Details for: RPL7

Gene ID: 6129

Symbol: RPL7

Ensembl ID: ENSG00000147604

Description: ribosomal protein L7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 608.8881
    Cell Significance Index: -250.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 527.0029
    Cell Significance Index: -248.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 491.3535
    Cell Significance Index: -252.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 373.1322
    Cell Significance Index: -250.3800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 40.8969
    Cell Significance Index: 240.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 21.9985
    Cell Significance Index: 561.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.1014
    Cell Significance Index: -51.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.2940
    Cell Significance Index: 1664.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 15.8124
    Cell Significance Index: 549.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 15.0804
    Cell Significance Index: 266.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.6553
    Cell Significance Index: 392.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.6133
    Cell Significance Index: 357.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 13.5341
    Cell Significance Index: 283.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 12.2065
    Cell Significance Index: 97.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 11.2617
    Cell Significance Index: 122.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.0738
    Cell Significance Index: 1430.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 10.3968
    Cell Significance Index: 774.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.0982
    Cell Significance Index: 103.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.9600
    Cell Significance Index: 421.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.5249
    Cell Significance Index: 1170.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.2652
    Cell Significance Index: 584.5500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.2486
    Cell Significance Index: 70.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.1209
    Cell Significance Index: 187.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.0915
    Cell Significance Index: 1037.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.0444
    Cell Significance Index: 989.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.9293
    Cell Significance Index: 416.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.6778
    Cell Significance Index: 1384.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.8097
    Cell Significance Index: 3010.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.8035
    Cell Significance Index: 3715.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.2821
    Cell Significance Index: 292.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.2150
    Cell Significance Index: 400.9600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.9212
    Cell Significance Index: 36.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.7980
    Cell Significance Index: 565.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.7639
    Cell Significance Index: 129.6700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.6632
    Cell Significance Index: 59.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.0557
    Cell Significance Index: 116.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.8070
    Cell Significance Index: 2881.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.7427
    Cell Significance Index: 3379.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.4830
    Cell Significance Index: 594.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1378
    Cell Significance Index: 28.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7104
    Cell Significance Index: 537.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.3893
    Cell Significance Index: 44.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1340
    Cell Significance Index: 56.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8902
    Cell Significance Index: 186.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8022
    Cell Significance Index: 52.9300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5734
    Cell Significance Index: 11.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2044
    Cell Significance Index: 34.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1039
    Cell Significance Index: 210.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.8327
    Cell Significance Index: 610.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.7946
    Cell Significance Index: 62.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4193
    Cell Significance Index: 68.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2906
    Cell Significance Index: 13.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0593
    Cell Significance Index: 3.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0349
    Cell Significance Index: 1.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0501
    Cell Significance Index: -10.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0828
    Cell Significance Index: -61.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0910
    Cell Significance Index: -171.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0955
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1322
    Cell Significance Index: -82.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1469
    Cell Significance Index: -270.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1769
    Cell Significance Index: -272.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1948
    Cell Significance Index: -109.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2127
    Cell Significance Index: -289.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3099
    Cell Significance Index: -10.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3312
    Cell Significance Index: -210.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3627
    Cell Significance Index: -130.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4113
    Cell Significance Index: -118.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4513
    Cell Significance Index: -95.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4617
    Cell Significance Index: -7.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5074
    Cell Significance Index: -230.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5523
    Cell Significance Index: -63.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9197
    Cell Significance Index: -105.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9866
    Cell Significance Index: -60.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1021
    Cell Significance Index: -18.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5290
    Cell Significance Index: -222.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6358
    Cell Significance Index: -113.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6882
    Cell Significance Index: -42.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.8473
    Cell Significance Index: -200.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.8921
    Cell Significance Index: -119.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.0424
    Cell Significance Index: -12.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.3849
    Cell Significance Index: -248.3200
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -2.9059
    Cell Significance Index: -6.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9855
    Cell Significance Index: -64.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.0763
    Cell Significance Index: -236.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.1224
    Cell Significance Index: -209.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.2375
    Cell Significance Index: -198.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.8134
    Cell Significance Index: -57.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.0309
    Cell Significance Index: -242.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -4.0518
    Cell Significance Index: -48.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.3639
    Cell Significance Index: -59.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.3644
    Cell Significance Index: -128.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.0105
    Cell Significance Index: -183.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.1965
    Cell Significance Index: -43.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.4239
    Cell Significance Index: -239.9100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -5.5846
    Cell Significance Index: -34.7000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -5.7610
    Cell Significance Index: -26.6000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -5.9590
    Cell Significance Index: -76.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.0526
    Cell Significance Index: -162.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -6.1534
    Cell Significance Index: -310.9800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.3710
    Cell Significance Index: -34.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL7 is a 90-kDa protein that belongs to the ribosomal protein L7 family. It is highly conserved across species, with high sequence identity between human and other eukaryotes. RPL7 is a component of the large ribosomal subunit, which is responsible for protein synthesis. It is also involved in the regulation of translation initiation and elongation, as well as the response to cellular stress and apoptosis. RPL7 has been shown to interact with various proteins, including eukaryotic translation initiation factor 2 alpha (eIF2α), which plays a key role in the response to amino acid deficiency and stress. **Pathways and Functions** RPL7 is involved in several key pathways, including: 1. **Translation initiation**: RPL7 plays a crucial role in the assembly and function of ribosomes, ensuring the accurate initiation of translation. 2. **Translation elongation**: RPL7 is involved in the elongation phase of translation, where it interacts with eIF2α to regulate the translation of mRNAs. 3. **Stress response**: RPL7 is activated in response to cellular stress, leading to the activation of stress-related genes and the regulation of protein synthesis. 4. **Apoptosis**: RPL7 has been shown to regulate apoptosis, with dysregulation of RPL7 leading to increased cell survival and resistance to apoptosis. 5. **Immune regulation**: RPL7 is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. **Clinical Significance** Dysregulation of RPL7 has been implicated in several diseases, including: 1. **Cancer**: RPL7 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Metabolic disorders**: RPL7 dysregulation has been linked to metabolic disorders, including type 2 diabetes and obesity. 3. **Infectious diseases**: RPL7 has been shown to play a role in the response to viral infections, including influenza and HIV. 4. **Neurodegenerative diseases**: RPL7 dysregulation has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's. In conclusion, RPL7 is a critical component of the eukaryotic ribosome, involved in multiple cellular pathways, including translation initiation, elongation, and stress response. Dysregulation of RPL7 has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the role of RPL7 in human health and disease.

