Details for: RAB5C

Gene ID: 5878

Symbol: RAB5C

Ensembl ID: ENSG00000108774

Description: RAB5C, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 302.0343
    Cell Significance Index: -46.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.6149
    Cell Significance Index: -47.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 127.7590
    Cell Significance Index: -52.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.9945
    Cell Significance Index: -56.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.3090
    Cell Significance Index: -53.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.9168
    Cell Significance Index: -56.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.8053
    Cell Significance Index: -54.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4467
    Cell Significance Index: -57.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0064
    Cell Significance Index: -43.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1503
    Cell Significance Index: -29.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.5034
    Cell Significance Index: 61.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2008
    Cell Significance Index: 164.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0581
    Cell Significance Index: 38.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8177
    Cell Significance Index: 20.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5167
    Cell Significance Index: 12.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4703
    Cell Significance Index: 94.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4417
    Cell Significance Index: 177.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3951
    Cell Significance Index: 65.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3934
    Cell Significance Index: 191.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3885
    Cell Significance Index: 40.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3739
    Cell Significance Index: 247.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3739
    Cell Significance Index: 8.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3216
    Cell Significance Index: 12.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2751
    Cell Significance Index: 26.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0706
    Cell Significance Index: 29.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0468
    Cell Significance Index: 571.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9246
    Cell Significance Index: 43.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8717
    Cell Significance Index: 45.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8386
    Cell Significance Index: 370.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8362
    Cell Significance Index: 108.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8235
    Cell Significance Index: 43.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7430
    Cell Significance Index: 95.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5769
    Cell Significance Index: 40.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5726
    Cell Significance Index: 114.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5576
    Cell Significance Index: 12.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5083
    Cell Significance Index: 14.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4535
    Cell Significance Index: 53.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2907
    Cell Significance Index: 55.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2428
    Cell Significance Index: 7.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2186
    Cell Significance Index: 78.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2184
    Cell Significance Index: 7.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2009
    Cell Significance Index: 19.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1632
    Cell Significance Index: 26.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1278
    Cell Significance Index: 21.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0793
    Cell Significance Index: 60.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0574
    Cell Significance Index: 0.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0567
    Cell Significance Index: 2.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0472
    Cell Significance Index: 1.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0296
    Cell Significance Index: 0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0257
    Cell Significance Index: 18.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0304
    Cell Significance Index: -57.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0375
    Cell Significance Index: -0.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0391
    Cell Significance Index: -72.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0464
    Cell Significance Index: -4.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0468
    Cell Significance Index: -71.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0526
    Cell Significance Index: -38.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0530
    Cell Significance Index: -72.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0783
    Cell Significance Index: -44.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0814
    Cell Significance Index: -51.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0951
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1184
    Cell Significance Index: -73.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1256
    Cell Significance Index: -57.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1531
    Cell Significance Index: -17.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1631
    Cell Significance Index: -10.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2688
    Cell Significance Index: -30.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2769
    Cell Significance Index: -54.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2963
    Cell Significance Index: -62.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3294
    Cell Significance Index: -1.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3718
    Cell Significance Index: -54.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3735
    Cell Significance Index: -4.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3745
    Cell Significance Index: -23.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3747
    Cell Significance Index: -29.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4137
    Cell Significance Index: -8.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4405
    Cell Significance Index: -14.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4439
    Cell Significance Index: -11.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4525
    Cell Significance Index: -34.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5000
    Cell Significance Index: -20.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5043
    Cell Significance Index: -6.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5217
    Cell Significance Index: -13.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5520
    Cell Significance Index: -14.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6146
    Cell Significance Index: -14.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6793
    Cell Significance Index: -38.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7075
    Cell Significance Index: -32.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7536
    Cell Significance Index: -21.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7651
    Cell Significance Index: -46.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8774
    Cell Significance Index: -59.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9399
    Cell Significance Index: -9.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0095
    Cell Significance Index: -29.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0327
    Cell Significance Index: -45.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1191
    Cell Significance Index: -9.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1769
    Cell Significance Index: -41.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1939
    Cell Significance Index: -20.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2372
    Cell Significance Index: -46.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2558
    Cell Significance Index: -46.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2723
    Cell Significance Index: -41.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3272
    Cell Significance Index: -42.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.3499
    Cell Significance Index: -11.0100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.3631
    Cell Significance Index: -9.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.4736
    Cell Significance Index: -36.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5071
    Cell Significance Index: -38.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB5C is a small GTPase that belongs to the RAS oncogene family, which is a group of proteins that play key roles in signal transduction pathways. RAB5C is specifically activated by GDP-GTP exchange factors (GEFs) and inactivated by GTP-GDP exchange inhibitors (GEIs), allowing it to cycle between active and inactive states. This cycling mechanism enables RAB5C to regulate membrane trafficking pathways, including clathrin-mediated endocytosis and vesicle-mediated transport. RAB5C has a distinct localization pattern, with a predominantly cytoplasmic localization and a specific interaction with the early endosome membrane. This localization is critical for its function, as it allows RAB5C to regulate the formation and function of early endosomes, which are essential for the internalization of pathogens and the presentation of antigens to the immune system. **Pathways and Functions** RAB5C is involved in several key pathways, including: 1. **Clathrin-mediated endocytosis**: RAB5C regulates the formation and function of clathrin-coated pits, which are essential for the internalization of pathogens and the uptake of nutrients. 2. **Vesicle-mediated transport**: RAB5C is involved in the regulation of vesicle-mediated transport, including the formation and movement of vesicles within the endosomal system. 3. **Endosomal sorting**: RAB5C regulates the sorting of proteins and lipids within the endosomal system, allowing for the efficient recycling of proteins and lipids. 4. **Immune response**: RAB5C is involved in the regulation of immune responses, including the presentation of antigens to the immune system and the internalization of pathogens. **Clinical Significance** RAB5C has been implicated in the pathogenesis of several diseases, including: 1. **Respiratory syncytial virus (RSV) infection**: RAB5C has been shown to play a critical role in the regulation of RSV attachment and entry, highlighting its potential as a therapeutic target for the treatment of RSV infection. 2. **Cancer**: RAB5C has been implicated in the regulation of cancer cell migration and invasion, suggesting its potential as a therapeutic target for the treatment of cancer. 3. **Neurological disorders**: RAB5C has been implicated in the regulation of neuroinflammation and neurodegeneration, suggesting its potential as a therapeutic target for the treatment of neurological disorders. In summary, RAB5C is a critical regulator of endocytic function and immune response, and its dysregulation has been implicated in the pathogenesis of several diseases. Further research is needed to fully understand the role of RAB5C in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1417963331

