Details for: RGS16

Gene ID: 6004

Symbol: RGS16

Ensembl ID: ENSG00000143333

Description: regulator of G protein signaling 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.4386
    Cell Significance Index: -23.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.1426
    Cell Significance Index: -23.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 58.0656
    Cell Significance Index: -23.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3218
    Cell Significance Index: -22.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 9.8691
    Cell Significance Index: 76.0700
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 8.9906
    Cell Significance Index: 51.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6786
    Cell Significance Index: -20.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1274
    Cell Significance Index: -18.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9433
    Cell Significance Index: -23.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.6295
    Cell Significance Index: 99.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2346
    Cell Significance Index: 64.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5566
    Cell Significance Index: 81.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3881
    Cell Significance Index: 15.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6722
    Cell Significance Index: 11.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4958
    Cell Significance Index: 27.8200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.4859
    Cell Significance Index: 4.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4841
    Cell Significance Index: 57.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4310
    Cell Significance Index: 42.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4251
    Cell Significance Index: 383.8200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.3963
    Cell Significance Index: 1.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3221
    Cell Significance Index: 4.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3178
    Cell Significance Index: 3.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3105
    Cell Significance Index: 55.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2782
    Cell Significance Index: 35.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2340
    Cell Significance Index: 38.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2032
    Cell Significance Index: 24.9800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1972
    Cell Significance Index: 2.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1873
    Cell Significance Index: 20.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1597
    Cell Significance Index: 7.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1152
    Cell Significance Index: 3.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1094
    Cell Significance Index: 5.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0990
    Cell Significance Index: 13.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0905
    Cell Significance Index: 17.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0870
    Cell Significance Index: 65.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0836
    Cell Significance Index: 45.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0775
    Cell Significance Index: 4.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0744
    Cell Significance Index: 26.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0610
    Cell Significance Index: 4.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0495
    Cell Significance Index: 1.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0443
    Cell Significance Index: 3.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0323
    Cell Significance Index: 0.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0217
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0001
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0012
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0099
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0196
    Cell Significance Index: -26.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0272
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0276
    Cell Significance Index: -20.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0283
    Cell Significance Index: -8.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0344
    Cell Significance Index: -15.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0453
    Cell Significance Index: -2.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0538
    Cell Significance Index: -5.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0561
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0598
    Cell Significance Index: -12.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0626
    Cell Significance Index: -10.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0947
    Cell Significance Index: -18.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1020
    Cell Significance Index: -20.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1115
    Cell Significance Index: -16.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1140
    Cell Significance Index: -13.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1321
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1373
    Cell Significance Index: -15.6800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1434
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1677
    Cell Significance Index: -19.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1687
    Cell Significance Index: -6.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1734
    Cell Significance Index: -4.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1832
    Cell Significance Index: -12.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1976
    Cell Significance Index: -9.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1982
    Cell Significance Index: -12.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2281
    Cell Significance Index: -6.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2289
    Cell Significance Index: -23.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2377
    Cell Significance Index: -4.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2642
