Details for: RAP1GDS1

Gene ID: 5910

Symbol: RAP1GDS1

Ensembl ID: ENSG00000138698

Description: Rap1 GTPase-GDP dissociation stimulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 329.2290
    Cell Significance Index: -51.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.5896
    Cell Significance Index: -49.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.8116
    Cell Significance Index: -50.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.2166
    Cell Significance Index: -52.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 104.1459
    Cell Significance Index: -42.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.3262
    Cell Significance Index: -48.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.2448
    Cell Significance Index: -53.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.7765
    Cell Significance Index: -42.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.3373
    Cell Significance Index: -52.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2690
    Cell Significance Index: -48.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.7645
    Cell Significance Index: -48.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4362
    Cell Significance Index: -53.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8165
    Cell Significance Index: -28.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.6378
    Cell Significance Index: 45.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6770
    Cell Significance Index: 118.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.5666
    Cell Significance Index: 30.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5618
    Cell Significance Index: 97.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2995
    Cell Significance Index: 824.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2814
    Cell Significance Index: 457.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1713
    Cell Significance Index: 121.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7881
    Cell Significance Index: 290.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7574
    Cell Significance Index: 121.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.6126
    Cell Significance Index: 27.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5724
    Cell Significance Index: 44.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4654
    Cell Significance Index: 144.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4214
    Cell Significance Index: 35.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4202
    Cell Significance Index: 39.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3762
    Cell Significance Index: 86.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3463
    Cell Significance Index: 931.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3367
    Cell Significance Index: 102.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3283
    Cell Significance Index: 263.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2952
    Cell Significance Index: 87.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2189
    Cell Significance Index: 1100.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2017
    Cell Significance Index: 73.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9265
    Cell Significance Index: 22.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7957
    Cell Significance Index: 86.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7607
    Cell Significance Index: 45.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6842
    Cell Significance Index: 14.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6746
    Cell Significance Index: 78.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5538
    Cell Significance Index: 99.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4898
    Cell Significance Index: 12.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4335
    Cell Significance Index: 22.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3636
    Cell Significance Index: 44.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2408
    Cell Significance Index: 152.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1671
    Cell Significance Index: 314.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1485
    Cell Significance Index: 81.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1060
    Cell Significance Index: 6.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0941
    Cell Significance Index: 41.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0889
    Cell Significance Index: 4.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0793
    Cell Significance Index: 107.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0748
    Cell Significance Index: 115.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0690
    Cell Significance Index: 13.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0492
    Cell Significance Index: 90.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0383
    Cell Significance Index: 17.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0185
    Cell Significance Index: 2.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0290
    Cell Significance Index: -4.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0429
    Cell Significance Index: -6.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0472
    Cell Significance Index: -1.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0480
    Cell Significance Index: -35.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0512
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0526
    Cell Significance Index: -38.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0607
    Cell Significance Index: -45.9700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0638
    Cell Significance Index: -0.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0806
    Cell Significance Index: -1.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0812
    Cell Significance Index: -45.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0926
    Cell Significance Index: -57.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1366
    Cell Significance Index: -13.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1545
    Cell Significance Index: -44.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1977
    Cell Significance Index: -4.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2191
    Cell Significance Index: -16.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2372
    Cell Significance Index: -30.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2390
    Cell Significance Index: -11.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2605
    Cell Significance Index: -13.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2698
    Cell Significance Index: -56.8300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2988
    Cell Significance Index: -1.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2996
    Cell Significance Index: -38.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3437
    Cell Significance Index: -39.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3500
    Cell Significance Index: -18.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3570
    Cell Significance Index: -7.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3633
    Cell Significance Index: -37.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3803
    Cell Significance Index: -17.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4376
    Cell Significance Index: -9.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4443
    Cell Significance Index: -6.3900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4459
    Cell Significance Index: -5.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4596
    Cell Significance Index: -8.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5021
    Cell Significance Index: -14.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5092
    Cell Significance Index: -36.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5409
    Cell Significance Index: -7.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5582
    Cell Significance Index: -44.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5790
    Cell Significance Index: -18.5500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5922
    Cell Significance Index: -7.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6248
    Cell Significance Index: -13.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6475
    Cell Significance Index: -21.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6625
    Cell Significance Index: -21.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6643
    Cell Significance Index: -13.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7340
    Cell Significance Index: -19.6000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7646
    Cell Significance Index: -9.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7943
    Cell Significance Index: -11.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8500
    Cell Significance Index: -52.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8956
    Cell Significance Index: -31.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Rap1 GDS is a small GTPase-GDP dissociation stimulator that regulates the activity of Rap1 GTPase. It interacts with Rap1 GTPase and facilitates its GTPase activity, thereby modulating its downstream signaling pathways. Rap1 GDS is characterized by its ability to stimulate the exchange of GDP for GTP on Rap1 GTPase, allowing the GTPase to activate its downstream targets. The RAP1GDS1 gene is highly conserved across species, suggesting its importance in fundamental cellular processes. **Pathways and Functions** Rap1 GDS regulates a wide range of cellular processes, including: 1. **Cell migration and adhesion**: Rap1 GDS promotes cell migration and adhesion by regulating the activity of Rap1 GTPase, which in turn affects the organization of the actin cytoskeleton. 2. **Signaling by Rho GTPases**: Rap1 GDS interacts with other Rho GTPases, such as RhoA and Rac1, to regulate their activity and downstream signaling pathways. 3. **Endoplasmic reticulum (ER) calcium regulation**: Rap1 GDS regulates the activity of proteins involved in ER calcium homeostasis, which is critical for cellular calcium signaling. 4. **Mitochondrial organization and calcium regulation**: Rap1 GDS regulates the organization of mitochondria and their calcium uptake, which is essential for cellular energy metabolism. **Clinical Significance** Dysregulation of Rap1 GDS has been implicated in various diseases, including: 1. **Cancer**: Rap1 GDS has been shown to promote cancer cell migration, invasion, and proliferation. 2. **Cardiovascular disorders**: Rap1 GDS has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurodegenerative diseases**: Rap1 GDS has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In summary, Rap1 GDS is a critical regulator of cellular processes, including cell migration, adhesion, and proliferation. Its dysregulation has been implicated in various diseases, highlighting the importance of RAP1GDS1 gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which Rap1 GDS regulates cellular processes and to explore its potential as a therapeutic target for disease treatment.

