Details for: ABCE1

Gene ID: 6059

Symbol: ABCE1

Ensembl ID: ENSG00000164163

Description: ATP binding cassette subfamily E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 218.2002
    Cell Significance Index: -33.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.5162
    Cell Significance Index: -32.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.1506
    Cell Significance Index: -42.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.1339
    Cell Significance Index: -34.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.5683
    Cell Significance Index: -39.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.2611
    Cell Significance Index: -34.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.2234
    Cell Significance Index: -39.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3419
    Cell Significance Index: -38.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.4421
    Cell Significance Index: -41.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.8297
    Cell Significance Index: -27.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6579
    Cell Significance Index: -16.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5728
    Cell Significance Index: 177.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8157
    Cell Significance Index: 211.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0674
    Cell Significance Index: 146.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0488
    Cell Significance Index: 30.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0063
    Cell Significance Index: 13.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0052
    Cell Significance Index: 27.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9960
    Cell Significance Index: 70.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8532
    Cell Significance Index: 104.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8479
    Cell Significance Index: 170.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8476
    Cell Significance Index: 168.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8279
    Cell Significance Index: 366.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7970
    Cell Significance Index: 37.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7899
    Cell Significance Index: 142.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7866
    Cell Significance Index: 50.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7749
    Cell Significance Index: 20.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7377
    Cell Significance Index: 8.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5734
    Cell Significance Index: 74.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5513
    Cell Significance Index: 301.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4209
    Cell Significance Index: 8.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4208
    Cell Significance Index: 150.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4172
    Cell Significance Index: 19.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4093
    Cell Significance Index: 30.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3941
    Cell Significance Index: 272.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3769
    Cell Significance Index: 19.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3382
    Cell Significance Index: 9.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3172
    Cell Significance Index: 16.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2933
    Cell Significance Index: 18.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2743
    Cell Significance Index: 46.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2325
    Cell Significance Index: 44.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2096
    Cell Significance Index: 11.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2049
    Cell Significance Index: 24.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1772
    Cell Significance Index: 28.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1742
    Cell Significance Index: 22.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1238
    Cell Significance Index: 5.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1082
    Cell Significance Index: 3.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0936
    Cell Significance Index: 2.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0901
    Cell Significance Index: 5.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0605
    Cell Significance Index: 1.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0507
    Cell Significance Index: 2.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0337
    Cell Significance Index: 63.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0290
    Cell Significance Index: 0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0196
    Cell Significance Index: 12.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0173
    Cell Significance Index: 15.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0091
    Cell Significance Index: 13.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0080
    Cell Significance Index: 14.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0134
    Cell Significance Index: -18.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0314
    Cell Significance Index: -2.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0424
    Cell Significance Index: -0.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0447
    Cell Significance Index: -25.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0612
    Cell Significance Index: -0.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0847
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0945
    Cell Significance Index: -19.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1122
    Cell Significance Index: -7.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1131
    Cell Significance Index: -32.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1163
    Cell Significance Index: -2.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1221
    Cell Significance Index: -13.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1324
    Cell Significance Index: -13.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1469
    Cell Significance Index: -21.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1575
    Cell Significance Index: -18.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1697
    Cell Significance Index: -3.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1825
    Cell Significance Index: -3.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2167
    Cell Significance Index: -1.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2179
    Cell Significance Index: -4.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2470
    Cell Significance Index: -7.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2585
    Cell Significance Index: -11.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3160
    Cell Significance Index: -2.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3647
    Cell Significance Index: -13.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3660
    Cell Significance Index: -38.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3897
    Cell Significance Index: -10.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4013
    Cell Significance Index: -3.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4014
    Cell Significance Index: -31.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4359
    Cell Significance Index: -11.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4921
    Cell Significance Index: -15.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5589
    Cell Significance Index: -34.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5608
    Cell Significance Index: -13.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6215
    Cell Significance Index: -10.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6533
    Cell Significance Index: -13.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6998
    Cell Significance Index: -15.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7166
    Cell Significance Index: -20.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7209
    Cell Significance Index: -18.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7368
    Cell Significance Index: -18.9400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.7421
    Cell Significance Index: -5.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7486
    Cell Significance Index: -12.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ABCE1 is a member of the ABC transporter family, characterized by its unique structure and function. Some key characteristics of ABCE1 include: 1. **ATP-binding cassette structure**: ABCE1 contains a characteristic ABC transporter fold, consisting of two transmembrane domains (TMDs) and two cytoplasmic domains (CPDs). 2. **Substrate specificity**: ABCE1 has been shown to transport a wide range of substrates, including proteins, lipids, and small molecules. 3. **ER membrane localization**: ABCE1 is primarily localized to the ER membrane, where it regulates protein quality control and translation. 4. **Cell-type restricted expression**: ABCE1 is highly expressed in specific cell types, such as skeletal muscle satellite stem cells and basal cells of prostate epithelium. **Pathways and Functions** ABCE1 is involved in multiple cellular pathways, including: 1. **Protein quality control**: ABCE1 regulates protein folding and degradation by transporting misfolded proteins to the ER for degradation. 2. **Translation regulation**: ABCE1 modulates translation initiation and termination by regulating the availability of ribosomes and translation factors. 3. **Antiviral defense**: ABCE1 has been implicated in the regulation of antiviral responses, particularly in the context of interferon-stimulated genes. 4. **Immune system regulation**: ABCE1 is involved in the regulation of cytokine signaling and immune response, particularly in the context of interferon-alpha/beta signaling. **Clinical Significance** ABCE1 has been implicated in various diseases and disorders, including: 1. **Muscular dystrophy**: ABCE1 has been shown to be involved in the regulation of protein quality control and translation in skeletal muscle, making it a potential therapeutic target for muscular dystrophy. 2. **Cancer**: ABCE1 has been implicated in the regulation of cell growth and survival, making it a potential therapeutic target for cancer treatment. 3. **Neurodegenerative disorders**: ABCE1 has been shown to be involved in the regulation of protein quality control and translation in neurons, making it a potential therapeutic target for neurodegenerative disorders such as Alzheimer's disease. In conclusion, ABCE1 is a critical component of the ER membrane that plays a vital role in various cellular processes, including protein quality control, translation regulation, and antiviral defense. Its expression is highly restricted to specific cell types, suggesting its specialized role in maintaining cellular homeostasis. Further research is needed to fully understand the clinical significance of ABCE1 and its potential therapeutic applications.

