PVT1 | ENSG00000249859 | NCBI 5820

Details for: PVT1

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 20.58

rCSI 14.46%

PRS 95.65
class switched memory B cell CL0000972

CSI 13.37

rCSI 9.98%

PRS 95.65
T follicular helper cell CL0002038

CSI 12.39

rCSI 9.27%

PRS 96
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 11.61

rCSI 25.19%

PRS 76.86
mucosal invariant T cell CL0000940

CSI 11.14

rCSI 9%

PRS 93.52
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 11.08

rCSI 12.79%

PRS 80.95
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 10.97

rCSI 39.49%

PRS 71.71
CD4-positive, alpha-beta memory T cell CL0000897

CSI 9.9

rCSI 7.11%

PRS 96.68
Kupffer cell CL0000091

CSI 9.77

rCSI 22.34%

PRS 89.07
epithelial cell of lower respiratory tract CL0002632

CSI 9.59

rCSI 7.44%

PRS 91.11
stromal cell of ovary CL0002132

CSI 9.45

rCSI 25.96%

PRS 91.83
alpha-beta T cell CL0000789

CSI 9.4

rCSI 11.01%

PRS 96.31
megakaryocyte-erythroid progenitor cell CL0000050

CSI 8.94

rCSI 8.07%

PRS 87.02
alveolar adventitial fibroblast CL4028006

CSI 8.62

rCSI 13.61%

PRS 89.01
innate lymphoid cell CL0001065

CSI 8.35

rCSI 17.25%

PRS 83.17
respiratory basal cell CL0002633

CSI 7.68

rCSI 7.96%

PRS 90.19
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 7.34

rCSI 4.34%

PRS 97.78
VIP GABAergic cortical interneuron CL4023016

CSI 7.32

rCSI 8.74%

PRS 73.85
Bergmann glial cell CL0000644

CSI 7.01

rCSI 9.59%

PRS 80.13
sncg GABAergic cortical interneuron CL4023015

CSI 6.99

rCSI 11.25%

PRS 74.86
blood vessel endothelial cell CL0000071

CSI 6.85

rCSI 14.21%

PRS 86.06
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 6.43

rCSI 6.31%

PRS 96.66
helper T cell CL0000912

CSI 6.09

rCSI 8.62%

PRS 84.76
chondrocyte CL0000138

CSI 6.03

rCSI 9.59%

PRS 82.93
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 5.93

rCSI 14.42%

PRS 71.48
endothelial cell of placenta CL0009092

CSI 5.71

rCSI 28.12%

PRS 92.72
L6b glutamatergic cortical neuron CL4023038

CSI 5.42

rCSI 16.94%

PRS 75.17
fibroblast of cardiac tissue CL0002548

CSI 5.35

rCSI 25.64%

PRS 88.71
mesothelial cell CL0000077

CSI 4.91

rCSI 19.19%

PRS 69.66
inhibitory interneuron CL0000498

CSI 4.87

rCSI 11.25%

PRS 78.35
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 4.87

rCSI 16%

PRS 75.92
cerebral cortex endothelial cell CL1001602

CSI 4.85

rCSI 8.39%

PRS 81.97
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.7

rCSI 8.3%

PRS 73.22
retinal blood vessel endothelial cell CL0002585

CSI 4.69

rCSI 7.49%

PRS 91.05
melanocyte CL0000148

CSI 4.64

rCSI 3.44%

PRS 83.66
glutamatergic neuron CL0000679

CSI 4.62

rCSI 9.49%

PRS 76.1
conjunctival epithelial cell CL1000432

CSI 4.29

rCSI 6.55%

PRS 87.48
astrocyte of the cerebral cortex CL0002605

CSI 4.23

rCSI 9.49%

PRS 74.34
endocardial cell CL0002350

CSI 4.19

rCSI 20.05%

PRS 84.19
cardiac endothelial cell CL0010008

CSI 4.15

rCSI 16.73%

PRS 88.67
interneuron CL0000099

CSI 4.09

rCSI 8.21%

PRS 81.26
intermediate monocyte CL0002393

CSI 4.08

rCSI 6.16%

PRS 92.32
hepatic stellate cell CL0000632

CSI 4.01

rCSI 15.01%

PRS 82.79
granulocyte CL0000094

CSI 3.96

rCSI 6.05%

PRS 93.06
extravillous trophoblast CL0008036

CSI 3.94

