Details for: RAB5C
Gene ID: 5878
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RAB5C
Ensembl ID: ENSG00000108774
Description: RAB5C, member RAS oncogene family
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 43rCSI 39.16%PRS 63.48
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CSI 39.21rCSI 36%PRS 56.52
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CSI 36.23rCSI 68.4%PRS 59.12
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CSI 33.68rCSI 25.95%PRS 47.73
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CSI 33.2rCSI 34.7%PRS 47.82
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CSI 27.85rCSI 25.7%PRS 49.46
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CSI 25.45rCSI 29.52%PRS 58.41
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CSI 24.5rCSI 79.48%PRS 51.07
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CSI 24.18rCSI 32.95%PRS 41.7
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CSI 22.21rCSI 23.26%PRS 51.86
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CSI 19.32rCSI 24.25%PRS 58.67
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CSI 18.78rCSI 41.49%PRS 36.44
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CSI 16.28rCSI 47.12%PRS 50.82
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CSI 15.72rCSI 21.84%PRS 48.09
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CSI 14.94rCSI 23.09%PRS 46.46
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CSI 12.03rCSI 23.4%PRS 50.88
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CSI 11.46rCSI 15.24%PRS 53.83
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CSI 10.91rCSI 20.62%PRS 70.73
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CSI 10.58rCSI 30.33%PRS 66.96
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CSI 10.44rCSI 19.93%PRS 71.31
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CSI 10.11rCSI 16.38%PRS 46.87
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CSI 9.69rCSI 20.63%PRS 63.13
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CSI 9.42rCSI 12.59%PRS 57.23
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CSI 9.33rCSI 9.16%PRS 64.17
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CSI 8.86rCSI 60.85%PRS 66.06
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CSI 8.63rCSI 12.76%PRS 53.88
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CSI 8.33rCSI 12.7%PRS 45.21
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CSI 8.11rCSI 11.04%PRS 75.75
-
CSI 8.1rCSI 15.6%PRS 77.84
-
CSI 7.95rCSI 46.28%PRS 59.32
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CSI 7.84rCSI 10.06%PRS 53.45
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CSI 7.71rCSI 9.35%PRS 41.83
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CSI 7.24rCSI 11.23%PRS 57.77
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CSI 7.13rCSI 7.44%PRS 49.19
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CSI 7.01rCSI 5.85%PRS 67.21
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CSI 7.01rCSI 11.55%PRS 54.12
-
CSI 6.87rCSI 41.56%PRS 72.04
-
CSI 6.82rCSI 33.61%PRS 60.54
-
CSI 6.59rCSI 4.58%PRS 57.92
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CSI 6.5rCSI 15.49%PRS 50.32
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CSI 6.49rCSI 11.46%PRS 31.39
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CSI 6.37rCSI 8.7%PRS 53.72
-
CSI 6.19rCSI 5.13%PRS 47.35
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CSI 5.91rCSI 11.27%PRS 65.52
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CSI 5.86rCSI 12.17%PRS 46.42
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CSI 5.68rCSI 6.5%PRS 71.13
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CSI 5.66rCSI 4.24%PRS 63.41
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CSI 5.64rCSI 6.81%PRS 56.76
