Details for: RELA

Gene ID: 5970

Symbol: RELA

Ensembl ID: ENSG00000173039

Description: RELA proto-oncogene, NF-kB subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.8682
    Cell Significance Index: -25.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.5566
    Cell Significance Index: -23.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.9376
    Cell Significance Index: -28.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.6266
    Cell Significance Index: -24.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.9782
    Cell Significance Index: -28.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.9420
    Cell Significance Index: -28.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.1327
    Cell Significance Index: -24.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1825
    Cell Significance Index: -27.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4070
    Cell Significance Index: -25.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0324
    Cell Significance Index: -27.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8209
    Cell Significance Index: -20.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2128
    Cell Significance Index: -9.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8424
    Cell Significance Index: 50.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4406
    Cell Significance Index: 41.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3341
    Cell Significance Index: 69.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1720
    Cell Significance Index: 60.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8331
    Cell Significance Index: 107.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7857
    Cell Significance Index: 13.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7546
    Cell Significance Index: 56.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5952
    Cell Significance Index: 41.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5765
    Cell Significance Index: 12.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5714
    Cell Significance Index: 36.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5652
    Cell Significance Index: 26.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5398
    Cell Significance Index: 74.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5388
    Cell Significance Index: 486.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5022
    Cell Significance Index: 61.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4808
    Cell Significance Index: 86.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4791
    Cell Significance Index: 261.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4131
    Cell Significance Index: 19.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3882
    Cell Significance Index: 11.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3489
    Cell Significance Index: 154.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3265
    Cell Significance Index: 38.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3057
    Cell Significance Index: 5.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3024
    Cell Significance Index: 8.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2624
    Cell Significance Index: 52.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2473
    Cell Significance Index: 2.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2247
    Cell Significance Index: 15.8900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1949
    Cell Significance Index: 1.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1870
    Cell Significance Index: 37.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1804
    Cell Significance Index: 23.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1789
    Cell Significance Index: 8.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1496
    Cell Significance Index: 3.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1348
    Cell Significance Index: 93.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1224
    Cell Significance Index: 3.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1221
    Cell Significance Index: 23.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1196
    Cell Significance Index: 11.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0981
    Cell Significance Index: 2.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0917
    Cell Significance Index: 32.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0202
    Cell Significance Index: 0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0031
    Cell Significance Index: 5.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0155
    Cell Significance Index: -11.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0199
    Cell Significance Index: -12.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0215
    Cell Significance Index: -15.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0230
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0254
    Cell Significance Index: -4.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0322
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0332
    Cell Significance Index: -24.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0441
    Cell Significance Index: -20.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0468
    Cell Significance Index: -26.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0515
    Cell Significance Index: -7.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0520
    Cell Significance Index: -32.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0542
    Cell Significance Index: -6.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0677
    Cell Significance Index: -19.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0699
    Cell Significance Index: -11.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0744
    Cell Significance Index: -8.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0788
    Cell Significance Index: -2.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0848
    Cell Significance Index: -1.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1374
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1545
    Cell Significance Index: -32.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1547
    Cell Significance Index: -2.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1690
    Cell Significance Index: -4.5200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2032
    Cell Significance Index: -1.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2137
    Cell Significance Index: -5.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2140
    Cell Significance Index: -13.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2185
    Cell Significance Index: -1.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2230
    Cell Significance Index: -7.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2374
    Cell Significance Index: -18.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2503
    Cell Significance Index: -5.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2509
    Cell Significance Index: -26.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3086
    Cell Significance Index: -18.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3095
    Cell Significance Index: -24.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3124
    Cell Significance Index: -15.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3375
    Cell Significance Index: -17.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3484
    Cell Significance Index: -8.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3609
    Cell Significance Index: -24.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3958
    Cell Significance Index: -5.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4001
    Cell Significance Index: -16.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4096
    Cell Significance Index: -25.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4402
    Cell Significance Index: -24.7000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4935
    Cell Significance Index: -8.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5497
    Cell Significance Index: -16.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5758
    Cell Significance Index: -25.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5952
    Cell Significance Index: -21.8500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6079
    Cell Significance Index: -10.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6680
    Cell Significance Index: -23.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: RELA is a 311-amino acid protein that contains a transcriptional activation domain (TA domain) and a DNA-binding domain (DBD). 2. **Function**: RELA is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, and cell survival. 3. **Expression**: RELA is highly expressed in immune cells, including B cells, macrophages, and T cells, as well as in other cell types, such as fibroblasts and epithelial cells. 4. **Regulation**: RELA is regulated by various stimuli, including cytokines, bacterial and viral infections, and stress. **Pathways and Functions** 1. **NF-kB signaling pathway**: RELA is a key component of the NF-kB signaling pathway, which is activated by various stimuli, including cytokines, bacterial and viral infections, and stress. 2. **Adaptive immune system**: RELA plays a crucial role in the regulation of adaptive immune responses, including B cell activation and differentiation. 3. **Innate immune system**: RELA is involved in the regulation of innate immune responses, including the activation of macrophages and neutrophils. 4. **Inflammation**: RELA promotes the expression of genes involved in inflammation, including cytokines, chemokines, and adhesion molecules. 5. **Cell survival**: RELA promotes the expression of genes involved in cell survival, including anti-apoptotic proteins and growth factors. 6. **Transcriptional regulation**: RELA regulates the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance** 1. **Immunodeficiency diseases**: Mutations in the RELA gene have been associated with immunodeficiency diseases, including X-linked lymphoproliferative disease (XLP) and autoimmune polyendocrine syndrome type II (APS II). 2. **Cancer**: RELA is overexpressed in various types of cancer, including lymphoma, leukemia, and solid tumors. 3. **Inflammatory disorders**: RELA is involved in the pathogenesis of inflammatory disorders, including rheumatoid arthritis, Crohn's disease, and ulcerative colitis. 4. **Infectious diseases**: RELA plays a crucial role in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 5. **Therapeutic targets**: RELA is a potential therapeutic target for the treatment of various diseases, including cancer, inflammatory disorders, and infectious diseases. In conclusion, the RELA gene is a critical component of the NF-kB signaling pathway, which plays a central role in the regulation of immune responses, inflammation, and cell survival. Understanding the functions and clinical significance of RELA can provide insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 4197098343