Genular Protein ID: 3442535749

Symbol: RL7_HUMAN

Name: 60S ribosomal protein L7

UniProtKB Accession Codes:

P18124 A8K504 Q15289 Q3KQU0 Q5I0X1 Q6IBM9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 80 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 94 PDBsum 94 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441630

Title: Structural and functional properties of ribosomal protein L7 from humans and rodents.

PubMed ID: 8441630

DOI: 10.1093/nar/21.2.223

PubMed ID: 8360149

Title: Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene.

PubMed ID: 8360149

DOI: 10.1016/s0021-9258(17)46650-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7862521

Title: Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells.

PubMed ID: 7862521

DOI: 10.1093/nar/23.2.195

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 248
  • Mass: 29226
  • Checksum: 070EB4C904E6795A
  • Sequence:
    • MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI YEKAKHYHKE 
YRQMYRTEIR MARMARKAGN FYVPAEPKLA FVIRIRGING VSPKVRKVLQ LLRLRQIFNG 
TFVKLNKASI NMLRIVEPYI AWGYPNLKSV NELIYKRGYG KINKKRIALT DNALIARSLG 
KYGIICMEDL IHEIYTVGKR FKEANNFLWP FKLSSPRGGM KKKTTHFVEG GDAGNREDQI 
NRLIRRMN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.