Details for: RP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: photoreceptor cell (CL0000210)
Fold Change: 14.2492
Cell Significance Index: 200.1300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 11.4792
Cell Significance Index: 723.5000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 5.5617
Cell Significance Index: -5.3100 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 1.5524
Cell Significance Index: 19.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.9988
Cell Significance Index: 145.1900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.7636
Cell Significance Index: 10.8700 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.6859
Cell Significance Index: 6.7100 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.5923
Cell Significance Index: 5.8700 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.4159
Cell Significance Index: 3.2000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3613
Cell Significance Index: 4.9300 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.3488
Cell Significance Index: 2.0900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2706
Cell Significance Index: 498.9900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2250
Cell Significance Index: 122.8700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.2156
Cell Significance Index: 4.9800 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.2007
Cell Significance Index: 1.2400 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.1287
Cell Significance Index: 1.5600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1198
Cell Significance Index: 8.9300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1167
Cell Significance Index: 2.0000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0891
Cell Significance Index: 61.6200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0864
Cell Significance Index: 1.0300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0749
Cell Significance Index: 14.8600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0598
Cell Significance Index: 43.8300 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.0414
Cell Significance Index: 0.3800 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.0360
Cell Significance Index: 0.3900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0330
Cell Significance Index: 1.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0319
Cell Significance Index: 11.4600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0239
Cell Significance Index: 36.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0213
Cell Significance Index: 40.0200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0130
Cell Significance Index: 8.2500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0122
Cell Significance Index: 16.6100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0091
Cell Significance Index: 0.1300 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.0029
Cell Significance Index: 0.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0064
Cell Significance Index: -2.9000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0078
Cell Significance Index: -5.8700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0081
Cell Significance Index: -1.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0091
Cell Significance Index: -6.7200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0110
Cell Significance Index: -6.2000 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0218
Cell Significance Index: -0.1800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0221
Cell Significance Index: -6.3600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0243
Cell Significance Index: -4.8700 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.0261
Cell Significance Index: -0.2400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0267
Cell Significance Index: -4.8100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0286
Cell Significance Index: -1.4900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0319
Cell Significance Index: -6.7100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0338
Cell Significance Index: -2.0800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0384
Cell Significance Index: -6.5500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0404
Cell Significance Index: -1.1900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0414
Cell Significance Index: -5.6900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0440
Cell Significance Index: -5.4100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0453
Cell Significance Index: -5.8500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0499
Cell Significance Index: -5.8100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0525
Cell Significance Index: -5.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0562
Cell Significance Index: -2.9500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0565
Cell Significance Index: -6.4800 - Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.0572
Cell Significance Index: -0.5600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0586
Cell Significance Index: -2.9600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0587
Cell Significance Index: -6.0000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0711
Cell Significance Index: -5.6300 - Cell Name: S cone cell (CL0003050)
Fold Change: -0.0721
Cell Significance Index: -0.8400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0741
Cell Significance Index: -4.9800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0743
Cell Significance Index: -3.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0750
Cell Significance Index: -5.7600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0792
Cell Significance Index: -0.9000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0793
Cell Significance Index: -1.9200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0913
Cell Significance Index: -2.5500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0989
Cell Significance Index: -3.6300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1087
Cell Significance Index: -4.8100 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.1168
Cell Significance Index: -1.6600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1215
Cell Significance Index: -4.6000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1307
Cell Significance Index: -6.7900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1313
Cell Significance Index: -6.1700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1315
Cell Significance Index: -6.1300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1381
Cell Significance Index: -3.5500 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.1422
Cell Significance Index: -1.7900 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.1492
Cell Significance Index: -1.8900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1674
Cell Significance Index: -5.4800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1704
Cell Significance Index: -5.3900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1727
Cell Significance Index: -6.0500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1764
Cell Significance Index: -6.2000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1809
Cell Significance Index: -3.5300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1848
Cell Significance Index: -8.0400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1890
Cell Significance Index: -6.0200 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.1894
Cell Significance Index: -2.1400 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.1916
Cell Significance Index: -1.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1935
Cell Significance Index: -4.0500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1952
Cell Significance Index: -5.5700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2037
Cell Significance Index: -5.8700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2047
Cell Significance Index: -4.9100 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.2058
Cell Significance Index: -2.6500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2189
Cell Significance Index: -5.3400 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.2214
Cell Significance Index: -1.9500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2230
Cell Significance Index: -5.9700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2264
Cell Significance Index: -6.4900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2273
Cell Significance Index: -6.0700 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.2317
Cell Significance Index: -2.3900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2322
Cell Significance Index: -6.3200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2407
Cell Significance Index: -6.3300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2429
Cell Significance Index: -6.0600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2433
Cell Significance Index: -6.5200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2435
Cell Significance Index: -3.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 813601132
Symbol: RP1_HUMAN
Name: Oxygen-regulated protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10391212
Title: Mutations in a novel retina-specific gene cause autosomal dominant retinitis pigmentosa.
