Details for: RAC1

Gene ID: 5879

Symbol: RAC1

Ensembl ID: ENSG00000136238

Description: Rac family small GTPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 775.1443
    Cell Significance Index: -120.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 524.4371
    Cell Significance Index: -133.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 334.0837
    Cell Significance Index: -137.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 317.3540
    Cell Significance Index: -149.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 275.0662
    Cell Significance Index: -141.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 223.9419
    Cell Significance Index: -150.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 115.4299
    Cell Significance Index: -142.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 42.5928
    Cell Significance Index: -114.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 37.9820
    Cell Significance Index: -116.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 37.2803
    Cell Significance Index: -147.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.9013
    Cell Significance Index: -52.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.2082
    Cell Significance Index: 145.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.1080
    Cell Significance Index: 177.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.7969
    Cell Significance Index: 225.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.5635
    Cell Significance Index: 626.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.4041
    Cell Significance Index: 81.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.2157
    Cell Significance Index: 314.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.0118
    Cell Significance Index: 493.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.9125
    Cell Significance Index: 205.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.7920
    Cell Significance Index: 683.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.7060
    Cell Significance Index: 2023.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6768
    Cell Significance Index: 100.0800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.6317
    Cell Significance Index: 22.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4933
    Cell Significance Index: 451.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1527
    Cell Significance Index: 82.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.9575
    Cell Significance Index: 379.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.8854
    Cell Significance Index: 32.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.7252
    Cell Significance Index: 1204.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6542
    Cell Significance Index: 70.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.6104
    Cell Significance Index: 54.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9899
    Cell Significance Index: 103.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9822
    Cell Significance Index: 56.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8580
    Cell Significance Index: 86.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7336
    Cell Significance Index: 122.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6029
    Cell Significance Index: 103.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5268
    Cell Significance Index: 14.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5121
    Cell Significance Index: 149.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4881
    Cell Significance Index: 175.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4811
    Cell Significance Index: 297.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0207
    Cell Significance Index: 28.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7603
    Cell Significance Index: 150.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6304
    Cell Significance Index: 107.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6275
    Cell Significance Index: 68.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6073
    Cell Significance Index: 115.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5852
    Cell Significance Index: 13.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5084
    Cell Significance Index: 182.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1651
    Cell Significance Index: 124.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1384
    Cell Significance Index: 101.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1319
    Cell Significance Index: 3.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0854
    Cell Significance Index: 1.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0348
    Cell Significance Index: 64.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0251
    Cell Significance Index: 2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0201
    Cell Significance Index: 37.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0516
    Cell Significance Index: -79.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0638
    Cell Significance Index: -47.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0657
    Cell Significance Index: -45.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0738
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0797
    Cell Significance Index: -108.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0965
    Cell Significance Index: -5.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1154
    Cell Significance Index: -11.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1349
    Cell Significance Index: -84.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1419
    Cell Significance Index: -90.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1947
    Cell Significance Index: -88.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1950
    Cell Significance Index: -109.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3342
    Cell Significance Index: -70.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3724
    Cell Significance Index: -2.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4215
    Cell Significance Index: -121.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6340
    Cell Significance Index: -38.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6546
    Cell Significance Index: -75.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6776
    Cell Significance Index: -78.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7490
    Cell Significance Index: -108.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8030
    Cell Significance Index: -8.7300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.9315
    Cell Significance Index: -6.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0139
    Cell Significance Index: -80.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0703
    Cell Significance Index: -82.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1551
    Cell Significance Index: -15.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1817
    Cell Significance Index: -79.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1827
    Cell Significance Index: -53.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2654
    Cell Significance Index: -40.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2770
    Cell Significance Index: -71.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2943
    Cell Significance Index: -134.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.6601
    Cell Significance Index: -42.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.8253
    Cell Significance Index: -31.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.8537
    Cell Significance Index: -40.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.8908
    Cell Significance Index: -66.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9249
    Cell Significance Index: -121.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.1136
    Cell Significance Index: -31.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.1690
    Cell Significance Index: -58.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.3427
    Cell Significance Index: -103.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.4037
    Cell Significance Index: -147.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.5900
    Cell Significance Index: -73.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.8682
    Cell Significance Index: -108.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.9015
    Cell Significance Index: -72.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.9809
    Cell Significance Index: -87.8000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.0874
    Cell Significance Index: -26.5300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -3.0933
    Cell Significance Index: -19.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -3.1086
    Cell Significance Index: -157.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.2962
    Cell Significance Index: -121.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.3313
    Cell Significance Index: -85.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.6423
    Cell Significance Index: -77.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAC1 is a small GTPase that belongs to the Ras superfamily of GTPases. It is characterized by its ability to bind and hydrolyze GTP, regulating its activity and interactions with downstream effectors. RAC1 is activated by guanine nucleotide exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). Its GTP-bound state is associated with active signaling, while its GDP-bound state is associated with inactive signaling. RAC1 has several key characteristics that distinguish it from other small GTPases: 1. **Cell migration**: RAC1 is a key regulator of cell migration, which is essential for immune cell function, wound healing, and tissue development. 2. **Immune responses**: RAC1 is involved in the regulation of immune responses, including the activation of immune cells, the production of cytokines, and the regulation of immune cell adhesion and migration. 3. **Neuronal development**: RAC1 is essential for neuronal development and function, including axon guidance, neuronal migration, and synaptogenesis. 4. **Cancer progression**: RAC1 is often overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression, metastasis, and poor prognosis. **Pathways and Functions** RAC1 is involved in multiple signaling pathways that regulate various cellular processes. Some of the key pathways and functions of RAC1 include: 1. **PI3K/AKT pathway**: RAC1 activates the PI3K/AKT signaling pathway, which regulates cell survival, proliferation, and metabolism. 2. **MAPK pathway**: RAC1 activates the MAPK signaling pathway, which regulates cell differentiation, proliferation, and apoptosis. 3. **JNK pathway**: RAC1 activates the JNK signaling pathway, which regulates cell survival, proliferation, and apoptosis. 4. **Rho GTPase pathway**: RAC1 activates the Rho GTPase pathway, which regulates actin cytoskeleton reorganization, cell migration, and cell adhesion. 5. **CD28 co-stimulation**: RAC1 is involved in the regulation of CD28 co-stimulation, which is essential for T cell activation and immune responses. **Clinical Significance** Dysregulation of RAC1 has been implicated in several diseases, including: 1. **Autoimmune disorders**: RAC1 dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: RAC1 overexpression is associated with tumor progression, metastasis, and poor prognosis in various types of cancer. 3. **Infectious diseases**: RAC1 dysregulation has been implicated in infectious diseases, such as HIV infection and Leishmaniasis. 4. **Neurological disorders**: RAC1 dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RAC1 is a small GTPase that plays a crucial role in various cellular processes, including cell migration, proliferation, differentiation, and survival. Its dysregulation has been implicated in several diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is needed to fully understand the mechanisms by which RAC1 regulates cellular processes and to develop therapeutic strategies for the treatment of RAC1-related diseases.