Symbol: TF65_HUMAN

Name: Transcription factor p65

UniProtKB Accession Codes:

Q04206 Q6GTV1 Q6SLK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 88 PDBsum 88 PIR 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 25 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2006423

Title: Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.

PubMed ID: 2006423

DOI: 10.1126/science.2006423

PubMed ID: 8281153

Title: Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing.

PubMed ID: 8281153

DOI: 10.1093/hmg/2.11.1895

PubMed ID: 7907305

Title: An alternatively spliced transcript, p65 delta 2, of the gene encoding the p65 subunit of the transcription factor NF-kappa B.

PubMed ID: 7907305

DOI: 10.1016/0378-1119(94)90823-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1732726

Title: Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.

PubMed ID: 1732726

DOI: 10.1128/mcb.12.2.444-454.1992

PubMed ID: 1740106

Title: A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

PubMed ID: 1740106

DOI: 10.1002/j.1460-2075.1992.tb05043.x

PubMed ID: 1493333

Title: I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.

PubMed ID: 1493333

DOI: 10.1091/mbc.3.12.1339

PubMed ID: 8152812

Title: Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.

PubMed ID: 8152812

PubMed ID: 9056676

Title: Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50.

PubMed ID: 9056676

PubMed ID: 9315679

Title: A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.

PubMed ID: 9315679

DOI: 10.1128/mcb.17.10.6184

PubMed ID: 9751059

Title: IKAP is a scaffold protein of the IkappaB kinase complex.

PubMed ID: 9751059

DOI: 10.1038/26254

PubMed ID: 10521409

Title: IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.

PubMed ID: 10521409

DOI: 10.1074/jbc.274.43.30353

PubMed ID: 10498867

Title: NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2.

PubMed ID: 10498867

DOI: 10.1038/sj.onc.1202904

PubMed ID: 10928981

Title: Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers.

PubMed ID: 10928981

DOI: 10.1096/fj.14.11.1471

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 10938077

Title: Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II.

PubMed ID: 10938077

DOI: 10.1074/jbc.m001358200

PubMed ID: 11526476

Title: The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

PubMed ID: 11526476

DOI: 10.1038/sj.onc.1204529

PubMed ID: 11533489

Title: Duration of nuclear NF-kappaB action regulated by reversible acetylation.

PubMed ID: 11533489

DOI: 10.1126/science.1062374

PubMed ID: 12398897

Title: A novel protein overexpressed in hepatoma accelerates export of NF-kappa B from the nucleus and inhibits p53-dependent apoptosis.

