Details for: RBBP6
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 11.58rCSI 31.83%PRS 32.29
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CSI 10.97rCSI 26.38%PRS 29.07
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CSI 10.95rCSI 13.14%PRS 19.3
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CSI 9.8rCSI 13.99%PRS 22.22
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CSI 8.65rCSI 6.55%PRS 27.02
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CSI 7.89rCSI 6.64%PRS 31.26
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CSI 7.65rCSI 34.01%PRS 19.35
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CSI 7.22rCSI 6.05%PRS 23.51
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CSI 6.42rCSI 6.18%PRS 20.44
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CSI 6.12rCSI 6.89%PRS 31.41
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CSI 6rCSI 31.52%PRS 33.68
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CSI 5.94rCSI 29.3%PRS 26.73
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CSI 5.12rCSI 20.87%PRS 20.11
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CSI 5rCSI 34.33%PRS 38.01
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CSI 4.93rCSI 6.59%PRS 37.32
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CSI 4.63rCSI 16.45%PRS 57.19
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CSI 4.62rCSI 5.8%PRS 25.51
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CSI 4.56rCSI 19.81%PRS 34.17
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CSI 4.3rCSI 22.63%PRS 33.27
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CSI 4.15rCSI 16.14%PRS 32.36
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CSI 3.97rCSI 3.9%PRS 30.59
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CSI 3.88rCSI 5.77%PRS 23.48
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CSI 3.86rCSI 3.35%PRS 24.69
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CSI 3.78rCSI 3.41%PRS 17.74
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CSI 3.7rCSI 2.78%PRS 20.91
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CSI 3.39rCSI 81.23%PRS 9.99
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CSI 3.37rCSI 81.4%PRS 10.94
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CSI 3.34rCSI 27.18%PRS 19.87
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CSI 3.28rCSI 60.08%PRS 54.11
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CSI 3.28rCSI 4.65%PRS 18.31
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CSI 3.24rCSI 8.11%PRS 52.52
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CSI 3.18rCSI 23.39%PRS 11.52
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CSI 3.18rCSI 34.6%PRS 37.4
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CSI 3.14rCSI 60.63%PRS 53.62
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CSI 2.99rCSI 8.06%PRS 25.55
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CSI 2.98rCSI 10.73%PRS 10.94
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CSI 2.89rCSI 2.03%PRS 45.75
-
CSI 2.43rCSI 2.91%PRS 34.05
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CSI 2.39rCSI 3.04%PRS 22.93
-
CSI 2.32rCSI 2.97%PRS 22.82
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CSI 2.28rCSI 1.85%PRS 19.75
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CSI 2.28rCSI 1.82%PRS 35.04
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CSI 2.22rCSI 5.28%PRS 24.38
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CSI 1.95rCSI 2.81%PRS 27.56
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CSI 1.95rCSI 11.46%PRS 12.18
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CSI 1.88rCSI 10.17%PRS 60.14
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CSI 1.86rCSI 1.54%PRS 19.99
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CSI 1.84rCSI 1.09%PRS 27.55
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CSI 1.83rCSI 8.02%PRS 36.22
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CSI 1.8rCSI 6.02%PRS 13.98
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CSI 1.76rCSI 1.81%PRS 31.95
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CSI 1.68rCSI 7.25%PRS 36.11
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CSI 1.67rCSI 5.23%PRS 12.42
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CSI 1.6rCSI 2.14%PRS 25.65
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CSI 1.6rCSI 4.67%PRS 55.56
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CSI 1.57rCSI 3.82%PRS 11.44
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CSI 1.5rCSI 3.5%PRS 45.09
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CSI 1.5rCSI 16.43%PRS 35.02
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CSI 1.5rCSI 5.66%PRS 11.98
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CSI 1.49rCSI 33.68%PRS 67.08
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CSI 1.48rCSI 9.45%PRS 30.26
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CSI 1.42rCSI 4.99%PRS 34.2
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CSI 1.41rCSI 1.95%PRS 27.87
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CSI 1.38rCSI 2.1%PRS 19.87
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CSI 1.37rCSI 4.64%PRS 31.31
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CSI 1.37rCSI 1.08%PRS 13.55
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CSI 1.37rCSI 3.12%PRS 16.95
