Details for: RBBP7
Gene ID: 5931
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RBBP7
Ensembl ID: ENSG00000102054
Description: RB binding protein 7, chromatin remodeling factor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 46.39rCSI 71.69%PRS 26.5
-
CSI 32.02rCSI 28.91%PRS 25.69
-
CSI 31.97rCSI 40.13%PRS 36.03
-
CSI 23.43rCSI 27.51%PRS 31.91
-
CSI 20.27rCSI 16.39%PRS 28.32
-
CSI 18.1rCSI 13.69%PRS 37.77
-
CSI 18.03rCSI 40.91%PRS 35.17
-
CSI 17.4rCSI 16.75%PRS 29.04
-
CSI 16.94rCSI 48.36%PRS 43.44
-
CSI 16.29rCSI 23.24%PRS 30.95
-
CSI 13.86rCSI 40.12%PRS 31.18
-
CSI 13.29rCSI 11.02%PRS 26.83
-
CSI 12.09rCSI 47.05%PRS 45.02
-
CSI 11.71rCSI 9.08%PRS 27.56
-
CSI 10.97rCSI 12.69%PRS 21.01
-
CSI 10.69rCSI 8.69%PRS 29.2
-
CSI 10.69rCSI 18.85%PRS 35.63
-
CSI 10.55rCSI 12.66%PRS 27.25
-
CSI 9.41rCSI 28.05%PRS 54.19
-
CSI 9.32rCSI 9.74%PRS 28.87
-
CSI 9.14rCSI 8.97%PRS 41.84
-
CSI 9.01rCSI 6.85%PRS 36.81
-
CSI 9.01rCSI 14.38%PRS 30.82
-
CSI 8.98rCSI 20.47%PRS 28.33
-
CSI 8.95rCSI 6.03%PRS 34.97
-
CSI 8.57rCSI 17.7%PRS 38.26
-
CSI 8.3rCSI 36.88%PRS 27.25
-
CSI 8.25rCSI 11.27%PRS 31.68
-
CSI 7.83rCSI 9.74%PRS 30.11
-
CSI 7.61rCSI 14.38%PRS 53
-
CSI 6.85rCSI 6.6%PRS 21.12
-
CSI 6.72rCSI 5.03%PRS 42.02
-
CSI 6.57rCSI 6.88%PRS 29.91
-
CSI 6.24rCSI 4.15%PRS 32.64
-
CSI 6.23rCSI 13.91%PRS 32.87
-
CSI 6.19rCSI 31.98%PRS 50.77
-
CSI 6.06rCSI 32.69%PRS 43.66
-
CSI 6.02rCSI 11.7%PRS 29.09
-
CSI 5.98rCSI 6.93%PRS 38.91
-
CSI 5.89rCSI 5.44%PRS 47.42
-
CSI 5.88rCSI 5.09%PRS 31.33
-
CSI 5.86rCSI 4.07%PRS 33.96
-
CSI 5.75rCSI 12.88%PRS 17.97
-
CSI 5.71rCSI 9.78%PRS 36.87
-
CSI 5.67rCSI 4.2%PRS 24.23
-
CSI 5.59rCSI 18.13%PRS 32.61
-
CSI 5.36rCSI 10.64%PRS 29.11
-
CSI 5.16rCSI 8.35%PRS 27.95
-
CSI 5.14rCSI 30.29%PRS 18.27
-
CSI 5.1rCSI 5.34%PRS 26.25
-
CSI 4.99rCSI 13.7%PRS 43.7
-
CSI 4.97rCSI 4.36%PRS 36.34
-
CSI 4.83rCSI 5.77%PRS 17.17
-
CSI 4.82rCSI 5.52%PRS 51.14
-
CSI 4.5rCSI 12.92%PRS 41.46
-
CSI 4.42rCSI 8.88%PRS 21.04
-
CSI 4.39rCSI 4.05%PRS 29.19
-
CSI 4.37rCSI 27.33%PRS 22.7
-
CSI 4.36rCSI 10.4%PRS 31.1
-
CSI 4.32rCSI 3.58%PRS 28.56
-
CSI 4.24rCSI 5.87%PRS 36.06
-
CSI 4.09rCSI 4.79%PRS 39.38
-
CSI 4.09rCSI 2.85%PRS 38.79
-
CSI 4.05rCSI 9.25%PRS 24.15
-
CSI 3.98rCSI 3.33%PRS 32.76
-
CSI 3.9rCSI 5.98%PRS 33.43
-
CSI 3.89rCSI 4.06%PRS 28.83
-
CSI 3.84rCSI 3.23%PRS 42.92
-
CSI 3.82rCSI 3.06%PRS 47.47