PubMed ID: 12398897

DOI: 10.1016/s1535-6108(02)00152-6

PubMed ID: 12456660

Title: Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

PubMed ID: 12456660

DOI: 10.1093/emboj/cdf660

PubMed ID: 11931769

Title: The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.

PubMed ID: 11931769

DOI: 10.1016/s1097-2765(02)00477-x

PubMed ID: 12628924

Title: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

PubMed ID: 12628924

DOI: 10.1093/emboj/cdg139

PubMed ID: 12419806

Title: Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65.

PubMed ID: 12419806

DOI: 10.1074/jbc.m209572200

PubMed ID: 12748188

Title: RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.

PubMed ID: 12748188

DOI: 10.1074/jbc.m211831200

PubMed ID: 12871932

Title: Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.

PubMed ID: 12871932

DOI: 10.1074/jbc.m305676200

PubMed ID: 14690596

Title: Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

PubMed ID: 14690596

DOI: 10.1016/s1097-2765(03)00490-8

PubMed ID: 15355351

Title: RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.

PubMed ID: 15355351

DOI: 10.1111/j.1432-1033.2004.04314.x

PubMed ID: 14769797

Title: Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.

PubMed ID: 14769797

DOI: 10.1074/jbc.m310737200

PubMed ID: 15073167

Title: Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation.

PubMed ID: 15073167

DOI: 10.1074/jbc.m402362200

PubMed ID: 15226358

Title: Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response.

PubMed ID: 15226358

DOI: 10.1084/jem.20040196

PubMed ID: 15125834

Title: Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.

PubMed ID: 15125834

DOI: 10.1016/s1097-2765(04)00216-3

PubMed ID: 15029197

Title: The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

PubMed ID: 15029197

DOI: 10.1038/nature02329

PubMed ID: 15775976

Title: Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor.

PubMed ID: 15775976

DOI: 10.1038/sj.emboj.7600608

PubMed ID: 16046471

Title: IKKbeta phosphorylates p65 at S468 in transactivation domain 2.

PubMed ID: 16046471

DOI: 10.1096/fj.05-3736fje

PubMed ID: 15516339

Title: cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.

PubMed ID: 15516339

DOI: 10.1074/jbc.m409344200

PubMed ID: 15799966

Title: COMMD proteins, a novel family of structural and functional homologs of MURR1.

PubMed ID: 15799966

DOI: 10.1074/jbc.m501928200

PubMed ID: 16135789

Title: NF-kappaB RelA phosphorylation regulates RelA acetylation.

PubMed ID: 16135789

DOI: 10.1128/mcb.25.18.7966-7975.2005

PubMed ID: 15790681

Title: Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.

PubMed ID: 15790681

DOI: 10.1073/pnas.0501675102

PubMed ID: 15629770

Title: Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B.

PubMed ID: 15629770

DOI: 10.1016/j.virol.2004.10.031

PubMed ID: 16452207

Title: Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis.

PubMed ID: 16452207

DOI: 10.1158/0008-5472.can-05-3029

PubMed ID: 16214042

Title: Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.

PubMed ID: 16214042

DOI: 10.1016/j.cellsig.2005.03.017

PubMed ID: 16407239

Title: Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

PubMed ID: 16407239

DOI: 10.1074/jbc.m508045200

PubMed ID: 17000776

Title: Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.

PubMed ID: 17000776

DOI: 10.1128/mcb.00940-06

PubMed ID: 16497732

Title: Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.

PubMed ID: 16497732

DOI: 10.1210/me.2005-0365

PubMed ID: 16477006

Title: IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.

PubMed ID: 16477006

DOI: 10.1073/pnas.0511096103

PubMed ID: 17785205

Title: LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.

PubMed ID: 17785205

DOI: 10.1016/j.ccr.2007.07.002

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 17620405

Title: UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome.

PubMed ID: 17620405

DOI: 10.1083/jcb.200611081

PubMed ID: 18577712

Title: The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.

PubMed ID: 18577712

DOI: 10.1182/blood-2008-01-134932

PubMed ID: 18405956

Title: Functional characterization of the atopy-associated gene PHF11.

PubMed ID: 18405956

DOI: 10.1016/j.jaci.2008.02.028

PubMed ID: 18178962

Title: AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.

PubMed ID: 18178962

DOI: 10.1074/jbc.m710285200

PubMed ID: 18212740

Title: Copine-I represses NF-kappaB transcription by endoproteolysis of p65.