Genular Protein ID: 691328534

Symbol: RAC1_HUMAN

Name: Cell migration-inducing gene 5 protein

UniProtKB Accession Codes:

P63000 O95501 P15154 Q3Y4D3 Q5JAA8 Q9BTB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 15 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 84 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 45 RefSeq 2 Rhea 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2674130

Title: Rac, a novel ras-related family of proteins that are botulinum toxin substrates.

PubMed ID: 2674130

DOI: 10.1016/s0021-9258(19)84716-6

PubMed ID: 2108320

Title: Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

PubMed ID: 2108320

DOI: 10.1128/mcb.10.4.1793-1798.1990

PubMed ID: 11062023

Title: Small GTPase Rac1: structure, localization, and expression of the human gene.

PubMed ID: 11062023

DOI: 10.1006/bbrc.2000.3743

PubMed ID: 10597294

Title: Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors.

PubMed ID: 10597294

DOI: 10.1038/sj.onc.1203233

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1903399

Title: Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA.

PubMed ID: 1903399

DOI: 10.1016/s0021-9258(18)92889-9

PubMed ID: 1643658

Title: The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

PubMed ID: 1643658

DOI: 10.1016/0092-8674(92)90164-8

PubMed ID: 7777059

Title: Glucosylation of Rho proteins by Clostridium difficile toxin B.

PubMed ID: 7777059

DOI: 10.1038/375500a0

PubMed ID: 7775453

Title: The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.

PubMed ID: 7775453

DOI: 10.1074/jbc.270.23.13932

PubMed ID: 7673236

Title: Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.

PubMed ID: 7673236

DOI: 10.1074/jbc.270.38.22473

PubMed ID: 8626575

Title: Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation.

PubMed ID: 8626575

DOI: 10.1074/jbc.271.17.10149

PubMed ID: 8810274

Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.

PubMed ID: 8810274

DOI: 10.1074/jbc.271.41.25173

PubMed ID: 9121475

Title: The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.

PubMed ID: 9121475

DOI: 10.1128/mcb.17.4.2247

PubMed ID: 9857026

Title: Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases.

PubMed ID: 9857026

DOI: 10.1074/jbc.273.52.34954

PubMed ID: 10559471

Title: Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.