-
CSI 3.79rCSI 5.44%PRS 36.38
-
CSI 3.78rCSI 63.96%PRS 68.53
-
CSI 3.74rCSI 5.65%PRS 28.89
-
CSI 3.72rCSI 3.72%PRS 24.11
-
CSI 3.68rCSI 2.76%PRS 64.4
-
CSI 3.64rCSI 3.8%PRS 63.46
-
CSI 3.54rCSI 9.33%PRS 33.49
-
CSI 3.53rCSI 8.74%PRS 26.33
-
CSI 3.52rCSI 11.3%PRS 37.34
-
CSI 3.5rCSI 3.31%PRS 29.35
-
CSI 3.44rCSI 3.87%PRS 42.9
-
CSI 3.4rCSI 6.48%PRS 43.19
-
CSI 3.38rCSI 3.9%PRS 24.38
-
CSI 3.37rCSI 3.31%PRS 30.13
-
CSI 3.36rCSI 4.59%PRS 30.88
-
CSI 3.33rCSI 4.72%PRS 26.17
-
CSI 3.33rCSI 4.8%PRS 37.59
-
CSI 3.31rCSI 4.27%PRS 17.97
-
CSI 3.27rCSI 10.45%PRS 24.62
-
CSI 3.26rCSI 4.36%PRS 49.3
-
CSI 3.26rCSI 9.62%PRS 32.67
-
CSI 3.24rCSI 2.88%PRS 28.09
-
CSI 3.23rCSI 2.94%PRS 41.28
-
CSI 3.21rCSI 4.89%PRS 25.99
-
CSI 3.21rCSI 2.5%PRS 40.85
-
CSI 3.16rCSI 11.22%PRS 67.91
-
CSI 3.14rCSI 8.12%PRS 25.95
-
CSI 3.07rCSI 2.7%PRS 20.68
-
CSI 3.07rCSI 4.26%PRS 28.33
-
CSI 3.06rCSI 2.68%PRS 32.07
-
CSI 3.02rCSI 3.74%PRS 24.9
-
CSI 0.1rCSI 0.6%PRS 45.0%
-
CSI 0.1rCSI 3.1%PRS 74.2%
-
CSI 0.1rCSI 0.7%PRS 39.9%
-
CSI 0.1rCSI 3.0%PRS 49.5%
-
CSI 0.2rCSI 0.6%PRS 21.7%
-
CSI 0.2rCSI 2.3%PRS 59.8%
-
CSI 0.3rCSI 3.9%PRS 58.1%
-
CSI 0.3rCSI 3.4%PRS 49.2%
-
CSI 0.3rCSI 1.8%PRS 69.8%
-
CSI 0.3rCSI 8.2%PRS 16.4%
-
CSI 0.4rCSI 0.6%PRS 17.4%
-
CSI 0.4rCSI 1.3%PRS 45.3%
-
CSI 0.4rCSI 3.0%PRS 47.8%
-
CSI 0.4rCSI 3.0%PRS 60.1%
-
CSI 0.4rCSI 2.8%PRS 61.0%
-
CSI 0.5rCSI 0.6%PRS 40.0%
-
CSI 0.5rCSI 2.4%PRS 44.3%
-
CSI 0.5rCSI 1.4%PRS 45.7%
-
CSI 0.5rCSI 2.6%PRS 37.5%
-
CSI 0.5rCSI 0.8%PRS 45.9%
-
CSI 0.5rCSI 2.5%PRS 58.2%
-
CSI 0.5rCSI 2.3%PRS 46.3%
-
CSI 0.6rCSI 3.4%PRS 39.7%
-
CSI 0.6rCSI 4.1%PRS 66.4%
-
CSI 0.6rCSI 2.2%PRS 40.7%
-
CSI 0.6rCSI 2.8%PRS 44.7%
-
CSI 0.7rCSI 1.0%PRS 37.9%
-
CSI 0.7rCSI 1.8%PRS 36.0%
-
CSI 0.7rCSI 1.1%PRS 18.9%
-
CSI 0.7rCSI 2.1%PRS 46.9%
-
CSI 0.8rCSI 1.4%PRS 20.9%
-
CSI 0.8rCSI 3.5%PRS 69.4%
-
CSI 0.8rCSI 2.4%PRS 18.2%
-
CSI 0.8rCSI 1.7%PRS 49.4%
-
CSI 0.8rCSI 1.5%PRS 42.0%
-
CSI 0.8rCSI 2.4%PRS 22.3%
-
CSI 0.9rCSI 3.8%PRS 25.1%
-
CSI 0.9rCSI 1.0%PRS 46.0%
-
CSI 0.9rCSI 1.3%PRS 42.6%
-
CSI 0.9rCSI 2.8%PRS 29.0%
-
CSI 0.9rCSI 3.2%PRS 16.5%
-
CSI 0.9rCSI 1.7%PRS 57.5%
-
CSI 0.9rCSI 2.2%PRS 61.8%
-
CSI 0.9rCSI 1.1%PRS 40.8%
-
CSI 0.9rCSI 1.9%PRS 50.6%
-
CSI 0.9rCSI 3.0%PRS 62.5%
-
CSI 0.9rCSI 22.4%PRS 17.2%
-
CSI 0.9rCSI 2.0%PRS 36.9%
-
CSI 0.9rCSI 2.2%PRS 39.9%
-
CSI 1.0rCSI 1.5%PRS 21.7%
