Details for: PVT1

Gene ID: 5820

Symbol: PVT1

Ensembl ID: ENSG00000249859

Description: Pvt1 oncogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1711
    Cell Significance Index: -31.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.8025
    Cell Significance Index: 235.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4244
    Cell Significance Index: -17.2100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.1279
    Cell Significance Index: 19.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2133
    Cell Significance Index: 439.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1852
    Cell Significance Index: 62.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.1455
    Cell Significance Index: 52.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8681
    Cell Significance Index: 87.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7767
    Cell Significance Index: 637.2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6860
    Cell Significance Index: 27.0500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.1506
    Cell Significance Index: 16.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0390
    Cell Significance Index: 208.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9389
    Cell Significance Index: 178.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8694
    Cell Significance Index: 32.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.8201
    Cell Significance Index: 10.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.8193
    Cell Significance Index: 4.9500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.7268
    Cell Significance Index: 9.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7228
    Cell Significance Index: 31.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6505
    Cell Significance Index: 43.7400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6092
    Cell Significance Index: 9.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5725
    Cell Significance Index: 56.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5490
    Cell Significance Index: 64.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4059
    Cell Significance Index: 366.5000
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.3266
    Cell Significance Index: 3.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3241
    Cell Significance Index: 52.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3148
    Cell Significance Index: 34.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3050
    Cell Significance Index: 18.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2654
    Cell Significance Index: 76.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2513
    Cell Significance Index: 32.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2400
    Cell Significance Index: 17.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2372
    Cell Significance Index: 32.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2154
    Cell Significance Index: 5.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1604
    Cell Significance Index: 4.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1426
    Cell Significance Index: 4.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1407
    Cell Significance Index: 76.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1184
    Cell Significance Index: 14.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0947
    Cell Significance Index: 2.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0896
    Cell Significance Index: 168.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0784
    Cell Significance Index: 5.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0686
    Cell Significance Index: 43.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0447
    Cell Significance Index: 3.4300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0417
    Cell Significance Index: 0.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0410
    Cell Significance Index: 0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0336
    Cell Significance Index: 6.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0182
    Cell Significance Index: 1.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0173
    Cell Significance Index: 0.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0120
    Cell Significance Index: 5.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -7.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0121
    Cell Significance Index: -5.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0187
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0247
    Cell Significance Index: -18.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0257
    Cell Significance Index: -0.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0259
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0272
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0302
    Cell Significance Index: -22.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0324
    Cell Significance Index: -1.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0442
    Cell Significance Index: -24.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0503
    Cell Significance Index: -3.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0509
    Cell Significance Index: -7.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0729
    Cell Significance Index: -3.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0973
    Cell Significance Index: -6.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1031
    Cell Significance Index: -12.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1164
    Cell Significance Index: -24.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1225
    Cell Significance Index: -12.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1269
    Cell Significance Index: -7.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1368
    Cell Significance Index: -9.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1545
    Cell Significance Index: -8.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1640
    Cell Significance Index: -3.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1764
    Cell Significance Index: -8.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1776
    Cell Significance Index: -30.3300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1847
    Cell Significance Index: -2.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2065
    Cell Significance Index: -2.9700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2147
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2210
    Cell Significance Index: -25.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2309
    Cell Significance Index: -29.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2316
    Cell Significance Index: -5.3500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.2338
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2348
    Cell Significance Index: -4.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2371
    Cell Significance Index: -5.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2702
    Cell Significance Index: -6.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2885
    Cell Significance Index: -6.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2887
    Cell Significance Index: -7.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3291
    Cell Significance Index: -10.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3331
    Cell Significance Index: -10.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3571
    Cell Significance Index: -3.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3571
    Cell Significance Index: -6.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3736
    Cell Significance Index: -3.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3857
    Cell Significance Index: -24.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3931
    Cell Significance Index: -13.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3943
    Cell Significance Index: -5.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3962
    Cell Significance Index: -8.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4098
    Cell Significance Index: -13.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4118
    Cell Significance Index: -21.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4584
    Cell Significance Index: -5.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4881
    Cell Significance Index: -8.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4882
    Cell Significance Index: -17.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5095
    Cell Significance Index: -13.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PVT1 is a 2.2-kb long lncRNA that is transcribed from the PVT1 gene located on chromosome 1q25.3. It is characterized by a unique structure, with a long, unspliced primary transcript that is processed into a mature RNA molecule. PVT1 is highly expressed in various cell types, including cancer cells, and its expression levels have been correlated with tumor progression and poor prognosis in several types of cancer. Notably, PVT1 is also expressed in non-cancerous tissues, including cortical cells of the adrenal gland, corneal endothelial cells, and cardiac endothelial cells. **Pathways and Functions:** PVT1 has been implicated in several cellular pathways, including the PI3K/AKT, MAPK/ERK, and Wnt/β-catenin signaling pathways. These pathways are critical for cell growth, differentiation, and survival, and their dysregulation has been linked to various diseases, including cancer. PVT1 has been shown to act as a tumor suppressor by inhibiting cell growth and inducing apoptosis in cancer cells. Additionally, PVT1 has been implicated in the regulation of cell migration and invasion, two critical processes in cancer metastasis. In addition to its oncogenic properties, PVT1 has also been shown to play a role in the regulation of cell differentiation and survival in non-cancerous tissues. For example, PVT1 has been implicated in the regulation of GABAergic cortical interneuron development and function in the brain. **Clinical Significance:** PVT1 has been implicated in several diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. In cancer, PVT1 has been shown to be a prognostic marker, with high expression levels associated with poor prognosis and shorter survival times. PVT1 has also been implicated in the development and progression of various types of cancer, including breast, lung, and colon cancer. In addition to its role in cancer, PVT1 has also been implicated in cardiovascular disease, where it has been shown to regulate cell growth and survival in cardiac endothelial cells. Furthermore, PVT1 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where it has been shown to regulate cell differentiation and survival in GABAergic cortical interneurons. **Conclusion:** PVT1 is a multifaceted oncogene with widespread expression in various cell types. Its dysregulation has been implicated in the development and progression of several diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further studies are needed to fully elucidate the mechanisms by which PVT1 regulates cellular processes and to explore its potential as a therapeutic target for these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.