PSMD3 | ENSG00000108344 | NCBI 5709

Details for: PSMD3

Gene ID: 5709

Symbol: PSMD3

Ensembl ID: ENSG00000108344

Description: proteasome 26S subunit, non-ATPase 3

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 206.3066
Cell Significance Index: -32.0900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 131.5232
Cell Significance Index: -33.3600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 85.7828
Cell Significance Index: -40.5000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 83.6170
Cell Significance Index: -33.9700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 75.1188
Cell Significance Index: -38.6400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 60.3706
Cell Significance Index: -40.5100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.8421
Cell Significance Index: -34.2200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.2234
Cell Significance Index: -39.7300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.3149
Cell Significance Index: -32.9900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.5777
Cell Significance Index: -41.7400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.4520
Cell Significance Index: -25.9600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.5248
Cell Significance Index: -14.2800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.9489
Cell Significance Index: 343.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.5923
Cell Significance Index: 17.3100
Cell Name: kidney cell (CL1000497)
Fold Change: 1.5349
Cell Significance Index: 12.2600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4940
Cell Significance Index: 242.9900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.2598
Cell Significance Index: 26.3700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1548
Cell Significance Index: 158.5900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.1371
Cell Significance Index: 39.5200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0659
Cell Significance Index: 68.7700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8009
Cell Significance Index: 37.3400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8000
Cell Significance Index: 21.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7866
Cell Significance Index: 429.6000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7176
Cell Significance Index: 317.2700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7146
Cell Significance Index: 18.7900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6822
Cell Significance Index: 18.5700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6819
Cell Significance Index: 87.4200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6754
Cell Significance Index: 79.6500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.6647
Cell Significance Index: 34.9000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6267
Cell Significance Index: 46.7100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6130
Cell Significance Index: 110.5100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6097
Cell Significance Index: 31.6700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5966
Cell Significance Index: 118.3900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5916
Cell Significance Index: 41.8400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.5906
Cell Significance Index: 8.9700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5853
Cell Significance Index: 117.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5773
Cell Significance Index: 70.9900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5683
Cell Significance Index: 16.6900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5367
Cell Significance Index: 69.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5146
Cell Significance Index: 14.7500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4602
Cell Significance Index: 23.9700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4577
Cell Significance Index: 21.5100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4491
Cell Significance Index: 9.7300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3764
Cell Significance Index: 17.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2978
Cell Significance Index: 8.5800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2921
Cell Significance Index: 263.7400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2592
Cell Significance Index: 92.9700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2149
Cell Significance Index: 36.6900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1706
Cell Significance Index: 10.7500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1526
Cell Significance Index: 29.0500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1250
Cell Significance Index: 12.3700
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1086
Cell Significance Index: 2.6500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0985
Cell Significance Index: 3.4600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0497
Cell Significance Index: 1.3900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0149
Cell Significance Index: 11.2700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0052
Cell Significance Index: 9.8100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0013
Cell Significance Index: -0.0200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0119
Cell Significance Index: -22.0000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0128
Cell Significance Index: -7.9800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0163
Cell Significance Index: -11.9300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0178
Cell Significance Index: -27.4700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0280
Cell Significance Index: -38.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0305
Cell Significance Index: -19.3900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0319
Cell Significance Index: -3.2600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0453
Cell Significance Index: -25.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0468
Cell Significance Index: -1.5000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0538
Cell Significance Index: -24.4400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0753
Cell Significance Index: -1.9400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0883
Cell Significance Index: -1.8800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0933
Cell Significance Index: -10.6900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1010
Cell Significance Index: -21.2700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1024
Cell Significance Index: -7.8600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1090
Cell Significance Index: -6.7000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1183
Cell Significance Index: -34.0500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1198
Cell Significance Index: -3.2100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1739
Cell Significance Index: -2.6100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1829
Cell Significance Index: -12.3000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1857
Cell Significance Index: -1.7100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1887
Cell Significance Index: -4.8200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1890
Cell Significance Index: -27.4800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2105
Cell Significance Index: -5.6300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2483
Cell Significance Index: -2.5700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3024
Cell Significance Index: -34.5200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3069
Cell Significance Index: -17.2200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3299
Cell Significance Index: -2.6900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3326
Cell Significance Index: -4.2600
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.3461
Cell Significance Index: -5.5900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3800
Cell Significance Index: -4.5300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3816
Cell Significance Index: -39.7300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3914
Cell Significance Index: -5.3400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4013
Cell Significance Index: -31.7800
Cell Name: peg cell (CL4033014)
Fold Change: -0.4415
Cell Significance Index: -10.2000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4833
Cell Significance Index: -29.6300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4849
Cell Significance Index: -8.3100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5334
Cell Significance Index: -6.0600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5402
Cell Significance Index: -15.9100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5520
Cell Significance Index: -9.7600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5919
Cell Significance Index: -10.9400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6662
Cell Significance Index: -19.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PSMD3 is a non-ATPase regulatory subunit of the 26S proteasome complex, which is composed of two subunits: the ATPase subunit (PSMD1) and the non-ATPase subunit (PSMD3). The non-ATPase subunit, PSMD3, is responsible for regulating the activity of the proteasome by interacting with other subunits and modulating the degradation of proteins. PSMD3 is characterized by its ability to bind to specific peptides and regulate the activity of the proteasome. **Pathways and Functions** The PSMD3 gene is involved in various cellular pathways, including: 1. **Proteasome-mediated degradation**: PSMD3 regulates the activity of the 26S proteasome complex, which is responsible for degrading damaged or misfolded proteins. 2. **Cell cycle regulation**: PSMD3 modulates the degradation of cell cycle regulators, such as cyclin-dependent kinases (CDKs), to regulate cell cycle progression. 3. **Immune responses**: PSMD3 regulates the degradation of immune molecules, such as major histocompatibility complex (MHC) class I and II molecules, to modulate immune responses. 4. **Apoptosis**: PSMD3 regulates the degradation of pro-apoptotic proteins, such as Bcl-2 family members, to modulate apoptosis. 5. **Wnt/β-catenin signaling**: PSMD3 regulates the degradation of β-catenin, a key component of the Wnt/β-catenin signaling pathway, to modulate cell proliferation and differentiation. **Clinical Significance** Dysregulation of the 26S proteasome complex, including PSMD3, has been implicated in various diseases, including: 1. **Cancer**: Dysregulation of the 26S proteasome complex has been linked to cancer progression and metastasis. 2. **Neurodegenerative diseases**: Dysregulation of the 26S proteasome complex has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: Dysregulation of the 26S proteasome complex has been linked to immune disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Infectious diseases**: Dysregulation of the 26S proteasome complex has been implicated in infectious diseases, such as HIV infection and tuberculosis. In summary, the PSMD3 gene plays a crucial role in regulating protein degradation, cell cycle progression, and immune responses. Dysregulation of PSMD3 has been implicated in various diseases, highlighting the importance of understanding the function and regulation of this gene in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 3

