RBBP7 | ENSG00000102054 | NCBI 5931

Details for: RBBP7

Gene ID: 5931

Symbol: RBBP7

Ensembl ID: ENSG00000102054

Description: RB binding protein 7, chromatin remodeling factor

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Adipogenesis
(R-HSA-9843745)
Cell cycle
(R-HSA-1640170)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Potential therapeutics for sars
(R-HSA-9679191)
Prc2 methylates histones and dna
(R-HSA-212300)
Pten regulation
(R-HSA-6807070)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of pten gene transcription
(R-HSA-8943724)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Sars-cov infections
(R-HSA-9679506)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of brown and beige adipocyte differentiation
(R-HSA-9843743)
Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
(R-HSA-9844594)
Viral infection pathways
(R-HSA-9824446)
Atpase complex
(GO:1904949)
Brain development
(GO:0007420)
Cellular heat acclimation
(GO:0070370)
Chromatin remodeling
(GO:0006338)
Chromosome, telomeric region
(GO:0000781)
Cytosol
(GO:0005829)
Dna replication
(GO:0006260)
Esc/e(z) complex
(GO:0035098)
Histone binding
(GO:0042393)
Histone deacetylase complex
(GO:0000118)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of stem cell population maintenance
(GO:1902455)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Nurd complex
(GO:0016581)
Nurf complex
(GO:0016589)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of stem cell population maintenance
(GO:1902459)
Protein binding
(GO:0005515)
Regulation of cell fate specification
(GO:0042659)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of stem cell differentiation
(GO:2000736)
Response to steroid hormone
(GO:0048545)
Rna binding
(GO:0003723)
Sin3-type complex
(GO:0070822)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 233.3083
Cell Significance Index: -36.2900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 154.6857
Cell Significance Index: -39.2400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 129.2883
Cell Significance Index: -53.2600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 115.0548
Cell Significance Index: -54.3200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 110.7058
Cell Significance Index: -44.9800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.1110
Cell Significance Index: -52.0100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 47.2483
Cell Significance Index: -45.1100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.9342
Cell Significance Index: -50.4700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.4622
Cell Significance Index: -44.1000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.3906
Cell Significance Index: -52.8400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.9520
Cell Significance Index: -36.7100
Cell Name: peg cell (CL4033014)
Fold Change: 5.5827
Cell Significance Index: 128.9800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 5.1177
Cell Significance Index: 137.1300
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.4781
Cell Significance Index: 48.7900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.0229
Cell Significance Index: 82.2800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.4433
Cell Significance Index: 65.2400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.1370
Cell Significance Index: 27.3700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.0376
Cell Significance Index: 240.3000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.8866
Cell Significance Index: 25.7400
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.8635
Cell Significance Index: 49.0000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.5818
Cell Significance Index: 33.1100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3854
Cell Significance Index: 1250.9000
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3653
Cell Significance Index: 745.6200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3311
Cell Significance Index: 182.8000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2462
Cell Significance Index: 153.2300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1708
Cell Significance Index: 211.0700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.1173
Cell Significance Index: 77.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1093
Cell Significance Index: 51.7200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0496
Cell Significance Index: 67.7200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9741
Cell Significance Index: 33.8500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8075
Cell Significance Index: 103.5200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7991
Cell Significance Index: 160.3000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7749
Cell Significance Index: 342.6000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7445
Cell Significance Index: 34.9900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6753
Cell Significance Index: 134.0200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6742
Cell Significance Index: 35.0300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6718
Cell Significance Index: 47.5100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5584
Cell Significance Index: 25.3100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3698
Cell Significance Index: 36.5800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3390
Cell Significance Index: 43.8000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3285
Cell Significance Index: 9.4700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3267
Cell Significance Index: 117.1800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3216
Cell Significance Index: 23.9700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3213
Cell Significance Index: 6.9600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2544
Cell Significance Index: 7.1100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2341
Cell Significance Index: 39.9700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2275
Cell Significance Index: 157.3700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1413
Cell Significance Index: 7.4200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1323
Cell Significance Index: 8.3400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0986
Cell Significance Index: 3.4700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0754
Cell Significance Index: 0.8200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0626
Cell Significance Index: 3.5100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0300
Cell Significance Index: 19.0600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0257
Cell Significance Index: 48.3900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0088
Cell Significance Index: 13.5200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0039
Cell Significance Index: 5.2500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0025
