Details for: RAC3

Gene ID: 5881

Symbol: RAC3

Ensembl ID: ENSG00000169750

Description: Rac family small GTPase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.7220
    Cell Significance Index: -18.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.2240
    Cell Significance Index: -16.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.6671
    Cell Significance Index: -13.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7126
    Cell Significance Index: -18.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.3599
    Cell Significance Index: -13.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6249
    Cell Significance Index: -18.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9354
    Cell Significance Index: 21.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7056
    Cell Significance Index: 35.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8282
    Cell Significance Index: 96.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7096
    Cell Significance Index: 50.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7067
    Cell Significance Index: 32.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6348
    Cell Significance Index: 62.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5649
    Cell Significance Index: 34.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5597
    Cell Significance Index: 247.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5005
    Cell Significance Index: 10.9600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4781
    Cell Significance Index: 3.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4636
    Cell Significance Index: 24.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4088
    Cell Significance Index: 2.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3984
    Cell Significance Index: 8.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3858
    Cell Significance Index: 49.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3252
    Cell Significance Index: 24.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3218
    Cell Significance Index: 52.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3150
    Cell Significance Index: 284.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3068
    Cell Significance Index: 167.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2976
    Cell Significance Index: 7.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2823
    Cell Significance Index: 3.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2686
    Cell Significance Index: 5.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2647
    Cell Significance Index: 9.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1982
    Cell Significance Index: 2.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1786
    Cell Significance Index: 12.3500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1659
    Cell Significance Index: 2.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1651
    Cell Significance Index: 33.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1628
    Cell Significance Index: 8.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1530
    Cell Significance Index: 2.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1478
    Cell Significance Index: 29.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1404
    Cell Significance Index: 8.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1210
    Cell Significance Index: 15.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1176
    Cell Significance Index: 42.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1133
    Cell Significance Index: 3.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1041
    Cell Significance Index: 72.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0974
    Cell Significance Index: 2.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0925
    Cell Significance Index: 17.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0850
    Cell Significance Index: 1.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0750
    Cell Significance Index: 10.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0722
    Cell Significance Index: 13.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0636
    Cell Significance Index: 4.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0543
    Cell Significance Index: 6.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0540
    Cell Significance Index: 2.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0448
    Cell Significance Index: 2.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0365
    Cell Significance Index: 1.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0285
    Cell Significance Index: 0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0219
    Cell Significance Index: 0.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0018
    Cell Significance Index: 0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0078
    Cell Significance Index: -14.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0129
    Cell Significance Index: -23.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0134
    Cell Significance Index: -20.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -10.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0175
    Cell Significance Index: -23.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0231
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0245
    Cell Significance Index: -18.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0269
    Cell Significance Index: -15.1500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0382
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0399
    Cell Significance Index: -24.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0412
    Cell Significance Index: -18.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0443
    Cell Significance Index: -12.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0767
    Cell Significance Index: -7.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0810
    Cell Significance Index: -2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1006
    Cell Significance Index: -14.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1017
    Cell Significance Index: -21.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1038
    Cell Significance Index: -11.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1053
    Cell Significance Index: -17.9800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1227
    Cell Significance Index: -0.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1303
    Cell Significance Index: -15.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1470
    Cell Significance Index: -9.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1797
    Cell Significance Index: -14.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1803
    Cell Significance Index: -1.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2086
    Cell Significance Index: -13.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2110
    Cell Significance Index: -11.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2187
    Cell Significance Index: -11.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2188
    Cell Significance Index: -5.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2335
    Cell Significance Index: -15.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2571
    Cell Significance Index: -19.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2856
    Cell Significance Index: -7.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2863
    Cell Significance Index: -5.9400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2953
    Cell Significance Index: -2.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3229
    Cell Significance Index: -9.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3404
    Cell Significance Index: -5.1300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3420
    Cell Significance Index: -4.8600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3429
    Cell Significance Index: -2.8300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3484
    Cell Significance Index: -4.8900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.3596
    Cell Significance Index: -2.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3660
    Cell Significance Index: -4.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3895
    Cell Significance Index: -17.2300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4058
    Cell Significance Index: -2.6400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4124
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4184
    Cell Significance Index: -11.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAC3 is a small GTPase that belongs to the Rho family of GTPases, which are characterized by their ability to bind to and hydrolyze GTP. RAC3 is specifically involved in regulating the actin cytoskeleton, which is a dynamic network of filaments that provides structural support and enables cell movement. The gene is highly expressed in various cell types, including neurons, immune cells, and cells of the nervous system. **Pathways and Functions:** RAC3 is involved in a wide range of cellular processes, including: 1. **Actin cytoskeleton organization**: RAC3 regulates the formation and dynamics of the actin cytoskeleton, which is essential for cell migration, growth, and differentiation. 2. **Cell chemotaxis**: RAC3 plays a crucial role in regulating the movement of cells in response to chemical signals, such as those involved in immune responses and cell migration. 3. **Cell polarity**: RAC3 is involved in establishing and maintaining cell polarity, which is essential for the proper functioning of cells and tissues. 4. **Neurotransmission**: RAC3 is expressed in neurons and plays a role in regulating synaptic transmission, the process by which neurons communicate with each other. 5. **Immune responses**: RAC3 is involved in regulating immune responses, including the activation of neutrophils and the regulation of inflammation. **Clinical Significance:** RAC3 has been implicated in various human diseases, including: 1. **Neurological disorders**: RAC3 has been associated with neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer**: RAC3 has been implicated in the development and progression of various types of cancer, including breast cancer and colon cancer. 3. **Neuromuscular disorders**: RAC3 has been associated with neuromuscular disorders, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. 4. **Immune-related disorders**: RAC3 has been implicated in immune-related disorders, such as rheumatoid arthritis and multiple sclerosis. **Conclusion:** In conclusion, RAC3 is a multifaceted gene that plays a crucial role in regulating various cellular processes, including cell migration, growth, and differentiation. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the functions and mechanisms of RAC3.

Genular Protein ID: 2731474104

Symbol: RAC3_HUMAN

Name: p21-Rac3

UniProtKB Accession Codes:

P60763 O14658 Q5U0M8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9252344

Title: Characterization of RAC3, a novel member of the Rho family.

PubMed ID: 9252344

DOI: 10.1074/jbc.272.33.20384

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852280

Title: Identification of a novel Rac3-interacting protein C1D.

PubMed ID: 9852280

DOI: 10.3892/ijmm.1.4.665

PubMed ID: 11956649

Title: Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.

PubMed ID: 11956649

PubMed ID: 11756406

Title: The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.

PubMed ID: 11756406

DOI: 10.1074/jbc.m105363200

PubMed ID: 16982419

Title: The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.

PubMed ID: 16982419

DOI: 10.1016/j.neuron.2006.07.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24684802

Title: F-box protein complex FBXL19 regulates TGFbeta1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation.

PubMed ID: 24684802

DOI: 10.1186/1476-4598-13-76

PubMed ID: 29276006

Title: WNT signaling perturbations underlie the genetic heterogeneity of Robinow syndrome.

PubMed ID: 29276006

DOI: 10.1016/j.ajhg.2017.10.002

PubMed ID: 30293988

Title: De novo missense variants in RAC3 cause a novel neurodevelopmental syndrome.

PubMed ID: 30293988

DOI: 10.1038/s41436-018-0323-y

Sequence Information:

  • Length: 192
  • Mass: 21379
  • Checksum: 560BBC26BB7CDF4A
  • Sequence:
    • MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 
QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR 
DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP 
PVKKPGKKCT VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.