance Index: -48.2700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8158
Cell Significance Index: -20.9700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8485
Cell Significance Index: -37.5300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9103
Cell Significance Index: -5.5000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.9947
Cell Significance Index: -24.2700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9954
Cell Significance Index: -34.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PSMC4 is a regulatory subunit of the 26S proteasome complex, which is composed of two main subunits: the 20S proteasome and the 19S regulatory particle. The 20S proteasome is responsible for the proteolytic degradation of proteins, while the 19S regulatory particle, including PSMC4, regulates the activity of the 20S proteasome through ATP hydrolysis. PSMC4 is a unique subunit that contains an ATPase domain, which is essential for the degradation process. **Pathways and Functions** The PSMC4 gene is involved in various cellular processes, including: 1. **Protein Degradation**: PSMC4 plays a crucial role in the degradation of damaged or misfolded proteins, which is essential for maintaining protein homeostasis and promoting cellular health. 2. **Cell Cycle Regulation**: The 26S proteasome, including PSMC4, regulates the cell cycle by degrading proteins that promote cell proliferation, such as cyclin-dependent kinases. 3. **Apoptosis**: PSMC4 is involved in the regulation of apoptosis (programmed cell death) by degrading pro-apoptotic proteins. 4. **Immune Response**: PSMC4 is significantly expressed in myeloid leukocytes, where it plays a crucial role in the regulation of immune responses. 5. **Developmental Biology**: PSMC4 is involved in the development of various tissues, including the formation of paraxial mesoderm and the regulation of Hedgehog signaling. **Clinical Significance** Dysregulation of the 26S proteasome complex, including PSMC4, has been implicated in various diseases, including: 1. **Cancer**: The 26S proteasome complex is often overexpressed in cancer cells, leading to the degradation of tumor suppressor proteins and promoting tumor growth. 2. **Neurodegenerative Diseases**: The 26S proteasome complex is involved in the degradation of misfolded proteins, which is impaired in neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Autoimmune Diseases**: Dysregulation of the 26S proteasome complex, including PSMC4, has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Infectious Diseases**: The 26S proteasome complex is involved in the regulation of immune responses, and dysregulation of PSMC4 has been implicated in infectious diseases, such as HIV infection. In conclusion, PSMC4 is a critical component of the 26S proteasome complex, which plays a vital role in protein degradation, cell cycle regulation, apoptosis, and immune response. Dysregulation of PSMC4 has been implicated in various diseases, highlighting the importance of understanding the function and regulation of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome regulatory subunit 6B

Genular Protein ID: 3783638976

Symbol: PRS6B_HUMAN

Name: 26S proteasome regulatory subunit 6B

UniProtKB Accession Codes:

P43686 Q96FV5 Q9UBM3 Q9UEX3

Database IDs:

Citations:

PubMed ID: 8419915

Title: The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.

PubMed ID: 8419915

DOI: 10.1073/pnas.90.1.138

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 8603043

Title: A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily.

PubMed ID: 8603043

DOI: 10.1016/0960-0760(95)00220-0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8060531

Title: Tat-binding protein 7 is a subunit of the 26S protease.

PubMed ID: 8060531

DOI: 10.1515/bchm3.1994.375.4.237

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 15831487

Title: Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.

PubMed ID: 15831487

DOI: 10.1128/mcb.25.9.3842-3853.2005

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22078707

Title: TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.

PubMed ID: 22078707

DOI: 10.1186/1742-4690-8-93

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29804830

Title: ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules.

PubMed ID: 29804830

DOI: 10.1016/j.molcel.2018.04.021

PubMed ID: 17292836

Title: Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.

PubMed ID: 17292836

DOI: 10.1016/j.str.2006.11.015

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 418
Mass: 47366
Checksum: 80F9523C61B88F0C
Sequence:

MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY 
IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID 
RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA 
VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL 
GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD 
QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL 
EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMC4

Associated with

Cells (max top 100)

Other Information

The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. PubMed ID: 8419915

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. PubMed ID: 8603043

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tat-binding protein 7 is a subunit of the 26S protease. PubMed ID: 8060531

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. PubMed ID: 15831487

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. PubMed ID: 22078707

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. PubMed ID: 29804830

Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome. PubMed ID: 17292836

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858