Details for: RFX2
Gene ID: 5990
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RFX2
Ensembl ID: ENSG00000087903
Description: regulatory factor X2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 33.03rCSI 67.03%PRS 52.6
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CSI 16.8rCSI 44.58%PRS 81.76
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CSI 13.12rCSI 17.96%PRS 66.43
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CSI 10.83rCSI 8.14%PRS 80.76
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CSI 10.37rCSI 8.04%PRS 77.88
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CSI 10.15rCSI 10.13%PRS 68.23
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CSI 9.86rCSI 11.4%PRS 66.2
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CSI 9.04rCSI 21.45%PRS 76.07
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CSI 7.57rCSI 9.17%PRS 56.81
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CSI 7.4rCSI 12.11%PRS 63.71
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CSI 6.11rCSI 8.48%PRS 73.15
-
CSI 5.98rCSI 33.48%PRS 77.34
-
CSI 5.9rCSI 22.09%PRS 66.59
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CSI 5.22rCSI 13.95%PRS 65.57
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CSI 5.1rCSI 26.78%PRS 76.9
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CSI 5.06rCSI 11.52%PRS 69.08
-
CSI 5.01rCSI 13.8%PRS 69.34
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CSI 4.84rCSI 18.92%PRS 51.93
-
CSI 4.8rCSI 19.39%PRS 73.92
-
CSI 4.5rCSI 7.17%PRS 66.13
-
CSI 4.48rCSI 8.38%PRS 62.31
-
CSI 4.36rCSI 3.84%PRS 63.09
-
CSI 4.36rCSI 12.86%PRS 73.45
-
CSI 4.24rCSI 10.76%PRS 64.48
-
CSI 4.19rCSI 23.37%PRS 79.38
-
CSI 4.06rCSI 5.02%PRS 72.04
-
CSI 3.98rCSI 3.7%PRS 75.25
-
CSI 3.97rCSI 4.94%PRS 53.92
-
CSI 3.9rCSI 5.95%PRS 82.84
-
CSI 3.81rCSI 21.83%PRS 80.45
-
CSI 3.75rCSI 5.99%PRS 78.31
-
CSI 3.72rCSI 5.16%PRS 72.84
-
CSI 3.57rCSI 12.06%PRS 74.26
-
CSI 3.55rCSI 5.75%PRS 70.09
-
CSI 3.52rCSI 2.61%PRS 67.49
-
CSI 3.39rCSI 4.53%PRS 73.57
