Details for: RELA
Gene ID: 5970
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RELA
Ensembl ID: ENSG00000173039
Description: RELA proto-oncogene, NF-kB subunit
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.73rCSI 10.33%PRS 72.81
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CSI 10.19rCSI 12.97%PRS 78.87
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CSI 7.03rCSI 22.8%PRS 71.98
-
CSI 6.99rCSI 5.86%PRS 76.49
-
CSI 6.43rCSI 14.58%PRS 74.95
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CSI 6.37rCSI 23.04%PRS 89.78
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CSI 5.61rCSI 11.39%PRS 51.4
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CSI 4.93rCSI 3.75%PRS 85.97
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CSI 4.76rCSI 3.21%PRS 86.45
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CSI 4.25rCSI 3.58%PRS 87.64
-
CSI 4.06rCSI 3.25%PRS 89.25
-
CSI 3.79rCSI 5.54%PRS 78.16
-
CSI 3.37rCSI 2.34%PRS 84.77
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CSI 3.36rCSI 4.57%PRS 82.95
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CSI 3.32rCSI 5.01%PRS 78.42
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CSI 3.28rCSI 7.66%PRS 86.63
-
CSI 3.28rCSI 6.58%PRS 62.72
-
CSI 3.24rCSI 2.69%PRS 73.58
-
CSI 3.21rCSI 2.3%PRS 86.39
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CSI 3.19rCSI 2.8%PRS 61.65
-
CSI 3.17rCSI 3.11%PRS 87.61
-
CSI 3.11rCSI 2.08%PRS 88.15
-
CSI 3.1rCSI 4.74%PRS 81.72
-
CSI 3rCSI 2.89%PRS 65.47
-
CSI 2.98rCSI 2.07%PRS 87.63
-
CSI 2.9rCSI 2.3%PRS 91.42
-
CSI 2.77rCSI 2.56%PRS 89.12
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CSI 2.76rCSI 1.83%PRS 76.1
-
CSI 2.76rCSI 2.57%PRS 74.05
-
CSI 2.73rCSI 2.46%PRS 70.73
-
CSI 2.7rCSI 2.37%PRS 81.25
-
CSI 2.67rCSI 1.58%PRS 89.15
-
CSI 2.66rCSI 1.98%PRS 85.27
-
CSI 2.59rCSI 3.04%PRS 87.66
-
CSI 2.55rCSI 2.66%PRS 72.97
-
CSI 2.54rCSI 1.92%PRS 86.17
-
CSI 2.48rCSI 1.91%PRS 75.43
-
CSI 2.47rCSI 2%PRS 75.37
-
CSI 2.47rCSI 1.94%PRS 79.56
-
CSI 2.46rCSI 3.36%PRS 78.49
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CSI 2.32rCSI 2.79%PRS 71.34
-
CSI 2.29rCSI 2.64%PRS 64.64
-
CSI 2.28rCSI 6.81%PRS 85.46
-
CSI 2.25rCSI 1.68%PRS 87.07
-
CSI 2.21rCSI 1.66%PRS 86.87
-
CSI 2.21rCSI 4.22%PRS 84.66
-
CSI 2.14rCSI 2.69%PRS 82.75
-
CSI 2.12rCSI 2.16%PRS 84.11
-
CSI 2.11rCSI 4.35%PRS 71.93
-
CSI 2.1rCSI 1.46%PRS 76.41
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CSI 2.06rCSI 2.97%PRS 81.71
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CSI 2.04rCSI 1.53%PRS 79.23
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CSI 2.03rCSI 1.87%PRS 81.95
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CSI 2.03rCSI 5.36%PRS 81.31
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CSI 2.03rCSI 1.78%PRS 78.55
