PTGS2 | ENSG00000073756 | NCBI 5743

Details for: PTGS2

Gene ID: 5743

Symbol: PTGS2

Ensembl ID: ENSG00000073756

Description: prostaglandin-endoperoxide synthase 2

Associated with

Arachidonate metabolism
(R-HSA-2142753)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of dpa-derived spms
(R-HSA-9018683)
Biosynthesis of dpan-3 spms
(R-HSA-9025094)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-HSA-9027604)
Biosynthesis of epa-derived spms
(R-HSA-9018679)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cytokine signaling in immune system
(R-HSA-1280215)
Fatty acid metabolism
(R-HSA-8978868)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Metabolism of water-soluble vitamins and cofactors
(R-HSA-196849)
Nicotinamide salvaging
(R-HSA-197264)
Nicotinate metabolism
(R-HSA-196807)
Signaling by interleukins
(R-HSA-449147)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-HSA-2142770)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-HSA-2162123)
Angiogenesis
(GO:0001525)
Bone mineralization
(GO:0030282)
Brown fat cell differentiation
(GO:0050873)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to atp
(GO:0071318)
Cellular response to fluid shear stress
(GO:0071498)
Cellular response to heat
(GO:0034605)
Cellular response to homocysteine
(GO:1905375)
Cellular response to hypoxia
(GO:0071456)
Cellular response to lead ion
(GO:0071284)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to non-ionic osmotic stress
(GO:0071471)
Cyclooxygenase pathway
(GO:0019371)
Cytoplasm
(GO:0005737)
Decidualization
(GO:0046697)
Embryo implantation
(GO:0007566)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Enzyme binding
(GO:0019899)
Hair cycle
(GO:0042633)
Heme binding
(GO:0020037)
Learning
(GO:0007612)
Maintenance of blood-brain barrier
(GO:0035633)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
(GO:1902219)
Negative regulation of smooth muscle contraction
(GO:0045986)
Negative regulation of synaptic transmission, dopaminergic
(GO:0032227)
Nuclear inner membrane
(GO:0005637)
Nuclear outer membrane
(GO:0005640)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Peroxidase activity
(GO:0004601)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of brown fat cell differentiation
(GO:0090336)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of fibroblast growth factor production
(GO:0090271)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of platelet-derived growth factor production
(GO:0090362)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of synaptic plasticity
(GO:0031915)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of transforming growth factor beta production
(GO:0071636)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Positive regulation of vasoconstriction
(GO:0045907)
Prostaglandin-endoperoxide synthase activity
(GO:0004666)
Prostaglandin biosynthetic process
(GO:0001516)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of blood pressure
(GO:0008217)
Regulation of inflammatory response
(GO:0050727)
Regulation of neuroinflammatory response
(GO:0150077)
Response to angiotensin
(GO:1990776)
Response to estradiol
(GO:0032355)
Response to fatty acid
(GO:0070542)
Response to fructose
(GO:0009750)
Response to glucocorticoid
(GO:0051384)
Response to manganese ion
(GO:0010042)
Response to nematode
(GO:0009624)
Response to oxidative stress
(GO:0006979)
Response to selenium ion
(GO:0010269)
Response to tumor necrosis factor
(GO:0034612)
Response to vitamin d
(GO:0033280)
Response to xenobiotic stimulus
(GO:0009410)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 109.0358
Cell Significance Index: -16.9600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 63.2778
Cell Significance Index: -16.0500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 33.3779
Cell Significance Index: -13.5600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.9988
Cell Significance Index: -14.3200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.7475
Cell Significance Index: -16.9500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 6.6662
Cell Significance Index: 191.0900
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 5.1698
Cell Significance Index: 24.6200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.2777
Cell Significance Index: -16.8800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.7524
Cell Significance Index: 142.9800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.6452
Cell Significance Index: 72.0000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.5261
Cell Significance Index: 154.8800
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.3907
Cell Significance Index: 7.1100
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.3222
Cell Significance Index: 25.6500
Cell Name: peg cell (CL4033014)
Fold Change: 1.9257
Cell Significance Index: 44.4900
Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.5548
Cell Significance Index: 8.9200
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.3193
Cell Significance Index: 14.4000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1855
Cell Significance Index: 37.9700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7865
Cell Significance Index: 100.8300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7792
Cell Significance Index: 148.3000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7272
Cell Significance Index: 397.1200
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.6217
Cell Significance Index: 3.8500
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.5694
Cell Significance Index: 6.0500
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5235
Cell Significance Index: 8.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4847
Cell Significance Index: 47.9500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4547
Cell Significance Index: 55.9100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4076
Cell Significance Index: 368.0400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2838
Cell Significance Index: 5.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2488
Cell Significance Index: 40.4700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1841
Cell Significance Index: 20.0300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1641
Cell Significance Index: 19.1200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1281
Cell Significance Index: 25.7000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0893
Cell Significance Index: 16.1000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0878
Cell Significance Index: 1.2500
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.0687
Cell Significance Index: 1.1800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0596
Cell Significance Index: 2.8000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0573
Cell Significance Index: 1.2200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0416
Cell Significance Index: 2.5000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0008
Cell Significance Index: 0.3600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0006
Cell Significance Index: -0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0044
Cell Significance Index: -8.3200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0063
Cell Significance Index: -3.9800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0078
Cell Significance Index: -4.8800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0085
Cell Significance Index: -6.2600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0111
Cell Significance Index: -0.5800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0111
