PSMC6 | ENSG00000100519 | NCBI 5706

Details for: PSMC6

Gene ID: 5706

Symbol: PSMC6

Ensembl ID: ENSG00000100519

Description: proteasome 26S subunit, ATPase 6

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 330.3219
Cell Significance Index: -51.3800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 209.7039
Cell Significance Index: -53.1900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 146.5720
Cell Significance Index: -60.3800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 127.9329
Cell Significance Index: -60.4000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 127.3332
Cell Significance Index: -51.7300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 113.3197
Cell Significance Index: -58.2900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 90.2653
Cell Significance Index: -60.5700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 54.2764
Cell Significance Index: -51.8200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 49.1745
Cell Significance Index: -60.6300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.0753
Cell Significance Index: -51.1000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.0186
Cell Significance Index: -63.2100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.8794
Cell Significance Index: -42.6300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.3491
Cell Significance Index: -22.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.6944
Cell Significance Index: 487.5400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.5580
Cell Significance Index: 41.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3597
Cell Significance Index: 186.7300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3369
Cell Significance Index: 36.3900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2640
Cell Significance Index: 227.8600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2467
Cell Significance Index: 250.0800
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2211
Cell Significance Index: 666.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2130
Cell Significance Index: 240.7300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1988
Cell Significance Index: 147.4000
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.1398
Cell Significance Index: 12.1100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0515
Cell Significance Index: 464.8900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.0484
Cell Significance Index: 36.4300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0179
Cell Significance Index: 47.8400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0096
Cell Significance Index: 28.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9738
Cell Significance Index: 72.5800
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.9551
Cell Significance Index: 25.1200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8532
Cell Significance Index: 44.3200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8438
Cell Significance Index: 53.1800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8337
Cell Significance Index: 17.4500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8182
Cell Significance Index: 57.8700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7822
Cell Significance Index: 100.2700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7694
Cell Significance Index: 49.6400
Cell Name: kidney cell (CL1000497)
Fold Change: 0.6350
Cell Significance Index: 5.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6254
Cell Significance Index: 13.5500
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.6208
Cell Significance Index: 7.4000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6131
Cell Significance Index: 219.9100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5620
Cell Significance Index: 66.2800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5353
Cell Significance Index: 24.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4898
Cell Significance Index: 48.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4763
Cell Significance Index: 25.0100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.4627
Cell Significance Index: 5.0300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4514
Cell Significance Index: 13.0100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.4321
Cell Significance Index: 55.8200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4248
Cell Significance Index: 29.3800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3774
Cell Significance Index: 3.4800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2969
Cell Significance Index: 22.7900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2848
Cell Significance Index: 46.3300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2735
Cell Significance Index: 16.8100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2249
Cell Significance Index: 38.4000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1928
Cell Significance Index: 8.7400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1590
Cell Significance Index: 143.5500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1322
Cell Significance Index: 7.4200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0568
Cell Significance Index: 106.8600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0242
Cell Significance Index: 37.2600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0236
Cell Significance Index: 15.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0102
Cell Significance Index: 1.9500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0096
Cell Significance Index: 17.6900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0058
Cell Significance Index: 7.9000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0018
Cell Significance Index: -1.2900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0098
Cell Significance Index: -7.3900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0127
Cell Significance Index: -5.7500
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0275
Cell Significance Index: -0.6700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0280
Cell Significance Index: -20.7100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0311
Cell Significance Index: -0.5200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0507
Cell Significance Index: -31.6700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0555
Cell Significance Index: -8.0700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0558
Cell Significance Index: -1.5600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0641
Cell Significance Index: -36.1500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0796
Cell Significance Index: -8.1300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1359
Cell Significance Index: -28.6300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2281
Cell Significance Index: -8.0200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2321
Cell Significance Index: -15.6100
Cell Name: peg cell (CL4033014)
Fold Change: -0.2407
Cell Significance Index: -5.5600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2579
Cell Significance Index: -29.5500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2660
Cell Significance Index: -4.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2856
Cell Significance Index: -33.2800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3823
Cell Significance Index: -2.3100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3875
Cell Significance Index: -11.3800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4010
Cell Significance Index: -8.5400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4050
Cell Significance Index: -6.9400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4119
Cell Significance Index: -5.6200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4746
Cell Significance Index: -15.2000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4886
Cell Significance Index: -55.7700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4952
Cell Significance Index: -12.6500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5350
Cell Significance Index: -42.3700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5448
Cell Significance Index: -56.7300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5855
Cell Significance Index: -35.1500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5886
Cell Significance Index: -15.1300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6029
Cell Significance Index: -16.1600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.6047
Cell Significance Index: -6.8700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7293
Cell Significance Index: -32.2600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.7775
Cell Significance Index: -4.7900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7908
Cell Significance Index: -41.1900
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.8295
Cell Significance Index: -16.1900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8302
Cell Significance Index: -22.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8741
Cell Significance Index: -53.5900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.8806
Cell Significance Index: -21.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Proteasome 26S Subunit**: PSMC6 is a subunit of the 26S proteasome, a large protein complex responsible for degrading proteins. 2. **ATPase 6**: PSMC6 is an ATPase, which means it uses energy from ATP hydrolysis to drive the degradation of proteins. 3. **Regulatory Subunit**: PSMC6 is a regulatory subunit of the 26S proteasome, which means it regulates the activity of the 26S proteasome. 4. **Ubiquitin-Proteasome Pathway**: PSMC6 is involved in the ubiquitin-proteasome pathway, which is a key cellular process for protein degradation. **Pathways and Functions:** 1. **Cell Cycle Regulation**: PSMC6 regulates the cell cycle by degrading proteins involved in cell cycle progression. 2. **Apoptosis**: PSMC6 is involved in apoptosis, or programmed cell death, by degrading proteins involved in cell survival. 3. **Immune Response**: PSMC6 plays a critical role in the immune response by regulating the degradation of proteins involved in immune cell activation. 4. **Protein Degradation**: PSMC6 is involved in the degradation of proteins, which is essential for maintaining protein homeostasis in cells. 5. **Regulation of Protein Stability**: PSMC6 regulates the stability of proteins by degrading proteins that are no longer needed or are damaged. **Clinical Significance:** 1. **Cancer**: PSMC6 has been implicated in cancer development and progression, as it regulates the degradation of proteins involved in cell cycle progression and apoptosis. 2. **Neurodegenerative Diseases**: PSMC6 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as it regulates the degradation of proteins involved in protein homeostasis. 3. **Immune Disorders**: PSMC6 plays a critical role in the immune response, and dysregulation of PSMC6 has been implicated in immune disorders, such as autoimmune diseases. 4. **Regenerative Medicine**: PSMC6 has been identified as a potential target for regenerative medicine, as it regulates the degradation of proteins involved in tissue repair and regeneration. In conclusion, PSMC6 is a critical regulator of cellular processes, including cell cycle regulation, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to fully understand the role of PSMC6 in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome regulatory subunit 10B
A0A087X2I1_HUMAN