-
CSI 2rCSI 1.65%PRS 75.66
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CSI 1.98rCSI 4.41%PRS 81.08
-
CSI 1.97rCSI 2.48%PRS 83.78
-
CSI 1.97rCSI 2.7%PRS 90.06
-
CSI 1.97rCSI 3.51%PRS 83.76
-
CSI 1.96rCSI 2.6%PRS 79.4
-
CSI 1.95rCSI 1.73%PRS 71.08
-
CSI 1.95rCSI 2.41%PRS 70.58
-
CSI 1.93rCSI 4.01%PRS 70.19
-
CSI 1.91rCSI 2.61%PRS 73.86
-
CSI 1.88rCSI 3.25%PRS 63.85
-
CSI 1.88rCSI 1.77%PRS 72.44
-
CSI 1.83rCSI 2.93%PRS 77.02
-
CSI 1.8rCSI 3.97%PRS 77.35
-
CSI 1.79rCSI 2.74%PRS 73.81
-
CSI 1.79rCSI 2.01%PRS 87.64
-
CSI 1.77rCSI 1.9%PRS 73.85
-
CSI 1.76rCSI 2.72%PRS 72.32
-
CSI 1.76rCSI 1.39%PRS 60.8
-
CSI 1.72rCSI 8.65%PRS 85.46
-
CSI 1.71rCSI 1.71%PRS 66.82
-
CSI 1.69rCSI 1.37%PRS 73.22
-
CSI 1.68rCSI 1.3%PRS 76.58
-
CSI 1.66rCSI 1.53%PRS 74.9
-
CSI 1.6rCSI 1.91%PRS 89.41
-
CSI 1.59rCSI 2.73%PRS 80.68
-
CSI 1.58rCSI 2.43%PRS 82.37
-
CSI 1.58rCSI 3.75%PRS 75.04
-
CSI 1.5rCSI 2.04%PRS 64.55
-
CSI 1.48rCSI 2.06%PRS 71.85
-
CSI 1.48rCSI 2.61%PRS 53.71
-
CSI 1.47rCSI 4.26%PRS 82.07
-
CSI 1.45rCSI 2.49%PRS 87.87
-
CSI 1.44rCSI 1.51%PRS 70.35
-
CSI 1.4rCSI 4.02%PRS 90.77
-
CSI 1.37rCSI 2.18%PRS 65.85
-
CSI 1.36rCSI 1.99%PRS 68.09
-
CSI 1.34rCSI 2.4%PRS 72.53
-
CSI 1.33rCSI 1.54%PRS 78.74
-
CSI 1.29rCSI 1.12%PRS 83.49
-
CSI 1.28rCSI 2.42%PRS 82.49
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CSI 1.12rCSI 1.72%PRS 77.51
-
CSI 1.11rCSI 2.21%PRS 87.13
-
CSI 1rCSI 1.94%PRS 76.5
-
CSI 0.91rCSI 2.31%PRS 66.83
-
CSI 0.6rCSI 3.3%PRS 79.4%
-
CSI 0.7rCSI 2.0%PRS 73.7%
-
CSI 0.8rCSI 4.5%PRS 82.4%
-
CSI 0.9rCSI 3.0%PRS 83.1%
-
CSI 0.9rCSI 2.3%PRS 66.8%
-
CSI 1.0rCSI 1.9%PRS 76.5%
-
CSI 1.1rCSI 2.2%PRS 87.1%
-
CSI 1.1rCSI 1.7%PRS 77.5%
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CSI 1.3rCSI 2.4%PRS 82.5%
-
CSI 1.3rCSI 1.1%PRS 83.5%
-
CSI 1.3rCSI 1.5%PRS 78.7%
-
CSI 1.3rCSI 2.4%PRS 72.5%
-
CSI 1.4rCSI 2.0%PRS 68.1%
-
CSI 1.4rCSI 2.2%PRS 65.9%
-
CSI 1.4rCSI 4.0%PRS 90.8%
-
CSI 1.4rCSI 1.5%PRS 70.4%
-
CSI 1.5rCSI 2.5%PRS 87.9%
-
CSI 1.5rCSI 4.3%PRS 82.1%
-
CSI 1.5rCSI 2.6%PRS 53.7%
-
CSI 1.5rCSI 2.1%PRS 71.9%
-
CSI 1.5rCSI 2.0%PRS 64.6%
-
CSI 1.6rCSI 3.8%PRS 75.0%
-
CSI 1.6rCSI 2.4%PRS 82.4%
-
CSI 1.6rCSI 2.7%PRS 80.7%
-
CSI 1.6rCSI 1.9%PRS 89.4%
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CSI 1.7rCSI 1.5%PRS 74.9%
-
CSI 1.7rCSI 1.3%PRS 76.6%
-
CSI 1.7rCSI 1.4%PRS 73.2%
-
CSI 1.7rCSI 1.7%PRS 66.8%
-
CSI 1.7rCSI 8.7%PRS 85.5%
-
CSI 1.8rCSI 1.4%PRS 60.8%
-
CSI 1.8rCSI 2.7%PRS 72.3%
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CSI 1.8rCSI 1.9%PRS 73.9%
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CSI 1.8rCSI 2.0%PRS 87.6%
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CSI 1.8rCSI 2.7%PRS 73.8%
-
CSI 1.8rCSI 4.0%PRS 77.4%
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CSI 1.8rCSI 2.9%PRS 77.0%