-
CSI 1.0rCSI 1.6%PRS 39.6%
-
CSI 1.0rCSI 2.1%PRS 42.3%
-
CSI 1.0rCSI 1.4%PRS 22.2%
-
CSI 1.0rCSI 2.8%PRS 33.2%
-
CSI 1.0rCSI 0.8%PRS 45.0%
-
CSI 1.1rCSI 3.0%PRS 42.2%
-
CSI 1.1rCSI 1.3%PRS 46.2%
-
CSI 1.1rCSI 1.5%PRS 56.7%
-
CSI 1.1rCSI 2.1%PRS 49.7%
-
CSI 1.2rCSI 4.2%PRS 44.8%
-
CSI 1.2rCSI 2.9%PRS 39.3%
-
CSI 1.2rCSI 1.6%PRS 31.0%
-
CSI 1.2rCSI 6.0%PRS 36.7%
-
CSI 1.2rCSI 2.9%PRS 45.7%
-
CSI 1.2rCSI 2.7%PRS 31.8%
-
CSI 1.2rCSI 3.6%PRS 50.7%
-
CSI 1.2rCSI 1.9%PRS 43.5%
-
CSI 1.3rCSI 1.1%PRS 35.0%
-
CSI 1.3rCSI 4.3%PRS 69.9%
-
CSI 1.3rCSI 2.4%PRS 52.8%
-
CSI 1.3rCSI 2.0%PRS 23.8%
-
CSI 1.3rCSI 4.3%PRS 20.1%
-
CSI 1.3rCSI 1.0%PRS 30.1%
-
CSI 1.3rCSI 3.2%PRS 43.0%
-
CSI 1.4rCSI 1.8%PRS 30.3%
-
CSI 1.4rCSI 1.4%PRS 39.2%
-
CSI 1.4rCSI 1.9%PRS 24.5%
-
CSI 1.4rCSI 2.1%PRS 36.7%
-
CSI 1.4rCSI 5.8%PRS 28.5%
-
CSI 1.4rCSI 1.8%PRS 32.3%
-
CSI 1.5rCSI 1.5%PRS 44.4%
-
CSI 1.5rCSI 2.0%PRS 48.8%
-
CSI 1.5rCSI 2.8%PRS 35.6%
-
CSI 1.5rCSI 2.1%PRS 41.9%
-
CSI 1.5rCSI 3.5%PRS 40.0%
-
CSI 1.5rCSI 7.7%PRS 69.7%
-
CSI 1.5rCSI 4.0%PRS 57.9%
-
CSI 1.6rCSI 5.5%PRS 42.7%
-
CSI 1.6rCSI 1.9%PRS 33.7%
-
CSI 1.6rCSI 6.2%PRS 48.7%
-
CSI 1.6rCSI 1.5%PRS 33.5%
-
CSI 1.7rCSI 1.6%PRS 51.7%
-
CSI 1.7rCSI 2.7%PRS 21.9%
-
CSI 1.7rCSI 6.7%PRS 44.4%
-
CSI 1.7rCSI 4.3%PRS 27.2%
-
CSI 1.7rCSI 2.6%PRS 32.0%
-
CSI 1.7rCSI 2.1%PRS 34.6%
-
CSI 1.7rCSI 1.3%PRS 39.8%
-
CSI 1.7rCSI 4.6%PRS 41.0%
-
CSI 1.8rCSI 1.9%PRS 31.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2749591931
Symbol: RBBP7_HUMAN
Name: Histone-binding protein RBBP7
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7503932
Title: Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast.
PubMed ID: 7503932
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 9150135
Title: Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.
PubMed ID: 9150135
PubMed ID: 9790534
Title: The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
PubMed ID: 9790534
PubMed ID: 9427644
Title: Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.
PubMed ID: 9427644
PubMed ID: 9651585
Title: SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
PubMed ID: 9651585
PubMed ID: 10444591
Title: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
PubMed ID: 10444591
PubMed ID: 10220405
Title: BRCA1 interacts with components of the histone deacetylase complex.
PubMed ID: 10220405
