PSMD13 | ENSG00000185627 | NCBI 5719

Details for: PSMD13

Gene ID: 5719

Symbol: PSMD13

Ensembl ID: ENSG00000185627

Description: proteasome 26S subunit, non-ATPase 13

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 269.0536
Cell Significance Index: -41.8500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 152.5567
Cell Significance Index: -38.7000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 125.0402
Cell Significance Index: -51.5100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 107.6203
Cell Significance Index: -50.8100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 103.5305
Cell Significance Index: -42.0600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 96.3869
Cell Significance Index: -49.5800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 75.6905
Cell Significance Index: -50.7900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 44.9545
Cell Significance Index: -42.9200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.6226
Cell Significance Index: -47.6200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.5341
Cell Significance Index: -49.4600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.4755
Cell Significance Index: -33.4200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.6985
Cell Significance Index: -32.8600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3217
Cell Significance Index: 85.2700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2467
Cell Significance Index: 17.0100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1940
Cell Significance Index: 56.1200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.0936
Cell Significance Index: 29.2000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.0775
Cell Significance Index: 31.6500
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0280
Cell Significance Index: 561.4300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0206
Cell Significance Index: 53.1600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0095
Cell Significance Index: 138.6300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.9221
Cell Significance Index: 19.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8441
Cell Significance Index: 62.9100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8376
Cell Significance Index: 150.9900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8032
Cell Significance Index: 98.7700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8007
Cell Significance Index: 94.4300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7925
Cell Significance Index: 350.4000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7635
Cell Significance Index: 35.6000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7532
Cell Significance Index: 122.5000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7078
Cell Significance Index: 141.9900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5736
Cell Significance Index: 40.5700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5679
Cell Significance Index: 19.7400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4731
Cell Significance Index: 93.9000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4725
Cell Significance Index: 60.5700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3809
Cell Significance Index: 20.0000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3744
Cell Significance Index: 19.4500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3494
Cell Significance Index: 45.1400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3430
Cell Significance Index: 237.2300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2731
Cell Significance Index: 51.9700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2667
Cell Significance Index: 16.8100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2639
Cell Significance Index: 94.6400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2503
Cell Significance Index: 24.7600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.2148
Cell Significance Index: 2.4400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2113
Cell Significance Index: 5.5500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2103
Cell Significance Index: 9.5300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2036
Cell Significance Index: 34.7600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1428
Cell Significance Index: 1.3200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1058
Cell Significance Index: 1.1500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0334
Cell Significance Index: 0.9100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0277
Cell Significance Index: 0.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0072
Cell Significance Index: 5.4500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0009
Cell Significance Index: 1.6500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0025
Cell Significance Index: -4.6000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0066
Cell Significance Index: -10.1400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0084
Cell Significance Index: -6.2100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0123
Cell Significance Index: -9.0200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0179
Cell Significance Index: -11.1800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0204
Cell Significance Index: -0.5700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0205
Cell Significance Index: -27.9100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0284
Cell Significance Index: -0.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0314
Cell Significance Index: -19.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0410
Cell Significance Index: -4.1900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0646
Cell Significance Index: -36.4200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0730
Cell Significance Index: -33.1200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1189
Cell Significance Index: -25.0400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1231
Cell Significance Index: -3.5300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1315
Cell Significance Index: -15.0700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1353
Cell Significance Index: -2.5000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1359
Cell Significance Index: -19.7500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1391
Cell Significance Index: -40.0200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1487
Cell Significance Index: -17.3300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1826