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CSI 1.9rCSI 1.8%PRS 72.4%
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CSI 1.9rCSI 3.3%PRS 63.9%
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CSI 1.9rCSI 2.6%PRS 73.9%
-
CSI 1.9rCSI 4.0%PRS 70.2%
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CSI 2.0rCSI 2.4%PRS 70.6%
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CSI 2.0rCSI 1.7%PRS 71.1%
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CSI 2.0rCSI 2.6%PRS 79.4%
-
CSI 2.0rCSI 3.5%PRS 83.8%
-
CSI 2.0rCSI 2.7%PRS 90.1%
-
CSI 2.0rCSI 2.5%PRS 83.8%
-
CSI 2.0rCSI 4.4%PRS 81.1%
-
CSI 2.0rCSI 1.7%PRS 75.7%
-
CSI 2.0rCSI 1.8%PRS 78.6%
-
CSI 2.0rCSI 5.4%PRS 81.3%
-
CSI 2.0rCSI 1.9%PRS 82.0%
-
CSI 2.0rCSI 1.5%PRS 79.2%
-
CSI 2.1rCSI 3.0%PRS 81.7%
-
CSI 2.1rCSI 1.5%PRS 76.4%
-
CSI 2.1rCSI 4.4%PRS 71.9%
-
CSI 2.1rCSI 2.2%PRS 84.1%
-
CSI 2.1rCSI 2.7%PRS 82.8%
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CSI 2.2rCSI 4.2%PRS 84.7%
-
CSI 2.2rCSI 1.7%PRS 86.9%
-
CSI 2.3rCSI 1.7%PRS 87.1%
-
CSI 2.3rCSI 6.8%PRS 85.5%
-
CSI 2.3rCSI 2.6%PRS 64.6%
-
CSI 2.3rCSI 2.8%PRS 71.3%
-
CSI 2.5rCSI 3.4%PRS 78.5%
-
CSI 2.5rCSI 1.9%PRS 79.6%
-
CSI 2.5rCSI 2.0%PRS 75.4%
-
CSI 2.5rCSI 1.9%PRS 75.4%
-
CSI 2.5rCSI 1.9%PRS 86.2%
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CSI 2.6rCSI 2.7%PRS 73.0%
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CSI 2.6rCSI 3.0%PRS 87.7%
-
CSI 2.7rCSI 2.0%PRS 85.3%
-
CSI 2.7rCSI 1.6%PRS 89.2%
-
CSI 2.7rCSI 2.4%PRS 81.3%
-
CSI 2.7rCSI 2.5%PRS 70.7%
-
CSI 2.8rCSI 2.6%PRS 74.1%
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CSI 2.8rCSI 1.8%PRS 76.1%
-
CSI 2.8rCSI 2.6%PRS 89.1%
-
CSI 2.9rCSI 2.3%PRS 91.4%
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CSI 3.0rCSI 2.1%PRS 87.6%
-
CSI 3.0rCSI 2.9%PRS 65.5%
-
CSI 3.1rCSI 4.7%PRS 81.7%
-
CSI 3.1rCSI 2.1%PRS 88.2%
-
CSI 3.2rCSI 3.1%PRS 87.6%
-
CSI 3.2rCSI 2.8%PRS 61.7%
-
CSI 3.2rCSI 2.3%PRS 86.4%
-
CSI 3.2rCSI 2.7%PRS 73.6%
-
CSI 3.3rCSI 6.6%PRS 62.7%
-
CSI 3.3rCSI 7.7%PRS 86.6%
-
CSI 3.3rCSI 5.0%PRS 78.4%
-
CSI 3.4rCSI 4.6%PRS 83.0%
-
CSI 3.4rCSI 2.3%PRS 84.8%
-
CSI 3.8rCSI 5.5%PRS 78.2%
-
CSI 4.1rCSI 3.3%PRS 89.3%
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CSI 4.3rCSI 3.6%PRS 87.6%
-
CSI 4.8rCSI 3.2%PRS 86.5%
-
CSI 4.9rCSI 3.8%PRS 86.0%
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CSI 5.6rCSI 11.4%PRS 51.4%
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CSI 6.4rCSI 23.0%PRS 89.8%
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CSI 6.4rCSI 14.6%PRS 75.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4197098343
Symbol: TF65_HUMAN
Name: Transcription factor p65
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2006423
Title: Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.