Genular Protein ID: 421824256

Symbol: GDS1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P52306 E9PH06 G5E9P9 Q499L7 Q4KMV2 Q4QQI8 Q9BUW9 Q9BUX6 Q9NYM2 Q9NZA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 6 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1549351

Title: Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21.

PubMed ID: 1549351

PubMed ID: 11948427

Title: SmgGDS displays differential binding and exchange activity towards different Ras isoforms.

PubMed ID: 11948427

DOI: 10.1038/sj.onc.1205306

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31406347

Title: Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer.

PubMed ID: 31406347

DOI: 10.1038/s41588-019-0475-y

PubMed ID: 10477737

Title: The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.

PubMed ID: 10477737

PubMed ID: 10929031

Title: t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia.

PubMed ID: 10929031

DOI: 10.1046/j.1365-2141.2000.02106.x

PubMed ID: 12551911

Title: Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

PubMed ID: 12551911

DOI: 10.1074/jbc.m211286200

PubMed ID: 20709748

Title: Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

PubMed ID: 20709748

DOI: 10.1074/jbc.m110.129916

PubMed ID: 21242305

Title: SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.

PubMed ID: 21242305

DOI: 10.1074/jbc.m110.191122

PubMed ID: 16419055

Title: Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.

PubMed ID: 16419055

DOI: 10.1002/gcc.20308

PubMed ID: 24349085

Title: Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1.

PubMed ID: 24349085

DOI: 10.1371/journal.pone.0081516

PubMed ID: 24415755

Title: The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

PubMed ID: 24415755

DOI: 10.1074/jbc.m113.527192

PubMed ID: 27716788

Title: Vimar Is a Novel Regulator of Mitochondrial Fission through Miro.

PubMed ID: 27716788

DOI: 10.1371/journal.pgen.1006359

PubMed ID: 32431071

Title: Mutated RAP1GDS1 causes a new syndrome of dysmorphic feature, intellectual disability & speech delay.

PubMed ID: 32431071

DOI: 10.1002/acn3.51059

PubMed ID: 33875846

Title: Combining exome/genome sequencing with data repository analysis reveals novel gene-disease associations for a wide range of genetic disorders.

PubMed ID: 33875846

DOI: 10.1038/s41436-021-01159-0

PubMed ID: 28630045

Title: Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.

PubMed ID: 28630045

DOI: 10.1074/jbc.m117.792556

PubMed ID: 30190425

Title: GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.

PubMed ID: 30190425

DOI: 10.1073/pnas.1804740115

Sequence Information:

  • Length: 607
  • Mass: 66317
  • Checksum: ED0F359DFA3F0510
  • Sequence:
    • MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP 
QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS 
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG 
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK 
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL 
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE 
KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF 
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK 
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR 
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE 
QRLTVES

Genular Protein ID: 454128086

Symbol: Q6U7G8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6U7G8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 516
  • Mass: 56488
  • Checksum: 6945502F7D3F895E
  • Sequence:
    • MADNLSDTLK KLKITADDKT EDSLEGCLDC LLQALAQNNT ETSEKIQASG ILQLFSSLLT 
PQSSCKAKVA NIIAEVAKNE FMRIPCVDAG LISPLVQLLN SKDQEVLLQT GRALGNICYD 
SQSSKEQFAS TNIAEELVKL FKKQIEHDKR EMTFEVLAPL AENDAIKLQL VEAGLVECLL 
EIVQQKVDSD KEDDITELKT GSDLMVLLLL GDESMQKLFE GGKGSVFQRV LSWIPSNNHQ 
LQLAGALATA NFARNDANCI HMVDNGIVEK LMDLLDRHVE DGNVTVQHAA LSALRNLAIP 
VINKAKMLSA GVTEAVLKFL KSEMPPVQFK LLGTLRMLID AQAEAAEQLG KNVKLVERLV 
EWCEAKDHAG VMGESNRLLS ALIRHSKSKD VIKTIAQSGG IKHLVTMATS EHVIMQSEAL 
VALALIAALE LGTAEKDLES AKLVQILHRL LADERSAPEI KYNSMVLICA LMGSECLHKE 
VQDLAFLDVV SKLRSHENKS VAQQASLTEQ RLTVES

Genular Protein ID: 3945820482

Symbol: B3KNU0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNU0

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 607
  • Mass: 66379
  • Checksum: 56BBA97534B5546B
  • Sequence:
    • MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP 
QSSCKVKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS 
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG 
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK 
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL 
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE 
KLMDLLDRHV EDGNVTVQHA ALSAFRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF 
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK 
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR 
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE 
QRLTVES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.