-
CSI 5.64rCSI 9.09%PRS 56.26
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CSI 5.6rCSI 16.14%PRS 65.6
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CSI 5.52rCSI 3.96%PRS 62.07
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CSI 5.51rCSI 4.08%PRS 41.96
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CSI 5.44rCSI 5.24%PRS 48.99
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CSI 5.44rCSI 4.09%PRS 52.48
-
CSI 5.3rCSI 5.11%PRS 39.33
-
CSI 5.3rCSI 6.59%PRS 59.85
-
CSI 5.12rCSI 8.86%PRS 39.27
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CSI 5.09rCSI 6.67%PRS 62.1
-
CSI 5.07rCSI 10.06%PRS 47.43
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CSI 4.98rCSI 3.73%PRS 79.75
-
CSI 4.97rCSI 6.32%PRS 54.37
-
CSI 4.97rCSI 9.11%PRS 67.94
-
CSI 4.89rCSI 6.05%PRS 44.53
-
CSI 4.85rCSI 9.61%PRS 69.3
-
CSI 4.79rCSI 5.09%PRS 62.84
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CSI 4.75rCSI 9.48%PRS 66.78
-
CSI 4.74rCSI 8.62%PRS 74.44
-
CSI 4.71rCSI 4.45%PRS 49.37
-
CSI 4.69rCSI 6%PRS 77.78
-
CSI 4.62rCSI 7.33%PRS 59.64
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CSI 4.6rCSI 23.08%PRS 60.07
-
CSI 4.56rCSI 6.31%PRS 52.83
-
CSI 4.37rCSI 15.82%PRS 68.2
-
CSI 4.31rCSI 5.41%PRS 82.36
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CSI 4.31rCSI 9.66%PRS 33.16
-
CSI 4.26rCSI 4.19%PRS 51.26
-
CSI 4.23rCSI 9.3%PRS 52.77
-
CSI 4.09rCSI 4.27%PRS 76.46
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CSI 4.06rCSI 4.7%PRS 38.77
-
CSI 4.01rCSI 6.43%PRS 75.73
-
CSI 3.94rCSI 3%PRS 60.47
-
CSI 3.86rCSI 8.75%PRS 53.91
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CSI 3.79rCSI 7.82%PRS 53.67
-
CSI 3.72rCSI 3.27%PRS 37.61
-
CSI 3.68rCSI 2.94%PRS 70.15
-
CSI 3.67rCSI 3.84%PRS 45.64
-
CSI 3.66rCSI 4.46%PRS 56.4
-
CSI 3.65rCSI 7.34%PRS 38.34
-
CSI 3.58rCSI 5.5%PRS 49.19
-
CSI 3.56rCSI 3.07%PRS 56.57
-
CSI 3.54rCSI 2.63%PRS 62
-
CSI 3.53rCSI 5.17%PRS 75.95
-
CSI 3.52rCSI 2.73%PRS 49.37
-
CSI 3.52rCSI 8.02%PRS 46.78
-
CSI 3.46rCSI 2.41%PRS 50.71
-
CSI 3.35rCSI 8.88%PRS 61.98
-
CSI 3.34rCSI 15.57%PRS 70.53
-
CSI 3.3rCSI 2.93%PRS 47.46
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CSI 3.29rCSI 8.68%PRS 56.68
-
CSI 3.22rCSI 16.94%PRS 56.11
-
CSI 0.1rCSI 3.1%PRS 72.7%
-
CSI 0.2rCSI 2.5%PRS 69.4%
-
CSI 0.2rCSI 1.0%PRS 60.2%
-
CSI 0.2rCSI 3.7%PRS 81.9%
-
CSI 0.2rCSI 5.3%PRS 71.2%
-
CSI 0.3rCSI 1.5%PRS 69.8%
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CSI 0.3rCSI 4.2%PRS 72.0%
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CSI 0.3rCSI 2.8%PRS 73.7%
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CSI 0.3rCSI 4.5%PRS 72.4%
-
CSI 0.3rCSI 2.5%PRS 42.8%
-
CSI 0.3rCSI 3.4%PRS 67.9%
-
CSI 0.4rCSI 1.9%PRS 63.2%
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CSI 0.4rCSI 0.9%PRS 38.9%
-
CSI 0.4rCSI 1.3%PRS 60.8%
-
CSI 0.4rCSI 2.1%PRS 50.2%
-
CSI 0.4rCSI 1.6%PRS 69.2%
-
CSI 0.4rCSI 3.2%PRS 76.1%
-
CSI 0.4rCSI 2.2%PRS 72.3%
-
CSI 0.4rCSI 2.0%PRS 72.6%
-
CSI 0.5rCSI 2.0%PRS 64.5%
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CSI 0.5rCSI 1.4%PRS 64.0%
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CSI 0.6rCSI 1.7%PRS 33.7%
-
CSI 0.6rCSI 0.9%PRS 64.6%
-
CSI 0.6rCSI 14.5%PRS 72.8%
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CSI 0.7rCSI 5.1%PRS 68.1%
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CSI 0.7rCSI 3.3%PRS 73.0%
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CSI 0.8rCSI 2.5%PRS 79.4%
-
CSI 0.8rCSI 3.7%PRS 66.3%
-
CSI 0.8rCSI 4.6%PRS 78.4%
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CSI 0.8rCSI 1.8%PRS 67.0%
-
CSI 0.9rCSI 1.2%PRS 56.5%
-
CSI 0.9rCSI 1.7%PRS 67.6%
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CSI 0.9rCSI 5.8%PRS 79.1%
