Gene RPL4 - ENSG00000174444 | NCBI Gene ID: 6124

Details for: RPL4

Gene ID: 6124

Symbol: RPL4

Ensembl ID: ENSG00000174444

Description: ribosomal protein L4

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rough endoplasmic reticulum
(GO:0005791)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 8.33
Marker Score: 6284
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.26
Marker Score: 11019
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.24
Marker Score: 25744
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.07
Marker Score: 7814
Cell Name: malignant cell (CL0001064)
Fold Change: 4.91
Marker Score: 66009
Cell Name: mature T cell (CL0002419)
Fold Change: 4.79
Marker Score: 47443
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.79
Marker Score: 1766
Cell Name: naive T cell (CL0000898)
Fold Change: 4.79
Marker Score: 3083
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.78
Marker Score: 8204
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 4.66
Marker Score: 2629
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.57
Marker Score: 241513
Cell Name: naive B cell (CL0000788)
Fold Change: 4.55
Marker Score: 4066
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.52
Marker Score: 14271
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.47
Marker Score: 151924
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.41
Marker Score: 58107
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.4
Marker Score: 3444
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.37
Marker Score: 12744
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.26
Marker Score: 2589
Cell Name: theca cell (CL0000503)
Fold Change: 4.25
Marker Score: 3045
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.11
Marker Score: 2111
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.09
Marker Score: 9981.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4.04
Marker Score: 2928
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4
Marker Score: 11052
Cell Name: blood cell (CL0000081)
Fold Change: 3.97
Marker Score: 46179
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.97
Marker Score: 4242
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.95
Marker Score: 943
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.95
Marker Score: 16917
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.94
Marker Score: 11060
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.93
Marker Score: 2304
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.92
Marker Score: 3858
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.92
Marker Score: 1273
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.91
Marker Score: 3333
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.91
Marker Score: 4078
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.89
Marker Score: 217288
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.88
Marker Score: 5058
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.87
Marker Score: 3036.5
Cell Name: acinar cell (CL0000622)
Fold Change: 3.85
Marker Score: 2714.5
Cell Name: elicited macrophage (CL0000861)
Fold Change: 3.85
Marker Score: 23383
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.83
Marker Score: 3259
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.77
Marker Score: 4192
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.74
Marker Score: 1930
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.7
Marker Score: 2492
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.7
Marker Score: 19438
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.7
Marker Score: 3574
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.68
Marker Score: 23931
Cell Name: supporting cell (CL0000630)
Fold Change: 3.67
Marker Score: 6896
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.67
Marker Score: 23893
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.64
Marker Score: 1939.5
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.63
Marker Score: 26985
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.58
Marker Score: 3370
Cell Name: memory B cell (CL0000787)
Fold Change: 3.58
Marker Score: 2709
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.55
Marker Score: 8096
Cell Name: club cell (CL0000158)
Fold Change: 3.55
Marker Score: 4144
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.51
Marker Score: 2955
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.49
Marker Score: 1148
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.49
Marker Score: 3111
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.47
Marker Score: 1917
Cell Name: immature B cell (CL0000816)
Fold Change: 3.46
Marker Score: 2291
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.45
Marker Score: 1574
Cell Name: granulocyte (CL0000094)
Fold Change: 3.44
Marker Score: 1544
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.44
Marker Score: 3062
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.43
Marker Score: 8369
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.43
Marker Score: 786
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.42
Marker Score: 944
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.41
Marker Score: 5590
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.41
Marker Score: 3188
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.4
Marker Score: 4014
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.4
Marker Score: 2820
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.39
Marker Score: 1528
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 3.38
Marker Score: 2575
Cell Name: basophil (CL0000767)
Fold Change: 3.38
Marker Score: 1606
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.37
Marker Score: 2437
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.37
Marker Score: 957
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.36
Marker Score: 1399
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.35
Marker Score: 915
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.34
Marker Score: 26083
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.33
Marker Score: 2940
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.33
Marker Score: 1951
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.32
Marker Score: 875
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.32
Marker Score: 5283.5
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 3.32
Marker Score: 880
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.31
Marker Score: 3666
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.31
Marker Score: 12779
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.3
Marker Score: 2075
Cell Name: hepatocyte (CL0000182)
Fold Change: 3.3
Marker Score: 2253
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.29
Marker Score: 1053
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.29
Marker Score: 927
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.29
Marker Score: 2165
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.29
Marker Score: 7940.5
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.29
Marker Score: 5874
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.28
Marker Score: 1640
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.28
Marker Score: 7440
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.28
Marker Score: 2581
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.27
Marker Score: 8133
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.26
Marker Score: 5522
Cell Name: basal cell (CL0000646)
Fold Change: 3.26
Marker Score: 4210
Cell Name: centroblast (CL0009112)
Fold Change: 3.26
Marker Score: 1606
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.26
Marker Score: 4613
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.26
Marker Score: 2668
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.25
Marker Score: 1867

Hover over a box to see details here...

**Key characteristics:** - RPL4 is a large protein with a molecular weight of approximately 110 kDa. - It is a key component of the ribosome, which is responsible for translating mRNA into proteins. - RPL4 is expressed in a variety of cell types, including hematopoietic stem cells, immune cells, and cancer cells. - It is involved in the initiation of protein synthesis by interacting with the initiator complex of the ribosome. **Pathways and functions:** - RPL4 is involved in the initiation of protein synthesis by interacting with the initiator complex of the ribosome. - It is a key component of the ribosome, which is responsible for translating mRNA into proteins. - RPL4 helps to ensure that the ribosome is properly assembled and that it is able to initiate translation correctly. - It is also involved in the regulation of protein synthesis. **Clinical significance:** - Mutations in RPL4 have been linked to a number of human diseases, including cancer and autoimmune disorders. - These mutations can lead to the production of a defective ribosome that cannot initiate translation correctly. - This can result in the production of abnormal proteins that can cause a variety of symptoms, including cancer, autoimmune disorders, and developmental abnormalities. **Additional information:** - RPL4 is a highly conserved protein, with a similar protein found in other eukaryotes. - It is a well-studied protein that has been extensively characterized in both vitro and in vivo models. - RPL4 is a promising target for the development of new therapies for cancer and other diseases that are caused by mutations in this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L1

Genular Protein ID: 2197680161

Symbol: RL4_HUMAN

Name: 60S ribosomal protein L1

UniProtKB Accession Codes:

P36578 A8K502 P39029 Q4VBR0 Q969Z9

Database IDs:

Citations:

PubMed ID: 8268230

Title: Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein.

PubMed ID: 8268230

DOI: 10.1016/0167-4781(93)90017-8

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11823430

Title: Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.

PubMed ID: 11823430

DOI: 10.1093/emboj/21.3.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 427
Mass: 47697
Checksum: 4785ED31699CD792
Sequence:

MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH 
QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR MFAPTKTWRR WHRRVNTTQK 
RYAICSALAA SALPALVMSK GHRIEEVPEL PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI 
KKVYASQRMR AGKGKMRNRR RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL 
APGGHVGRFC IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR 
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR VDKAAAAAAA 
LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK AAATKKPAPE KKPAEKKPTT 
EEKKPAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPL4

Associated with

Cells (max top 100)

Other Information

Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. PubMed ID: 8268230

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. PubMed ID: 11823430

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547