rCSI 4.87%

PRS 86.68
epithelial cell of proximal tubule CL0002306

CSI 3.85

rCSI 9.41%

PRS 81.15
endothelial cell of vascular tree CL0002139

CSI 3.83

rCSI 20.92%

PRS 84.76
cerebral cortex neuron CL0010012

CSI 3.75

rCSI 15.29%

PRS 80.71
luminal epithelial cell of mammary gland CL0002326

CSI 3.72

rCSI 6.76%

PRS 93.93
brush cell of tracheobronchial tree CL0002075

CSI 3.69

rCSI 10.94%

PRS 94.09
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.5

rCSI 9.06%

PRS 84.73
myoepithelial cell CL0000185

CSI 3.49

rCSI 8.84%

PRS 91.17
glioblast CL0000030

CSI 3.37

rCSI 5.37%

PRS 80.44
respiratory suprabasal cell CL4033048

CSI 3.35

rCSI 4.29%

PRS 90.1
parietal epithelial cell CL1000452

CSI 3.31

rCSI 8.84%

PRS 81.88
mature T cell CL0002419

CSI 3.29

rCSI 2.56%

PRS 96.25
alveolar macrophage CL0000583

CSI 3.25

rCSI 5.35%

PRS 90.4
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.24

rCSI 8.45%

PRS 89.45
vascular associated smooth muscle cell CL0000359

CSI 3.24

rCSI 10.5%

PRS 86.25
renal interstitial pericyte CL1001318

CSI 3.21

rCSI 8.85%

PRS 84.83
lung ciliated cell CL1000271

CSI 3.13

rCSI 3.61%

PRS 82.1
kidney connecting tubule epithelial cell CL1000768

CSI 3.05

rCSI 7.73%

PRS 80.95
lamp5 GABAergic cortical interneuron CL4023011

CSI 3.02

rCSI 5.08%

PRS 73.7
activated CD4-positive, alpha-beta T cell CL0000896

CSI 3.01

rCSI 2.78%

PRS 97.02
IgG plasma cell CL0000985

CSI 2.92

rCSI 3.49%

PRS 93.36
renal principal cell CL0005009

CSI 2.8

rCSI 7.28%

PRS 87.68
skeletal muscle satellite stem cell CL0008011

CSI 2.76

rCSI 12.29%

PRS 94.16
adipocyte CL0000136

CSI 2.75

rCSI 3.53%

PRS 79.25
sst GABAergic cortical interneuron CL4023017

CSI 2.67

rCSI 3.45%

PRS 74.83
amacrine cell CL0000561

CSI 2.67

rCSI 7.73%

PRS 79.17
epicardial adipocyte CL1000309

CSI 2.62

rCSI 8.52%

PRS 85.3
plasmablast CL0000980

CSI 2.62

rCSI 2.06%

PRS 91.05
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.61

rCSI 10.16%

PRS 97.01
vascular leptomeningeal cell CL4023051

CSI 2.57

rCSI 4.5%

PRS 83.94
elicited macrophage CL0000861

CSI 2.54

rCSI 2.33%

PRS 93.23
pvalb GABAergic cortical interneuron CL4023018

CSI 2.39

rCSI 2.98%

PRS 71.51
lung secretory cell CL1000272

CSI 2.32

rCSI 5.75%

PRS 88.48
T-helper 17 cell CL0000899

CSI 2.31

rCSI 1.83%

PRS 97.58
erythroid lineage cell CL0000764

CSI 2.31

rCSI 14.85%

PRS 92.11
ON midget ganglion cell CL4033046

CSI 2.29

rCSI 46.57%

PRS 78.95
basal-myoepithelial cell of mammary gland CL0002324

CSI 2.27

rCSI 4.3%

PRS 94.12
basal cell CL0000646

CSI 2.23

rCSI 2.98%

PRS 85.55
near-projecting glutamatergic cortical neuron CL4023012

CSI 2.2

rCSI 8.32%

PRS 74
stem cell CL0000034

CSI 2.12

rCSI 2.04%

PRS 83.58
OFF midget ganglion cell CL4033047

CSI 2.06

rCSI 41.91%

PRS 79.75
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 2.06

rCSI 12.1%

PRS 74.21
GABAergic amacrine cell CL4030027

CSI 2.04

rCSI 7%

PRS 75.16
CD14-low, CD16-positive monocyte CL0002396

CSI 1.99

rCSI 1.53%

PRS 91.29
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.99

rCSI 11.09%

PRS 89.33
CD14-positive monocyte CL0001054

CSI 1.97

rCSI 2.45%

PRS 94.29
indirect pathway medium spiny neuron CL4023029

CSI 1.9