-
CSI 3.34rCSI 7.49%PRS 56.66
-
CSI 3.08rCSI 3.02%PRS 77.28
-
CSI 3.07rCSI 3.54%PRS 66.67
-
CSI 3.06rCSI 2.42%PRS 62.27
-
CSI 2.99rCSI 3.28%PRS 77.11
-
CSI 2.96rCSI 5.64%PRS 85.73
-
CSI 2.89rCSI 5.81%PRS 64.06
-
CSI 2.73rCSI 6.23%PRS 65.67
-
CSI 2.65rCSI 11.28%PRS 66.45
-
CSI 2.62rCSI 2.17%PRS 75.05
-
CSI 2.55rCSI 2.34%PRS 83.07
-
CSI 2.55rCSI 4.02%PRS 76.37
-
CSI 2.51rCSI 4.13%PRS 79.26
-
CSI 2.44rCSI 2.53%PRS 79.41
-
CSI 2.39rCSI 3.8%PRS 67.15
-
CSI 2.33rCSI 4.81%PRS 73.09
-
CSI 2.29rCSI 1.92%PRS 77.76
-
CSI 2.29rCSI 2.85%PRS 84.28
-
CSI 2.23rCSI 3.4%PRS 74.86
-
CSI 2.17rCSI 4.51%PRS 71.56
-
CSI 2.14rCSI 3.04%PRS 70.93
-
CSI 2.07rCSI 6.63%PRS 71.58
-
CSI 2.06rCSI 2.64%PRS 78.31
-
CSI 2.03rCSI 3.56%PRS 67.43
-
CSI 2rCSI 2.1%PRS 77.87
-
CSI 1.99rCSI 1.61%PRS 76.86
-
CSI 1.97rCSI 6.06%PRS 79.99
-
CSI 1.97rCSI 3.47%PRS 55.09
-
CSI 1.96rCSI 5.58%PRS 70.86
-
CSI 1.91rCSI 2.29%PRS 55.91
-
CSI 1.91rCSI 3.37%PRS 80.85
-
CSI 1.91rCSI 4.91%PRS 71.9
-
CSI 1.9rCSI 1.72%PRS 72.32
-
CSI 1.89rCSI 4.17%PRS 78.74
-
CSI 1.86rCSI 2.75%PRS 79.28
-
CSI 1.82rCSI 8.69%PRS 71.68
-
CSI 1.78rCSI 4.24%PRS 79.79
-
CSI 1.76rCSI 4.3%PRS 67.34
-
CSI 1.73rCSI 3.78%PRS 80.79
-
CSI 1.73rCSI 5.56%PRS 71.65
-
CSI 1.68rCSI 6.49%PRS 85.18
-
CSI 1.67rCSI 1.61%PRS 66.94
-
CSI 1.66rCSI 4.05%PRS 54.08
-
CSI 1.66rCSI 4.21%PRS 80.4
-
CSI 1.6rCSI 1.23%PRS 76.94
-
CSI 1.53rCSI 2.37%PRS 73.61
-
CSI 1.51rCSI 3.34%PRS 73.55
-
CSI 1.47rCSI 2.36%PRS 57.65
-
CSI 1.46rCSI 3.22%PRS 84.03
-
CSI 1.46rCSI 3.78%PRS 69.62
-
CSI 1.46rCSI 2.26%PRS 79.49
-
CSI 1.45rCSI 1.75%PRS 82.89
-
CSI 1.44rCSI 2.49%PRS 65.39
-
CSI 1.4rCSI 1.8%PRS 57.2
-
CSI 1.36rCSI 3.26%PRS 78.89
-
CSI 1.35rCSI 1.94%PRS 63.98
-
CSI 1.33rCSI 2.01%PRS 79.91
-
CSI 1.29rCSI 5.74%PRS 85.93
-
CSI 1.28rCSI 5.63%PRS 63.12
-
CSI 1.28rCSI 3.51%PRS 83.12
-
CSI 1.26rCSI 2.11%PRS 55.96
-
CSI 1.25rCSI 3.09%PRS 73.69
-
CSI 1.2rCSI 3.91%PRS 72.71
-
CSI 1.18rCSI 5.53%PRS 86.84
-
CSI 0.3rCSI 2.3%PRS 61.3%
-
CSI 0.3rCSI 2.6%PRS 68.1%
-
CSI 0.5rCSI 1.9%PRS 54.0%
-
