Details for: RBBP6

Gene ID: 5930

Symbol: RBBP6

Ensembl ID: ENSG00000122257

Description: RB binding protein 6, ubiquitin ligase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 404.3197
    Cell Significance Index: -62.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 241.5202
    Cell Significance Index: -61.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 172.4734
    Cell Significance Index: -71.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.8840
    Cell Significance Index: -72.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 152.0958
    Cell Significance Index: -61.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 135.7348
    Cell Significance Index: -69.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.6418
    Cell Significance Index: -72.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.9599
    Cell Significance Index: -62.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.7928
    Cell Significance Index: -68.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.6336
    Cell Significance Index: -65.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.6937
    Cell Significance Index: -69.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.8943
    Cell Significance Index: -51.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1552
    Cell Significance Index: -30.9800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.7728
    Cell Significance Index: 93.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2474
    Cell Significance Index: 60.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1281
    Cell Significance Index: 346.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7447
    Cell Significance Index: 112.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6614
    Cell Significance Index: 93.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6607
    Cell Significance Index: 333.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2974
    Cell Significance Index: 257.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2480
    Cell Significance Index: 159.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2473
    Cell Significance Index: 33.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2040
    Cell Significance Index: 72.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1962
    Cell Significance Index: 54.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1527
    Cell Significance Index: 30.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1486
    Cell Significance Index: 141.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1034
    Cell Significance Index: 51.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0773
    Cell Significance Index: 147.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0205
    Cell Significance Index: 366.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0172
    Cell Significance Index: 183.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9921
    Cell Significance Index: 28.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9894
    Cell Significance Index: 540.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9244
    Cell Significance Index: 48.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7932
    Cell Significance Index: 350.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7714
    Cell Significance Index: 40.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7514
    Cell Significance Index: 21.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7038
    Cell Significance Index: 52.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6178
    Cell Significance Index: 79.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5779
    Cell Significance Index: 39.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5552
    Cell Significance Index: 42.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5314
    Cell Significance Index: 367.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5051
    Cell Significance Index: 59.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4970
    Cell Significance Index: 35.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4667
    Cell Significance Index: 46.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4478
    Cell Significance Index: 8.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3166
    Cell Significance Index: 14.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2590
    Cell Significance Index: 487.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2326
    Cell Significance Index: 6.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1588
    Cell Significance Index: 3.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1513
    Cell Significance Index: 28.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1512
    Cell Significance Index: 136.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1490
    Cell Significance Index: 25.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1434
    Cell Significance Index: 7.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1103
    Cell Significance Index: 6.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0969
    Cell Significance Index: 61.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0962
    Cell Significance Index: 6.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0778
    Cell Significance Index: 3.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0403
    Cell Significance Index: 18.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0217
    Cell Significance Index: 33.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0082
    Cell Significance Index: 15.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0067
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -17.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0365
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0468
    Cell Significance Index: -29.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0634
    Cell Significance Index: -48.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0804
    Cell Significance Index: -1.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0833
    Cell Significance Index: -46.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0869
    Cell Significance Index: -3.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1066
    Cell Significance Index: -10.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1665
    Cell Significance Index: -35.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2146
    Cell Significance Index: -61.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2203
    Cell Significance Index: -32.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2483
    Cell Significance Index: -28.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2800
    Cell Significance Index: -31.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2813
    Cell Significance Index: -6.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2893
    Cell Significance Index: -10.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3223
    Cell Significance Index: -8.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3271
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3626
    Cell Significance Index: -41.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3669
    Cell Significance Index: -7.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4353
    Cell Significance Index: -11.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4364
    Cell Significance Index: -47.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4983
    Cell Significance Index: -8.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5006
    Cell Significance Index: -6.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5286
    Cell Significance Index: -55.0400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7040
    Cell Significance Index: -4.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7701
    Cell Significance Index: -60.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8267
    Cell Significance Index: -15.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8292
    Cell Significance Index: -5.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9861
    Cell Significance Index: -17.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9999
    Cell Significance Index: -61.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0513
    Cell Significance Index: -28.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0755
    Cell Significance Index: -31.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1095
    Cell Significance Index: -28.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2264
    Cell Significance Index: -39.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2855
    Cell Significance Index: -30.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3236
    Cell Significance Index: -37.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3271
    Cell Significance Index: -15.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RBBP6 is a ubiquitin ligase that forms a heterodimer with RB binding protein 5 (RBBP5) to regulate the activity of the retinoblastoma protein (Rb). This complex is involved in the ubiquitination and degradation of proteins that are targeted for cell cycle regulation, DNA damage response, and transcriptional control. RBBP6 has been shown to interact with a variety of proteins, including protein kinases, transcription factors, and RNA-binding proteins, suggesting its involvement in multiple signaling pathways. **Pathways and Functions** RBBP6 is involved in several key pathways, including: 1. **Adaptive Immune System**: RBBP6 has been implicated in the regulation of immune cell development and function, including the ubiquitination and degradation of proteins involved in the activation and differentiation of T cells and B cells. 2. **Antigen Processing and Presentation**: RBBP6 has been shown to regulate the ubiquitination and degradation of proteins involved in the processing and presentation of antigens to the immune system. 3. **DNA Damage Response**: RBBP6 has been implicated in the regulation of the DNA damage response, including the ubiquitination and degradation of proteins involved in the repair of DNA damage. 4. **DNA Replication**: RBBP6 has been shown to regulate the ubiquitination and degradation of proteins involved in the regulation of DNA replication and the maintenance of genome stability. **Clinical Significance** Dysregulation of RBBP6 has been implicated in several diseases, including: 1. **Cancer**: RBBP6 has been shown to be overexpressed in several types of cancer, including breast cancer, prostate cancer, and lung cancer. This overexpression is often associated with poor prognosis and increased tumor aggressiveness. 2. **Autoimmune Disorders**: RBBP6 has been implicated in the regulation of immune cell function and has been shown to be involved in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. 3. **Neurological Disorders**: RBBP6 has been implicated in the regulation of neuronal function and has been shown to be involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RBBP6 is a critical regulator of various cellular processes, including the adaptive immune system, DNA damage response, and embryonic development. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the mechanisms of RBBP6 function and its role in human disease.