rCSI 45.85%

PRS 71.72
choroid plexus epithelial cell CL0000706

CSI 1.81

rCSI 2.97%

PRS 80.13
direct pathway medium spiny neuron CL4023026

CSI 1.75

rCSI 41.86%

PRS 71.3
erythroid progenitor cell CL0000038

CSI 1.75

rCSI 10.01%

PRS 90.98
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.55

rCSI 2.82%

PRS 81.21
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.52

rCSI 4.36%

PRS 97.87
placental villous trophoblast CL2000060

CSI 1.41

rCSI 2.19%

PRS 86.79
tissue-resident macrophage CL0000864

CSI 1.35

rCSI 6.31%

PRS 95.09
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.33

rCSI 3.19%

PRS 76.97
keratocyte CL0002363

CSI 1.24

rCSI 2.99%

PRS 89.48

starburst amacrine cell CL0004232

CSI 0.6

rCSI 5.3%

PRS 75.1%
blood vessel smooth muscle cell CL0019018

CSI 0.6

rCSI 5.2%

PRS 84.4%
primitive red blood cell CL0002355

CSI 0.7

rCSI 3.6%

PRS 90.9%
erythroblast CL0000765

CSI 0.7

rCSI 1.9%

PRS 90.4%
airway submucosal gland duct basal cell CL4033024

CSI 1.1

rCSI 6.7%

PRS 90.0%
stromal cell CL0000499

CSI 1.1

rCSI 3.1%

PRS 83.9%
retinal ganglion cell CL0000740

CSI 1.2

rCSI 2.6%

PRS 76.6%
mature alpha-beta T cell CL0000791

CSI 1.2

rCSI 4.2%

PRS 97.6%
keratocyte CL0002363

CSI 1.2

rCSI 3.0%

PRS 89.5%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.3

rCSI 3.2%

PRS 77.0%
tissue-resident macrophage CL0000864

CSI 1.4

rCSI 6.3%

PRS 95.1%
placental villous trophoblast CL2000060

CSI 1.4

rCSI 2.2%

PRS 86.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.5

rCSI 4.4%

PRS 97.9%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.6

rCSI 2.8%

PRS 81.2%
erythroid progenitor cell CL0000038

CSI 1.8

rCSI 10.0%

PRS 91.0%
direct pathway medium spiny neuron CL4023026

CSI 1.8

rCSI 41.9%

PRS 71.3%
choroid plexus epithelial cell CL0000706

CSI 1.8

rCSI 3.0%

PRS 80.1%
indirect pathway medium spiny neuron CL4023029

CSI 1.9

rCSI 45.9%

PRS 71.7%
CD14-positive monocyte CL0001054

CSI 2.0

rCSI 2.5%

PRS 94.3%
mesenchymal stem cell of adipose tissue CL0002570

CSI 2.0

rCSI 11.1%

PRS 89.3%
CD14-low, CD16-positive monocyte CL0002396

CSI 2.0

rCSI 1.5%

PRS 91.3%
GABAergic amacrine cell CL4030027

CSI 2.0

rCSI 7.0%

PRS 75.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 2.1

rCSI 12.1%

PRS 74.2%
OFF midget ganglion cell CL4033047

CSI 2.1

rCSI 41.9%

PRS 79.8%
stem cell CL0000034

CSI 2.1

rCSI 2.0%

PRS 83.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 2.2

rCSI 8.3%

PRS 74.0%
basal cell CL0000646

CSI 2.2

rCSI 3.0%

PRS 85.6%
basal-myoepithelial cell of mammary gland CL0002324

CSI 2.3

rCSI 4.3%

PRS 94.1%
ON midget ganglion cell CL4033046

CSI 2.3

rCSI 46.6%

PRS 79.0%
erythroid lineage cell CL0000764

CSI 2.3

rCSI 14.9%

PRS 92.1%
T-helper 17 cell CL0000899

CSI 2.3

rCSI 1.8%

PRS 97.6%
lung secretory cell CL1000272

CSI 2.3

rCSI 5.8%

PRS 88.5%
pvalb GABAergic cortical interneuron CL4023018

CSI 2.4

rCSI 3.0%

PRS 71.5%
elicited macrophage CL0000861

CSI 2.5

rCSI 2.3%

PRS 93.2%
vascular leptomeningeal cell CL4023051

CSI 2.6

rCSI 4.5%

PRS 83.9%
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.6

rCSI 10.2%

PRS 97.0%
plasmablast CL0000980

CSI 2.6

rCSI 2.1%

PRS 91.1%
epicardial adipocyte CL1000309

CSI 2.6