Cell Significance Index: -8.3700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0120
Cell Significance Index: -6.7400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0126
Cell Significance Index: -19.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0142
Cell Significance Index: -0.4100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0143
Cell Significance Index: -19.4300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0188
Cell Significance Index: -0.4700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0199
Cell Significance Index: -9.0400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0214
Cell Significance Index: -15.7000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0343
Cell Significance Index: -7.2300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0366
Cell Significance Index: -0.5000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0371
Cell Significance Index: -1.6800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0388
Cell Significance Index: -0.8400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0409
Cell Significance Index: -14.6600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0430
Cell Significance Index: -6.2500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0470
Cell Significance Index: -8.0300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0485
Cell Significance Index: -13.9600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0587
Cell Significance Index: -8.0600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0621
Cell Significance Index: -1.6600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0648
Cell Significance Index: -3.2800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0721
Cell Significance Index: -7.3600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0757
Cell Significance Index: -0.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0805
Cell Significance Index: -15.9700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0973
Cell Significance Index: -3.9900
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0993
Cell Significance Index: -0.8100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1170
Cell Significance Index: -15.1100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1224
Cell Significance Index: -13.9700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.1321
Cell Significance Index: -1.1400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1399
Cell Significance Index: -0.8400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1510
Cell Significance Index: -17.8100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1521
Cell Significance Index: -17.4200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1622
Cell Significance Index: -16.8900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1659
Cell Significance Index: -2.5000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1755
Cell Significance Index: -3.6400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1786
Cell Significance Index: -12.6300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2231
Cell Significance Index: -10.4000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2261
Cell Significance Index: -16.8500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2264
Cell Significance Index: -6.0500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2315
Cell Significance Index: -6.4700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2477
Cell Significance Index: -15.9800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2532
Cell Significance Index: -19.4300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2612
Cell Significance Index: -17.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2921
Cell Significance Index: -17.9600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2981
Cell Significance Index: -15.6500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3029
Cell Significance Index: -11.1200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3160
Cell Significance Index: -2.9100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3459
Cell Significance Index: -19.4100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4029
Cell Significance Index: -13.1900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4085
Cell Significance Index: -14.3100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.4193
Cell Significance Index: -5.8900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4393
Cell Significance Index: -13.9900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4424
Cell Significance Index: -19.5700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4658
Cell Significance Index: -7.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4711
Cell Significance Index: -16.3700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4895
Cell Significance Index: -8.6500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4921
Cell Significance Index: -21.4000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5179
Cell Significance Index: -19.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Enzyme Function:** PTGS2 catalyzes the conversion of arachidonic acid into prostaglandin H2 (PGH2), which is then converted into various prostaglandins and thromboxanes by other enzymes. 2. **Expression Pattern:** PTGS2 is highly expressed in fibroblasts of connective tissue, prostate, and mammary gland, as well as in immune cells like basophils and neutrophils. 3. **Isoform:** There are two isoforms of PTGS2, PHS I and PHS II, which differ in their N-terminal sequence and tissue expression patterns. 4. **Regulation:** PTGS2 expression is regulated by various factors, including transcriptional activators and inhibitors, as well as post-translational modifications. **Pathways and Functions:** 1. **Arachidonic Acid Metabolism:** PTGS2 is involved in the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. 2. **Inflammation:** PTGS2-derived prostaglandins and thromboxanes play key roles in mediating inflammation, including pain, fever, and immune responses. 3. **Cell Signaling:** PTGS2 products interact with various receptors and signaling pathways, influencing cell proliferation, differentiation, and survival. 4. **Cancer:** Dysregulation of PTGS2 has been implicated in various cancers, including prostate, breast, and colon cancer. 5. **Cardiovascular Disease:** PTGS2-derived prostaglandins and thromboxanes contribute to cardiovascular disease, including hypertension, atherosclerosis, and thrombosis. **Clinical Significance:** 1. **Cancer Therapy:** PTGS2 inhibitors have been investigated as potential cancer therapeutics, targeting the biosynthesis of prostaglandins and thromboxanes. 2. **Inflammatory Disorders:** PTGS2 inhibitors have been explored as treatments for inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. 3. **Cardiovascular Disease:** PTGS2 inhibitors may offer therapeutic benefits in cardiovascular disease, including hypertension and atherosclerosis. 4. **Neurological Disorders:** PTGS2-derived prostaglandins and thromboxanes have been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 5. **Pregnancy Complications:** PTGS2 expression is altered during pregnancy, and its dysregulation has been linked to complications such as preeclampsia and preterm labor. In conclusion, PTGS2 is a critical enzyme involved in various physiological and pathological processes, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms of PTGS2 and its clinical significance, and to explore its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PHS II