Genular Protein ID: 8466751

Symbol: RBBP6_HUMAN

Name: E3 ubiquitin-protein ligase RBBP6

UniProtKB Accession Codes:

Q7Z6E9 Q147T5 Q15290 Q6DKH4 Q6P4C2 Q6YNC9 Q7Z6E8 Q8N0V2 Q96PH3 Q9H3I8 Q9H5M5 Q9NPX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 20 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8595913

Title: cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product.

PubMed ID: 8595913

DOI: 10.1006/geno.1995.0017

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12064457

Title: P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity.

PubMed ID: 12064457

DOI: 10.1002/jcp.10084

PubMed ID: 15475430

Title: Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.

PubMed ID: 15475430

DOI: 10.1158/1078-0432.ccr-04-0841

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17470788

Title: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.

PubMed ID: 17470788

DOI: 10.1073/pnas.0701916104

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18851979

Title: RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.

PubMed ID: 18851979

DOI: 10.1016/j.jmb.2008.09.060

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24726359

Title: The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.

PubMed ID: 24726359

DOI: 10.1016/j.celrep.2014.03.030

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16396680

Title: DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.

PubMed ID: 16396680

DOI: 10.1186/1472-6807-6-1

PubMed ID: 22130672

Title: Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box.

PubMed ID: 22130672

DOI: 10.1074/jbc.m110.217059

PubMed ID: 30550789

Title: Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.