rCSI 8.5%

PRS 85.3%
amacrine cell CL0000561

CSI 2.7

rCSI 7.7%

PRS 79.2%
sst GABAergic cortical interneuron CL4023017

CSI 2.7

rCSI 3.5%

PRS 74.8%
adipocyte CL0000136

CSI 2.8

rCSI 3.5%

PRS 79.3%
skeletal muscle satellite stem cell CL0008011

CSI 2.8

rCSI 12.3%

PRS 94.2%
renal principal cell CL0005009

CSI 2.8

rCSI 7.3%

PRS 87.7%
IgG plasma cell CL0000985

CSI 2.9

rCSI 3.5%

PRS 93.4%
activated CD4-positive, alpha-beta T cell CL0000896

CSI 3.0

rCSI 2.8%

PRS 97.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI 3.0

rCSI 5.1%

PRS 73.7%
kidney connecting tubule epithelial cell CL1000768

CSI 3.1

rCSI 7.7%

PRS 81.0%
lung ciliated cell CL1000271

CSI 3.1

rCSI 3.6%

PRS 82.1%
renal interstitial pericyte CL1001318

CSI 3.2

rCSI 8.9%

PRS 84.8%
vascular associated smooth muscle cell CL0000359

CSI 3.2

rCSI 10.5%

PRS 86.3%
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.2

rCSI 8.5%

PRS 89.5%
alveolar macrophage CL0000583

CSI 3.3

rCSI 5.4%

PRS 90.4%
mature T cell CL0002419

CSI 3.3

rCSI 2.6%

PRS 96.3%
parietal epithelial cell CL1000452

CSI 3.3

rCSI 8.8%

PRS 81.9%
respiratory suprabasal cell CL4033048

CSI 3.4

rCSI 4.3%

PRS 90.1%
glioblast CL0000030

CSI 3.4

rCSI 5.4%

PRS 80.4%
myoepithelial cell CL0000185

CSI 3.5

rCSI 8.8%

PRS 91.2%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.5

rCSI 9.1%

PRS 84.7%
brush cell of tracheobronchial tree CL0002075

CSI 3.7

rCSI 10.9%

PRS 94.1%
luminal epithelial cell of mammary gland CL0002326

CSI 3.7

rCSI 6.8%

PRS 93.9%
cerebral cortex neuron CL0010012

CSI 3.8

rCSI 15.3%

PRS 80.7%
endothelial cell of vascular tree CL0002139

CSI 3.8

rCSI 20.9%

PRS 84.8%
epithelial cell of proximal tubule CL0002306

CSI 3.9

rCSI 9.4%

PRS 81.2%
extravillous trophoblast CL0008036

CSI 3.9

rCSI 4.9%

PRS 86.7%
granulocyte CL0000094

CSI 4.0

rCSI 6.1%

PRS 93.1%
hepatic stellate cell CL0000632

CSI 4.0

rCSI 15.0%

PRS 82.8%
intermediate monocyte CL0002393

CSI 4.1

rCSI 6.2%

PRS 92.3%
interneuron CL0000099

CSI 4.1

rCSI 8.2%

PRS 81.3%
cardiac endothelial cell CL0010008

CSI 4.2

rCSI 16.7%

PRS 88.7%
endocardial cell CL0002350

CSI 4.2

rCSI 20.1%

PRS 84.2%
astrocyte of the cerebral cortex CL0002605

CSI 4.2

rCSI 9.5%

PRS 74.3%
conjunctival epithelial cell CL1000432

CSI 4.3

rCSI 6.6%

PRS 87.5%
glutamatergic neuron CL0000679

CSI 4.6

rCSI 9.5%

PRS 76.1%
melanocyte CL0000148

CSI 4.6

rCSI 3.4%

PRS 83.7%
retinal blood vessel endothelial cell CL0002585

CSI 4.7

rCSI 7.5%

PRS 91.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.7

rCSI 8.3%

PRS 73.2%
cerebral cortex endothelial cell CL1001602

CSI 4.9

rCSI 8.4%

PRS 82.0%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 4.9

rCSI 16.0%

PRS 75.9%
inhibitory interneuron CL0000498

CSI 4.9

rCSI 11.3%

PRS 78.4%
mesothelial cell CL0000077

CSI 4.9

rCSI 19.2%

PRS 69.7%
fibroblast of cardiac tissue CL0002548

CSI 5.4

rCSI 25.6%

PRS 88.7%
L6b glutamatergic cortical neuron CL4023038

CSI 5.4

rCSI 16.9%

PRS 75.2%
endothelial cell of placenta CL0009092

CSI 5.7

rCSI 28.1%

PRS 92.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 5.9

rCSI 14.4%

PRS 71.5%
chondrocyte CL0000138

CSI 6.0

rCSI 9.6%

PRS 82.9%
helper T cell CL0000912