PubMed ID: 10391212
DOI: 10.1038/10314
PubMed ID: 10391211
Title: Mutations in a gene encoding a new oxygen-regulated photoreceptor protein cause dominant retinitis pigmentosa.
PubMed ID: 10391211
DOI: 10.1038/10305
PubMed ID: 10401003
Title: A nonsense mutation in a novel gene is associated with retinitis pigmentosa in a family linked to the RP1 locus.
PubMed ID: 10401003
DOI: 10.1093/hmg/8.8.1541
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 11773008
Title: Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors.
PubMed ID: 11773008
PubMed ID: 22052604
Title: RP1 and autosomal dominant rod-cone dystrophy: Novel mutations, a review of published variants, and genotype-phenotype correlation.
PubMed ID: 22052604
DOI: 10.1002/humu.21640
PubMed ID: 10484783
Title: Mutations in the RP1 gene causing autosomal dominant retinitis pigmentosa.
PubMed ID: 10484783
PubMed ID: 11095597
Title: RP1 protein truncating mutations predominate at the RP1 adRP locus.
PubMed ID: 11095597
PubMed ID: 11527933
Title: Clinical features and mutations in patients with dominant retinitis pigmentosa-1 (RP1).
PubMed ID: 11527933
PubMed ID: 12764676
Title: Hypertriglyceridemia associated with amino acid variation Asn985Tyr of the RP1 gene.
PubMed ID: 12764676
PubMed ID: 15863674
Title: Novel association of RP1 gene mutations with autosomal recessive retinitis pigmentosa.
PubMed ID: 15863674
PubMed ID: 15933747
Title: A novel missense RP1 mutation in retinitis pigmentosa.
PubMed ID: 15933747
PubMed ID: 19956407
Title: Molecular characterization of retinitis pigmentosa in Saudi Arabia.
PubMed ID: 19956407
PubMed ID: 20664799
Title: Differential pattern of RP1 mutations in retinitis pigmentosa.
PubMed ID: 20664799
PubMed ID: 22334370
Title: Next-generation genetic testing for retinitis pigmentosa.
