PSMD12 | ENSG00000197170 | NCBI 5718

Details for: PSMD12

Gene ID: 5718

Symbol: PSMD12

Ensembl ID: ENSG00000197170

Description: proteasome 26S subunit, non-ATPase 12

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 227.6508
Cell Significance Index: -35.4100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 169.5294
Cell Significance Index: -43.0000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 117.7820
Cell Significance Index: -48.5200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 98.6690
Cell Significance Index: -40.0900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 98.3749
Cell Significance Index: -46.4500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 69.5283
Cell Significance Index: -46.6600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.3412
Cell Significance Index: -40.4300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.3979
Cell Significance Index: -46.1100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.5995
Cell Significance Index: -39.1100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.3269
Cell Significance Index: -48.6400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.5027
Cell Significance Index: -35.3300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.6318
Cell Significance Index: -21.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.6944
Cell Significance Index: 101.7200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.6742
Cell Significance Index: 45.5700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2908
Cell Significance Index: 158.7200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1239
Cell Significance Index: 58.3900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1168
Cell Significance Index: 29.8200
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.0465
Cell Significance Index: 8.7900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0447
Cell Significance Index: 188.3300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0349
Cell Significance Index: 207.6000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9863
Cell Significance Index: 195.7300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8609
Cell Significance Index: 470.1400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8276
Cell Significance Index: 365.9100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8274
Cell Significance Index: 38.8900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8109
Cell Significance Index: 111.3600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7917
Cell Significance Index: 714.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7204
Cell Significance Index: 33.5900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7140
Cell Significance Index: 32.3700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6909
Cell Significance Index: 48.8600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6555
Cell Significance Index: 18.7900
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.6512
Cell Significance Index: 9.8900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6351
Cell Significance Index: 82.0500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.6092
Cell Significance Index: 16.3300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5833
Cell Significance Index: 209.2100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5656
Cell Significance Index: 35.6500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5350
Cell Significance Index: 27.8700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5276
Cell Significance Index: 39.3200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5047
Cell Significance Index: 14.5400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.4735
Cell Significance Index: 12.1700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3978
Cell Significance Index: 51.0000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3888
Cell Significance Index: 25.0900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3282
Cell Significance Index: 7.1100
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.3234
Cell Significance Index: 7.8900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3231
Cell Significance Index: 38.1000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2442
Cell Significance Index: 46.4800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2206
Cell Significance Index: 16.9300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2120
Cell Significance Index: 11.1300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1721
Cell Significance Index: 10.5800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.1674
Cell Significance Index: 1.3700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1225
Cell Significance Index: 3.2200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1107
Cell Significance Index: 6.2100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0576
Cell Significance Index: 108.5300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0530
Cell Significance Index: 1.8400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0192
Cell Significance Index: 29.5100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0149
Cell Significance Index: 10.9400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0146
Cell Significance Index: 19.8900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0122
Cell Significance Index: 22.5100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0115
Cell Significance Index: 1.9600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0035
Cell Significance Index: 2.2400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0019
Cell Significance Index: 0.8800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0143
Cell Significance Index: -10.8000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0371
Cell Significance Index: -27.4900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0517
Cell Significance Index: -7.5100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0573
Cell Significance Index: -5.8500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0727
Cell Significance Index: -40.9900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0733
Cell Significance Index: -4.9300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0847
Cell Significance Index: -52.8700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1021
Cell Significance Index: -1.7500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1368
Cell Significance Index: -15.9400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1449
Cell Significance Index: -41.6900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1507
Cell Significance Index: -3.2100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1721
Cell Significance Index: -1.0400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1726
Cell Significance Index: -5.0700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1745