Cell Significance Index: 1.1300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0022
Cell Significance Index: 4.1000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0107
Cell Significance Index: -7.9500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0125
Cell Significance Index: -9.1900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0189
Cell Significance Index: -3.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0203
Cell Significance Index: -15.3500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0301
Cell Significance Index: -18.8200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0490
Cell Significance Index: -3.7600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0556
Cell Significance Index: -31.3300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0598
Cell Significance Index: -9.7300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0670
Cell Significance Index: -4.1200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0707
Cell Significance Index: -7.2200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0890
Cell Significance Index: -0.8200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0963
Cell Significance Index: -2.4600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1142
Cell Significance Index: -24.0600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1168
Cell Significance Index: -7.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1517
Cell Significance Index: -17.3800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1555
Cell Significance Index: -4.9800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1571
Cell Significance Index: -45.1900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1636
Cell Significance Index: -1.9500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1706
Cell Significance Index: -24.8000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2094
Cell Significance Index: -4.4600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2289
Cell Significance Index: -2.6000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2630
Cell Significance Index: -30.6500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3260
Cell Significance Index: -14.4200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3337
Cell Significance Index: -9.8000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3711
Cell Significance Index: -6.2100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3736
Cell Significance Index: -10.7100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4034
Cell Significance Index: -46.0500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.4096
Cell Significance Index: -3.2700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4500
Cell Significance Index: -11.2500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4750
Cell Significance Index: -49.4600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4774
Cell Significance Index: -32.1000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4955
Cell Significance Index: -25.8100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5008
Cell Significance Index: -39.6600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5408
Cell Significance Index: -20.4800
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6379
Cell Significance Index: -12.4500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6718
Cell Significance Index: -17.9700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.7095
Cell Significance Index: -5.9600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7733
Cell Significance Index: -47.4100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7932
Cell Significance Index: -20.3900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8233
Cell Significance Index: -24.2500
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.9026
Cell Significance Index: -9.5900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.9078
Cell Significance Index: -45.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RBBP7 is a member of the RB binding protein family, which is characterized by its ability to bind to RB protein, a tumor suppressor that regulates cell cycle progression. RBBP7 is a chromatin remodeling factor that interacts with histone-modifying enzymes, such as histone deacetylases and methyltransferases, to regulate chromatin structure and gene expression. It is also involved in the regulation of DNA replication, repair, and transcription. RBBP7 has several key characteristics, including: * **Histone-binding activity**: RBBP7 binds to histones, which are the main components of chromatin, and modulates their acetylation and methylation status. * **Chromatin remodeling**: RBBP7 interacts with chromatin-modifying enzymes to remodel chromatin structure and regulate gene expression. * **Cell cycle regulation**: RBBP7 is involved in the regulation of cell cycle progression, particularly in the G2/M phase. * **Stress response**: RBBP7 is activated in response to stress, including heat shock, oxidative stress, and DNA damage. **Pathways and Functions** RBBP7 is involved in several pathways and functions, including: * **Cell cycle regulation**: RBBP7 regulates cell cycle progression by interacting with cyclin-dependent kinases and the RB protein. * **Chromatin remodeling**: RBBP7 interacts with chromatin-modifying enzymes to remodel chromatin structure and regulate gene expression. * **DNA replication**: RBBP7 is involved in the regulation of DNA replication, repair, and transcription. * **Transcriptional regulation**: RBBP7 regulates transcriptional activity by interacting with transcription factors and RNA polymerase II. * **Stress response**: RBBP7 is activated in response to stress, including heat shock, oxidative stress, and DNA damage. **Clinical Significance** RBBP7 has been implicated in several diseases, including: * **Cancer**: RBBP7 is overexpressed in several types of cancer, including breast, colon, and prostate cancer. * **Neurodegenerative disorders**: RBBP7 is involved in the regulation of gene expression in neurons and is implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. * **Infectious diseases**: RBBP7 is involved in the regulation of gene expression in response to viral infections, including HIV and SARS-CoV. * **Autoimmune diseases**: RBBP7 is involved in the regulation of immune responses and is implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Overall, RBBP7 is a critical regulator of cellular processes, including development, cell cycle regulation, and response to stress. Its dysregulation has significant implications for human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone-binding protein RBBP7

Genular Protein ID: 2749591931

Symbol: RBBP7_HUMAN

Name: Histone-binding protein RBBP7

UniProtKB Accession Codes:

Q16576 Q5JP00

Database IDs:

Citations:

PubMed ID: 7503932

Title: Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast.