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CSI 1.29rCSI 2.31%PRS 18.28
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CSI 1.28rCSI 1.26%PRS 63.6
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CSI 1.26rCSI 6.51%PRS 38.2
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CSI 1.25rCSI 1.2%PRS 39.69
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CSI 1.22rCSI 2.21%PRS 30.05
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CSI 1.21rCSI 1.27%PRS 20.22
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CSI 1.12rCSI 2.1%PRS 38.41
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CSI 1.11rCSI 1.63%PRS 18.16
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CSI 1.08rCSI 1.04%PRS 14.25
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CSI 1.07rCSI 0.8%PRS 17.2
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CSI 1.07rCSI 3.5%PRS 50.87
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CSI 1.06rCSI 0.86%PRS 20.84
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CSI 1.04rCSI 0.82%PRS 23.79
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CSI 1.03rCSI 2.94%PRS 34.65
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CSI 1.02rCSI 1.02%PRS 16.84
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CSI 1.01rCSI 23.64%PRS 36.56
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CSI 1.01rCSI 0.76%PRS 52.65
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CSI 0.97rCSI 2.31%PRS 29.96
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CSI 0.96rCSI 2.79%PRS 41.86
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CSI 0.96rCSI 1.64%PRS 26.7
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CSI 0.95rCSI 1.31%PRS 38.65
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CSI 0.91rCSI 1.93%PRS 39.15
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CSI 0.9rCSI 0.78%PRS 22.19
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CSI 0.89rCSI 1.26%PRS 27.17
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CSI 0.89rCSI 1.14%PRS 19.05
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CSI 0.86rCSI 1.06%PRS 54.51
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CSI 0.85rCSI 0.65%PRS 26.03
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CSI 0.84rCSI 0.59%PRS 20.96
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CSI 0.84rCSI 0.79%PRS 19.8
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CSI 0.84rCSI 12.55%PRS 53.45
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CSI 0.83rCSI 1.46%PRS 14.94
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CSI 0.83rCSI 0.64%PRS 18.26
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CSI 0.83rCSI 2.69%PRS 23.78
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CSI -1.9rCSI -3.3%PRS 11.6%
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CSI -1.7rCSI -5.3%PRS 15.6%
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CSI -1.5rCSI -2.0%PRS 29.8%
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CSI -1.3rCSI -3.2%PRS 19.8%
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CSI -0.9rCSI -8.2%PRS 13.1%
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CSI -0.6rCSI -0.6%PRS 18.4%
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CSI -0.3rCSI -0.5%PRS 25.9%
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CSI -0.2rCSI -1.0%PRS 43.4%
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CSI -0.1rCSI -0.2%PRS 30.4%
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CSI -0.1rCSI -0.1%PRS 27.0%
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CSI -0.1rCSI -0.3%PRS 33.7%
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CSI -0.1rCSI -0.1%PRS 18.2%
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CSI 0.0rCSI 0.1%PRS 18.3%
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CSI 0.1rCSI 0.3%PRS 28.9%
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CSI 0.1rCSI 0.1%PRS 19.7%
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CSI 0.1rCSI 0.3%PRS 15.4%
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CSI 0.1rCSI 0.1%PRS 20.6%
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CSI 0.1rCSI 2.2%PRS 85.2%
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CSI 0.1rCSI 0.3%PRS 41.2%
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CSI 0.1rCSI 0.2%PRS 18.4%
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CSI 0.1rCSI 0.3%PRS 15.1%
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CSI 0.1rCSI 0.1%PRS 30.8%
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CSI 0.1rCSI 0.2%PRS 15.0%
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CSI 0.1rCSI 0.2%PRS 20.7%
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CSI 0.1rCSI 0.2%PRS 31.9%
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CSI 0.1rCSI 0.3%PRS 30.5%
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CSI 0.1rCSI 0.2%PRS 16.6%
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CSI 0.1rCSI 0.3%PRS 44.6%
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CSI 0.1rCSI 0.7%PRS 60.3%
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CSI 0.1rCSI 1.0%PRS 9.8%
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CSI 0.1rCSI 1.5%PRS 56.1%
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CSI 0.1rCSI 0.3%PRS 15.0%
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CSI 0.1rCSI 0.8%PRS 53.1%
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CSI 0.1rCSI 0.6%PRS 34.3%
-
CSI 0.1rCSI 0.2%PRS 19.7%
-