Cell Significance Index: -28.3800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1888
Cell Significance Index: -3.1600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2040
Cell Significance Index: -7.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2040
Cell Significance Index: -5.7000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2099
Cell Significance Index: -20.7600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2199
Cell Significance Index: -3.0000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2260
Cell Significance Index: -4.7300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2354
Cell Significance Index: -49.5800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2762
Cell Significance Index: -31.6400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2784
Cell Significance Index: -4.6900
Cell Name: germ cell (CL0000586)
Fold Change: -0.2794
Cell Significance Index: -2.1100
Cell Name: peg cell (CL4033014)
Fold Change: -0.2809
Cell Significance Index: -6.4900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3003
Cell Significance Index: -3.5800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3305
Cell Significance Index: -8.8400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3531
Cell Significance Index: -6.2400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3870
Cell Significance Index: -40.3000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3919
Cell Significance Index: -42.6300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3949
Cell Significance Index: -31.2800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4344
Cell Significance Index: -4.0000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4461
Cell Significance Index: -19.7300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4771
Cell Significance Index: -15.2800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4875
Cell Significance Index: -12.4600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5466
Cell Significance Index: -8.1900
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.5479
Cell Significance Index: -8.8400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5934
Cell Significance Index: -22.4700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6475
Cell Significance Index: -39.7000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.6534
Cell Significance Index: -15.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit**: PSMD12 is a non-ATPase regulatory subunit of the 26S proteasome complex, which is responsible for degrading proteins. 2. **Cellular expression**: PSMD12 is significantly expressed in various cell types, including pancreatic acinar cells, erythroid progenitor cells, and skeletal muscle satellite stem cells. 3. **Protein degradation**: PSMD12 plays a key role in the degradation of proteins, particularly those involved in cell cycle regulation, protein homeostasis, and signal transduction pathways. 4. **Regulation of cell cycle**: PSMD12 is involved in regulating the cell cycle, particularly in the G1/S transition and G2/M phases. 5. **Signaling pathways**: PSMD12 is involved in various signaling pathways, including Wnt/β-catenin, Hedgehog, and Notch signaling pathways. **Pathways and Functions** 1. **Abc-family proteins mediated transport**: PSMD12 is involved in the transport of proteins across cellular membranes. 2. **Adaptive immune system**: PSMD12 plays a role in the adaptive immune system, particularly in the regulation of T cell receptor signaling. 3. **Antigen processing-cross presentation**: PSMD12 is involved in the processing and presentation of antigens to the immune system. 4. **Apc/c-mediated degradation of cell cycle proteins**: PSMD12 regulates the degradation of cell cycle proteins, particularly those involved in the G1/S transition. 5. **Apoptosis**: PSMD12 is involved in regulating apoptosis, particularly in the degradation of pro-apoptotic proteins. 6. **Assembly of the pre-replicative complex**: PSMD12 regulates the assembly of the pre-replicative complex, which is essential for DNA replication. 7. **Cell cycle checkpoints**: PSMD12 is involved in regulating cell cycle checkpoints, particularly in the G1/S transition and G2/M phases. **Clinical Significance** 1. **Cancer**: PSMD12 mutations have been associated with various types of cancer, including pancreatic cancer, breast cancer, and colon cancer. 2. **Neurological disorders**: PSMD12 mutations have been associated with neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Immunodeficiency**: PSMD12 mutations can lead to immunodeficiency, particularly in individuals with impaired T cell function. 4. **Protein aggregation**: PSMD12 mutations can lead to protein aggregation, particularly in individuals with neurodegenerative disorders. 5. **Therapeutic applications**: PSMD12 inhibitors have been explored as potential therapeutic agents for various diseases, including cancer and neurodegenerative disorders. In conclusion, PSMD12 is a critical gene involved in various cellular processes, including protein degradation, cell cycle regulation, and signaling pathways. Its dysregulation has been associated with various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 12

Genular Protein ID: 442856162

Symbol: PSD12_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 12

UniProtKB Accession Codes:

O00232 A6NP15 Q53HA2 Q6P053

Database IDs:

Citations:

PubMed ID: 9426256

Title: cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome.

PubMed ID: 9426256

DOI: 10.1016/s0378-1119(97)00524-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 28132691

Title: De novo disruption of the proteasome regulatory subunit PSMD12 causes a syndromic neurodevelopmental disorder.

PubMed ID: 28132691

DOI: 10.1016/j.ajhg.2017.01.003

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 456
Mass: 52904
Checksum: 97D0BDBDB0C96195
Sequence:

MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM 
VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI 
KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK 
ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY 
LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP 
KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE 
HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD 
PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ

Database document:

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Details for: PSMD12

Associated with

Cells (max top 100)

Other Information

cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. PubMed ID: 9426256

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PubMed ID: 26030138

De novo disruption of the proteasome regulatory subunit PSMD12 causes a syndromic neurodevelopmental disorder. PubMed ID: 28132691

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858