Symbol: RAB5C_HUMAN

Name: Ras-related protein Rab-5C

UniProtKB Accession Codes:

P51148 F8W1H5 Q6FH55 Q9P0Y5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 5 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8646882

Title: Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene.

PubMed ID: 8646882

DOI: 10.1159/000134325

PubMed ID: 7951316

Title: A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.

PubMed ID: 7951316

DOI: 10.1038/ng0894-472

PubMed ID: 10768959

Title: Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.

PubMed ID: 10768959

DOI: 10.1128/iai.68.5.2671-2684.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12493736

Title: Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1.

PubMed ID: 12493736

DOI: 10.1074/jbc.m211514200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21750715

Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.

PubMed ID: 21750715

DOI: 10.1371/journal.pone.0021505

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 32974215

Title: The Salmonella effector SseK3 targets small Rab GTPases.

PubMed ID: 32974215

DOI: 10.3389/fcimb.2020.00419

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 216
  • Mass: 23483
  • Checksum: AA42096C6EED77ED
  • Sequence:
    • MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ ESTIGAAFLT 
QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNTDTFA RAKNWVKELQ 
RQASPNIVIA LAGNKADLAS KRAVEFQEAQ AYADDNSLLF METSAKTAMN VNEIFMAIAK 
KLPKNEPQNA TGAPGRNRGV DLQENNPASR SQCCSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.