PubMed ID: 2006423
PubMed ID: 8281153
Title: Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing.
PubMed ID: 8281153
PubMed ID: 7907305
Title: An alternatively spliced transcript, p65 delta 2, of the gene encoding the p65 subunit of the transcription factor NF-kappa B.
PubMed ID: 7907305
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1732726
Title: Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.
PubMed ID: 1732726
PubMed ID: 1740106
Title: A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.
PubMed ID: 1740106
PubMed ID: 1493333
Title: I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.
PubMed ID: 1493333
PubMed ID: 8152812
Title: Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.
PubMed ID: 8152812
PubMed ID: 9056676
Title: Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50.
PubMed ID: 9056676
PubMed ID: 9315679
Title: A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.
PubMed ID: 9315679
PubMed ID: 9751059
Title: IKAP is a scaffold protein of the IkappaB kinase complex.
PubMed ID: 9751059
DOI: 10.1038/26254
PubMed ID: 10521409
Title: IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.
PubMed ID: 10521409
PubMed ID: 10498867
Title: NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2.
PubMed ID: 10498867
PubMed ID: 10928981
Title: Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers.
PubMed ID: 10928981
PubMed ID: 10660609
Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.
PubMed ID: 10660609
PubMed ID: 10938077
Title: Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II.
PubMed ID: 10938077
PubMed ID: 11526476
Title: The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.
PubMed ID: 11526476
PubMed ID: 11533489
Title: Duration of nuclear NF-kappaB action regulated by reversible acetylation.
PubMed ID: 11533489
PubMed ID: 12398897
Title: A novel protein overexpressed in hepatoma accelerates export of NF-kappa B from the nucleus and inhibits p53-dependent apoptosis.
PubMed ID: 12398897
PubMed ID: 12456660
Title: Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
PubMed ID: 12456660
DOI: 10.1093/emboj/cdf660
PubMed ID: 11931769
Title: The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
PubMed ID: 11931769
PubMed ID: 12628924
Title: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
PubMed ID: 12628924
DOI: 10.1093/emboj/cdg139
PubMed ID: 12419806
Title: Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65.
PubMed ID: 12419806
PubMed ID: 12748188
Title: RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.
PubMed ID: 12748188
PubMed ID: 12871932
Title: Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.
PubMed ID: 12871932
PubMed ID: 14690596
Title: Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
PubMed ID: 14690596
PubMed ID: 15355351
Title: RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.
PubMed ID: 15355351
PubMed ID: 14769797
Title: Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.
PubMed ID: 14769797
PubMed ID: 15073167
Title: Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation.
PubMed ID: 15073167
PubMed ID: 15226358
Title: Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response.
PubMed ID: 15226358
DOI: 10.1084/jem.20040196
PubMed ID: 15125834
Title: Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.
PubMed ID: 15125834
PubMed ID: 15029197
Title: The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
PubMed ID: 15029197
DOI: 10.1038/nature02329
PubMed ID: 15775976
Title: Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor.
PubMed ID: 15775976
PubMed ID: 16046471
Title: IKKbeta phosphorylates p65 at S468 in transactivation domain 2.
PubMed ID: 16046471
PubMed ID: 15516339
Title: cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.
PubMed ID: 15516339
PubMed ID: 15799966
Title: COMMD proteins, a novel family of structural and functional homologs of MURR1.
PubMed ID: 15799966
PubMed ID: 16135789
Title: NF-kappaB RelA phosphorylation regulates RelA acetylation.
PubMed ID: 16135789
PubMed ID: 15790681
Title: Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
PubMed ID: 15790681
PubMed ID: 15629770
Title: Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B.
PubMed ID: 15629770
PubMed ID: 16452207
Title: Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis.
PubMed ID: 16452207
PubMed ID: 16214042
Title: Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.
PubMed ID: 16214042
PubMed ID: 16407239
Title: Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.
PubMed ID: 16407239
PubMed ID: 17000776
Title: Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.