CSI 0.1rCSI 0.3%PRS 38.2%
-
CSI 0.1rCSI 0.3%PRS 12.2%
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CSI 0.1rCSI 0.7%PRS 21.4%
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CSI 0.2rCSI 0.4%PRS 22.3%
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CSI 0.2rCSI 0.6%PRS 26.8%
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CSI 0.2rCSI 4.6%PRS 43.0%
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CSI 0.2rCSI 1.0%PRS 56.7%
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CSI 0.2rCSI 0.3%PRS 14.2%
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CSI 0.2rCSI 0.3%PRS 24.9%
-
CSI 0.2rCSI 0.3%PRS 32.7%
-
CSI 0.2rCSI 0.3%PRS 19.9%
-
CSI 0.2rCSI 0.3%PRS 29.6%
-
CSI 0.2rCSI 0.8%PRS 48.6%
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CSI 0.2rCSI 0.3%PRS 34.4%
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CSI 0.2rCSI 0.4%PRS 31.2%
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CSI 0.2rCSI 2.0%PRS 46.2%
-
CSI 0.2rCSI 0.2%PRS 17.3%
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CSI 0.2rCSI 0.3%PRS 25.9%
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CSI 0.2rCSI 1.7%PRS 62.9%
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CSI 0.2rCSI 0.3%PRS 45.4%
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CSI 0.2rCSI 0.4%PRS 43.9%
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CSI 0.2rCSI 0.7%PRS 32.0%
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CSI 0.2rCSI 0.3%PRS 25.4%
-
CSI 0.2rCSI 0.3%PRS 23.5%
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CSI 0.2rCSI 1.0%PRS 15.4%
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CSI 0.2rCSI 2.3%PRS 64.6%
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CSI 0.2rCSI 0.3%PRS 16.7%
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CSI 0.2rCSI 0.5%PRS 14.1%
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CSI 0.2rCSI 0.2%PRS 34.9%
-
CSI 0.2rCSI 1.1%PRS 10.7%
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CSI 0.2rCSI 0.6%PRS 16.4%
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CSI 0.2rCSI 4.9%PRS 56.9%
-
CSI 0.2rCSI 0.4%PRS 47.1%
-
CSI 0.2rCSI 0.9%PRS 27.9%
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CSI 0.2rCSI 3.4%PRS 46.9%
-
CSI 0.2rCSI 0.4%PRS 18.4%
-
CSI 0.2rCSI 0.3%PRS 15.3%
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CSI 0.2rCSI 0.4%PRS 16.3%
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CSI 0.2rCSI 1.6%PRS 48.8%
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CSI 0.2rCSI 0.3%PRS 21.0%
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CSI 0.3rCSI 0.5%PRS 31.4%
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CSI 0.3rCSI 0.9%PRS 59.9%
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CSI 0.3rCSI 1.5%PRS 29.3%
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CSI 0.3rCSI 0.5%PRS 42.3%
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CSI 0.3rCSI 0.4%PRS 19.8%
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CSI 0.3rCSI 0.7%PRS 31.3%
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CSI 0.3rCSI 1.5%PRS 49.1%
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CSI 0.3rCSI 0.4%PRS 15.2%
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CSI 0.3rCSI 2.6%PRS 67.8%
-
CSI 0.3rCSI 0.3%PRS 34.2%
-
CSI 0.3rCSI 0.3%PRS 36.2%
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CSI 0.3rCSI 0.7%PRS 29.5%
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CSI 0.3rCSI 0.3%PRS 11.4%
-
CSI 0.3rCSI 1.8%PRS 60.7%
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CSI 0.3rCSI 1.7%PRS 25.2%
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CSI 0.3rCSI 0.4%PRS 17.5%
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CSI 0.3rCSI 0.7%PRS 19.4%
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CSI 0.3rCSI 1.9%PRS 48.1%
-
CSI 0.3rCSI 0.4%PRS 10.6%
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CSI 0.3rCSI 0.7%PRS 20.4%
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CSI 0.3rCSI 0.4%PRS 12.2%
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CSI 0.3rCSI 0.9%PRS 23.6%
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CSI 0.3rCSI 0.4%PRS 19.2%
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CSI 0.3rCSI 2.4%PRS 51.2%
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CSI 0.3rCSI 0.5%PRS 20.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 8466751
Symbol: RBBP6_HUMAN
Name: E3 ubiquitin-protein ligase RBBP6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8595913
Title: cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product.
PubMed ID: 8595913
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12064457
Title: P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity.
PubMed ID: 12064457
DOI: 10.1002/jcp.10084
PubMed ID: 15475430
Title: Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.
PubMed ID: 15475430
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17470788
Title: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
PubMed ID: 17470788
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18851979
Title: RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.
PubMed ID: 18851979
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20873783
Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
PubMed ID: 20873783
DOI: 10.1021/pr100562w
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24726359
Title: The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.
