Details for: RFX2

Gene ID: 5990

Symbol: RFX2

Ensembl ID: ENSG00000087903

Description: regulatory factor X2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.2895
    Cell Significance Index: -25.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.3878
    Cell Significance Index: -25.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.8317
    Cell Significance Index: -28.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.8898
    Cell Significance Index: -28.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.4513
    Cell Significance Index: -22.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1176
    Cell Significance Index: -27.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3141
    Cell Significance Index: -27.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9411
    Cell Significance Index: -27.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9330
    Cell Significance Index: -12.9900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.4667
    Cell Significance Index: 20.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3433
    Cell Significance Index: 75.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2293
    Cell Significance Index: 34.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1933
    Cell Significance Index: 23.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9777
    Cell Significance Index: 186.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9523
    Cell Significance Index: 49.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8487
    Cell Significance Index: 65.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6158
    Cell Significance Index: 15.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5938
    Cell Significance Index: 117.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5644
    Cell Significance Index: 37.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5411
    Cell Significance Index: 13.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5361
    Cell Significance Index: 62.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.4844
    Cell Significance Index: 6.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4680
    Cell Significance Index: 46.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4506
    Cell Significance Index: 90.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4368
    Cell Significance Index: 5.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2933
    Cell Significance Index: 264.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2599
    Cell Significance Index: 42.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2554
    Cell Significance Index: 91.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2206
    Cell Significance Index: 97.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2054
    Cell Significance Index: 9.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2047
    Cell Significance Index: 111.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1837
    Cell Significance Index: 19.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1812
    Cell Significance Index: 82.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1800
    Cell Significance Index: 3.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1698
    Cell Significance Index: 6.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1695
    Cell Significance Index: 4.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1411
    Cell Significance Index: 17.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1407
    Cell Significance Index: 97.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1400
    Cell Significance Index: 25.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1381
    Cell Significance Index: 8.4900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1115
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0910
    Cell Significance Index: 171.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0830
    Cell Significance Index: 4.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0646
    Cell Significance Index: 8.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0646
    Cell Significance Index: 1.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0627
    Cell Significance Index: 96.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0418
    Cell Significance Index: 1.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0331
    Cell Significance Index: 61.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0287
    Cell Significance Index: 18.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0172
    Cell Significance Index: 23.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0082
    Cell Significance Index: 0.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0071
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0211
    Cell Significance Index: -13.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0247
    Cell Significance Index: -13.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0307
    Cell Significance Index: -22.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0320
    Cell Significance Index: -24.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0327
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0396
    Cell Significance Index: -6.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0492
    Cell Significance Index: -0.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0564
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0583
    Cell Significance Index: -12.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0613
    Cell Significance Index: -4.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0719
    Cell Significance Index: -20.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0786
    Cell Significance Index: -5.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0906
    Cell Significance Index: -10.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0945
    Cell Significance Index: -0.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0979
    Cell Significance Index: -6.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1230
    Cell Significance Index: -17.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1231
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1575
    Cell Significance Index: -18.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1693
    Cell Significance Index: -17.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1973
    Cell Significance Index: -5.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2012
    Cell Significance Index: -12.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2049
    Cell Significance Index: -5.4700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2253
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2392
    Cell Significance Index: -11.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2494
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2508
    Cell Significance Index: -28.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2548
    Cell Significance Index: -4.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2624
    Cell Significance Index: -4.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2743
    Cell Significance Index: -5.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3114
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3207
    Cell Significance Index: -25.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3593
    Cell Significance Index: -18.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3712
    Cell Significance Index: -9.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3808
    Cell Significance Index: -8.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3817
    Cell Significance Index: -20.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3982
    Cell Significance Index: -20.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4686
    Cell Significance Index: -15.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4829
    Cell Significance Index: -7.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5006
    Cell Significance Index: -7.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5129
    Cell Significance Index: -12.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5271
    Cell Significance Index: -9.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5289
    Cell Significance Index: -24.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5456
    Cell Significance Index: -18.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5578
    Cell Significance Index: -10.3100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5673
    Cell Significance Index: -5.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5937
    Cell Significance Index: -13.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RFX2 is a transcription factor protein that exhibits the following characteristics: 1. **DNA-binding activity**: RFX2 binds to specific DNA sequences, which are essential for regulating gene expression. 2. **RNA polymerase II specificity**: RFX2 interacts with RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 3. **Transcriptional activation**: RFX2 acts as a transcriptional activator, promoting the expression of target genes. 4. **Cell-type specificity**: RFX2 expression is highly restricted to specific cell types, including astrocytes, ciliated cells, and kidney epithelial cells. 5. **Spermatogenesis involvement**: RFX2 is essential for spermatogenesis, the process of sperm development in the testes. **Pathways and Functions** RFX2 is involved in several cellular pathways, including: 1. **Acrosome assembly**: RFX2 regulates the expression of genes involved in acrosome formation, a critical step in sperm development. 2. **Chromatin regulation**: RFX2 interacts with chromatin remodeling complexes to regulate gene expression and maintain chromatin structure. 3. **Cilium assembly**: RFX2 is involved in the assembly of cilia, specialized organelles involved in cell movement and signaling. 4. **Cellular response to leukemia inhibitory factor (LIF)**: RFX2 regulates the expression of genes involved in the cellular response to LIF, a cytokine involved in cell survival and differentiation. **Clinical Significance** RFX2 dysregulation has been implicated in various diseases, including: 1. **Spermatogenic failure**: RFX2 mutations have been associated with male infertility and spermatogenic failure. 2. **Ciliary dysfunction**: RFX2 mutations have been linked to ciliary dysfunction, a condition characterized by respiratory and motility disorders. 3. **Kidney disease**: RFX2 dysregulation has been implicated in kidney disease, including chronic kidney disease and nephrotic syndrome. 4. **Neurological disorders**: RFX2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RFX2 is a critical transcription factor protein that plays a vital role in regulating gene expression, spermatogenesis, and chromatin structure. Its dysregulation has been implicated in various diseases, highlighting the importance of RFX2 in maintaining tissue homeostasis and function.