PubMed ID: 17000776
DOI: 10.1128/mcb.00940-06
PubMed ID: 16497732
Title: Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.
PubMed ID: 16497732
DOI: 10.1210/me.2005-0365
PubMed ID: 16477006
Title: IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.
PubMed ID: 16477006
PubMed ID: 17785205
Title: LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
PubMed ID: 17785205
PubMed ID: 17467953
Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.
PubMed ID: 17467953
PubMed ID: 17620405
Title: UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome.
PubMed ID: 17620405
PubMed ID: 18577712
Title: The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.
PubMed ID: 18577712
PubMed ID: 18405956
Title: Functional characterization of the atopy-associated gene PHF11.
PubMed ID: 18405956
PubMed ID: 18178962
Title: AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.
PubMed ID: 18178962
PubMed ID: 18212740
Title: Copine-I represses NF-kappaB transcription by endoproteolysis of p65.
PubMed ID: 18212740
PubMed ID: 19058135
Title: The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription.
PubMed ID: 19058135
DOI: 10.1002/jcb.22004
PubMed ID: 19103749
Title: Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
PubMed ID: 19103749
DOI: 10.1128/mcb.01365-08
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20164180
Title: A novel LZAP-binding protein, NLBP, inhibits cell invasion.
PubMed ID: 20164180
PubMed ID: 21081649
Title: SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310.
PubMed ID: 21081649
DOI: 10.1242/jcs.073783
PubMed ID: 20547752
Title: Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.
PubMed ID: 20547752
DOI: 10.1128/mcb.00087-10
PubMed ID: 20855622
Title: The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.
PubMed ID: 20855622
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21518757
Title: TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.
PubMed ID: 21518757
PubMed ID: 21697472
Title: Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.
PubMed ID: 21697472
DOI: 10.1128/jvi.00733-11
PubMed ID: 21515635
Title: Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
PubMed ID: 21515635
DOI: 10.1093/nar/gkr256
PubMed ID: 22649547
Title: NF-kappaB repression by PIAS3 mediated RelA SUMOylation.
PubMed ID: 22649547
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24553141
Title: C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma.
PubMed ID: 24553141
DOI: 10.1038/nature13109
PubMed ID: 24807716
Title: Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-kappaB activation.
PubMed ID: 24807716
DOI: 10.1128/jvi.03394-13
PubMed ID: 26041281
Title: Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation.
PubMed ID: 26041281
DOI: 10.1128/jvi.00799-15
PubMed ID: 25355951
Title: Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-kappaBs in Toll-like receptor 4 signaling.
PubMed ID: 25355951
PubMed ID: 27736973
Title: The DEAD-Box RNA Helicase DDX3 Interacts with NF-kappaB Subunit p65 and Suppresses p65-Mediated Transcription.
PubMed ID: 27736973
PubMed ID: 28600438
Title: Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration.
PubMed ID: 28600438
DOI: 10.1084/jem.20160724
PubMed ID: 29044191
Title: LRRC25 functions as an inhibitor of NF-kappaB signaling pathway by promoting p65/RelA for autophagic degradation.
PubMed ID: 29044191
PubMed ID: 29813070
Title: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.
PubMed ID: 29813070
PubMed ID: 31432514
Title: The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation.
PubMed ID: 31432514
PubMed ID: 30867312
Title: Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kappaB-Mediated Transcription.
PubMed ID: 30867312
DOI: 10.1128/jvi.00181-19
PubMed ID: 33440148
Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
PubMed ID: 33440148
PubMed ID: 9865693
Title: Structure of an IkappaBalpha/NF-kappaB complex.
PubMed ID: 9865693
PubMed ID: 29305315
Title: RELA haploinsufficiency in CD4 lymphoproliferative disease with autoimmune cytopenias.
PubMed ID: 29305315
Sequence Information:
- Length: 551
- Mass: 60219
- Checksum: 8147A6AF9F2445C6
- Sequence:
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQAPAPV PVLAPGPPQA VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL GALLGNSTDP AVFTDLASVD NSEFQQLLNQ GIPVAPHTTE PMLMEYPEAI TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM DFSALLSQIS S
Genular Protein ID: 1262497260
Symbol: A0A087X0W8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 448
- Mass: 49569
- Checksum: FD6DD09BB48F1F62
- Sequence:
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQRPPDP APAPLGAPGL PNGLLSGDED FSSIADMDFS ALLSQISS