CSI 0.6rCSI 14.9%PRS 55.1%
-
CSI 0.6rCSI 15.3%PRS 54.5%
-
CSI 0.7rCSI 2.2%PRS 60.2%
-
CSI 0.7rCSI 2.3%PRS 57.7%
-
CSI 0.8rCSI 2.9%PRS 56.4%
-
CSI 0.8rCSI 2.2%PRS 83.0%
-
CSI 0.8rCSI 2.3%PRS 69.9%
-
CSI 1.0rCSI 5.5%PRS 71.8%
-
CSI 1.1rCSI 6.7%PRS 66.1%
-
CSI 1.1rCSI 1.9%PRS 44.9%
-
CSI 1.1rCSI 1.6%PRS 75.5%
-
CSI 1.2rCSI 5.5%PRS 86.8%
-
CSI 1.2rCSI 3.9%PRS 72.7%
-
CSI 1.3rCSI 3.1%PRS 73.7%
-
CSI 1.3rCSI 2.1%PRS 56.0%
-
CSI 1.3rCSI 3.5%PRS 83.1%
-
CSI 1.3rCSI 5.6%PRS 63.1%
-
CSI 1.3rCSI 5.7%PRS 85.9%
-
CSI 1.3rCSI 2.0%PRS 79.9%
-
CSI 1.4rCSI 1.9%PRS 64.0%
-
CSI 1.4rCSI 3.3%PRS 78.9%
-
CSI 1.4rCSI 1.8%PRS 57.2%
-
CSI 1.4rCSI 2.5%PRS 65.4%
-
CSI 1.5rCSI 1.8%PRS 82.9%
-
CSI 1.5rCSI 2.3%PRS 79.5%
-
CSI 1.5rCSI 3.8%PRS 69.6%
-
CSI 1.5rCSI 3.2%PRS 84.0%
-
CSI 1.5rCSI 2.4%PRS 57.7%
-
CSI 1.5rCSI 3.3%PRS 73.6%
-
CSI 1.5rCSI 2.4%PRS 73.6%
-
CSI 1.6rCSI 1.2%PRS 76.9%
-
CSI 1.7rCSI 4.2%PRS 80.4%
-
CSI 1.7rCSI 4.1%PRS 54.1%
-
CSI 1.7rCSI 1.6%PRS 66.9%
-
CSI 1.7rCSI 6.5%PRS 85.2%
-
CSI 1.7rCSI 5.6%PRS 71.7%
-
CSI 1.7rCSI 3.8%PRS 80.8%
-
CSI 1.8rCSI 4.3%PRS 67.3%
-
CSI 1.8rCSI 4.2%PRS 79.8%
-
CSI 1.8rCSI 8.7%PRS 71.7%
-
CSI 1.9rCSI 2.8%PRS 79.3%
-
CSI 1.9rCSI 4.2%PRS 78.7%
-
CSI 1.9rCSI 1.7%PRS 72.3%
-
CSI 1.9rCSI 4.9%PRS 71.9%
-
CSI 1.9rCSI 3.4%PRS 80.9%
-
CSI 1.9rCSI 2.3%PRS 55.9%
-
CSI 2.0rCSI 5.6%PRS 70.9%
-
CSI 2.0rCSI 3.5%PRS 55.1%
-
CSI 2.0rCSI 6.1%PRS 80.0%
-
CSI 2.0rCSI 1.6%PRS 76.9%
-
CSI 2.0rCSI 2.1%PRS 77.9%
-
CSI 2.0rCSI 3.6%PRS 67.4%
-
CSI 2.1rCSI 2.6%PRS 78.3%
-
CSI 2.1rCSI 6.6%PRS 71.6%
-
CSI 2.1rCSI 3.0%PRS 70.9%
-
CSI 2.2rCSI 4.5%PRS 71.6%
-
CSI 2.2rCSI 3.4%PRS 74.9%
-
CSI 2.3rCSI 2.9%PRS 84.3%
-
CSI 2.3rCSI 1.9%PRS 77.8%
-
CSI 2.3rCSI 4.8%PRS 73.1%
-
CSI 2.4rCSI 3.8%PRS 67.2%
-
CSI 2.4rCSI 2.5%PRS 79.4%
-
CSI 2.5rCSI 4.1%PRS 79.3%
-
CSI 2.6rCSI 4.0%PRS 76.4%
-
CSI 2.6rCSI 2.3%PRS 83.1%
-
CSI 2.6rCSI 2.2%PRS 75.1%
-
CSI 2.7rCSI 11.3%PRS 66.5%
-
CSI 2.7rCSI 6.2%PRS 65.7%
-
CSI 2.9rCSI 5.8%PRS 64.1%
-
CSI 3.0rCSI 5.6%PRS 85.7%
-
CSI 3.0rCSI 3.3%PRS 77.1%
-
CSI 3.1rCSI 2.4%PRS 62.3%