PubMed ID: 10559471

DOI: 10.1016/s0167-4889(99)00133-0

PubMed ID: 10954424

Title: The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.

PubMed ID: 10954424

DOI: 10.1242/jcs.113.18.3267

PubMed ID: 11130076

Title: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

PubMed ID: 11130076

DOI: 10.1038/35047107

PubMed ID: 11035813

Title: The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.

PubMed ID: 11035813

DOI: 10.1073/pnas.220421797

PubMed ID: 10617634

Title: Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

PubMed ID: 10617634

DOI: 10.1074/jbc.275.1.423

PubMed ID: 11260256

Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.

PubMed ID: 11260256

DOI: 10.1046/j.1365-2443.2001.00404.x

PubMed ID: 11955434

Title: P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

PubMed ID: 11955434

DOI: 10.1016/s0092-8674(02)00663-3

PubMed ID: 11807099

Title: The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.

PubMed ID: 11807099

DOI: 10.1083/jcb.200108030

PubMed ID: 12134158

Title: Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.

PubMed ID: 12134158

DOI: 10.1038/ncb824

PubMed ID: 12551911

Title: Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

PubMed ID: 12551911

DOI: 10.1074/jbc.m211286200

PubMed ID: 12716910

Title: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.

PubMed ID: 12716910

DOI: 10.1074/jbc.m212856200

PubMed ID: 12695502

Title: Synapse formation is regulated by the signaling adaptor GIT1.

PubMed ID: 12695502

DOI: 10.1083/jcb.200211002

PubMed ID: 12612085

Title: The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.

PubMed ID: 12612085

DOI: 10.1128/mcb.23.6.2151-2161.2003

PubMed ID: 15169762

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 15169762

DOI: 10.1074/jbc.m401878200

PubMed ID: 26048998

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 26048998

DOI: 10.1074/jbc.a115.401878

PubMed ID: 15642721

Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.

PubMed ID: 15642721

DOI: 10.1096/fj.04-2377fje

PubMed ID: 16464467

Title: An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).

PubMed ID: 16464467

DOI: 10.1016/j.jmb.2006.01.017

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16982419

Title: The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.

PubMed ID: 16982419

DOI: 10.1016/j.neuron.2006.07.020

PubMed ID: 17121847

Title: Cooperation of DEF6 with activated Rac in regulating cell morphology.

PubMed ID: 17121847

DOI: 10.1074/jbc.m605153200

PubMed ID: 17430976

Title: Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.

PubMed ID: 17430976

DOI: 10.1242/jcs.001776

PubMed ID: 17145773

Title: Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element.

PubMed ID: 17145773

DOI: 10.1128/mcb.01608-06

PubMed ID: 18499456

Title: CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.

PubMed ID: 18499456

DOI: 10.1016/j.cub.2008.04.050

PubMed ID: 18093184

Title: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process.

PubMed ID: 18093184

DOI: 10.1111/j.1742-4658.2007.06209.x

PubMed ID: 19029984

Title: Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.

PubMed ID: 19029984

DOI: 10.1038/nm.1879

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19744486

Title: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin.

PubMed ID: 19744486

DOI: 10.1016/j.febslet.2009.09.006

PubMed ID: 19934221

Title: The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.

PubMed ID: 19934221

DOI: 10.1242/jcs.053728

PubMed ID: 20875796

Title: Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1.

PubMed ID: 20875796

DOI: 10.1016/j.bbrc.2010.09.087

PubMed ID: 20148946

Title: The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt.

PubMed ID: 20148946

DOI: 10.1111/j.1742-4658.2010.07575.x

PubMed ID: 19403692

Title: BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.

PubMed ID: 19403692

DOI: 10.1091/mbc.e09-01-0051

PubMed ID: 19362538

Title: The fic domain: regulation of cell signaling by adenylylation.

PubMed ID: 19362538

DOI: 10.1016/j.molcel.2009.03.008

PubMed ID: 19039103

Title: AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.

PubMed ID: 19039103

DOI: 10.1126/science.1166382

PubMed ID: 20116244

Title: Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.

PubMed ID: 20116244

DOI: 10.1016/j.cub.2009.12.053

PubMed ID: 20696164

Title: POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain.

PubMed ID: 20696164

DOI: 10.1016/j.febslet.2010.07.060

PubMed ID: 20696765

Title: Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.

PubMed ID: 20696765

DOI: 10.1074/jbc.m110.120451

PubMed ID: 19948726

Title: Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro.

PubMed ID: 19948726

DOI: 10.1074/jbc.m109.088427

PubMed ID: 20709748

Title: Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

PubMed ID: 20709748

DOI: 10.1074/jbc.m110.129916

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21565175

Title: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.