Genular Protein ID: 669540766

Symbol: RFX2_HUMAN

Name: DNA-binding protein RFX2

UniProtKB Accession Codes:

P48378 A8K581 B3KNC4 Q6IQ44 Q8SNA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8289803

Title: RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

PubMed ID: 8289803

DOI: 10.1128/mcb.14.2.1230-1244.1994

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 10330134

Title: Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

PubMed ID: 10330134

DOI: 10.1128/mcb.19.6.3940

Sequence Information:

  • Length: 723
  • Mass: 79987
  • Checksum: 0F299954977A9218
  • Sequence:
    • MQNSEGGADS PASVALRPSA AAPPVPASPQ RVLVQAASSN PKGAQMQPIS LPRVQQVPQQ 
VQPVQHVYPA QVQYVEGGDA VYTNGAIRTA YTYNPEPQMY APSSTASYFE APGGAQVTVA 
ASSPPAVPSH SMVGITMDVG GSPIVSSAGA YLIHGGMDST RHSLAHTSRS SPATLEMAIE 
NLQKSEGITS HKSGLLNSHL QWLLDNYETA EGVSLPRSSL YNHYLRHCQE HKLDPVNAAS 
FGKLIRSVFM GLRTRRLGTR GNSKYHYYGI RLKPDSPLNR LQEDTQYMAM RQQPMHQKPR 
YRPAQKTDSL GDSGSHSGLH STPEQTMAVQ SQHHQQYIDV SHVFPEFPAP DLGSFLLQDG 
VTLHDVKALQ LVYRRHCEAT VDVVMNLQFH YIEKLWLSFW NSKASSSDGP TSLPASDEDP 
EGAVLPKDKL ISLCQCDPIL RWMRSCDHIL YQALVEILIP DVLRPVPSTL TQAIRNFAKS 
LEGWLTNAMS DFPQQVIQTK VGVVSAFAQT LRRYTSLNHL AQAARAVLQN TSQINQMLSD 
LNRVDFANVQ EQASWVCQCE ESVVQRLEQD FKLTLQQQSS LDQWASWLDS VVTQVLKQHA 
GSPSFPKAAR QFLLKWSFYS SMVIRDLTLR SAASFGSFHL IRLLYDEYMF YLVEHRVAEA 
TGETPIAVMG EFNDLASLSL TLLDKDDMGD EQRGSEAGPD ARSLGEPLVK RERSDPNHSL 
QGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.