PubMed ID: 22334370
DOI: 10.1002/humu.22045
Sequence Information:
- Length: 2156
- Mass: 240661
- Checksum: 55AEDBEC43D6A507
- Sequence:
MSDTPSTGFS IIHPTSSEGQ VPPPRHLSLT HPVVAKRISF YKSGDPQFGG VRVVVNPRSF KSFDALLDNL SRKVPLPFGV RNISTPRGRH SITRLEELED GESYLCSHGR KVQPVDLDKA RRRPRPWLSS RAISAHSPPH PVAVAAPGMP RPPRSLVVFR NGDPKTRRAV LLSRRVTQSF EAFLQHLTEV MQRPVVKLYA TDGRRVPSLQ AVILSSGAVV AAGREPFKPG NYDIQKYLLP ARLPGISQRV YPKGNAKSES RKISTHMSSS SRSQIYSVSS EKTHNNDCYL DYSFVPEKYL ALEKNDSQNL PIYPSEDDIE KSIIFNQDGT MTVEMKVRFR IKEEETIKWT TTVSKTGPSN NDEKSEMSFP GRTESRSSGL KLAACSFSAD VSPMERSSNQ EGSLAEEINI QMTDQVAETC SSASWENATV DTDIIQGTQD QAKHRFYRPP TPGLRRVRQK KSVIGSVTLV SETEVQEKMI GQFSYSEERE SGENKSEYHM FTHSCSKMSS VSNKPVLVQI NNNDQMEESS LERKKENSLL KSSAISAGVI EITSQKMLEM SHNNGLPSTI SNNSIVEEDV VDCVVLDNKT GIKNFKTYGN TNDRFSPISA DATHFSSNNS GTDKNISEAP ASEASSTVTA RIDRLINEFA QCGLTKLPKN EKKILSSVAS KKKKKSRQQA INSRYQDGQL ATKGILNKNE RINTKGRITK EMIVQDSDSP LKGGILCEED LQKSDTVIES NTFCSKSNLN STISKNFHRN KLNTTQNSKV QGLLTKRKSR SLNKISLGAP KKREIGQRDK VFPHNESKYC KSTFENKSLF HVFNILEQKP KDFYAPQSQA EVASGYLRGM AKKSLVSKVT DSHITLKSQK KRKGDKVKAS AILSKQHATT RANSLASLKK PDFPEAIAHH SIQNYIQSWL QNINPYPTLK PIKSAPVCRN ETSVVNCSNN SFSGNDPHTN SGKISNFVME SNKHITKIAG LTGDNLCKEG DKSFIANDTG EEDLHETQVG SLNDAYLVPL HEHCTLSQSA INDHNTKSHI AAEKSGPEKK LVYQEINLAR KRQSVEAAIQ VDPIEEETPK DLLPVLMLHQ LQASVPGIHK TQNGVVQMPG SLAGVPFHSA ICNSSTNLLL AWLLVLNLKG SMNSFCQVDA HKATNKSSET LALLEILKHI AITEEADDLK AAVANLVEST TSHFGLSEKE QDMVPIDLSA NCSTVNIQSV PKCSENERTQ GISSLDGGCS ASEACAPEVC VLEVTCSPCE MCTVNKAYSP KETCNPSDTF FPSDGYGVDQ TSMNKACFLG EVCSLTDTVF SDKACAQKEN HTYEGACPID ETYVPVNVCN TIDFLNSKEN TYTDNLDSTE ELERGDDIQK DLNILTDPEY KNGFNTLVSH QNVSNLSSCG LCLSEKEAEL DKKHSSLDDF ENCSLRKFQD ENAYTSFDME EPRTSEEPGS ITNSMTSSER NISELESFEE LENHDTDIFN TVVNGGEQAT EELIQEEVEA SKTLELIDIS SKNIMEEKRM NGIIYEIISK RLATPPSLDF CYDSKQNSEK ETNEGETKMV KMMVKTMETG SYSESSPDLK KCIKSPVTSD WSDYRPDSDS EQPYKTSSDD PNDSGELTQE KEYNIGFVKR AIEKLYGKAD IIKPSFFPGS TRKSQVCPYN SVEFQCSRKA SLYDSEGQSF GSSEQVSSSS SMLQEFQEER QDKCDVSAVR DNYCRGDIVE PGTKQNDDSR ILTDIEEGVL IDKGKWLLKE NHLLRMSSEN PGMCGNADTT SVDTLLDNNS SEVPYSHFGN LAPGPTMDEL SSSELEELTQ PLELKCNYFN MPHGSDSEPF HEDLLDVRNE TCAKERIANH HTEEKGSHQS ERVCTSVTHS FISAGNKVYP VSDDAIKNQP LPGSNMIHGT LQEADSLDKL YALCGQHCPI LTVIIQPMNE EDRGFAYRKE SDIENFLGFY LWMKIHPYLL QTDKNVFREE NNKASMRQNL IDNAIGDIFD QFYFSNTFDL MGKRRKQKRI NFLGLEEEGN LKKFQPDLKE RFCMNFLHTS LLVVGNVDSN TQDLSGQTNE IFKAVDENNN LLNNRFQGSR TNLNQVVREN INCHYFFEML GQACLLDICQ VETSLNISNR NILELCMFEG ENLFIWEEED ILNLTDLESS REQEDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.