PubMed ID: 7503932

DOI: 10.1074/jbc.270.43.25507

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9150135

Title: Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.

PubMed ID: 9150135

DOI: 10.1016/s0092-8674(00)80216-0

PubMed ID: 9790534

Title: The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.

PubMed ID: 9790534

DOI: 10.1016/s0092-8674(00)81758-4

PubMed ID: 9427644

Title: Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.

PubMed ID: 9427644

DOI: 10.1016/s0960-9822(98)70040-5

PubMed ID: 9651585

Title: SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.

PubMed ID: 9651585

DOI: 10.1016/s1097-2765(00)80102-1

PubMed ID: 10444591

Title: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.

PubMed ID: 10444591

DOI: 10.1101/gad.13.15.1924

PubMed ID: 10220405

Title: BRCA1 interacts with components of the histone deacetylase complex.

PubMed ID: 10220405

DOI: 10.1073/pnas.96.9.4983

PubMed ID: 10866654

Title: Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB.

PubMed ID: 10866654

DOI: 10.1128/mcb.20.14.4970-4978.2000

PubMed ID: 11102443

Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

PubMed ID: 11102443

DOI: 10.1074/jbc.m007372200

PubMed ID: 11118440

Title: Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.

PubMed ID: 11118440

DOI: 10.1074/jbc.m007664200

PubMed ID: 12435631

Title: Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

PubMed ID: 12435631

DOI: 10.1101/gad.1035902

PubMed ID: 11784859

Title: Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

PubMed ID: 11784859

DOI: 10.1128/mcb.22.3.835-848.2002

PubMed ID: 14609955

Title: Isolation of human NURF: a regulator of Engrailed gene expression.

PubMed ID: 14609955

DOI: 10.1093/emboj/cdg582

PubMed ID: 12920132

Title: The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.

PubMed ID: 12920132

DOI: 10.1074/jbc.m302955200

PubMed ID: 15310751

Title: A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling.

PubMed ID: 15310751

DOI: 10.1074/jbc.m406212200

PubMed ID: 15456747

Title: MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.

PubMed ID: 15456747

DOI: 10.1074/jbc.m409149200

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25556658

Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

PubMed ID: 25556658

DOI: 10.1016/j.devcel.2014.11.030

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 18571423

Title: Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.

PubMed ID: 18571423

DOI: 10.1016/j.str.2008.05.006

Sequence Information:

Length: 425
Mass: 47820
Checksum: 1A4B4CD1A8E96815
Sequence:

MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI 
NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV FDYTKHPAKP DPSGECNPDL RLRGHQKEGY 
GLSWNSNLSG HLLSASDDHT VCLWDINAGP KEGKIVDAKA IFTGHSAVVE DVAWHLLHES 
LFGSVADDQK LMIWDTRSNT TSKPSHLVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW 
DLRNLKLKLH TFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG EEQSAEDAED 
GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI WQMAENIYND EESDVTTSEL 
EGQGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RBBP7

Associated with

Cells (max top 100)

Other Information

Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. PubMed ID: 7503932

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. PubMed ID: 9150135

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. PubMed ID: 9790534

Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. PubMed ID: 9427644

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. PubMed ID: 9651585

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. PubMed ID: 10444591

BRCA1 interacts with components of the histone deacetylase complex. PubMed ID: 10220405

Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. PubMed ID: 10866654

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. PubMed ID: 11102443

Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. PubMed ID: 11118440

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. PubMed ID: 12435631

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). PubMed ID: 11784859

Isolation of human NURF: a regulator of Engrailed gene expression. PubMed ID: 14609955

The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. PubMed ID: 12920132

A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. PubMed ID: 15310751

MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. PubMed ID: 15456747

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. PubMed ID: 15701600

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. PubMed ID: 16428440

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. PubMed ID: 20523938

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. PubMed ID: 25556658

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PubMed ID: 28977666

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. PubMed ID: 33283408

Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. PubMed ID: 18571423