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CSI 0.9rCSI 4.0%PRS 41.6%
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CSI 1.0rCSI 2.7%PRS 62.8%
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CSI 1.0rCSI 3.4%PRS 83.4%
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CSI 1.0rCSI 2.1%PRS 58.3%
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CSI 1.0rCSI 4.2%PRS 64.0%
-
CSI 1.0rCSI 2.7%PRS 57.3%
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CSI 1.0rCSI 1.4%PRS 69.0%
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CSI 1.1rCSI 5.7%PRS 63.6%
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CSI 1.1rCSI 20.9%PRS 71.5%
-
CSI 1.1rCSI 3.3%PRS 70.2%
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CSI 1.1rCSI 2.9%PRS 70.5%
-
CSI 1.2rCSI 1.9%PRS 39.2%
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CSI 1.2rCSI 2.1%PRS 46.6%
-
CSI 1.2rCSI 2.3%PRS 81.3%
-
CSI 1.2rCSI 1.2%PRS 42.7%
-
CSI 1.2rCSI 1.6%PRS 71.3%
-
CSI 1.2rCSI 1.5%PRS 46.7%
-
CSI 1.2rCSI 4.3%PRS 63.6%
-
CSI 1.2rCSI 5.1%PRS 45.4%
-
CSI 1.3rCSI 1.7%PRS 58.0%
-
CSI 1.3rCSI 1.5%PRS 69.0%
-
CSI 1.3rCSI 4.3%PRS 57.2%
-
CSI 1.3rCSI 1.9%PRS 52.0%
-
CSI 1.3rCSI 2.0%PRS 53.4%
-
CSI 1.3rCSI 4.4%PRS 78.5%
-
CSI 1.3rCSI 5.3%PRS 68.9%
-
CSI 1.3rCSI 2.1%PRS 49.2%
-
CSI 1.4rCSI 1.3%PRS 72.6%
-
CSI 1.4rCSI 4.0%PRS 39.7%
-
CSI 1.4rCSI 1.6%PRS 52.5%
-
CSI 1.4rCSI 3.2%PRS 55.5%
-
CSI 1.4rCSI 2.2%PRS 65.7%
-
CSI 1.5rCSI 3.8%PRS 70.0%
-
CSI 1.5rCSI 5.8%PRS 64.0%
-
CSI 1.5rCSI 3.9%PRS 44.2%
-
CSI 1.5rCSI 2.2%PRS 61.9%
-
CSI 1.6rCSI 2.2%PRS 58.5%
-
CSI 1.6rCSI 2.0%PRS 62.0%
-
CSI 1.6rCSI 2.3%PRS 47.3%
-
CSI 1.6rCSI 2.5%PRS 52.7%
-
CSI 1.6rCSI 2.3%PRS 65.0%
-
CSI 1.6rCSI 2.4%PRS 60.1%
-
CSI 1.7rCSI 1.3%PRS 36.3%
-
CSI 1.7rCSI 2.7%PRS 75.6%
-
CSI 1.7rCSI 4.2%PRS 44.0%
-
CSI 1.7rCSI 4.0%PRS 72.2%
-
CSI 1.7rCSI 2.6%PRS 51.1%
-
CSI 1.7rCSI 1.5%PRS 58.6%
-
CSI 1.8rCSI 17.2%PRS 72.3%
-
CSI 1.8rCSI 3.9%PRS 46.2%
-
CSI 1.8rCSI 11.7%PRS 69.8%
-
CSI 1.8rCSI 2.3%PRS 51.2%
-
CSI 1.8rCSI 3.3%PRS 42.0%
-
CSI 1.8rCSI 1.2%PRS 59.8%
-
CSI 1.9rCSI 4.6%PRS 46.6%
-
CSI 1.9rCSI 2.0%PRS 54.5%
-
CSI 1.9rCSI 7.9%PRS 57.3%
-
CSI 2.0rCSI 5.6%PRS 62.7%
-
CSI 2.0rCSI 3.1%PRS 49.9%
-
CSI 2.0rCSI 5.7%PRS 65.4%
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CSI 2.0rCSI 3.1%PRS 58.0%
-
CSI 2.0rCSI 3.5%PRS 56.9%
-
CSI 2.0rCSI 2.3%PRS 65.2%
-
CSI 2.0rCSI 3.0%PRS 66.1%
-
CSI 2.1rCSI 2.7%PRS 46.7%
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CSI 2.1rCSI 5.0%PRS 60.4%
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CSI 2.2rCSI 2.3%PRS 46.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1417963331
Symbol: RAB5C_HUMAN
Name: Ras-related protein Rab-5C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8646882
Title: Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene.
PubMed ID: 8646882
DOI: 10.1159/000134325
PubMed ID: 7951316
Title: A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.
PubMed ID: 7951316
DOI: 10.1038/ng0894-472
PubMed ID: 10768959
Title: Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.
PubMed ID: 10768959
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12493736
Title: Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1.
PubMed ID: 12493736
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21750715
Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
PubMed ID: 21750715
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29125462
Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
PubMed ID: 29125462
DOI: 10.7554/elife.31012
PubMed ID: 32974215
Title: The Salmonella effector SseK3 targets small Rab GTPases.
PubMed ID: 32974215
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 216
- Mass: 23483
- Checksum: AA42096C6EED77ED
- Sequence:
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA TGAPGRNRGV DLQENNPASR SQCCSN