    Cell Significance Index: -20.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2864
    Cell Significance Index: -5.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2873
    Cell Significance Index: -17.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2985
    Cell Significance Index: -9.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3329
    Cell Significance Index: -25.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3449
    Cell Significance Index: -9.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3453
    Cell Significance Index: -23.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3491
    Cell Significance Index: -22.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3784
    Cell Significance Index: -13.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3829
    Cell Significance Index: -8.1600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3977
    Cell Significance Index: -3.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3988
    Cell Significance Index: -9.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4003
    Cell Significance Index: -6.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4027
    Cell Significance Index: -11.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4643
    Cell Significance Index: -21.6500
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.4763
    Cell Significance Index: -5.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5203
    Cell Significance Index: -19.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5259
    Cell Significance Index: -23.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5278
    Cell Significance Index: -4.8600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5569
    Cell Significance Index: -3.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5604
    Cell Significance Index: -14.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6065
    Cell Significance Index: -9.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6088
    Cell Significance Index: -17.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS16 is a member of the regulator of G-protein signaling (RGS) family, which comprises a group of proteins that negatively regulate G-protein coupled receptor signaling. RGS16 is specifically involved in the regulation of G-protein coupled receptor signaling events, particularly those mediated by Gαi, Gαq, and Gαz subunits. Its expression is widespread, with significant levels detected in various cell types, including thyroid follicular cells, B-2 B cells, GABAergic amacrine cells, and inflammatory cells. **Pathways and Functions:** RGS16's primary function is to act as a GTPase activator, accelerating the hydrolysis of GTP to GDP in G-protein α subunits. This process terminates the signaling cascade, thereby modulating the cellular response to GPCR stimulation. RGS16's involvement in GPCR signaling pathways is exemplified by its binding to calmodulin, a calcium-binding protein, which facilitates its interaction with G-proteins. The protein's ability to regulate G-protein coupled receptor signaling events is further underscored by its association with various signaling pathways, including Gαi, Gαq, and Gαz signaling events, as well as its involvement in the regulation of G-protein coupled receptor signaling pathway. **Clinical Significance:** RGS16's dysregulation has been implicated in various diseases, including thyroid disorders, inflammatory conditions, and visual disorders. For instance, alterations in RGS16 expression have been observed in thyroid follicular cells, suggesting a potential link between RGS16 dysfunction and thyroid disease. Additionally, RGS16's involvement in GPCR signaling pathways has been implicated in the pathogenesis of inflammatory conditions, such as arthritis and asthma. Furthermore, the protein's role in regulating G-protein coupled receptor signaling events has been linked to visual disorders, including retinal degeneration and glaucoma. In conclusion, RGS16 is a vital gene that plays a crucial role in regulating G-protein coupled receptor signaling pathways. Its dysregulation has far-reaching implications for various diseases, underscoring the importance of RGS16 in maintaining cellular homeostasis. Further research is necessary to elucidate the mechanisms underlying RGS16's function and to explore its therapeutic potential in disease treatment. **Signaling Pathways:** 1. Calmodulin binding 2. Cytoplasm 3. G alpha (i) signalling events 4. G alpha (q) signalling events 5. G alpha (z) signalling events 6. Gpcr downstream signalling 7. G protein-coupled receptor signaling pathway 8. Gtpase activator activity 9. Gtpase activity 10. Membrane 11. Negative regulation of signal transduction 12. Plasma membrane 13. Positive regulation of gtpase activity 14. Protein binding 15. Regulation of g protein-coupled receptor signaling pathway 16. Signaling by gpcr 17. Signal transduction 18. Visual perception **Significantly Expressed Cells:** 1. Thyroid follicular cell 2. B-2 B cell 3. GABAergic amacrine cell 4. Inflammatory cell 5. Glycinergic neuron 6. Rod bipolar cell 7. Mueller cell 8. Type II pneumocyte 9. Glycinergic amacrine cell 10. Pneumocyte

Genular Protein ID: 3432602309

Symbol: RGS16_HUMAN

Name: Regulator of G-protein signaling 16

UniProtKB Accession Codes:

O15492 B2R4M4 Q5VYN9 Q99701

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9223279

Title: The p53 tumor suppressor targets a novel regulator of G protein signaling.

PubMed ID: 9223279

DOI: 10.1073/pnas.94.15.7868

PubMed ID: 9469939

Title: Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene.

PubMed ID: 9469939

DOI: 10.1016/s0378-1119(97)00593-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11602604

Title: RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation.

PubMed ID: 11602604

DOI: 10.1074/jbc.m108862200

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

Sequence Information:

  • Length: 202
  • Mass: 22749
  • Checksum: 19B384E935F3E5D1
  • Sequence:
    • MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL 
GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE 
FICSEAPKEV NIDHETHELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL 
AAQASAASAT LSSCSLDEPS HT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.