Genular Protein ID: 3432922835

Symbol: PGH2_HUMAN

Name: PHS II

UniProtKB Accession Codes:

P35354 A8K802 Q16876

Database IDs:

Citations:

PubMed ID: 8473346

Title: Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

PubMed ID: 8473346

DOI: 10.1016/s0021-9258(18)52976-8

PubMed ID: 1380156

Title: Human cyclooxygenase-2 cDNA.

PubMed ID: 1380156

DOI: 10.1073/pnas.89.16.7384

PubMed ID: 8181472

Title: Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2.

PubMed ID: 8181472

DOI: 10.1111/j.1432-1033.1994.tb18804.x

PubMed ID: 7945196

Title: Structure of the human cyclo-oxygenase-2 gene.

PubMed ID: 7945196

DOI: 10.1042/bj3020723

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7947975

Title: Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system.

PubMed ID: 7947975

DOI: 10.1016/0167-4838(94)90148-1

PubMed ID: 7592599

Title: Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2.

PubMed ID: 7592599

DOI: 10.1074/jbc.270.41.24019

PubMed ID: 9048568

Title: Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.

PubMed ID: 9048568

DOI: 10.1021/bi962476u

PubMed ID: 9261177

Title: Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation.

PubMed ID: 9261177

DOI: 10.1074/jbc.272.34.21565

PubMed ID: 9545330

Title: Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.

PubMed ID: 9545330

DOI: 10.1074/jbc.273.16.9886

PubMed ID: 11034610

Title: Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.

PubMed ID: 11034610

DOI: 10.1084/jem.192.8.1197

PubMed ID: 11192938

Title: Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions.

PubMed ID: 11192938

PubMed ID: 11939906

Title: Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.

PubMed ID: 11939906

DOI: 10.1042/bj20011798

PubMed ID: 12391014

Title: Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.

PubMed ID: 12391014

DOI: 10.1084/jem.20020760

PubMed ID: 16373578

Title: Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.

PubMed ID: 16373578

DOI: 10.1126/science.1119407

PubMed ID: 17113084

Title: Glycosylation regulates turnover of cyclooxygenase-2.