PubMed ID: 10866654
Title: Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB.
PubMed ID: 10866654
PubMed ID: 11102443
Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
PubMed ID: 11102443
PubMed ID: 11118440
Title: Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.
PubMed ID: 11118440
PubMed ID: 12435631
Title: Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
PubMed ID: 12435631
DOI: 10.1101/gad.1035902
PubMed ID: 11784859
Title: Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).
PubMed ID: 11784859
PubMed ID: 14609955
Title: Isolation of human NURF: a regulator of Engrailed gene expression.
PubMed ID: 14609955
DOI: 10.1093/emboj/cdg582
PubMed ID: 12920132
Title: The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
PubMed ID: 12920132
PubMed ID: 15310751
Title: A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling.
PubMed ID: 15310751
PubMed ID: 15456747
Title: MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
PubMed ID: 15456747
PubMed ID: 15701600
Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
PubMed ID: 15701600
PubMed ID: 16428440
Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
PubMed ID: 16428440
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20523938
Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.
PubMed ID: 20523938
DOI: 10.1039/c004108d
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25556658
Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.
PubMed ID: 25556658
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28977666
Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
PubMed ID: 28977666
DOI: 10.1093/nar/gkx711
PubMed ID: 33283408
Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.
PubMed ID: 33283408
DOI: 10.1111/febs.15650
PubMed ID: 18571423
Title: Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.
PubMed ID: 18571423
Sequence Information:
- Length: 425
- Mass: 47820
- Checksum: 1A4B4CD1A8E96815
- Sequence:
MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV FDYTKHPAKP DPSGECNPDL RLRGHQKEGY GLSWNSNLSG HLLSASDDHT VCLWDINAGP KEGKIVDAKA IFTGHSAVVE DVAWHLLHES LFGSVADDQK LMIWDTRSNT TSKPSHLVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW DLRNLKLKLH TFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG EEQSAEDAED GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI WQMAENIYND EESDVTTSEL EGQGS