CSI 6.1

rCSI 8.6%

PRS 84.8%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 6.4

rCSI 6.3%

PRS 96.7%
blood vessel endothelial cell CL0000071

CSI 6.9

rCSI 14.2%

PRS 86.1%
sncg GABAergic cortical interneuron CL4023015

CSI 7.0

rCSI 11.3%

PRS 74.9%
Bergmann glial cell CL0000644

CSI 7.0

rCSI 9.6%

PRS 80.1%
VIP GABAergic cortical interneuron CL4023016

CSI 7.3

rCSI 8.7%

PRS 73.9%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 7.3

rCSI 4.3%

PRS 97.8%
respiratory basal cell CL0002633

CSI 7.7

rCSI 8.0%

PRS 90.2%
innate lymphoid cell CL0001065

CSI 8.4

rCSI 17.3%

PRS 83.2%
alveolar adventitial fibroblast CL4028006

CSI 8.6

rCSI 13.6%

PRS 89.0%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 8.9

rCSI 8.1%

PRS 87.0%
alpha-beta T cell CL0000789

CSI 9.4

rCSI 11.0%

PRS 96.3%
stromal cell of ovary CL0002132

CSI 9.5

rCSI 26.0%

PRS 91.8%
epithelial cell of lower respiratory tract CL0002632

CSI 9.6

rCSI 7.4%

PRS 91.1%
Kupffer cell CL0000091

CSI 9.8

rCSI 22.3%

PRS 89.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [PVT1](/details-gene/5820) is a long non-coding RNA (lncRNA) located on chromosome 8q24.21, a region frequently amplified in various cancers, and is described as an oncogene. The expression profile of [PVT1](/details-gene/5820) suggests it plays a significant and diverse role across multiple biological systems. **Overall**, it demonstrates particularly high significance in cell types of the adaptive immune system, including [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) and [class switched memory B cell](/details-cell/CL0000972). Concurrently, it shows prominent significance in specific neuronal populations, such as [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059), indicating a complex, pleiotropic regulatory function. ## Cellular Roles and Expression Landscape The expression landscape of [PVT1](/details-gene/5820) highlights its importance in distinct and functionally diverse cellular contexts. A primary role for [PVT1](/details-gene/5820) is strongly indicated within the immune system. It ranks as a top significant transcript in multiple lymphocyte populations, including [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) (CSI: 20.58), [class switched memory B cell](/details-cell/CL0000972) (CSI: 13.37), [T follicular helper cell](/details-cell/CL0002038) (CSI: 12.39), and [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) (CSI: 9.90). This pattern suggests its involvement in fundamental processes of lymphocyte development, activation, differentiation, and the establishment of immunological memory. Its high significance in [Kupffer cell](/details-cell/CL0000091) and [innate lymphoid cell](/details-cell/CL0001065) further expands its potential role to include tissue-resident macrophage function and innate immunity. Distinct from its immune profile, [PVT1](/details-gene/5820) also exhibits high significance in specific subtypes of neurons. It is a key marker for [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059) (CSI: 11.61), [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) (CSI: 11.08), and [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041) (CSI: 10.97). This suggests a specialized