PubMed ID: 17113084

DOI: 10.1016/j.febslet.2006.10.073

PubMed ID: 21206090

Title: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

PubMed ID: 21206090

DOI: 10.1172/jci42545

PubMed ID: 22942274

Title: Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid.

PubMed ID: 22942274

DOI: 10.1074/jbc.m112.381202

PubMed ID: 22068350

Title: COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes.

PubMed ID: 22068350

DOI: 10.1194/jlr.m017822

PubMed ID: 26282205

Title: Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway.

PubMed ID: 26282205

DOI: 10.1016/j.bbrc.2015.08.054

PubMed ID: 26236990

Title: Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.

PubMed ID: 26236990

DOI: 10.1038/nm.3911

PubMed ID: 27642067

Title: Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways.

PubMed ID: 27642067

DOI: 10.1016/j.chembiol.2016.08.009

PubMed ID: 10966456

Title: Cyclooxygenases: structural, cellular, and molecular biology.

PubMed ID: 10966456

DOI: 10.1146/annurev.biochem.69.1.145

PubMed ID: 19540099

Title: The essentiality of arachidonic acid and docosahexaenoic acid.

PubMed ID: 19540099

DOI: 10.1016/j.plefa.2009.05.020

PubMed ID: 24605250

Title: Aspirin, cyclooxygenase inhibition and colorectal cancer.

PubMed ID: 24605250

DOI: 10.4292/wjgpt.v5.i1.40

PubMed ID: 27710942

Title: Crystal structure of rofecoxib bound to human cyclooxygenase-2.

PubMed ID: 27710942

DOI: 10.1107/s2053230x16014230

PubMed ID: 26859324

Title: Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.

PubMed ID: 26859324

DOI: 10.1021/acs.biochem.5b01378

PubMed ID: 27226593

Title: Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.

PubMed ID: 27226593

DOI: 10.1074/jbc.m116.725713

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

Sequence Information:

Length: 604
Mass: 68996
Checksum: 72FBD699F6128519
Sequence:

MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY GENCSTPEFL 
TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS YVLTSRSHLI DSPPTYNADY 
GYKSWEAFSN LSYYTRALPP VPDDCPTPLG VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS 
NMMFAFFAQH FTHQFFKTDH KRGPAFTNGL GHGVDLNHIY GETLARQRKL RLFKDGKMKY 
QIIDGEMYPP TVKDTQAEMI YPPQVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD 
VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNKQFQYQ 
NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL LEHGITQFVE SFTRQIAGRV 
AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN EYRKRFMLKP YESFEELTGE KEMSAELEAL 
YGDIDAVELY PALLVEKPRP DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV 
GFQIINTASI QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER 
STEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PTGS2

Associated with

Cells (max top 100)

Other Information

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. PubMed ID: 8473346

Human cyclooxygenase-2 cDNA. PubMed ID: 1380156

Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. PubMed ID: 8181472

Structure of the human cyclo-oxygenase-2 gene. PubMed ID: 7945196

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. PubMed ID: 7947975

Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2. PubMed ID: 7592599

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2. PubMed ID: 9048568

Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation. PubMed ID: 9261177

Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. PubMed ID: 9545330

Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. PubMed ID: 11034610

Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. PubMed ID: 11192938

Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. PubMed ID: 11939906

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. PubMed ID: 12391014

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. PubMed ID: 16373578

Glycosylation regulates turnover of cyclooxygenase-2. PubMed ID: 17113084

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. PubMed ID: 21206090

Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid. PubMed ID: 22942274

COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes. PubMed ID: 22068350

Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway. PubMed ID: 26282205

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. PubMed ID: 26236990

Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways. PubMed ID: 27642067

Cyclooxygenases: structural, cellular, and molecular biology. PubMed ID: 10966456

The essentiality of arachidonic acid and docosahexaenoic acid. PubMed ID: 19540099

Aspirin, cyclooxygenase inhibition and colorectal cancer. PubMed ID: 24605250

Crystal structure of rofecoxib bound to human cyclooxygenase-2. PubMed ID: 27710942

Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. PubMed ID: 26859324

Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. PubMed ID: 27226593

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. PubMed ID: 15308583