Genular Protein ID: 4022866496

Symbol: PRS10_HUMAN

Name: 26S proteasome regulatory subunit 10B

UniProtKB Accession Codes:

P62333 B2R975 P49719 Q6IBU3 Q92524

Database IDs:

Citations:

PubMed ID: 8674546

Title: cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family.

PubMed ID: 8674546

DOI: 10.1016/0014-5793(96)00489-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8621709

Title: Identification, purification, and characterization of a PA700-dependent activator of the proteasome.

PubMed ID: 8621709

DOI: 10.1074/jbc.271.6.3112

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 15831487

Title: Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.

PubMed ID: 15831487

DOI: 10.1128/mcb.25.9.3842-3853.2005

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 389
Mass: 44173
Checksum: B26421295742CACD
Sequence:

MADPRDKALQ DYRKKLLEHK EIDGRLKELR EQLKELTKQY EKSENDLKAL QSVGQIVGEV 
LKQLTEEKFI VKATNGPRYV VGCRRQLDKS KLKPGTRVAL DMTTLTIMRY LPREVDPLVY 
NMSHEDPGNV SYSEIGGLSE QIRELREVIE LPLTNPELFQ RVGIIPPKGC LLYGPPGTGK 
TLLARAVASQ LDCNFLKVVS SSIVDKYIGE SARLIREMFN YARDHQPCII FMDEIDAIGG 
RRFSEGTSAD REIQRTLMEL LNQMDGFDTL HRVKMIMATN RPDTLDPALL RPGRLDRKIH 
IDLPNEQARL DILKIHAGPI TKHGEIDYEA IVKLSDGFNG ADLRNVCTEA GMFAIRADHD 
FVVQEDFMKA VRKVADSKKL ESKLDYKPV

Genular Protein ID: 3171103684

Symbol: A0A087X2I1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2I1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 32783951

Title: Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome.

PubMed ID: 32783951

DOI: 10.1016/j.str.2020.07.011

PubMed ID: 35477760

Title: USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.

PubMed ID: 35477760

DOI: 10.1038/s41586-022-04671-8

Sequence Information:

Length: 403
Mass: 45797
Checksum: 0A05EF978A6D5E37
Sequence:

MAIPGIPYER RLLIMADPRD KALQDYRKKL LEHKEIDGRL KELREQLKEL TKQYEKSEND 
LKALQSVGQI VGEVLKQLTE EKFIVKATNG PRYVVGCRRQ LDKSKLKPGT RVALDMTTLT 
IMRYLPREVD PLVYNMSHED PGNVSYSEIG GLSEQIRELR EVIELPLTNP ELFQRVGIIP 
PKGCLLYGPP GTGKTLLARA VASQLDCNFL KVVSSSIVDK YIGESARLIR EMFNYARDHQ 
PCIIFMDEID AIGGRRFSEG TSADREIQRT LMELLNQMDG FDTLHRVKMI MATNRPDTLD 
PALLRPGRLD RKIHIDLPNE QARLDILKIH AGPITKHGEI DYEAIVKLSD GFNGADLRNV 
CTEAGMFAIR ADHDFVVQED FMKAVRKVAD SKKLESKLDY KPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMC6

Associated with

Cells (max top 100)

Other Information

cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. PubMed ID: 8674546

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification, purification, and characterization of a PA700-dependent activator of the proteasome. PubMed ID: 8621709

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. PubMed ID: 15831487

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome. PubMed ID: 32783951

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. PubMed ID: 35477760

Database document:

PubMed ID: 8674546

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 8621709

PubMed ID: 1317798

PubMed ID: 15831487

PubMed ID: 17323924

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 27428775

PubMed ID: 27342858

PubMed ID: 11237011

PubMed ID: 12508121

PubMed ID: 15496913

PubMed ID: 17323924

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 32783951

PubMed ID: 35477760