Details for: RPL4

Gene ID: 6124

Symbol: RPL4

Ensembl ID: ENSG00000174444

Description: ribosomal protein L4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 456.6843
    Cell Significance Index: -188.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 428.6448
    Cell Significance Index: -174.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 389.2633
    Cell Significance Index: -183.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 372.7362
    Cell Significance Index: -191.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 275.1176
    Cell Significance Index: -184.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 185.6416
    Cell Significance Index: -177.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.0558
    Cell Significance Index: 435.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2154
    Cell Significance Index: -40.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.5319
    Cell Significance Index: 147.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 11.4792
    Cell Significance Index: 1172.6000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.3123
    Cell Significance Index: 66.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.2077
    Cell Significance Index: 299.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.7193
    Cell Significance Index: 372.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.3924
    Cell Significance Index: 217.5300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 9.6903
    Cell Significance Index: 77.3700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.5989
    Cell Significance Index: 169.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 9.1921
    Cell Significance Index: 99.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.9751
    Cell Significance Index: 236.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.7519
    Cell Significance Index: 411.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.3572
    Cell Significance Index: 1079.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.3427
    Cell Significance Index: 1008.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.8750
    Cell Significance Index: 512.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 6.7014
    Cell Significance Index: 473.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.5400
    Cell Significance Index: 804.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.1522
    Cell Significance Index: 725.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.8022
    Cell Significance Index: 1045.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.6479
    Cell Significance Index: 2497.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.5865
    Cell Significance Index: 360.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.3558
    Cell Significance Index: 157.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.2774
    Cell Significance Index: 151.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.8420
    Cell Significance Index: 2644.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.7401
    Cell Significance Index: 53.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.2701
    Cell Significance Index: 98.6600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.2548
    Cell Significance Index: 26.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1759
    Cell Significance Index: 113.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.8800
    Cell Significance Index: 180.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.5756
    Cell Significance Index: 610.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.0385
    Cell Significance Index: 389.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9005
    Cell Significance Index: 26.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2671
    Cell Significance Index: 119.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1958
    Cell Significance Index: 58.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1889
    Cell Significance Index: 434.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0580
    Cell Significance Index: 107.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2705
    Cell Significance Index: 1147.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1984
    Cell Significance Index: 22.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.1908
    Cell Significance Index: 901.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0789
    Cell Significance Index: 31.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9088
    Cell Significance Index: 47.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5981
    Cell Significance Index: 59.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5046
    Cell Significance Index: 96.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3541
    Cell Significance Index: 16.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3130
    Cell Significance Index: 62.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2128
    Cell Significance Index: 156.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0622
    Cell Significance Index: -46.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0627
    Cell Significance Index: -117.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0771
    Cell Significance Index: -12.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0884
    Cell Significance Index: -31.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1059
    Cell Significance Index: -195.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1072
    Cell Significance Index: -12.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1287
    Cell Significance Index: -198.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1362
    Cell Significance Index: -76.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1453
    Cell Significance Index: -90.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1535
    Cell Significance Index: -208.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2514
    Cell Significance Index: -159.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2536
    Cell Significance Index: -8.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3097
    Cell Significance Index: -9.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3217
    Cell Significance Index: -67.7500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3247
    Cell Significance Index: -2.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3891
    Cell Significance Index: -176.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4049
    Cell Significance Index: -22.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5632
    Cell Significance Index: -162.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6062
    Cell Significance Index: -69.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6991
    Cell Significance Index: -11.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7210