-
CSI 3.1rCSI 3.5%PRS 66.7%
-
CSI 3.1rCSI 3.0%PRS 77.3%
-
CSI 3.3rCSI 7.5%PRS 56.7%
-
CSI 3.4rCSI 4.5%PRS 73.6%
-
CSI 3.5rCSI 2.6%PRS 67.5%
-
CSI 3.6rCSI 5.8%PRS 70.1%
-
CSI 3.6rCSI 12.1%PRS 74.3%
-
CSI 3.7rCSI 5.2%PRS 72.8%
-
CSI 3.8rCSI 6.0%PRS 78.3%
-
CSI 3.8rCSI 21.8%PRS 80.5%
-
CSI 3.9rCSI 6.0%PRS 82.8%
-
CSI 4.0rCSI 4.9%PRS 53.9%
-
CSI 4.0rCSI 3.7%PRS 75.3%
-
CSI 4.1rCSI 5.0%PRS 72.0%
-
CSI 4.2rCSI 23.4%PRS 79.4%
-
CSI 4.2rCSI 10.8%PRS 64.5%
-
CSI 4.4rCSI 12.9%PRS 73.5%
-
CSI 4.4rCSI 3.8%PRS 63.1%
-
CSI 4.5rCSI 8.4%PRS 62.3%
-
CSI 4.5rCSI 7.2%PRS 66.1%
-
CSI 4.8rCSI 19.4%PRS 73.9%
-
CSI 4.8rCSI 18.9%PRS 51.9%
-
CSI 5.0rCSI 13.8%PRS 69.3%
-
CSI 5.1rCSI 11.5%PRS 69.1%
-
CSI 5.1rCSI 26.8%PRS 76.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 669540766
Symbol: RFX2_HUMAN
Name: DNA-binding protein RFX2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8289803
Title: RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.
PubMed ID: 8289803
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 10330134
Title: Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.
PubMed ID: 10330134
Sequence Information:
- Length: 723
- Mass: 79987
- Checksum: 0F299954977A9218
- Sequence:
MQNSEGGADS PASVALRPSA AAPPVPASPQ RVLVQAASSN PKGAQMQPIS LPRVQQVPQQ VQPVQHVYPA QVQYVEGGDA VYTNGAIRTA YTYNPEPQMY APSSTASYFE APGGAQVTVA ASSPPAVPSH SMVGITMDVG GSPIVSSAGA YLIHGGMDST RHSLAHTSRS SPATLEMAIE NLQKSEGITS HKSGLLNSHL QWLLDNYETA EGVSLPRSSL YNHYLRHCQE HKLDPVNAAS FGKLIRSVFM GLRTRRLGTR GNSKYHYYGI RLKPDSPLNR LQEDTQYMAM RQQPMHQKPR YRPAQKTDSL GDSGSHSGLH STPEQTMAVQ SQHHQQYIDV SHVFPEFPAP DLGSFLLQDG VTLHDVKALQ LVYRRHCEAT VDVVMNLQFH YIEKLWLSFW NSKASSSDGP TSLPASDEDP EGAVLPKDKL ISLCQCDPIL RWMRSCDHIL YQALVEILIP DVLRPVPSTL TQAIRNFAKS LEGWLTNAMS DFPQQVIQTK VGVVSAFAQT LRRYTSLNHL AQAARAVLQN TSQINQMLSD LNRVDFANVQ EQASWVCQCE ESVVQRLEQD FKLTLQQQSS LDQWASWLDS VVTQVLKQHA GSPSFPKAAR QFLLKWSFYS SMVIRDLTLR SAASFGSFHL IRLLYDEYMF YLVEHRVAEA TGETPIAVMG EFNDLASLSL TLLDKDDMGD EQRGSEAGPD ARSLGEPLVK RERSDPNHSL QGI