Cell Significance Index: -4.8900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2123
Cell Significance Index: -16.3000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2260
Cell Significance Index: -13.8900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2262
Cell Significance Index: -7.9500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2446
Cell Significance Index: -6.2500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2845
Cell Significance Index: -6.0600
Cell Name: peg cell (CL4033014)
Fold Change: -0.2852
Cell Significance Index: -6.5900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2906
Cell Significance Index: -7.4700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3258
Cell Significance Index: -18.2800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3497
Cell Significance Index: -39.9200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3913
Cell Significance Index: -26.3100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3943
Cell Significance Index: -12.6300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4619
Cell Significance Index: -48.0900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4769
Cell Significance Index: -11.9200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4838
Cell Significance Index: -38.3200
Cell Name: kidney cell (CL1000497)
Fold Change: -0.4947
Cell Significance Index: -3.9500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4980
Cell Significance Index: -13.3500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5239
Cell Significance Index: -7.8500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5694
Cell Significance Index: -3.4400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6367
Cell Significance Index: -7.5900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6756
Cell Significance Index: -41.4200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6921
Cell Significance Index: -12.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6999
Cell Significance Index: -30.9600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8089
Cell Significance Index: -30.6300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8986
Cell Significance Index: -15.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9839
Cell Significance Index: -28.9800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.0278
Cell Significance Index: -29.3300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.0287
Cell Significance Index: -25.1000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0696
Cell Significance Index: -35.0200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0766
Cell Significance Index: -34.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PSMD13 is a non-ATPase subunit of the 26S proteasome, which is a large protein complex responsible for degrading ubiquitinated proteins. The 26S proteasome complex is composed of two subunits: the 19S regulatory subunit and the 20S catalytic subunit. PSMD13 is a regulatory subunit that interacts with the 20S catalytic subunit to regulate protein degradation. The gene is highly conserved across species, suggesting its essential role in cellular processes. **Pathways and Functions** PSMD13 is involved in various signaling pathways, including: 1. **Abc-family proteins mediated transport**: PSMD13 regulates the transport of proteins across cellular membranes, influencing cell signaling and homeostasis. 2. **Adaptive immune system**: PSMD13 is involved in the regulation of immune responses, including the degradation of antigen-presenting molecules and the presentation of antigens to T cells. 3. **Antigen processing-cross presentation**: PSMD13 plays a crucial role in the processing and presentation of antigens to T cells, influencing immune system regulation. 4. **Apc/c-mediated degradation of cell cycle proteins**: PSMD13 regulates the degradation of cell cycle proteins, influencing cell cycle progression and apoptosis. 5. **Apoptosis**: PSMD13 is involved in the regulation of apoptosis, influencing cellular homeostasis and disease. **Clinical Significance** PSMD13 is significantly expressed in various tissues, including myeloid leukocytes, placental villous trophoblasts, and blood cells. The gene's involvement in immune system regulation and disease suggests its potential as a therapeutic target for various conditions, including: 1. **Autoimmune diseases**: PSMD13's role in antigen processing and presentation makes it a potential target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: PSMD13's involvement in cell cycle regulation and apoptosis suggests its potential as a therapeutic target for cancer treatment. 3. **Immune system disorders**: PSMD13's role in immune system regulation makes it a potential target for immune system disorders, such as immunodeficiency diseases. In conclusion, PSMD13 is a crucial component of the 26S proteasome complex, involved in various signaling pathways that regulate cellular homeostasis and disease. Its significant expression in various tissues and potential as a therapeutic target make it an important area of research for understanding immune system regulation and developing novel treatments for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 13

Genular Protein ID: 2570671359

Symbol: PSD13_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 13

UniProtKB Accession Codes:

Q9UNM6 B3KT15 O75831 Q53XU2 Q9UNV3

Database IDs:

Citations:

PubMed ID: 9714768

Title: cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome.

PubMed ID: 9714768

DOI: 10.1016/s0378-1119(98)00309-6

PubMed ID: 10225435

Title: Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome.

PubMed ID: 10225435

DOI: 10.1016/s0014-5793(99)00403-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

Sequence Information:

Length: 376
Mass: 42945
Checksum: E96C99A49CAC5ED3
Sequence:

MKDVPGFLQQ SQNSGPGQPA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY 
ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT REKVKSSDEA VILCKTAIGA 
LKLNIGDLQV TKETIEDVEE MLNNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL 
GCVDIKDLPV SEQQERAFTL GLAGLLGEGV FNFGELLMHP VLESLRNTDR QWLIDTLYAF 
NSGNVERFQT LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA 
KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV 
KSMEMLVEHQ AHDILT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD13

Associated with

Cells (max top 100)

Other Information

cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. PubMed ID: 9714768

Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome. PubMed ID: 10225435

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924