    Cell Significance Index: -12.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8111
    Cell Significance Index: -51.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.1040
    Cell Significance Index: -76.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1566
    Cell Significance Index: -91.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1681
    Cell Significance Index: -169.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.7199
    Cell Significance Index: -179.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.8226
    Cell Significance Index: -122.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9613
    Cell Significance Index: -26.7600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.0110
    Cell Significance Index: -12.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.3331
    Cell Significance Index: -179.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.4439
    Cell Significance Index: -61.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.5244
    Cell Significance Index: -154.7700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.5555
    Cell Significance Index: -13.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.6137
    Cell Significance Index: -160.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.7126
    Cell Significance Index: -162.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9458
    Cell Significance Index: -63.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.3683
    Cell Significance Index: -99.2100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -3.7266
    Cell Significance Index: -23.1600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -4.0541
    Cell Significance Index: -84.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.1137
    Cell Significance Index: -181.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.1181
    Cell Significance Index: -110.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.1250
    Cell Significance Index: -70.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.1477
    Cell Significance Index: -152.2600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -4.3903
    Cell Significance Index: -33.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -4.4327
    Cell Significance Index: -52.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.5015
    Cell Significance Index: -67.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -4.9042
    Cell Significance Index: -185.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL4 is a conserved protein that belongs to the ribosomal protein family, which is essential for the structure and function of the 60S ribosomal subunit. It is highly expressed in various cell types, including hematopoietic stem cells, T cells, and epithelial cells. RPL4 is a key player in the translation process, interacting with other ribosomal proteins to facilitate the assembly of the 60S subunit and the elongation of the protein chain. **Pathways and Functions:** RPL4 is involved in several critical pathways, including: 1. **Translation Elongation:** RPL4 plays a crucial role in the elongation phase of translation, where it interacts with other ribosomal proteins to facilitate the assembly of the 60S subunit and the elongation of the protein chain. 2. **Cap-dependent Translation Initiation:** RPL4 is involved in the initiation of translation, where it interacts with the small nuclear ribonucleoprotein (snRNP) complex to facilitate the binding of the mRNA to the ribosome. 3. **Stress Response:** RPL4 is activated in response to stress, where it helps to regulate the expression of genes involved in the stress response. 4. **Amino Acid Metabolism:** RPL4 is involved in the regulation of amino acid metabolism, where it helps to regulate the synthesis and degradation of amino acids. **Clinical Significance:** RPL4 has been implicated in various diseases, including: 1. **Influenza Infection:** RPL4 has been shown to be a key player in the replication of influenza virus, where it interacts with the viral RNA to facilitate the translation of viral proteins. 2. **Neurological Disorders:** RPL4 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of protein synthesis and degradation. 3. **Cancer:** RPL4 has been shown to be overexpressed in various types of cancer, where it is involved in the regulation of protein synthesis and cell proliferation. In conclusion, RPL4 is a vital component of the 60S ribosomal subunit, playing a crucial role in the process of translation in eukaryotic cells. Its involvement in various pathways, including translation elongation, cap-dependent translation initiation, and stress response, highlights its importance in maintaining cellular homeostasis. Furthermore, its clinical significance in diseases such as influenza infection, neurological disorders, and cancer underscores the need for further research into the role of RPL4 in human disease. **References:** * [Insert references to relevant research articles and studies] **Future Directions:** Further research is needed to fully understand the role of RPL4 in eukaryotic translation and its implications in human disease. Future studies should focus on: 1. **Structural Analysis:** The structure of RPL4 and its interactions with other ribosomal proteins should be further elucidated. 2. **Functional Analysis:** The functional significance of RPL4 in various pathways, including translation elongation and stress response, should be further investigated. 3. **Therapeutic Applications:** The potential therapeutic applications of RPL4 in diseases such as influenza infection and cancer should be explored.

Genular Protein ID: 2197680161

Symbol: RL4_HUMAN

Name: 60S ribosomal protein L1

UniProtKB Accession Codes:

P36578 A8K502 P39029 Q4VBR0 Q969Z9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 15 EMDB 80 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 96 PDBsum 96 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268230

Title: Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein.

PubMed ID: 8268230

DOI: 10.1016/0167-4781(93)90017-8

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11823430

Title: Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.

PubMed ID: 11823430

DOI: 10.1093/emboj/21.3.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 427
  • Mass: 47697
  • Checksum: 4785ED31699CD792
  • Sequence:
    • MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH 
QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR MFAPTKTWRR WHRRVNTTQK 
RYAICSALAA SALPALVMSK GHRIEEVPEL PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI 
KKVYASQRMR AGKGKMRNRR RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL 
APGGHVGRFC IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR 
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR VDKAAAAAAA 
LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK AAATKKPAPE KKPAEKKPTT 
EEKKPAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.