PubMed ID: 18212740

DOI: 10.1038/sj.onc.1211030

PubMed ID: 19058135

Title: The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription.

PubMed ID: 19058135

DOI: 10.1002/jcb.22004

PubMed ID: 19103749

Title: Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.

PubMed ID: 19103749

DOI: 10.1128/mcb.01365-08

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20164180

Title: A novel LZAP-binding protein, NLBP, inhibits cell invasion.

PubMed ID: 20164180

DOI: 10.1074/jbc.m109.065920

PubMed ID: 21081649

Title: SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310.

PubMed ID: 21081649

DOI: 10.1242/jcs.073783

PubMed ID: 20547752

Title: Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

PubMed ID: 20547752

DOI: 10.1128/mcb.00087-10

PubMed ID: 20855622

Title: The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.

PubMed ID: 20855622

DOI: 10.1073/pnas.1007765107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21518757

Title: TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.

PubMed ID: 21518757

DOI: 10.1074/jbc.m110.215426

PubMed ID: 21697472

Title: Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.

PubMed ID: 21697472

DOI: 10.1128/jvi.00733-11

PubMed ID: 21515635

Title: Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.

PubMed ID: 21515635

DOI: 10.1093/nar/gkr256

PubMed ID: 22649547

Title: NF-kappaB repression by PIAS3 mediated RelA SUMOylation.

PubMed ID: 22649547

DOI: 10.1371/journal.pone.0037636

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24553141

Title: C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma.

PubMed ID: 24553141

DOI: 10.1038/nature13109

PubMed ID: 24807716

Title: Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-kappaB activation.

PubMed ID: 24807716

DOI: 10.1128/jvi.03394-13

PubMed ID: 26041281

Title: Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation.

PubMed ID: 26041281

DOI: 10.1128/jvi.00799-15

PubMed ID: 25355951

Title: Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-kappaBs in Toll-like receptor 4 signaling.

PubMed ID: 25355951

DOI: 10.1091/mbc.e14-08-1277

PubMed ID: 27736973

Title: The DEAD-Box RNA Helicase DDX3 Interacts with NF-kappaB Subunit p65 and Suppresses p65-Mediated Transcription.

PubMed ID: 27736973

DOI: 10.1371/journal.pone.0164471

PubMed ID: 28600438

Title: Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration.

PubMed ID: 28600438

DOI: 10.1084/jem.20160724

PubMed ID: 29044191

Title: LRRC25 functions as an inhibitor of NF-kappaB signaling pathway by promoting p65/RelA for autophagic degradation.

PubMed ID: 29044191

DOI: 10.1038/s41598-017-12573-3

PubMed ID: 29813070

Title: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.

PubMed ID: 29813070

DOI: 10.1371/journal.pbio.2004526

PubMed ID: 31432514

Title: The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation.

PubMed ID: 31432514

DOI: 10.1002/1873-3468.13583

PubMed ID: 30867312

Title: Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kappaB-Mediated Transcription.

PubMed ID: 30867312

DOI: 10.1128/jvi.00181-19

PubMed ID: 33440148

Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.

PubMed ID: 33440148

DOI: 10.1016/j.celrep.2020.108628

PubMed ID: 9865693

Title: Structure of an IkappaBalpha/NF-kappaB complex.

PubMed ID: 9865693

DOI: 10.1016/s0092-8674(00)81698-0

PubMed ID: 29305315

Title: RELA haploinsufficiency in CD4 lymphoproliferative disease with autoimmune cytopenias.

PubMed ID: 29305315

DOI: 10.1016/j.jaci.2017.11.036

Sequence Information:

  • Length: 551
  • Mass: 60219
  • Checksum: 8147A6AF9F2445C6
  • Sequence:
    • MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT 
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC 
VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS 
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS 
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 
KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY 
DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQAPAPV PVLAPGPPQA 
VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL GALLGNSTDP AVFTDLASVD NSEFQQLLNQ 
GIPVAPHTTE PMLMEYPEAI TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM 
DFSALLSQIS S

Genular Protein ID: 1262497260

Symbol: A0A087X0W8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X0W8

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 448
  • Mass: 49569
  • Checksum: FD6DD09BB48F1F62
  • Sequence:
    • MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT 
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC 
VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS 
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS 
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 
KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY 
DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQRPPDP APAPLGAPGL 
PNGLLSGDED FSSIADMDFS ALLSQISS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.