PubMed ID: 21565175

DOI: 10.1016/j.bbrc.2011.04.116

PubMed ID: 22036506

Title: The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1.

PubMed ID: 22036506

DOI: 10.1016/j.devcel.2011.08.015

PubMed ID: 21693584

Title: The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration.

PubMed ID: 21693584

DOI: 10.1242/jcs.080630

PubMed ID: 20974804

Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

PubMed ID: 20974804

DOI: 10.1128/mcb.01001-10

PubMed ID: 22843693

Title: Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between beta1 integrins and small GTPases.

PubMed ID: 22843693

DOI: 10.1074/jbc.m111.314443

PubMed ID: 23209303

Title: The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization.

PubMed ID: 23209303

DOI: 10.1083/jcb.201205041

PubMed ID: 23512198

Title: SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation.

PubMed ID: 23512198

DOI: 10.1096/fj.12-223099

PubMed ID: 23434736

Title: ARHGDIA: a novel gene implicated in nephrotic syndrome.

PubMed ID: 23434736

DOI: 10.1136/jmedgenet-2012-101442

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 23375260

Title: Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.

PubMed ID: 23375260

DOI: 10.1016/j.str.2013.01.001

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28886345

Title: RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.

PubMed ID: 28886345

DOI: 10.1016/j.ajhg.2017.08.007

PubMed ID: 29074776

Title: Nepsilon-fatty acylation of Rho GTPases by a MARTX toxin effector.

PubMed ID: 29074776

DOI: 10.1126/science.aam8659

PubMed ID: 30250061

Title: Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

PubMed ID: 30250061

DOI: 10.1038/s41556-018-0198-9

PubMed ID: 31285585

Title: CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.

PubMed ID: 31285585

DOI: 10.1038/s41564-019-0484-8

PubMed ID: 31871319

Title: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.

PubMed ID: 31871319

DOI: 10.1038/s41556-019-0438-7

PubMed ID: 32460619

Title: TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.

PubMed ID: 32460619

DOI: 10.1080/15548627.2020.1761748

PubMed ID: 35986704

Title: Germline intergenic duplications at Xq26.1 underlie Bazex-Dupre-Christol basal cell carcinoma susceptibility syndrome.

PubMed ID: 35986704

DOI: 10.1111/bjd.21842

PubMed ID: 9033596

Title: The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.

PubMed ID: 9033596

DOI: 10.1038/nsb0297-147

PubMed ID: 11090627

Title: Structure of the TPR domain of p67phox in complex with Rac.GTP.

PubMed ID: 11090627

DOI: 10.1016/s1097-2765(05)00091-2

PubMed ID: 11130063

Title: Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

PubMed ID: 11130063

DOI: 10.1038/35047014

PubMed ID: 11163217

Title: Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1.

PubMed ID: 11163217

DOI: 10.1016/s1097-2765(00)00141-6

PubMed ID: 11135665

Title: How the Pseudomonas aeruginosa ExoS toxin downregulates Rac.

PubMed ID: 11135665

DOI: 10.1038/83007

PubMed ID: 11513578

Title: Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation.

PubMed ID: 11513578

DOI: 10.1021/bi010288k

PubMed ID: 11346801

Title: The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.

PubMed ID: 11346801

DOI: 10.1038/35075620

PubMed ID: 14625275

Title: Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase.

PubMed ID: 14625275

DOI: 10.1074/jbc.m310281200

PubMed ID: 16959567

Title: Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors.

PubMed ID: 16959567

DOI: 10.1016/j.cell.2006.06.056

PubMed ID: 17115053

Title: Crystal structure of Rac1 bound to its effector phospholipase C-beta2.

PubMed ID: 17115053

DOI: 10.1038/nsmb1175

PubMed ID: 21613211

Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.

PubMed ID: 21613211

DOI: 10.1074/jbc.m111.236455

Sequence Information:

  • Length: 192
  • Mass: 21450
  • Checksum: ACEDF83A45E5EA67
  • Sequence:
    • MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 
QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR 
DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP 
PVKKRKRKCL LL

Genular Protein ID: 3330018535

Symbol: A4D2P0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4D2P0

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 ExpressionAtlas 1 GO 14 Gene3D 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 2 SMART 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

Sequence Information:

  • Length: 211
  • Mass: 23467
  • Checksum: 93745E0CFBA5281F
  • Sequence:
    • MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 
QEDYDRLRPL SYPQTVGETY GKDITSRGKD KPIADVFLIC FSLVSPASFE NVRAKWYPEV 
RHHCPNTPII LVGTKLDLRD DKDTIEKLKE KKLTPITYPQ GLAMAKEIGA VKYLECSALT 
QRGLKTVFDE AIRAVLCPPP VKKRKRKCLL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.