function in neuronal identity, maturation, or the maintenance of specific cortical circuits. Furthermore, the data points to a role in progenitor and stromal cells, as evidenced by its significance in [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), [alveolar adventitial fibroblast](/details-cell/CL4028006), and [stromal cell of ovary](/details-cell/CL0002132). This may indicate involvement in hematopoiesis, tissue remodeling, and organ structure maintenance. ## Research Directions Given its established role as an oncogene and its diverse expression profile, research on [PVT1](/details-gene/5820) can proceed in several promising directions. ### Testable Hypotheses 1. **[PVT1](/details-gene/5820) is a critical regulator of T-cell and B-cell memory formation.** Its high significance in both [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) and memory lymphocyte populations like [class switched memory B cell](/details-cell/CL0000972) suggests it may control the transcriptional programs that mediate the transition from a naive to a memory state. Its dysregulation in this context could contribute to lymphomagenesis. 2. **[PVT1](/details-gene/5820) is essential for the specification and long-term survival of cortical glutamatergic neurons.** The high CSI in specific L2/3 and L5 neuronal subtypes suggests a role in maintaining the molecular identity of these cells. Aberrant expression could disrupt cortical function and may be implicated in neurodevelopmental or neurodegenerative diseases. ### Proposed Key Experiment To test the hypothesis that [PVT1](/details-gene/5820) regulates lymphocyte memory, a conditional knockout mouse model could be employed. Specifically, crossing a mouse with floxed *Pvt1* alleles to a CD4-Cre mouse would allow for T-cell specific deletion of the lncRNA. Following immunization, the primary and memory T-cell responses in these knockout mice could be compared to wild-type controls using flow cytometry to quantify cell populations and single-cell RNA sequencing to analyze the transcriptional changes in responding T cells. A failure to efficiently generate or maintain memory T cells would support the hypothesis. ### Therapeutic Potential As a lncRNA oncogene, [PVT1](/details-gene/5820) presents a compelling target for therapeutic **inhibition**. Its mechanism as a non-coding RNA makes it amenable to targeting by nucleic acid-based therapeutics, such as antisense oligonucleotides (ASOs) or siRNA delivered via lipid nanoparticles. Given its expression in multiple critical cell types, including immune and neuronal cells, a key challenge will be developing strategies for targeted delivery to cancer cells to minimize off-target effects and potential toxicity in healthy tissues. Such approaches could hold promise for treating hematological malignancies or solid tumors where the 8q24 locus is amplified.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Occipital cortex UBERON0016540
	Placenta UBERON0001987
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Small cell lung carcinoma MONDO0008433
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: PVT1

Cell Significance Landscape

Significant Cells

Network Configuration

Legend:

Other Information