PubMed ID: 30550789

DOI: 10.1016/j.cell.2018.08.044

Sequence Information:

  • Length: 1792
  • Mass: 201564
  • Checksum: 550F7BBA5125DA06
  • Sequence:
    • MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADCDLQITN AQTKEEYTDD 
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPAMATTK AIDDSSASIS LAQLTKTANL 
AEANASEEDK IKAMMSQSGH EYDPINYMKK PLGPPPPSYT CFRCGKPGHY IKNCPTNGDK 
NFESGPRIKK STGIPRSFMM EVKDPNMKGA MLTNTGKYAI PTIDAEAYAI GKKEKPPFLP 
EEPSSSSEED DPIPDELLCL ICKDIMTDAV VIPCCGNSYC DECIRTALLE SDEHTCPTCH 
QNDVSPDALI ANKFLRQAVN NFKNETGYTK RLRKQLPPPP PPIPPPRPLI QRNLQPLMRS 
PISRQQDPLM IPVTSSSTHP APSISSLTSN QSSLAPPVSG NPSSAPAPVP DITATVSISV 
HSEKSDGPFR DSDNKILPAA ALASEHSKGT SSIAITALME EKGYQVPVLG TPSLLGQSLL 
HGQLIPTTGP VRINTARPGG GRPGWEHSNK LGYLVSPPQQ IRRGERSCYR SINRGRHHSE 
RSQRTQGPSL PATPVFVPVP PPPLYPPPPH TLPLPPGVPP PQFSPQFPPG QPPPAGYSVP 
PPGFPPAPAN LSTPWVSSGV QTAHSNTIPT TQAPPLSREE FYREQRRLKE EEKKKSKLDE 
FTNDFAKELM EYKKIQKERR RSFSRSKSPY SGSSYSRSSY TYSKSRSGST RSRSYSRSFS 
RSHSRSYSRS PPYPRRGRGK SRNYRSRSRS HGYHRSRSRS PPYRRYHSRS RSPQAFRGQS 
PNKRNVPQGE TEREYFNRYR EVPPPYDMKA YYGRSVDFRD PFEKERYREW ERKYREWYEK 
YYKGYAAGAQ PRPSANRENF SPERFLPLNI RNSPFTRGRR EDYVGGQSHR SRNIGSNYPE 
KLSARDGHNQ KDNTKSKEKE SENAPGDGKG NKHKKHRKRR KGEESEGFLN PELLETSRKS 
REPTGVEENK TDSLFVLPSR DDATPVRDEP MDAESITFKS VSEKDKRERD KPKAKGDKTK 
RKNDGSAVSK KENIVKPAKG PQEKVDGERE RSPRSEPPIK KAKEETPKTD NTKSSSSSQK 
DEKITGTPRK AHSKSAKEHQ ETKPVKEEKV KKDYSKDVKS EKLTTKEEKA KKPNEKNKPL 
DNKGEKRKRK TEEKGVDKDF ESSSMKISKL EVTEIVKPSP KRKMEPDTEK MDRTPEKDKI 
SLSAPAKKIK LNRETGKKIG STENISNTKE PSEKLESTSS KVKQEKVKGK VRRKVTGTEG 
SSSTLVDYTS TSSTGGSPVR KSEEKTDTKR TVIKTMEEYN NDNTAPAEDV IIMIQVPQSK 
WDKDDFESEE EDVKSTQPIS SVGKPASVIK NVSTKPSNIV KYPEKESEPS EKIQKFTKDV 
SHEIIQHEVK SSKNSASSEK GKTKDRDYSV LEKENPEKRK NSTQPEKESN LDRLNEQGNF 
KSLSQSSKEA RTSDKHDSTR ASSNKDFTPN RDKKTDYDTR EYSSSKRRDE KNELTRRKDS 
PSRNKDSASG QKNKPREERD LPKKGTGDSK KSNSSPSRDR KPHDHKATYD TKRPNEETKS 
VDKNPCKDRE KHVLEARNNK ESSGNKLLYI LNPPETQVEK EQITGQIDKS TVKPKPQLSH 
SSRLSSDLTR ETDEAAFEPD YNESDSESNV SVKEEESSGN ISKDLKDKIV EKAKESLDTA 
AVVQVGISRN QSHSSPSVSP SRSHSPSGSQ TRSHSSSASS AESQDSKKKK KKKEKKKHKK 
HKKHKKHKKH AGTEVELEKS QKHKHKKKKS KKNKDKEKEK EKDDQKVKSV TV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.