Genular Protein ID: 2629474618

Symbol: ABCE1_HUMAN

Name: ATP-binding cassette sub-family E member 1

UniProtKB Accession Codes:

P61221 O88793 Q13181 Q13864 Q6NR76 Q96AL0 Q96B10 Q99K66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 CarbonylDB 1 ChEBI 22 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 6 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7539425

Title: Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway.

PubMed ID: 7539425

DOI: 10.1074/jbc.270.22.13308

PubMed ID: 8641422

Title: Chromosomal localization and expression pattern of the RNase L inhibitor gene.

PubMed ID: 8641422

DOI: 10.1016/0014-5793(96)00099-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9660177

Title: RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells.

PubMed ID: 9660177

DOI: 10.1046/j.1432-1327.1998.2540248.x

PubMed ID: 9847332

Title: RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells.

PubMed ID: 9847332

DOI: 10.1128/jvi.73.1.290-296.1999

PubMed ID: 11585831

Title: The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells.

PubMed ID: 11585831

DOI: 10.1074/jbc.m107482200

PubMed ID: 11780123

Title: Identification of a host protein essential for assembly of immature HIV-1 capsids.

PubMed ID: 11780123

DOI: 10.1038/415088a

PubMed ID: 14747530

Title: Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells.

PubMed ID: 14747530

DOI: 10.1128/jvi.78.4.1645-1656.2004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20122402

Title: The role of ABCE1 in eukaryotic posttermination ribosomal recycling.

PubMed ID: 20122402

DOI: 10.1016/j.molcel.2009.12.034

PubMed ID: 21448132

Title: Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.

PubMed ID: 21448132

DOI: 10.1038/emboj.2011.93

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29861391

Title: Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.

PubMed ID: 29861391

DOI: 10.1016/j.cmet.2018.05.007

PubMed ID: 17488105

Title: Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.

PubMed ID: 17488105

DOI: 10.1021/pr0700908

Sequence Information:

  • Length: 599
  • Mass: 67314
  • Checksum: 5D582B62E95BC7A6
  • Sequence:
    • MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI 
CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL 
KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA 
KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF 
DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT 
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF 
ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS 
TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA 
DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS 
KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.