Genular Protein ID: 312676188

Symbol: PSMD3_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 3

UniProtKB Accession Codes:

O43242 B3KMW9 B4DT72 Q96EI2 Q9BQA4

Database IDs:

Citations:

PubMed ID: 9017604

Title: Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.

PubMed ID: 9017604

DOI: 10.1091/mbc.8.1.171

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 15147878

Title: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.

PubMed ID: 15147878

DOI: 10.1016/j.febslet.2004.04.031

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 534
Mass: 60978
Checksum: 3B3FB5593542C078
Sequence:

MKQEGSARRR GADKAKPPPG GGEQEPPPPP APQDVEMKEE AATGGGSTGE ADGKTAAAAA 
EHSQRELDTV TLEDIKEHVK QLEKAVSGKE PRFVLRALRM LPSTSRRLNH YVLYKAVQGF 
FTSNNATRDF LLPFLEEPMD TEADLQFRPR TGKAASTPLL PEVEAYLQLL VVIFMMNSKR 
YKEAQKISDD LMQKISTQNR RALDLVAAKC YYYHARVYEF LDKLDVVRSF LHARLRTATL 
RHDADGQATL LNLLLRNYLH YSLYDQAEKL VSKSVFPEQA NNNEWARYLY YTGRIKAIQL 
EYSEARRTMT NALRKAPQHT AVGFKQTVHK LLIVVELLLG EIPDRLQFRQ PSLKRSLMPY 
FLLTQAVRTG NLAKFNQVLD QFGEKFQADG TYTLIIRLRH NVIKTGVRMI SLSYSRISLA 
DIAQKLQLDS PEDAEFIVAK AIRDGVIEAS INHEKGYVQS KEMIDIYSTR EPQLAFHQRI 
SFCLDIHNMS VKAMRFPPKS YNKDLESAEE RREREQQDLE FAKEMAEDDD DSFP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD3

Associated with

Cells (max top 100)

Other Information

Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. PubMed ID: 9017604

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. PubMed ID: 15147878

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PubMed ID: 26030138

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858