PubMed ID: 24726359
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 16396680
Title: DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.
PubMed ID: 16396680
PubMed ID: 22130672
Title: Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box.
PubMed ID: 22130672
PubMed ID: 30550789
Title: Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
PubMed ID: 30550789
Sequence Information:
- Length: 1792
- Mass: 201564
- Checksum: 550F7BBA5125DA06
- Sequence:
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADCDLQITN AQTKEEYTDD NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPAMATTK AIDDSSASIS LAQLTKTANL AEANASEEDK IKAMMSQSGH EYDPINYMKK PLGPPPPSYT CFRCGKPGHY IKNCPTNGDK NFESGPRIKK STGIPRSFMM EVKDPNMKGA MLTNTGKYAI PTIDAEAYAI GKKEKPPFLP EEPSSSSEED DPIPDELLCL ICKDIMTDAV VIPCCGNSYC DECIRTALLE SDEHTCPTCH QNDVSPDALI ANKFLRQAVN NFKNETGYTK RLRKQLPPPP PPIPPPRPLI QRNLQPLMRS PISRQQDPLM IPVTSSSTHP APSISSLTSN QSSLAPPVSG NPSSAPAPVP DITATVSISV HSEKSDGPFR DSDNKILPAA ALASEHSKGT SSIAITALME EKGYQVPVLG TPSLLGQSLL HGQLIPTTGP VRINTARPGG GRPGWEHSNK LGYLVSPPQQ IRRGERSCYR SINRGRHHSE RSQRTQGPSL PATPVFVPVP PPPLYPPPPH TLPLPPGVPP PQFSPQFPPG QPPPAGYSVP PPGFPPAPAN LSTPWVSSGV QTAHSNTIPT TQAPPLSREE FYREQRRLKE EEKKKSKLDE FTNDFAKELM EYKKIQKERR RSFSRSKSPY SGSSYSRSSY TYSKSRSGST RSRSYSRSFS RSHSRSYSRS PPYPRRGRGK SRNYRSRSRS HGYHRSRSRS PPYRRYHSRS RSPQAFRGQS PNKRNVPQGE TEREYFNRYR EVPPPYDMKA YYGRSVDFRD PFEKERYREW ERKYREWYEK YYKGYAAGAQ PRPSANRENF SPERFLPLNI RNSPFTRGRR EDYVGGQSHR SRNIGSNYPE KLSARDGHNQ KDNTKSKEKE SENAPGDGKG NKHKKHRKRR KGEESEGFLN PELLETSRKS REPTGVEENK TDSLFVLPSR DDATPVRDEP MDAESITFKS VSEKDKRERD KPKAKGDKTK RKNDGSAVSK KENIVKPAKG PQEKVDGERE RSPRSEPPIK KAKEETPKTD NTKSSSSSQK DEKITGTPRK AHSKSAKEHQ ETKPVKEEKV KKDYSKDVKS EKLTTKEEKA KKPNEKNKPL DNKGEKRKRK TEEKGVDKDF ESSSMKISKL EVTEIVKPSP KRKMEPDTEK MDRTPEKDKI SLSAPAKKIK LNRETGKKIG STENISNTKE PSEKLESTSS KVKQEKVKGK VRRKVTGTEG SSSTLVDYTS TSSTGGSPVR KSEEKTDTKR TVIKTMEEYN NDNTAPAEDV IIMIQVPQSK WDKDDFESEE EDVKSTQPIS SVGKPASVIK NVSTKPSNIV KYPEKESEPS EKIQKFTKDV SHEIIQHEVK SSKNSASSEK GKTKDRDYSV LEKENPEKRK NSTQPEKESN LDRLNEQGNF KSLSQSSKEA RTSDKHDSTR ASSNKDFTPN RDKKTDYDTR EYSSSKRRDE KNELTRRKDS PSRNKDSASG QKNKPREERD LPKKGTGDSK KSNSSPSRDR KPHDHKATYD TKRPNEETKS VDKNPCKDRE KHVLEARNNK ESSGNKLLYI LNPPETQVEK EQITGQIDKS TVKPKPQLSH SSRLSSDLTR ETDEAAFEPD YNESDSESNV SVKEEESSGN ISKDLKDKIV EKAKESLDTA AVVQVGISRN QSHSSPSVSP SRSHSPSGSQ TRSHSSSASS AESQDSKKKK KKKEKKKHKK HKKHKKHKKH AGTEVELEKS QKHKHKKKKS KKNKDKEKEK EKDDQKVKSV TV